Cover Page
The handle http://hdl.handle.net/1887/23080 holds various files of this Leiden University
dissertation.
Author: Commandeur, Susanna
Title: Facing the phases of Mycobacterium tuberculosis : hunting for better TB vaccines
Issue Date: 2014-01-22
Facing the phases of Mycobacterium tuberculosis
Hunting for better TB vaccines
SUSANNA COMMANDEUR
Copyright: © 2013 Susanna Commandeur
All rights reserved. No part of this publication may be reproduced or transmitted in any form by
any means without permission of the author.
ISBN: 978-94-6108-576-4
Cover: Amino acid sequences of Mycobacterium tuberculosis vaccine candidates analyzed in this
thesis
Cover design: Susanna Commandeur - Nicole Nijhuis (Gildeprint)
Lay-out and printing: Gildeprint, Enschede, The Netherlands
Publication of this thesis was financially supported by KNCV Tuberculosis Foundation, U-CyTech
Biosciences, Greiner Bio-One and BD Biosciences.
Facing the phases of Mycobacterium tuberculosis
Hunting for better TB vaccines
Proefschrift
ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M Stolker, volgens besluit van het College voor Promoties te verdedigen op woensdag 22 januari 2014 klokke 13.45 uur
door
Susanna Commandeur
geboren te Kreileroord in 1984
Promotiecommissie
Promotor:
Prof. dr. T.H.M. Ottenhoff
Co-promotor:
Dr. A. Geluk
Overige leden:
Prof. dr. W. Bitter (Vrije Universiteit Amsterdam)
Prof. dr. H.M. Dockrell (London School of Hygiene and Tropical Medicine)
Prof. dr. W. van Eden (Universiteit Utrecht)
Contents
Chapter 1.7
Introduction
Chapter 2.33
Identification of human T-cell responses to Mycobacterium tuberculosis
resuscitation-promoting factors in long-term latently infected individuals
Clin Vaccine Immunol. 2011. Apr;18(4):676-83
Chapter 3.53
Double- and monofunctional CD4+ and CD8+ T-cell responses to Mycobacterium
tuberculosis DosR antigens and peptides in long-term latently infected individuals
Eur J Immunol. 2011 Oct;41(10):2925-36
Chapter 4.85
An unbiased genome-wide Mycobacterium tuberculosis gene expression approach
to discover antigens targeted by human T cells expressed during pulmonary infection
J Immunol. 2013 Feb 15;190(4):1659-71
Chapter 5.125
The newly identified Mycobacterium tuberculosis antigen Rv2034 induces
CD4+ T cells that protect against pulmonary infection in HLA-DR transgenic mice
Submitted
Chapter 6.149
Clonal analysis of the T-cell response to in vivo expressed Mycobacterium tuberculosis
protein Rv2034, using a CD154 expression based T cell cloning method
Submitted
Chapter 7.183
Summary and Discussion
Addendum.
Nederlandse samenvatting Curriculum Vitae
List of publications
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