ABIO540 SBDG 107 Cancer Biology MW 1:00‐2:15 pm 3 credit hours Instructor: Dr. Stephanie J. Muga Office: SBDG 208 Phone: 803.641.3371 Email: stephaniem@usca.edu Office Hours: By Appointment Required lecture text: The Biology of Cancer, Robert A. Weinberg Course Objectives: This course will introduce the student to human cancer biology. Upon completion of this course, students will be expected to understand the following: 1.
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The basic biochemical operations of dysfunctional cells and tissues including gene expression. The pathology of cancer. Growth factor signaling and oncogenes Cell Cycle. Growth inhibition and tumor suppressor genes. Apoptosis. Stem Cells and Differentiation. Cell Immortalization and Multistep Tumorigenesis Invasion and Metastasis. The role of inflammation and inflammatory processes in cancer. Nutrients, hormones, and gene interactions. The Cancer industry: diagnostics, therapeutics, immunotherapy. Methods of Presentation and Evaluation: Information will be presented through lectures and class discussion along with appropriate visual aids, usually presented in PowerPoint format. Traditional lecture exams will be used to evaluate student progress in the class. These exams will consist largely of discussion questions and from time to time will include multiple choice questions and questions regarding terms/definitions. Students are expected to read book chapters on their own. 4 Lecture exams @ 100 pts. each 400 1 Final exam @ 100 pts. 100 Attendance & Participation 100 600 total points available Changes: The instructor reserves the right to make changes in the lecture schedule, number of exams given, grading scheme, and the contents of each exam as deemed necessary. Attendance Policy: It is mandatory for students to attend lecture class; the instructor may impose a penalty for absences in excess of 25% of regularly scheduled class meetings (lectures and labs) by assigning an “F” in the course. Absences, neither excused nor unexcused, do not absolve the student from meeting class assignments. Attending lecture and lab and taking notes is the sole responsibility of the student. Under no circumstance will the instructor provide copies of PowerPoint slides for students. Lecture and laboratory exam dates are clearly stated in the syllabus, and all students are expected to take exams at the regularly scheduled time. Make‐up lecture exams will be considered only for a documented, excusable reason. If there is an illness or emergency, you are expected to contact the instructor immediately and be prepared to show documentation (doctor’s excuse, etc.). Failure to contact the instructor within 24 hours will forfeit any chance of making up the exam. Electronic Devices: Plan to be out of touch and to have your cell phone stored out of sight during lecture and lab time. This includes leaving the room to answer silent rings or using the phone for text messages. If cell phones become a problem in this class, all phones will be collected and placed in a basket at the instructor’s desk; the phones will only be given back at the end of the class period. Classroom Behavior: It is the instructor’s right to remove from the classroom any student who disrupts or disturbs the proceeding of the class. Disruption of the class includes but is not limited to the use of any portable electronic devices, including cell phones, MP3 players; iPods, etc. unless prior approval has been given to a student or unless required for the course. In extreme cases the faculty member can request assistance from University Police. If the student who has been ejected causes similar disturbances in subsequent meetings of the class, he/she may be denied admittance to the class for the remainder of the semester and assigned a grade of F. Computer Use and Email: All official email communications, including class announcements, are made to USCA email accounts. Students should check their USCA email account on a regular basis and use this account for communication with the instructor. In order to protect the privacy of the student, the instructor will not reply to emails sent from non‐
USCA accounts (e.g., Hotmail, Yahoo, etc.). Grades and other pertinent class information will be posted to Blackboard which may be accessed through VIP (http://vip.sc.edu). Disability Statement: If you have a physical, psychological, and/or learning disability which might affect your performance in this class, please contact the Office of Disability Services, 126A B&E, (803) 641‐3609, as soon as possible. The Disability Services Office will determine appropriate accommodations based on medical documentation. Honor Pledge: Students will be expected to endorse the USCA HONOR PLEDGE on every assignment: 'On my honor as a University of South Carolina Aiken student, I have neither given nor received any unauthorized aid on this assignment/examination. To the best of my knowledge, I am not in violation of academic honesty'. Lecture Schedule
Date
Lecture Topic
Aug 23 M
Introduction – Review of General Cell Biology, Translation,
Transcription, Genotype, Phenotype, Genetics
Aug 25 W
What is Cancer?
Aug 30 M
Pathobiology of Cancer
Benign vs. Malignant; Diagnosis, Grading & Staging
(Histological Analysis)
Sept 1 W
Pathology of Cancer
Classification & Nomenclature, Terms of Cancer
Sept 6 M
LABOR DAY - HOLIDAY NO CLASSES
Sept 8 W
Exam I
Sept 13 M
Tumor Viruses
Sept 15 W
Growth Factor Signaling & Oncogenes
Sept 20 M
Growth Factor Signaling & Oncogenes
Sept 22 W
Growth Inhibition & Tumor Suppressor Genes
Sept 27 M
Growth Inhibition & Tumor Suppressor Genes
Sept 29 W
Cell Cycle Control & pRb
Oct 4 M
Interaction of pRb and p53
Oct 6 W
p53 and Apoptosis
Oct 11 M
Exam II
Oct 13 W
Cell Immortalization (Telomeres) & Tumorigenesis
Oct 18 M
Transcription Factors and Transcriptional Regulation
Oct 20 W
Multi-step Tumorigenesis
Tumor Promotion, Tumor promoters
Oct 25 M
Multi-step Tumorigenesis
Infections & Inflammation (Acute vs. Chronic)
Oct 27 W
Multistep Tumorigenesis
Nutrients, Hormones, & Gene Interactions
Nov 1 M
Exam III
Nov 3 W
Maintenance of Genomic Integrity & Development of Cancer
Nov 8 M
DNA Structure & Stability: mutation vs. repair
Mutations, carcinogenic agents
Nov 10 W
Angiogenesis & Invasion
Nov 15 M
Metastases
Nov 17 W
Exam IV
Nov 22 M
Treatment of Cancer – Chemotherapy;
Tumor Immunology & Immunotherapy
Nov 24 W
Thanksgiving NO CLASSES
Nov 29 M
Treatment of Cancer: Drug Development
& Clinical Trial Design
Treatment of Cancer: Drug Development
Dec 1 W
& Clinical Trial Design
Dec 6 M
Final Exam 2 pm
Book Chapter
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4, 5, 6
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8, 9
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13, 14
14
15, 16
15, 16
15, 16
Cumulative