Name: _______________________
Period:_________________________
On-line Karyotyping
Objectives:
 To understand that homologous chromosomes are a matching pair – each coming from a
different gamete.
 To understand how a karyotype is made.
 To determine what types of information we can obtain from a karyotype.
 To know how to interpret a karyotype.
Part 1
1.
Go to http://www.lancaster.k12.oh.us/olc/teacher.aspx?s=412 click on Biology Tech, then on
Karyotyping File, Web Karyotyping.
2. Read the introduction VERY CAREFULLY!
3. Complete Patient A’s karyotype by matching the homologous chromosomes (look carefully for
patterns):
4. Answer the following questions:
a. What notation would you use to characterize Patient A's karyotype?
b. What diagnosis would you give patient A?
5. Continue the activity with patient B and C:
a. What notation would you use to characterize Patient B's karyotype?
b. What diagnosis would you give patient B?
c. What notation would you use to characterize Patient B's karyotype?
d. What diagnosis would you give patient B?
Part II
1. Go back to http://www.lancaster.k12.oh.us/olc/teacher.aspx?s=412 Biology Tech, Karyotyping
File.
2. Click on Down syndrome link to read and view video.
3. Answer the following questions:
a. What is nondisjunction?
b. Which chromosome is involved in Down syndrome?
c. What is the life expectancy of someone with Down syndrome?
d. What percentage of time does the extra chromosome come from mom? From dad?
e. When was Down syndrome first described?
f.
When was the syndrome discovered to be caused by as extra 21st chromosome?
4. Go back to http://www.lancaster.k12.oh.us/olc/teacher.aspx?s=412 to access the videos on
Turner and Klinefelter syndromes.
5. Create a graphic organizer below to compare and contrast Down syndrome, Turner syndrome
and Klinfelter syndrome.
Part III
1. Take a few minutes to look around both of the websites (Learn Genetics and Web Karyotyping)
you visited today.
2. When you find something interesting, look through it and then write one paragraph about what
you learned.
Site:_________________________
Activity:____________________________
Paragraph: