Text S4. List of excluded studies and reasons for their exclusion
1. Achkar JM, Dong Y, Holzman RS, Belisle J, Kourbeti IS, Sherpa T, et al.
Mycobacterium tuberculosis malate synthase- and MPT51-based serodiagnostic assay as an adjunct to rapid identification of pulmonary tuberculosis. Clin Vaccine Immunol. 2006
Nov;13(11):1291-3. Noncommercial test
2. Achkar JM, Jenny-Avital E, Yu X, Burger S, Leibert E, Bilder PW, et al. Antibodies against Immunodominant Antigens of Mycobacterium tuberculosis in Tuberculosis Suspects in the US: A Comparison by HIV Status. Clin Vaccine Immunol. 2010 Jan 13. Noncommercial test
3. Ahmed S O, Kharal S A, Hasan S S, Shah E S, Rahat N, Begum B. Elisa method for evaluation of anti A60 IgG for the diagnosis of tuberculosis. Journal of the Liaquat University of
Medical and Health Sciences. 2008;7(1):25-30. Reference standard not satisfied
4. Alavi-Naini R, Metanat M, Alijani E, Mozaffar H. Patho-TB test for the rapid diagnosis of pulmonary tuberculosis. Journal of Research in Medical Sciences. 2009 Sep-Oct;14(5):301-7.
Antigen detection
5. Almeida CM, Vasconcelos AC, Kipnis A, Andrade AL, Junqueira-Kipnis AP. Humoral immune responses of tuberculosis patients in Brazil indicate recognition of Mycobacterium tuberculosis MPT-51 and GlcB. Clinical and Vaccine Immunology. 2008 Mar;15(3):579-81.
Noncommercial test
6. Amor YB, Shashkina E, Johnson S, Bifani PJ, Kurepina N, Kreiswirth B, et al.
Immunological characterization of novel secreted antigens of Mycobacterium tuberculosis.
Scandinavian Journal of Immunology. 2005 Feb;61(2):139-46. Noncommercial test
7. Araujo Z, Giampietro F, Cancado LC, Singh M, Wide A. Comparison of serological responses in two different populations with pulmonary tuberculosis. Mem Inst Oswaldo Cruz.
2008 Nov;103(7):661-7. Noncommercial test
8. Asceric M, Nadarevic A, Avdic S, Vrabac-Mujcinagic M, Nukic S, Mujcinovic Z.
Hexagon TB for the rapid diagnosis of lung TBC in praxis. Bosn J Basic Med Sci. 2007
Aug;7(3):218-21. Fewer than 10
9. Ashino J, Ashino Y, Guio H, Saitoh H, Mizusawa M, Hattori T. Low antibody response against tuberculous glycolipid (TBGL) in elderly gastrectomised tuberculosis patients. Int J
Tuberc Lung Dis. 2005 Sep;9(9):1052-3. Active TB, unspecified
10. Azzurri A, Kanaujia GV, Sow OY, Bah B, Diallo A, Del Prete G, et al. Serological markers of pulmonary tuberculosis and of response to anti-tuberculosis treatment in a patient population in Guinea. International Journal of Immunopathology and Pharmacology. 2006 Jan-
Mar;19(1):199-208. Noncommercial test

11. Baassi L, El Fenniri L, Bourkkadi J, et al. [Diagnosis of pulmonary tuberculosis: evaluation of the TB IgA EIA assay in Morocco]. East Mediterr Health J. 2007 Jan-
Feb;13(1):72-8. Reference standard not satisfied
12. Bahk YY, Kim SA, Kim JS, Euh HJ, Bai GH, Cho SN, et al. Antigens secreted from
Mycobacterium tuberculosis: Identification by proteomics approach and test for diagnostic marker. Proteomics. 2004 Nov;4(11):3299-307. Noncommercial test
13. Bai X, Wei Q, Li J, Li G. [Recombinant phosphoenolpyruvate carboxykinase from
Mycobacterium tuberculosis for sero diagnosis]. Wei Sheng Wu Xue Bao. 2008 Oct
4;48(10):1383-6. Noncommercial test
14. Beck ST, Leite OM, Arruda RS, Ferreira AW. Combined use of Western Blot/ELISA to improve the serological diagnosis of human tuberculosis. Brazilian Journal of Infectious
Diseases. 2005;9(1):35-43. Noncommercial test
15. Beck ST, Leite OM, Arruda RS, Ferreira AW. Humoral response to low molecular weight antigens of Mycobacterium tuberculosis by tuberculosis patients and contacts. Brazilian
Journal of Medical and Biological Research. 2005 Apr;38(4):587-96. Noncommercial test
16. Benabdesselem C, Fathallah DM, Huard RC, Zhu H, Jarboui MA, Dellagi K, et al.
Enhanced patient serum immunoreactivity to recombinant Mycobacterium tuberculosis CFP32 produced in the yeast Pichia pastoris compared to Escherichia coli and its potential for serodiagnosis of tuberculosis. J Clin Microbiol. 2006 Sep;44(9):3086-93. Noncommercial test
17. Ben-Selma W, Ben-Kahla I, Marzouk M, Ferjeni A, Ghezal S, Ben-Said M, et al. Rapid detection of Mycobacterium tuberculosis in sputum by Patho-TB kit in comparison with direct microscopy and culture. Diagn Microbiol Infect Dis. 2009 Nov;65(3):232-5. Antigen detection
18. Bera S, Shende N, Kumar S, Harinath BC. Detection of antigen and antibody in childhood tuberculous meningitis. Indian J Pediatr. 2006 Aug;73(8):675-9. Noncommercial test
19. Bethunaickan R, Baulard AR, Locht C, Raja A. Antibody response in pulmonary tuberculosis against recombinant 27kDa (MPT51, Rv3803c) protein of Mycobacterium tuberculosis. Scand J Infect Dis. 2007;39(10):867-74. Noncommercial test
20. Beyene D, Lumc Franken K, Yamuah L, Aseffa A, Wiker HG, Kolk A, et al.
Serodiagnosis of tuberculous lymphadenitis using a combination of antigens. J Infect Dev Ctries.
2010;4(2):96-102. Noncommercial test
21. Bezerra JM, Beck ST, Kanunfre KA, Leite OM, Ferreira AW. A study of IgA antibody response to different mycobacterium tuberculosis antigens in the diagnosis and monitoring of pulmonary tuberculosis. Braz J Infect Dis. 2009 Feb;13(1):53-8. Noncommercial test

22. Bhatia AS, Gupta S, Shende N, Kumar S, Harinath BC. Serodiagnosis of childhood tuberculosis by ELISA. Indian Journal of Pediatrics. 2005 May;72(5):383-7. Noncommercial test
23. Bi A-x, Ding Y-s, Liu Z-h, Hu Z-y. [Expression and purification of CFP32 of
Mycobacterium tuberculosis and its serodiagnostic analysis]. Zhonghua Yufang Yixue Zazhi.
2008 Feb 6;42(2):81-5. Noncommercial test
24. Castro CM, Porras TB, Guerrero MI, Leon CI, Mojica MA, Lara M, et al. [Development of a multiantigenic serological test for tuberculosis diagnosis]. Biomedica. 2005 Mar;25(1):55-
64. Noncommercial test
25. Chaudhary VK, Kulshreshta A, Gupta G, Verma N, Kumari S, Sharma SK, et al.
Expression and purification of recombinant 38-kDa and Mtb81 antigens of Mycobacterium tuberculosis for application in serodiagnosis. Protein Expression and Purification. 2005
Mar;40(1):169-76. Noncommercial test
26. Chou CH, Huang YT, Hsu HL, Lai CC, Liao CH, Hsueh PR. Rapid identification of the
Mycobacterium tuberculosis complex by an enzyme-linked immunosorbent assay. Int J Tuberc
Lung Dis. 2009 Aug;13(8):996-1001. Antigen detection
27. Corstjens PL, Chen Z, Zuiderwijk M, Bau HH, Abrams WR, Malamud D, et al. Rapid assay format for multiplex detection of humoral immune responses to infectious disease pathogens (HIV, HCV, and TB). Ann N Y Acad Sci. 2007 Mar;1098:437-45. Noncommercial test
28. Das AK, Harinath BC. Comparative analysis of ES-31 and ES-41 antigens in the detection of tubercular IgG antibodies and study on combine sensitivity of antibody-antigen.
Biosciences Biotechnology Research Asia. 2008;5(1):359-62. Noncommercial test
29. Davidow A, Kanaujia GV, Shi L, Kaviar J, Guo X, Sung N, et al. Antibody profiles characteristic of Mycobacterium tuberculosis infection state. Infection and Immunity.
2005;73(10):6846-51. Noncommercial test
30. Dayal R, Singh A, Katoch VM, Joshi B, Chauhan DS, Singh P, et al. Serological diagnosis of tuberculosis. Indian J Pediatr. 2008 Dec;75(12):1219-21. Noncommercial test
31. Dayal R, Sirohi G, Singh MK, Mathur PP, Agarwal BM, Katoch VM, et al. Diagnostic value of Elisa serological tests in childhood tuberculosis. J Trop Pediatr. 2006 Dec;52(6):433-7.
Noncommercial test
32. de Larrea CF, de Waard JH, Giampietro F, Araujo Z. The secretory immunoglobulin A response to Mycobacterium tuberculosis in a childhood population. Rev Soc Bras Med Trop.
2006 Sep-Oct;39(5):456-61. Noncommercial test
33. Demissie A, Leyten EMS, Abebe M, Wassie L, Aseffa A, Abate G, et al. Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with

Mycobacterium tuberculosis. Clinical and Vaccine Immunology. 2006 Feb;13(2):179-86.
Noncommercial test
34. Demkow U, Filewska M, Michalowska-Mitczuk D, Kus J, Jagodzinski J, Zielonka T, et al. Heterogeneity of antibody response to myobacterial antigens in different clinical manifestations of pulmonary tuberculosis. J Physiol Pharmacol. 2007 Nov;58 Suppl 5(Pt 1):117-
27. Insufficient data
35. Demkow U, Ziolkowski J, Bialas-Chromiec B, Filewska M, Zielonka T, Wasik M, et al.
Humoral immune response against mycobacterial antigens in children with tuberculosis. J
Physiol Pharmacol. 2006 Sep;57 Suppl 4:63-73. Insufficient data
36. Diaz FA, Martinez RA. Serological tests in the diagnosis of tuberculosis. Biomedica: revista del Instituto Nacional de Salud. 2005;25(3):422-3; author reply 3-4. Insufficient data
37. Dinnes J, Deeks J, Kunst H, et al. A systematic review of rapid diagnostic tests for the detection of tuberculosis infection. Health Technol Assess. 2007 Jan;11(3):1-196. Review, not primary study
38. Doveren RFC, Goudswaard J, Hendriks JCM, Bins MC, van Belzen C. Prognostic variables for high titres in a fluorescent antibody test to diagnose tuberculosis. Respiratory
Medicine. 2005 Apr;99(4):477-84. Noncommercial test
39. El-Shazly S, Mustafa AS, Ahmad S, Al-Attiyah R. Utility of three mammalian cell entry proteins of Mycobacterium tuberculosis in the serodiagnosis of tuberculosis. Int J Tuberc Lung
Dis. 2007 Jun;11(6):676-82. Noncommercial test
40. Fabre M, Gerome P, Maslin J, Herve V, Vong R, Carpentier G, et al. Assessment of the
Patho-TBTM kit for diagnosis of tuberculosis. Pathologie Biologie. 2007;55(10):482-5. Antigen detection
41. Fujita Y, Doi T, Maekura R, Ito M, Yano I. Differences in serological responses to specific glycopeptidolipid-core and common lipid antigens in patients with pulmonary disease due to Mycobacterium tuberculosis and Mycobacterium avium complex. Journal of Medical
Microbiology. 2006;55(2):189-99. Noncommercial test
42. Fujita Y, Doi T, Sato K, Yano I. Diverse humoral immune responses and changes in IgG antibody levels against mycobacterial lipid antigens in active tuberculosis. Microbiology-Sgm.
2005 Jun;151:2065-74. Noncommercial test
43. Fujita Y, Ogata H, Yano I. Clinical evaluation of serodiagnosis of active tuberculosis by multiple-antigen ELISA using lipids from Mycobacterium bovis BCG Tokyo 172. Clinical
Chemistry and Laboratory Medicine. 2005;43(11):1253-62. Noncommercial test

44. Gennaro ML, Affouf M, Kanaujia GV, Brusasca PN, Mangura B, Reichman L. Antibody markers of incident tuberculosis among HIV-infected adults in the USA: a historical prospective study. Int J Tuberc Lung Dis. 2007 Jun;11(6):624-31. Noncommercial test
45. Greenaway C, Lienhardt C, Adegbola R, Brusasca P, McAdam K, Menzies D. Humoral response to Mycobacterium tuberculosis antigens in patients with tuberculosis in the Gambia.
International Journal of Tuberculosis and Lung Disease. 2005;9(10):1112-9. Noncommercial test
46. Gupta S, Shende N, Bhatia AS, Kumar S, Harinath BC. IgG subclass antibody response to mycobacterial serine protease at different stages of pulmonary tuberculosis. Medical Science
Monitor. 2005;11(12):CR585-CR8. Noncommercial test
47. Gupta S, Shende N, Kumar S, Harinath BC. Detection of antibodies to a cocktail of mycobacterial excretory-secretory antigens in tuberculosis by ELISA and immunoblotting.
Current Science. 2005 Jun;88(11):1825-7. Noncommercial test
48. Harinath BC, Kumar S, Roy SS, Hirudkar S, Upadhye V, Shende N. A cocktail of affinity-purified antibodies reactive with diagnostically useful mycobacterial antigens ES-31,
ES-43, and EST-6 for detecting the presence of Mycobacterium tuberculosis. Diagnostic
Microbiology and Infectious Disease. 2006;55(1):65-8. Noncommercial test
49. Hauer B, Diel R, Priwitzer M, Rusch-Gerdes S, Schaberg T, Loddenkemper R. [The new tuberculosis rapid assay from DiaVita - no improvement of diagnostic]. Pneumologie. 2008
Aug;62(8):480-1. Editorial and commentary
50. Hauer B, Mauch H, Loddenkemper R, Forssbohm M, Fruh J, Loytved G, et al. The tuberculosis rapid assay from DiaVita - No alternative to the tuberculin skin test. Pneumologie.
2005;59(10):681-4. Editorial and commentary
51. Hoff ST, Abebe M, Ravn P, Range N, Malenganisho W, Rodriques DS, et al. Evaluation of Mycobacterium tuberculosis--specific antibody responses in populations with different levels of exposure from Tanzania, Ethiopia, Brazil, and Denmark. Clin Infect Dis. 2007 Sep
1;45(5):575-82. Noncommercial test
52. Iacob G, Iacob S, Banica D, Cojocaru M. Diagnostic utility of Elisa method using mycobacterial antigen A60 in neurotuberculosis diagnosis. Archives of the Balkan Medical
Union. 2007;42(2):75-9. Could not obtain
53. Imaz MS, Schmelling MF, Kaempfer S, Spallek R, Singh M. Serodiagnosis of tuberculosis: specific detection of free and complex-dissociated antibodies anti-mycobacterium tuberculosis recombinant antigens. Braz J Infect Dis. 2008 Jun;12(3):234-44. Noncommercial test
54. Jackson M, Gicquel B. Desaturase antigen of mycobacterium tuberculosis. 2006 Jul 4
2006. Noncommercial test

55. Jain AK, Jena SK, Singh M, Dhammi I, Ramachadran V, Dev G. Evaluation of clinicoradiological, bacteriological, serological, molecular and histological diagnosis of osteoarticular tuberculosis. Indian J Orthop. 2008 Apr;42(2):173-7. Insufficient data
56. Kaisermann MC, Sardella IG, Trajman A, Coelho LV, Kampfer S, Jonas F, et al. IgA antibody responses to Mycobacterium tuberculosis recombinant MPT-64 and MT-10.3
(Rv3019c) antigens in pleural fluid of patients with tuberculous pleurisy. International Journal of
Tuberculosis and Lung Disease. 2005 Apr;9(4):461-6. Noncommercial test
57. Kalra M, Khuller GK, Grover A, Behera D, Wanchu A, Verma I. Utility of a combination of RD1 and RD2 antigens as a diagnostic marker for tuberculosis. Diagn Microbiol Infect Dis.
Feb;66(2):153-61. Noncommercial test
58. Kanaujia GV, Lam PK, Perry S, Brusasca PN, Catanzaro A, Gennaro ML. Integration of microscopy and serodiagnostic tests to screen for active tuberculosis. International Journal of
Tuberculosis and Lung Disease. 2005;9(10):1120-6. Noncommercial test
59. Kashino SS, Pollock N, Napolitano DR, Rodrigues V, Jr., Campos-Neto A. Identification and characterization of Mycobacterium tuberculosis antigens in urine of patients with active pulmonary tuberculosis: an innovative and alternative approach of antigen discovery of useful microbial molecules. Clin Exp Immunol. 2008 Jul;153(1):56-62. Antigen detection
60. Katti MK, Azeem M. A novel erythrocyte-based immunoassay for simultaneous detection of both antimycobacterial antibody response and mycobacterial antigen in human serum samples of pulmonary tuberculosis and a control group of patients using 'a single probe'.
Fems Immunology and Medical Microbiology. 2006 Jun;47(1):134-7. Noncommercial test
61. Khan N, Alam K, Nair S, Valluri VL, Murthy KJ, Mukhopadhyay S. Association of strong immune responses to PPE protein Rv1168c with active tuberculosis. Clin Vaccine
Immunol. 2008 Jun;15(6):974-80. Noncommercial test
62. Khan N, Mian I, Zia U, Muhammad J. Performance of ICT-TB test in the detection of pulmonary and extra-pulmonary tuberculosis. J Ayub Med Coll Abbottabad. 2004 Apr-
Jun;16(2):55-6. Reference standard not satisfied
63. Khosravi A D, Torabizadeh R, Landi A. Investigation of the level of IgG, IgM and IgA antibodies against A60 antigen in tuberculosis patients referred to PHLS, Ahvaz, Iran. Pakistan
Journal of Medical Sciences. 2005;21(4):465-9. Reference standard not satisfied
64. Kim SY, Shin AR, Kim HJ, Cho SN, Park JK, Shin SJ. Identification of Rv2041c, a
Novel Immunogenic Antigen from Mycobacterium tuberculosis with Serodiagnostic Potential.
Scandinavian Journal of Immunology. 2009;70(5):457-64. Duplicate

65. Kochak HE, Ahmad S, Alinaghi S, Zarghom O, Hekmat S, Jam S, et al. Evaluation of serological tests using A60 antigen for diagnosis of tuberculosis. Acta Medica Iranica.
2010;48(1):21-6. Insufficient data
66. Koh KW, Soh SE, Seah GT. Strong Antibody Responses to Mycobacterium tuberculosis
PE-PGRS62 Protein Are Associated with Latent and Active Tuberculosis. Infection and
Immunity. 2009 Aug;77(8):3337-43. Noncommercial test
67. Kondo A, Oketani N, Maruyama M, et al. [Serological diagnosis of pulmonary tuberculosis and nontuberculous pulmonary mycobacteriosis]. Kekkaku. 2001 Sep;76(9):603-14.
Reference standard not satisfied
68. Kozlowska I, Filewska M, Rozy A, Augustynowicz-Kopec E, Krawiecka D, Broniarek-
Samson B, et al. [Evaluation of humoral immune response against mycobacterial antigens in bronchoalveolar lavage fluid from patients with pulmonary tuberculosis confirmed by genetic and culture methods]. Pneumonol Alergol Pol. 2007;75(4):355-62. Serological not
69. Kulikovskaia NV, Vaneeva TV, Moroz IA, Nosova EI, Lazareva OL, Lovacheva OV, et al. Potentialities of laboratory diagnosis in tuberculous meningitis. Problemy tuberkuleza i boleznei legkikh. 2005(8):39-42. Noncommercial test
70. Kulshrestha A, Gupta A, Verma N, Sharma SK, Tyagi AK, Chaudhary VK. Expression and purification of recombinant antigens of Mycobacterium tuberculosis for application in serodiagnosis. Protein Expression and Purification. 2005;44(1):75-85. Noncommercial test
71. Kumar G, Dagur PK, Singh M, Yadav VS, Dayal R, Singh HB, et al. Diagnostic potential of Ag85C in comparison to various secretory antigens for childhood tuberculosis. Scand J
Immunol. 2008 Aug;68(2):177-83. Noncommercial test
72. Kumar G, Dagur PK, Singh PK, Shankar H, Yadav VS, Katoch VM, et al. Serodiagnostic
Efficacy of Mycobacterium tuberculosis 30/32-kDa Mycolyl Transferase Complex, ESAT-6, and
CFP-10 in Patients with Active Tuberculosis. Arch Immunol Ther Exp (Warsz). 2010
Feb;58(1):57-65. Noncommercial test
73. Lawn SD, Edwards DJ, Kranzer K, Vogt M, Bekker LG, Wood R. Urine lipoarabinomannan assay for tuberculosis screening before antiretroviral therapy diagnostic yield and association with immune reconstitution disease. AIDS. 2009 Sep 10;23(14):1875-80.
Antigen detection
74. Le Moigne V, Robreau G, Borot C, Guesdon JL, Mahana W. Expression, immunochemical characterization and localization of the Mycobacterium tuberculosis protein p27. Tuberculosis. 2005 Jul;85(4):213-9. Noncommercial test
75. Lee JS, Jo EK, Noh YK, Shin AR, Shin DM, Son JW, et al. Diagnosis of pulmonary tuberculosis using MTB12 and 38-kDa antigens. Respirology. 2008 May;13(3):432-7.
Noncommercial test

76. Liu ZH, Qin LH, Feng YH, Bi AX, Yang H, Ding YS, et al. [Identification of the
Mycobacterium tuberculosis complex by detecting recombinant secretory protein MPT64.].
Zhonghua Jie He He Hu Xi Za Zhi. 2009 Aug;32(8):608-12. Noncommercial test
77. Majumdar A, Upadhye V, Harinath BC. Peroxidase enzyme immunoassay for circulating
SEVA TB ES-31 antigen in pulmonary tuberculosis sera. Biomedical Research. 2008;19(3):201-
6. Antigen detection
78. Majumdar A, Upadhye V, Harinath BC. A prospective study of inhouse developed SEVA
TB ELISA using cocktail of antigens and their immunoglobulins in the diagnosis of tuberculosis suspected patients in a tertiary care hospital located in rural area. Biomedical Research.
2009;20(1):59-63. Noncommercial test
79. Malen H, Softeland T, Wiker HG. Antigen analysis of Mycobacterium tuberculosis
H37Rv culture filtrate proteins. Scandinavian Journal of Immunology. 2008 Mar;67(3):245-52.
Noncommercial test
80. Mathur ML, LoBue PA, Catanzaro A. Evaluation of a serologic test for the diagnosis of tuberculosis. Int J Tuberc Lung Dis. 1999 Aug;3(8):732-5. Active TB, unspecified; information requested from author
81. Morimoto T, Takanashi S, Hasegawa Y, Fujimoto K, Okudera K, Hayashi A, et al. Level of antibodies against mycobacterial glycolipid in the effusion for diagnosis of tuberculous pleural effusion. Respiratory Medicine. 2006;100(10):1775-80. Serological not
82. Mudaliar AV, Kashyap RS, Purohit HJ, Taori GM, Daginawala HF. Detection of 65 kD heat shock protein in cerebrospinal fluid of tuberculous meningitis patients. BMC Neurol.
2006;6:34. Antigen detection
83. Mukherjee P, Dutta M, Datta P, Dasgupta A, Pradhan R, Pradhan M, et al. The RD1encoded antigen Rv3872 of Mycobacterium tuberculosis as a potential candidate for serodiagnosis of tuberculosis. Clin Microbiol Infect. 2007 Feb;13(2):146-52. Noncommercial test
84. Muramira M N. Evaluation of TB-ST tuberculosis rapid test in adult pulmonary tuberculosis in Rwanda Universite Nationale du Rwanda; 2007. Reference standard not satisfied
85. Murthy MK, Parasa RR, Deenadayalan A, Sharma P, Raja A. Evaluation of the diagnostic potential of region of deletion-1-encoded antigen culture filtrate protein-10 in pulmonary tuberculosis. Diagn Microbiol Infect Dis. 2007 Nov;59(3):295-302. Fewer than 10
86. Nabeshima S, Murata M, Kashiwagi K, Fujita M, Furusyo N, Hayashi J. Serum antibody response to tuberculosis-associated glycolipid antigen after BCG vaccination in adults. Journal of
Infection and Chemotherapy. 2005;11(5):256-8. Fewer than 10

87. Nagel T, Ehrentreich-Forster E, Singh M, Schmitt K, Brandenburg A, Berka A, et al.
Direct detection of tuberculosis infection in blood serum using three optical label-free approaches. Sensors and Actuators B-Chemical. 2008 Feb;129(2):934-40. Noncommercial test
88. Narayana Y, Joshi B, Katoch VA, Mishra KC, Balaji KN. Differential B-cell responses are induced by Mycobactelium tuberculosis PE antigens RV1169c, RV0978c, and RV1818c.
Clinical and Vaccine Immunology. 2007 Oct;14(10):1334-41. Noncommercial test
89. Omrani M, Ansari MH, Agaverdizadae D. PCR and Elisa methods (IgG and IgM): their comparison with conventional techniques for diagnosis of Mycobacterium tuberculosis. Pak J
Biol Sci. 2009 Feb 15;12(4):373-7. Insufficient data
90. Ongut G, Ogunc D, Gunseren F, et al. Evaluation of the ICT tuberculosis test for the routine diagnosis of tuberculosis. BMC Infectious Diseases. 2006;6. Duplicate
91. Platonova IL, Sakheloshvili MI. [Diagnostic efficiency of the rapid "SEROCHEK MBT" test for the determination of antibodies to mycobacterium tuberculosis]. Klin Lab Diagn. 2008
Apr(4):10-2. Duplicate
92. Poddubnaia LV, Romanov VV. [Implication of tuberculosis antibodies in the determination of tuberculous infection]. Probl Tuberk Bolezn Legk. 2006(3):37-40.
Noncommercial test
93. Quan C, Lu CZ, Qiao J, Xiao BG, Li X. Comparative evaluation of early diagnosis of tuberculous meningitis by different assays. J Clin Microbiol. 2006 Sep;44(9):3160-6.
Noncommercial test
94. Raja A, Devi KRU, Ramalingam B, Brennan PJ. Improved diagnosis of pulmonary tuberculosis by detection of free and immune complex-bound anti-30kDa antibodies. Diagnostic
Microbiology and Infectious Disease. 2004 Dec;50(4):253-9. Noncommercial test
95. Raja A, Ranganathan UD, Bethunaickan R. Improved diagnosis of pulmonary tuberculosis by detection of antibodies against multiple Mycobacterium tuberculosis antigens.
Diagn Microbiol Infect Dis. 2008 Apr;60(4):361-8. Noncommercial test
96. Rajan AN, Kashyap RS, Purohit HJ, Taori GM, Daginawala HF. Serodiagnosis of tuberculosis based on the analysis of the 65 kD heat shock protein of Mycobacterium tuberculosis. Int J Tuberc Lung Dis. 2007 Jul;11(7):792-7. Antigen detection
97. Rajavelu P, Madhumathi J, Das SD. Humoral immune responses of normals and tuberculosis patients to multiple sonicate antigens prepared from the most prevalent strains of
Mycobacterium tuberculosis harbouring single copy of IS6110 from South India. Current
Science. 2006 Oct;91(7):918-22. Noncommercial test
98. Rao L, Padmavathy L. Utility of MycoDot test in the diagnosis of cutaneous tuberculosis
[2]. Indian Journal of Dermatology, Venereology and Leprology. 2003;69(6):428-9. Insufficient data

99. Rao PV, Murthy MK, Basirudeen S, Sharma P, Swaminathan S, Raja A. Improved diagnosis of tuberculosis in HIV-positive patients using RD1-encoded antigen CFP-10. Int J
Infect Dis. 2009 Sep;13(5):613-22. Noncommercial test
100. Raqib R, Mondal D, Karim MA, Chowdhury F, Ahmed S, Luby S, et al. Detection of antibodies secreted from circulating Mycobacterium tuberculosis-specific plasma cells in the diagnosis of pediatric tuberculosis. Clin Vaccine Immunol. 2009 Apr;16(4):521-7.
Noncommercial test
101. Reither K, Saathoff E, Jung J, Minja LT, Machibya H, Maboko L, et al. Evaluation of
Diagnos TB AG, a flow-through immunoassay for rapid detection of pulmonary tuberculosis.
International Journal of Tuberculosis and Lung Disease. 2010 Feb;14(2):238-40. Antigen detection
102. Restrepo BI, Pino PA, Volcy M, Franco AF, Kanaujia GV, Robledo J. Interpretation of mycobacterial antibodies in the cerebrospinal fluid of adults with tuberculous meningitis. Trop
Med Int Health. 2008 May;13(5):653-8. Noncommercial test
103. Rosenkrands I, Aagaard C, Weldingh K, Brock I, Dziegiel MH, Singh M, et al.
Identification of Rv0222 from RD4 as a novel serodiagnostic target for tuberculosis.
Tuberculosis (Edinb). 2008 Jul;88(4):335-43. Noncommercial test
104. Sartain MJ, Slayden RA, Singh KK, Laal S, Belisle JT. Disease state differentiation and identification of tuberculosis biomarkers via native antigen array profiling. Mol Cell Proteomics.
2006 Nov;5(11):2102-13. Noncommercial test
105. Savolainen L, Pusa L, Kim HJ, Sillanpaa H, Seppala I, Tuuminen T. Pilot study of diagnostic potential of the Mycobacterium tuberculosis recombinant HBHA protein in a vaccinated population in Finland. PLoS One. 2008;3(9):e3272. Noncommercial test
106. Senol G, Ecevit C, Ozturk A. Humoral immune response against 38- and 16-kDa mycobacterial antigens in childhood tuberculosis. Pediatr Pulmonol. 2009 Sep;44(9):839-44.
Reference standard not satisfied
107. Shah M, Variava E, Holmes CB, Coppin A, Golub JE, McCallum J, et al. Diagnostic accuracy of a urine lipoarabinomannan test for tuberculosis in hospitalized patients in a High
HIV prevalence setting. J Acquir Immune Defic Syndr. 2009 Oct 1;52(2):145-51. Antigen detection
108. Shamsuzzaman A K, Akhter S, Shamsuzzaman S M, Siddique A. Comparison between
ELISA and ICT- MycoDot in adult pulmonary tuberculosis. Mymensingh medical journal :
MMJ. 2006;15(1):33-9. Reference standard not satisfied
109. Shen G, Behera D, Bhalla M, Nadas A, Laal S. Peptide-based antibody detection for tuberculosis diagnosis. Clin Vaccine Immunol. 2009 Jan;16(1):49-54. Noncommercial test

110. Shende N, Gupt S, Upadhye V, Kumar S, Harinath BC. Detection of in vitro and in vivo released antigens of diagnostic interest in Mycobacterium tuberculosis by immunoblotting.
Indian J Exp Biol. 2008 Jan;46(1):18-21. Antigen detection
111. Shende N, Gupta S, Bhatia AS, Kumar S, Harinath BC. Detection of free and immunecomplexed serine protease and its antibody in TB patients with and without HIV co-infection.
International Journal of Tuberculosis and Lung Disease. 2005 Aug;9(8):915-9. Noncommercial test
112. Shende N, Gupta S, Upadhye V, Kumar S, Harinath BC. Isolation and analysis of circulating tuberculous antigens in Mycobacterium tuberculosis. Indian J Tuberc. 2007
Jul;54(3):125-9. Antigen detection
113. Shende N, Upadhye V, Kumar S, Gangane N, Harinath BC. Study of M. tuberculosis ES-
31 and ES-20 antigen levels in different pathogenic grades of lymph node tuberculosis. Int J
Tuberc Lung Dis. 2007 Feb;11(2):222-6. Antigen detection
114. Shende N, Upadhye V, Kumar S, Harinath BC. A low molecular weight ES-20 protein released in vivo and in vitro with diagnostic potential in lymph node tuberculosis. Indian J Med
Microbiol. 2008 Jan-Mar;26(1):29-33. Noncommercial test
115. Shi KY, Hu ZY. [The application of enzyme-linked immunosorbent spot in the diagnosis of tuberculosis]. Zhonghua Jie He He Hu Xi Za Zhi. 2006 Jun;29(6):414-6. Latent TB infection
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