Online Karyotyping Activity - (LS 5-8)
Objectives:
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To understand that homologous chromosomes are a matching pair – each
coming from a different gamete;
To understand how a karyotype is made;
To determine what types of information we can obtain from a karyotype;
To know how to interpret a karyotype.
PART 1
 Go to website:
http://www.biology.arizona.edu/human_bio/activities/karyotyping/karyotyping.html
 Read Introduction – Very Carefully!
 Go to Patient Histories – check those out;
 Complete Patient A Karyotype by matching homologous chromosomes (look
carefully for patterns):
o Answer Questions A1 and A2 on a clean sheet of paper.
 Continue the Activity with patient B and patient C:
o Answer B1 & B2 and C1 & C2 on the same page as Patient A answers.
PART 2
 Go to website:
http://learn.genetics.utah.edu/search/index.cfm?qt=nondisjunction&search=Search
 Read about Down Syndrome and view the video on Trisomy.
 Answer the following questions:
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What is Nondisjunction?
Which chromosome is involved with Down Syndrome?
What is the life expectancy of someone with Down Syndrome?
Does the extra chromosome usually come from the mother or the father?
What is the percentage?
o When was Down Syndrome first described? When was it discovered to
be caused by an extra #21 chromosome?
 Read and view the videos about Turner Syndrome and Klinefelter Syndrome.
 On a separate sheet of paper using a graphic organizer (Chart, Venn Diagram,
etc) compare and Contrast Down Syndrome, Turner Syndrome, and Klinefelter
Syndrome.
PART 3
 Take 5-10 minutes to look around each of the two websites.
 Find something that grabs your attention and write one paragraph about what
you have learned. Be sure to put this in your own words!