BIOGRAPHICAL SKETCH
Provide the following information for the key personnel in the order listed for Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Han, Xiang-Yang
Professor of pathology and microbiology
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
Shanghai Medical University, Shanghai, China
Shanghai Medical University, Shanghai, China
The Ohio State University, Columbus, Ohio
The Ohio State University, Columbus, Ohio
Temple University Hospital, Philadelphia, PA
DEGREE
(if applicable)
M.D.
M.P.H.
Ph.D.
YEAR(s)
1984
1987
1994
1995
95-99
FIELD OF STUDY
Medicine
Epidemiology
Microbiology
Post-doctoral fellow
Residency in pathology
NOTE: The Biographical Sketch may not exceed four pages. Items A and B (together) may not exceed two
of the four-page limit. Follow the formats and instructions on the attached sample.
A. Positions and Honors. List in chronological order previous positions, concluding with your present position.
List any honors. Include present membership on any Federal Government public advisory committee.
1987-89, instructor of epidemiology, Shanghai Medical University, Shanghai, China
1989-95, post-doc fellow and graduate associate of microbiology, Ohio State University, Columbus, Ohio
1995-1999, resident physician, Temple University Hospital, Philadelphia, Pennsylvania
1999-8/2005, assistant professor, Dept. of Laboratory Medicine, U. T. M. D. Anderson Cancer Center,
Houston, Texas
2005 Sept. to Dec. 2009, associate professor and vice chairman, Dept. of Laboratory Medicine, U. T. M. D.
Anderson Cancer Center, Houston, Texas
2007 Sept. to Aug. 2011, associate professor and medical director, Regional Care Centers Laboratories, Dept.
of Laboratory Medicine, U. T. M. D. Anderson Cancer Center, Houston, Texas
2011 Sept. to present time, Professor and medical director, Regional Care Centers Laboratories, Dept. of
Laboratory Medicine, U. T. M. D. Anderson Cancer Center, Houston, Texas
B. Selected peer-reviewed publications (in chronological order). Do not include publications submitted or in
preparation.
Recent Publications selected from 76 peer-reviewed publications.
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Han XY, Silva FJ. On the age of leprosy. PLoS Negl Trop Dis. 2014 Feb 13;8(2):2544.
Tran QT, Han XY. Subspecies identification and significance of 257 clinical strains of Mycobacterium
avium. J Clin Microbiol. 2014 Feb 5. [Epub ahead of print].
Ricci KS, Marrtinez F, Lichtiger B, Han XY. Septic transfusion reactions during blood transfusion via
indwelling central venous catheters. Transfusion. 2014, in press.
Han XY, Jessurun J. Severe leprosy reactions due to Mycobacterium lepromatosis. Am J Med Sci.
2013; 345:65-69.
Han XY, Sizer KC, Tan HH. Identification of the leprosy agent Mycobacterium lepromatosis in
Singapore. J Drugs Dermatol. 2012 Feb;11(2):168-72.
Han XY, Sizer KC, Velarde-Felix JS, Frias-Castro LO, Vargas-Ocampo F. The leprosy agents
Mycobacterium lepromatosis and Mycobacterium leprae in Mexico. Int. J. Dermatol. 2012;51:952-957.
Han XY, Tarrand JJ, Dickey BF, Esteva FJ. Helicobacter pylori bacteremia with sepsis syndrome. J
Clin Microbiol. 2010;48(12): 4661-4663.
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Han XY, Hellerstedt B A, Koller CA. Postsplenectomy cytomegalovirus mononucleosis is a distinct
clinicopathologic syndrome. Am J Med Sci. 2010;339 (4): 395-399.
Han XY, Sizer KC, Thompson EJ, Kabanja J, Li J, Hu P, Gómez-Valero L, Silva FJ. Comparative
sequence analysis of Mycobacterium leprae and the new leprosy-causing Mycobacterium
lepromatosis. J Bacteriol. 2009;191 (19): 6067-74.
Han XY, Seo YH, Sizer KC, Taylor S, May GS, Li W, Spencer JS, Nair RG. A new Mycobacterium
species causing diffuse lepromatous leprosy. Am J Clin Pathol, 130: 856-864, 2008.
Han XY, Han FS, Segal J. Chromobacterium haemolyticum sp. nov., a strong hemolytic species. Int J
Syst Evo Microbiol, in press, 2008.
Han XY. Epidemiologic analysis of reactivated cytomegalovirus antigenemia in patients with cancer. J
Clin Microbiol. 45:1126-32, 2007.
Han XY. Seasonality of clinical isolation of rapidly growing mycobacteria, Epidemiology and Infection,
2007, Nov 16, on-line edition.
LaSala PR, Segal J, Han FS, Tarrand JJ, and Han XY. First Reported Infections Caused by Three
Newly Described Genera in the Family Xanthomonadaceae. J Clin Microbiol. 45(2):641-644, 2007.
Kapadia M, Rolston K VI, Han XY. Invasive Streptomyces infections: six cases and literature review.
Am J Clin Pathol. 127:619-24, 2007
Carlier JP, K’ouas G, Han XY. Moryella indoligenes gen. nov., sp. nov., a new anaerobic bacterium
isolated from clinical specimens. Int J Syst Evo Microbiol. 57:725-9, 2007.
Han XY, De I, Jacobson KL. Rapidly growing mycobacteria: clinical and microbiologic studies of 115
cases. Am. J. Clin. Pathol. 128:612-621, 2007.
Han XY, Hong T, Falsen E. Neisseria bacilliformis sp. nov., isolated from human infections. J Clin
Microbiol. 2006;44:474-9.
Han XY, Kamana M, Rolston KV. Viridans streptococci isolated by cultures from blood of cancer
patients: clinical and microbiologic analysis of 50 cases. J Clin Microbiol, 44:160-165, 2006.
Han XY, Tarrand JJ, Infante R, Jacobson KL, Truong M. Clinical Significance and epidemiologic
analysis of Mycobacterium avium and Mycobacterium intracellulare among non-AIDS Patients. J Clin
Microbiol. 43:4407-12, 2005.
Han XY, Lin P, Amin HM, Ferrajoli A. Post-splenectomy cytomegaloviral mononucleosis: marked
lymphocytosis, TCR-gamma gene rearrangements, and impaired IgM response. Am. J. Clin. Pathol.
2005;123:612-7.
Han XY and Falsen E. Characterization of oral strains of Cardiobacterium valvarum and emended
description of the organism. J Clin Microbiol. 2005;43:2370-4.
Han XY, Tarrand JJ, Rice DC. Oral Camylobacter species involved in extraoral abscess: a report of
three cases. J Clin Microbiol. 2005;43:2513-5.
Han XY and Andrade RA. Brevundimonas diminuta infections and its resistance of fluoroquinolones. J.
Antimicrob Chemother. 2005;55:853-9.
Lee SA, Raad II, Adachi JA, Han XY. Catheter-related bloodstream infection caused by
Mycobacterium brumae. J. Clin. Microbiol. 2004;42: 5429-31.
Han XY, Ho LX, Safdar A. Francisella tularensis peritonitis in stomach cancer patient. Emerg. Infect.
Dis. 2004;10:2238-40.
Han XY, Meltzer MC, Woods JT, Fainstein V. Endocarditis with ruptured cerebral aneurysm caused by
Cardiobacterium valvarum sp. nov. J. Clin. Microbiol. 2004;42 1590-5.
Han XY, Tarrand JJ. Moraxella osloensis blood and catheter infections: clinical and microbiological
studies of 10 cases. Am. J. Clin. Pathol. 2004;121:581-8.
Cohen MF, Han XY, Mazzola M. Molecular and physiological comparison of Azospirillum spp. isolated
from Rhizoctonia solani mycelia, wheat rhizosphere and human skin wounds. Can. J. Microbiol.
2004;50:291-7.
Han XY, Tarrand JJ, Escudero E. Infections by the Yeast Kodamaea (Pichia) ohmeri: Two Cases and
Literature Review. Eur J Clin Microbiol Infect Dis. 2004;23(2):127-30.
De I, Rolston KV, Han XY. Clinical Significance of Roseomonas species Isolated from Blood and
Catheter Samples: Analysis of 36 Cases in Patients with Cancer. Clin. Infect. Dis. 2004;38:1579-1584.
Han XY, Pham AS, Tarrand JJ, Rolston KV, Helsel LO, Levett PN. Bacteriologic characterization of 36
strains of Roseomonas species and proposal of Roseomonas mucosa sp. nov. and Roseomonas
gilardii subsp. rosea subsp. nov. Am J Clin Pathol 2003; 120:256-64.
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Han XY, Weinberg J, Prahbu S, Hassenbusch S, Fuller NG, Tarrand JJ, Kontoyiannis DP.
Fusobacterial brain abscess: a review of 5 cases and an analysis of possible pathogenesis. J.
Neurosurg. 2003;99:693-700.
Pham, AS, De I, Rolston KV, Tarrand JJ, Han XY. Catheter-related bacteremia caused by Gordonia
terrae, a nocardioform actinomycetes. Clin Infect Dis. 2003;36:524-7.
Pham, A.S., Tarrand JJ, May GS, Lee MS, Kontiyiannis DP, Han XY. Diagnosis of Invasive Mold
Infection by Real-time Quantitative PCR. Am. J. Clin. Pathol. 2003;119:38-44.
Han XY, Pham AS, Tarrand J, Sood PK, Luthra R. Rapid and accurate identification of mycobacteria
by sequencing the hypervariable regions of the 16S ribosomal RNA gene. Am. J. Clin. Pathol.
2002;118:796-801.
Han, X.Y., Anderlini P., Tarrand J. Diagnosis and monitoring of primary cytomegalovirus infection by
antigenemia test in stem cell donor. Bone Marrow Transplantation. 2002;30:411.
Han X.Y., Pham A.S., Nguyen K.U., Smythe W.R., Ordonez N.G., Jacobson K.L.,Tarrand J.J.
Pulmonary Granuloma Caused by Pseudomonas andersonii sp. nov. Am. J. Clin. Pathol.
2001;116:347-53.
Han X.Y., Wu S.H., Conway D.H., Pawel B.R., Punnett H.H., Martin R.A., de Chadaravian J.P.
Truncus arteriosus and other internal anomalies in Goltz syndrome. Am. J. Med. Genet. 2000;90:4548.
Han X.Y., Truant A.L. The detection of positive blood cultures by the Accumed ESP-384 system: the
clinical significance of three day testing. Diagn. Microbiol. Infect. Dis. 1999;33:1-6.
Han XY, Galloway DR. Active site mutations of Pseudomonas aeruginosa exotoxin A: analysis of the
histidine 440 residue. J Biol Chem 270:679-84, 1995.
Woziak DJ, Han XY, Galloway DR. Construction and use of a nontoxigenic strain of Pseudomonas
aeruginosa for the production of recombinant exotoxin A. Appl Env Microbiol 61:1739-44, 1995.
Han XY, Wu ZM, Yuan GJ, Xu ZY. Vaccination against Japanese encephalitis and long-term change
of the disease prevalence in Shanghai. Acta Academiae Medicinae Shanghai 15:280-4, 1988.
Han XY, Ren QW, Xu ZY,Tsai TF. Serum and cerebrospinal fluid immunoglobulins M, A, and G in
Japanese encephalitis. J Clin Microbiol 26:976-8, 1988.
C. Research Support. List selected ongoing or completed (during the last three years) research projects (federal
and non-federal support). Begin with the projects that are most relevant to the research proposed in this
application. Briefly indicate the overall goals of the projects and your role (e.g. PI, Co-Investigator, Consultant)
in the research project. Do not list award amounts or percent effort in projects.
Start-up fund (1999-2004) from M.D. Anderson Cancer Center, to establish a molecular microbiology
laboratory for basic and translational research, role - P.I., completed with 8 published papers
University Cancer Foundation grant from M. D. Anderson Cancer Center (April 2003 to March 2008), rapid
identification of unknown bacteria and acid-fast bacilli by 16S rDNA sequencing, role – P.I., completed with 10
publications
Diagnostic Products Corporation sponsored grant, (2008 to 2012), detection of IgM antibodies to cytomegalovirus
and Toxoplasma, role-PI, completed with one publication.
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