Name C~6ec~r~c A~n~s Period Ms. Foglia Date AP: CHAPTER 12: CELL CYCLE 1. What is meant by the concept that cells go through a cell cycle? It.] /~tY’V 1) CAn L. ~ /v\ VrCA ~rfl-&$~ A..4(CA ~. c., pt4.A5c ,A~~nExnvA~nr5 ék!~tt~QL~ kYflt 2. What are the key roles of ceU division? rt~ ~. ./a]r~ 3. What is the significance of chromosome replication? Cvf~~-~ ,~caz~i.~: (2AEPC_ rca~n~ aAEStj cm~-’J4- ~f~’~’t~e] w4~ A 7w> ~ • ~ 4. Sketch and label replicated chromosomes. g U. Ui: ~4 7$ I_ 7$ ‘5 / —7$ 5. List the phases of the cell cycle with a brief description of what occurs in each phase. ft F,z4-r 6A~P Ca.] 6/Zo.]TAt .Tva~4~~,55 1) frJA J~? Al e. :2J~~ &AP - C~L AJ~i.C LA. A. i. C’ji~Ic~t’~1C~5 4yp~tt/ 1~tJ 9) z r 0) 2CD A) 0 A CD C,) CD CO CD 0, CD a CD ‘C C) -4 C ‘51 -S 4~ CD CD A ‘5 0 :4> CD 0) C) ‘.3 ‘3 -t CD C) CO 51 CD C) C) ‘5 .51 V CL 7$ 0 A) Name Ms. Foglia ___________________________ 7. How does the spindle apparatus distribute chromosomes to the daughter cells? j~ç ~P#r~’p or tc- CtLL, ~ T~ ~ ~ntcs ~okJE3 c~rt.osor~’e5 ~ P~o ~-C t~F L.tC4Tt~ft~ ,tJ 7~tE ~ cësL. 8. What is the role of the kinetochores and the microtubules? ¶ftc ~AI1VV3c Zr NnZ~ç: Pvtu _.:(~. 4~ ,4~1C ~4tirAtMtQ TIC -it -n~ci~c~: ~i~j: c~.ts~~: n~y ~ ~u~Z~r 0/: 9. How does cytokinesis differ in animal and plant cells? Label the diagrams below. iAJA.~ hi A ~.. LtH ~ Li A &. t ft~ C Lt~. t~E..::~ ~: ~ p~a~re I /p:: :~: ~ p IA.Mr .~W? c~ >7 -~ mi C L iA CE jf~/~ —‘ •nh — I / \~> <:2 ~ ~ • e~. Nanie Ms. Foglia 10. Euka~ioticmitosis is thought to have evolved from C7~ 4 ~ L L) 11. Why is the regulation of the cell cycle critical to normal cells? ~t. P’~t~~ ~ ~ 1. p ~. c. c ~.. /•~i:: 12. What s the Cl checkpoint and where does it fit into the cycle? S-t F ~j u ~- Cor’~P(~:::~r~E 4 ~: ~r+rL:.~ S~ c L:kP ~CycuzE C pc kP,1’L: 13. What evidence is there that regulalion is chemical in nature? 5 •~t.•S t~j\~nr~ [Yr u..CCu I )*/~ C: :::~~/~ / ~ ~ C: /:. : [.):~~i: ::r .:::. : : 14. Identify the role of the following in the cell cycle clock: a. Kin ase — ~ ..cei <•~••~ Z. I I4c:i :•~:. /AT~:~D 0~ ~7:~ b. Cycfln c. CDKs ~ V& a rv~:.:: (1 ~ ~jC. t.r~ ~ ~ .~ .:.;: t~~J C. o ~. ______________________________________________ (~f: 15. Describe the mechanism for regulaflng the passage of the cell into anaphase. Cot~ ±Y~~ Cfl~C.f ~ ~ c~v~ P~4. h. 4 &c:*~fA c ~ ~ .J :rLc s .. kr ~, C Name Ms. Foglia 16. Describe what tdggers mitosis from G2. ,4c~ys1il4/eI ~ f~%4/fl~.~fc$iualnatc tA~A p~~i~ ~h J<P~5S ~ L~kc~-Lt C* 44Ff (2Jk #t~ recycled i~OLtC:~J4~S ~ 17. What is the role of ubiquitin? cdt t~flt4t7 ~flro4n C’S-cs’ £~ 4S fl,~krJLs ~oItj ~4r c&c~c~4c~ I 18. Describe a model for an external signal for growth. ~ relta..cel C. (Hp bt~ ~ h ~:) j 13 ce r — ~ :~ ~.. 4 c ~r c~c a ~1~ cc .~:::~Ic #~ipA 4 p~~ ro LJL .~ 4: S p~4..y( 4e ~4ncckpo~~ happens when cancer develops? ~ 19. What (ance:r ca:Ji ~::.C~ ~ ç :r:~%Ø~~ tn :Jj~, ?h 4cC. ~ C::: t ~ L0a~.~ ~:v~ ~ r~ O:t~M~! ~ 20. What is the role ofpb3? :4: ~) (ii,: ~.:. rr~n( ~ . £C4~k 4 r~ ~k.C — Jk: c&Ak.~1r~- ~ ~tor 4I ~S ~ ~ vsj H i~t~c cfrrL~J~ :~ch ~Av 1~::._ 4~~ <~ Dr~O~~era~it Cj~~)~ ‘~~: ~ 0,1CC: r