Prof. Uri Rosenschein MD
RESUME
1.
PERSONAL DETAILS
Name:
Uri Rosenschein, M.D.
e-mail:
uri.rosenschein@b-zion.org.il
Website:
http://www.urclinic.co.il
Date and Place of Birth: 1953, Buenos Aires, Argentina
Military Service:
1971-1973
Captain
Decoration of Valor
Marital Status:
2.
1973
Married + 3
ACADEMIC DEGREES
I
Medicine
1973-1979
II
Management
2000 – 2002
3.
Sackler School of Medicine
Tel Aviv University
Kellogg-Recanati Executive MBA
Tel Aviv University
Northwestern University
ACADEMIC APPOINTMENTS
1995-2005
Senior Lecturer
Faculty of Medicine ,Tel Aviv
University.
1
2005-present
4.
Associated Professor
Faculty of Medicine-Technion.
PROFESSIONAL EXPERIENCE
Period
Institution/Organization
1980-1981
Tel Aviv Medical Center
Sackler School of Medicine
Department
Rank/Function
Internship
1981-1984
Meir General Hospital
Sackler School of Medicine
Internal
Medicine B
Resident
1985-1988
Meir General Hospital
Sackler School of Medicine
Cardiology
Fellow
1988-1989
College of Physicians &
Surgeons,
Columbia University.
Echocardiography
Cardiac &
Catheterization
Fellow
1990-1991
The University of Michigan
Hospitals. University of
Michigan.
Interventional
Cardiology
Fellow
1992-2003
Tel Aviv Medical Center
Sackler School of Medicine
Cardiology
Attending
Physician
2003-Present
Bnai-Zion Medical Center
Haifa, Israel
Cardiology
Department
Director
5.
Fellow
RESEARCH INTERESTS
1. Therapeutic applications of ultrasound
2. Acute coronary syndromes- biology, therapeutic strategy, device therapy
3. Medical device development
6.
TEACHING EXPERIENCE
Courses
2
1. 2000 - Established the course & curriculum for the training of cardiac
catheterization teams for the Working Group For Interventional
Cardiology.
2. 2001- 2004 Interventional Cardiology
Post graduate Cardiology Course
Sackler School of Medicine.
3. 2007- 2008 Introduction to Clinical Medicine course
Cardiac Catheterization and Coronary Interventions,
The Ruth & Bruce Rappaport, Faculty of Medicine, Technion.
4. 2008 - Present Technology Development & Enterprising ,
Course Director,
The Ruth & Bruce Rappaport, Faculty of Medicine, Technion.
5. 2011- Establish curriculum of Cardiology
The Ruth & Bruce Rappaport, Faculty of Medicine, Technion.
Clerkships:
1. 1991-2002 Routine teaching of cardiology to students & residents
Department of Cardiology, Tel Aviv Medical Center.
2. 2003-2011 Supervising the teaching program and active participation
in teaching and training of students and residents
Department of Cardiology, Bnai-Zion Medical Center.
The Ruth & Bruce Rappaport, Faculty of Medicine, Technion.
7.
TECHNION ACTIVITIES
3
1. Course Director
2008-Present Technology Development & Enterprising
The Ruth & Bruce Rappaport, Faculty of
Medicine, Technion.
2. Chairman of Cardiology
2010 – Present
3. Vice Dean, The Ruth & Bruce 2011 - Present
Rappaport, Faculty of Medicine,
Technion.
3. T2Med
8.
2011 –present
Technion-Technology-Medicine (T2Med)
activities encourage medical related R&D and
collaboration across the Technion faculties
PUBLIC PROFESSIONAL ACTIVITIES
1990 - 2001
Founder,
Chief Medical Officer
Angiosonics Ltd.
1999 – 2001
General Secretary
The Working Group for Interventional Cardiology
The Israeli Society of Cardiology
2000 – 2005
Member
The Working Group on Coronary Intervention
European Society of Cardiology
2001- Present
Co-Founder,
Yearly cardiology meeting "Point Counter Point".
2006- Present
Founder,
Chief Medical Officer
Gardia Ltd.
2006 - 2008
Director
CMT Ltd.
4
Reviewer
Circulation
Journal American College of Cardiology
Catheterization and Cardiovascular Intervention
Journal of Endovascular Therapy
GIF
Israel Academy of Science
BSF International Journal of Cardiovascular
Intervention.
Guest editor
Seminars in Interventional Cardiology (2002)
Consultant
TEVA Pharmaceutics
Medinol.
9.
MEMBERSHIP IN PROFESSIONAL SOCIETIES
NATIONAL
1992 - present
Israel Heart Society
1997 - present
The Working Group for Interventional Cardiology
INTERNATIONAL
1990 - present
American college of Cardiology
Fellow
1992 - present
The Society for Cardiac Angiography
and Interventions
Fellow
2001 – present European Society of Cardiology
10.
Fellow
HONORS
1988
Israel Board of Cardiology
5
Award of Excellence
1996
The Kellerman Young Investigator Prize
11. GRADUET STUDENTS
PHD
1. 2000-2004 Frida Klein
Ph.D
Co-Supervision w/ Prof S. Grossman, Bar Ilan University
Title : Pathways controlling the apoptotic process in human malignant
lymphoid cells exposed to therapeutic ultrasound.
Grade: Cum Laude
2. 2000-2004 Liron Shemesh
Ph.D
Co-Supervision w/ Prof H. Breitbart , Bar Ilan University
Title: Induction of apoptosis in human cancer cells exposed to therapeutic
ultrasound: Determination of the apoptotic pathways.
Grade: Cum Laude
MD Thesis
1. 2005 Guy Rofe
MD Thesis
Faculty of Medicine, Technion
Title: Coronary Flow Patterns after Primary PCI in AMI Patients.
Grade: Cum laude
2. 2006 Ofer Kobo
MD Thesis
Faculty of Medicine, Technion
6
Screening, diagnosis and treatment of Renal Artery Stenosis by PTRA with
stenting.
Basic Science
1.
2002-2003 Roi ilan
Basic Science Thesis
The Scientific Council of the Israel Medical Association
Title: Enhancement of myocyte gene trasfection with the use of therapeutic
ultrasound
12. RESEARCH GRANTS
1987 - 1988
US-Israel Binational Industrial
R& D Foundation
$ 36,000
1991 - 1993
Abbot Laboratories
$ 10,000
1993 - 1996
Joint German-Israeli Research Program DM 261.000
1996 – 2001
Angiosonics Inc
$ 250,000
2012- Present Gorwin Family Foundation
2012 – Present Novartis Inc
$ 30,172
NIS 500,000
13. SIGNIFICANT PROFESSIONAL PROJECTS.
7
1. 1990 - present Therapeutic Ultrasound - Conception followed by R&D on the
biological effects of ultrasound (high power, low frequency) followed by
technology development for ultrasound thrombolysis systems followed by animal
studies, First in Man study, "Live Case" at prestigious meetings (TCT 1999) and
clinical randomized US trial under the FDA. Currently development of non
invasive system for treatment of acute stroke
2. 2007- Present
Embolic protection device - Conception followed by
development of embolic protection device to be used during interventional
procedures. Technology development was followed by animal studies and First
Man study, "Live Case" at prestigious meetings (TCT & LINC 2010). Multicenter
trial design has been finalized and a multicenter European clinical trial for Carotid
Stenting under the FDA will start soon
3. Principal Investigator
2005.2007
in Multicenter International Trials-
2004-2005
EVOLVE
2004-2005
ACCLAIM
TIMI 36 - (No 1 globally)
2005.2007
TIMI 38
2007-2008
VENT-HEFT
2007-20011
HORIZONS
2006- Ongoing IMPROVE IT
2006- 2010
TIMI 42
2007- 2010
PLATO
2007- 2010
EARLY AC - (Top 10 globally)
2008-Ongoing
BLAST
2008-Ongoing
TRACER
2009-Ongoing
DAL
2009-Ongoing
ALPHEE
2009-2011
KAI
2009-2011
BOREALIS
2010-Ongoing
ACT V
2010-Ongoing
TAO
2010-Ongoing
GARDIA
2011- Ongoing
PRESERVATION
8
14. PUBLICATIONS
Refereed papers in professional journals:
1.
Basic research (Hypothesis-driven)
1.
Rosenschein U, Radnay J, Shoham D, Shainberg A, Klajman A,
Rozenszajn LA.
Human muscle-derived, tissue specific, myocytotoxic T-cell lines in
dermatomyositis.
Clin Exp Immunol, 1987; 67:309-318.
2.
Rosenschein U, Bernstein J, DiSegni E, Kaplinsky E, Bernheim J,
Rozenszajn LA.
Experimental ultrasonic angioplasty: disruption of atherosclerotic
plaques and thrombi in vitro and arterial recanalization in vivo.
J Am Coll Cardiol, 1990;15:711-717.
3.
Rosenschein U, Lenz R, Radnay J, Ben-Tovim T, Rozenszajn LA.
Streptokinase immunogenicity in thrombolytic therapy for acute
myocardial infarction.
Isr J Med Sci, 1991;27:541-545.
9
4.
Rosenschein U, Ellis SG, Yakubov SJ, Haudenschild CC, Dick RJ,
Topol EJ.
Histopathologic correlates of coronary lesion angiographic morphology:
lessons from a directional atherectomy experience.
Coronary Artery Disease,1991;3:953-961.
5.
Rosenschein U, Rozenszajn LA, Kraus L, Marboe CC,
Watkins JF, Rose EA, David D, Cannon JP, Weinstein JS.
Ultrasonic angioplasty in totally occluded peripheral arteries:
initial clinical, histologic and angiographic results.
Circulation, 1991;83:1976-1986.
6.
Det Wiler P, Watkins JF, Rose EA, Ratner A, Rosenschein U.
Mechanical and acoustic analysis in ultrasonic angioplasty.
Diagnostic and Therapeutic Cardiovascular Interventions, George
S. Abela, M.D. Editor.
Proc. SPIE, 1991;1425:149-155.
7.
Rosenschein U, Yakubov SJ, Guberinich D, Bach DS, Sonda PL,
Abrams GD, Topol EJ.
Shock wave thrombus ablation: a new method for noninvasive
mechanical thrombolysis.
Am J Cardiol, 1992;70:1358-1361.
8.
Bach DS, Armstrong WF, Erbel R. Ellis SG, Sousa J, Rosenschein U.
Ultrasound detection of cavitation as a phenomenon common to
intervention devices causing tissue ablation.
Diagnostic and Therapeutic Cardiovascular Interventions, George S.
Abela, M.D., Editor.
Proc .SPIE 1992;1624:224-228.
9.
Hartnell, GG, Saxton JM, Friedl SE, Abela GS, Rosenschein U.
Ultrasonic thrombus ablation: in vitro assessment of a novel device
for intracoronary use.
J Interven Cardiol, 1993;6:69-76.
10.
Rosenschein U, Frimerman A, Laniado S, Miller HI.
Study of the mechanism of ultrasound angioplasty from human
thrombi and bovine aorta.
Am J. Cardiol, 1994;74:1263-1266.
11.
Rosenschein U, Ellis SG, Haudenschild CC, Yakubov SJ, Muller
DWM, Dick R, Topol EJ.
Comparison of histopathologic coronary lesions obtained from
directional atherectomy in stable angina versus acute coronary
syndromes.
Am J Cardiol, 1994;73:508-510.
10
12.
Roth A, Eshchar Y, Keren G, Kerbel S, Harsat A, Villa Y, Laniado S, Miller HI
The Ichilov Magnesium Study Group. Effect of magnesium on restenosis
after percutaneous transluminal coronary angioplasty: a clinical and
angiographic evaluation in a randomized patient population - a pilot study.
Eur Heart J, 1994;15:1164-1173.
13.
Rosenschein U, Rozenszajn LA, Bernheim J, Keren G, Alter A,
Frimerman A, Laniado S, Roth A, Miller H.
Safety of coronary ultrasound angioplasty: effects of sonication on
intact canine coronary arteries.
Cathet Cardiovasc Diagn, 1995;35:64-71.
14.
Roth A, Eshchar Y, Keren G, Kerbel S, Harsat A, Villa Y, Laniado S, Miller HI
and the Ichilov Magnesium Study Group.
Effect of magnesium on restenosis after percutaneous transluminal coronary
angioplasty: a clinical and angiographic evaluation in a randomized patient
population - a pilot study.
Eur Heart J, 1994;15:1164-1173.
15.
Alter A, Rozenszajn LA, Miller HI, Rosenschein U.
Ultrasound inhibits the adhesion and migration of smooth muscle
cells in vitro.
Ultrasound in medicine and biology, 1998; 24:711-721.
16.
Ashush H, Rozenszajn LA, Blass M, Barda-Saad M, Azimov D,
Zipori D, Rosenschein U.
Apoptosis induction of human myeloid leukemic cells by ultrasound
exposure.
Cancer Res, 2000;60:1014-1020.
17.
Rosenschein U, Furman V, Kerner E, Fabian I, Bernheim J, Eshel Y.
Ultrasound imaging-guided non-invasive ultrasound thrombolysis: preclinical results
Circulation, 2000;102: 238-245.
18.
L.A.Rozenszajn, L. Shemesh-Darvish, R. Elimelech, J. Radnay,
F. Firestein,and U. Rosenschein.
Induction of Apoptosis by Ultrasound Application in Human Mlignant
Lymphoid Cells:Role of Mitochondria-Caspase Pathway Activation.
Annals of The New York Academy of Sciences, 2003;1010.
19.
Singh M, Rosenschein U, Kalon KH, Berger PB, Kuntz R, Holmes DR
Treatment of Saphenous Vein Bypass Grafts with Ultrasound Trombolysis: A
Randomized Trial (ATLAS)
Circulation 2003;107:2331-2336.
20.
Schafer S, Kliner S , Klinghammer L,Kaarmann H, Lucic I,Nixdorff
11
U, Rosenschein U , Werner G.Daniel,
F. A. Flachskampf.
Influence of Ultrasound Operating Parameters on Ultrasound-Induced
Thrombolysis in Vitro.
Ultrasound in Med & Biol. 2005:31;841-847.
21.
22.
23.
2.
E. Goldhammer, A. Tanchilevitch, I. Maor, Y. Biniamini, Rosenschein U,
M. Sagiv.
Exercise Training Modulates Cytokines Activity in Coronary Heart
Disease Patients.
Year Book of Sports Medicine (Mosby Editors).2006;211-213.
Sharif D, Rofe G, Sharif-Rasslan A, Goldhammer E, Makhoul N, Shefer
A, Hassan A, Rauchfleisch S, Rosenschein U.
Analysis of serial coronary artery flow patterns early after primary
angioplasty:new insights into the dynamics of the microcirculation.
IMAJ 2008;10(6):440-44.
Sharif D, Sharif-Rasslan A, Shahla C, Rosenschein U.
Application of Mitral Annular Systolic Displacements and Velocities for
the Evaluation of Left Ventricular Systolic Function and Reserve.
Cardiol 2011;2 (1):36-41
Clinical Descriptive Research
1.
DiSegni E, Bakst A, Levi A, Rosenchein U, Klein Z, Beker B,
Dean H, Kaplinksy E.
Percutaneous balloon valvuloplasty for calcific aortic stenosis
in the elderly.
Harefuah, 1988; CXIV: 268-273.
2.
DiSegni E, Bakst A, Levi A, Rosenchein U, Klein HO.
The mechanism of the obstruction in calcific aortic stenosis
with bicuspid aortic valve.
Cardiology, 1989; 76:450-454.
3.
Nath FC, Muller DWM, Ellis SG, Rosenschein U, Chapekis A,
Quain L, Zimmerman C, Topol EJ.
Thrombosis of a flexible coil coronary stent: frequency,
predictors and clinical outcome.
J Am Coll Cardiol, 1993; 21:622-627.
12
4.
Nath CF, Muller DWM, Rosenschein U, Ellis SG, Topol EJ.
Heparin monitoring during coronary interventions: activated
clotting time versus activated partial thromboplastin time.
Canad J Cardiol, 1993; 9: 797-801.
5.
Shapira I, Frimerman A, Rosenschein U, Roth A, Keren G,
Laniado S,Miller HI.
Percutaneous transluminal coronary angioplasty in elderly
patients.
Cardiology, 1994; 85:88-93.
6.
Hartnell GG, Abela GSA, Rosenschein U.
Thrombectomie par ultrasons: quelles utilisations intra-vasculaire et intracoronaire?
Le Mouvement Cardio Vasculaire, 1995;211-214.
7.
Lincoff AM, Topol EJ, Califf RM, Sigmon KN, Lee KL, Ohman M,
Rosenschein U, Ellis SG.
Significance of a coronary artery with thrombolysis in myocardial
infarction grade 2 flow “patency” (outcome in the thrombolysis and
angioplasty in myocardial infarction trials).
Am J Cardiol, 1995;75:871-876.
8.
Roller M, Miller HI, Laniado S, Rosenschein U.
Coronary ultrasound angioplasty - an update of an expanding
technology.
J Interven Cardiol, 1995; 8(6): 671-675.
9.
Rosenschein U, Topol EJ.
Uncoupling clinical outcomes and coronary angiography: a review and
perspective of recent trials in coronary artery disease.
American Heart Journal, 1996;132: 910-920.
10.
Rosenschein U, Roth A, Rassin T, Bassan S, Laniado S, Miller HI.
Analysis of coronary ultrasound thrombolysis endpoints in acute
myocardial infarction (ACUTE Trial): results of the feasibility phase.
Circulation, 1997; 95:1411-1416.
11.
Rosenschein U, Budde-Schwartzman B.
Koronare ultraschallangioplastie: Standpunkt und neue klinische
aspekte
Herz, 1997;22:308-17.
12.
Brosh D, Miller HI, Hertz I, Laniado S, Rosenschein U.
Ultrasound angioplasty: An Update Review
Int J Cardiovasc Interventions, 1998;1:11-18.
13
13.
Rosenschein U.
Ultrasound thrombolysis- an alternative to the pharmacologic approach.
J Interven Cardiol, 1998;11:603-607.
14.
Rosenschein U, Gaul G, Erbel R, Amann F, Velasguez D, Stoerger H,
Simon R, Gomez G, Troster J, Bartorelli A, Pieper M, Kyriakidis
Z,Laniado S, Miller HI, Fajadet J.
Percutaneous Transluminal Therapy of Occluded Saphenous Vein
Grafts: Can the Challenge be met with Ultrasound Thrombolysis?
Circulation, 1999; 99: 26-29.
15.
Blum A, Porat R, Rosenschein U, Keren G, Roth A, Laniado S, Miller HI.
Clinical and inflammatory effects of dietary L-arginine in patients with
intractable angina pectoris.
Am J Cardiol, 1999;83(10):1488-90.
16.
Frimerman A, Miller HI, Siegal RJ, Rosenschein U, Roth A, Keren G.
Intravascular ultrasound imaging of myocardial-infarction-related arteries
after percutaneous transluminal coronary angioplasty reveals significant
plaque burden and compensatory enlargement.
Int J Cardiovasc Interventions, 1999;2:101-107.
17.
Viskin S, Brosh D, Rosenschein U, Barron HV.
Prevention of cardiac arrest: risk assessment after myocardial infarction.
Cardiac Electrophysiol Rev, 1999;3:20-23
18.
Brosh D, Rosenschein U.
Catheter-Based Ultrasound Thrombolysis – A New Promising
Thrombus-Debulking Device for the Treatment of intracoronary
Thrombosis
Semin Intervent Cardiol 2000;5:149-155
19.
Rosenschein U, Kuntz R.
Treatment of Lesions with Thrombus:
Beyond Stents and GP IIb/IIIa Inhibitors
Semin Intervent Cardiol 2000;5:157-160.
20.
Rosenschein U, Brosh D, Halkin A.
Coronary ultrasound thrombolysis: from acute myocardial infraction to
saphenous vein grafts and beyond.
Current Interven Cardiol Rep 2001;3:5-9.
21.
Halkin A, Rosenschein U.
Catheter-Delivered Ultrasound Therapy for Native Coronary Arterial
Thrombosis and Occluded Saphenous Vein Grafts.
Echocardiography 2001; 8: 225-231.
14
22.
Brosh D, Bartorelli AL, Fajadet J, Cribier A, Mesa J, Calderon L, Martyn
T, Amann F, Sampaolesi A, Desmet W, Rosenschein U for the
Acolysis Registry Study Group.
Percutaneous Transluminal Ultrasound Thrombolysis in Native
Coronaries in the Setting of Acute Coronary Syndromes.
Catheter Cardiovasc Interven , 2002;55:43-50.
23.
Halkin A, Rosenschein U, Barron HV, Viskin S.
Prevention of Cardiac Arrest:Risk Assessment after myocardial Infarction
Cardiac Electrophysiology Rev 2002;6(1-2):9-14.
24.
Topaz O, Perin EC, Jesse RL, Mohanty PK, Carr M, Rosenschein U
Power Thrombectomy in Acute Coronary Syndromes
Angiology. 2003;54:457-468.
25.
Halkin A, Holmes DR, Stone GW, Rosenschein U.
Percutaneous Treatment of Thrombus Rich Coronary Lesions: Beyond
Stents and GP IIb/IIIa Inhibitors.
IMAJ 2003; 5:795-800.
26.
Atar S, Rosenschein U. Perspectives on the Role of
Ultrasonic Devices in Thrombolysis.
Journal of Thrombosis and Thrombolysis. 2004;17(2):107-114.
27.
Goldhammer E., Tanchilevitch A, Rosenschein U, Maor I, Sagiv M,
Beniamini Y.
Exercise training modulates cytokines activity in coronary heart disease
patient.
Int J of Cardiology 2005;8(1):93-99.
28.
Bar-Meir E, Zeina AR, Blinder J, Rosenschein U.
Assessment of coronary artery bypass grafts by cardiac tomography
angiography.
IMAJ 2005;7(4):275-6.
29.
Hatem H , Nabeel M, Amin H, Shefer A, Rosenschein U.
Embolic protection: Limitations of current technology and novel
concepts.
Int J Cardiovasc Intervent. 2005;7(4):176-82
30.
Zeina AR, E Barmeir, J Blinder, Roseschein U.
Coronary Artery Imaging Using Cardiac CTA.
Harefuah. 2005;144(10):705-10
31.
Hatem H, Nabeel M, E Grenadir, F Kusniec, Rosenschein U.
Anchor Wire Technique Improves Device Deliverability during PCI of
15
CTOs and Other Complex Subsets.
Acute Cardiac Care. 2006;8:139-142.
32.
Zeina AR, Odeh M, Blinder J, Rosenschein U, Barmeir, E.
Myocardial Bridging: Evaluation on Multidetector-Computed
Tomography.
AJR, 2007;188(4):1069-1073.
33.
Zeina AR, Blinder J, Sharif D, Rosenschein U, Barmeir E.
Congenital coronary artery anomalies in adults: non-invasive
assessment with multidetector computed tomography.
The British Journal of Radiology, 2009; 82:254-261.
34.
Zeina AR, Sharif D, Blinder J, Rosenschein U, Barmeir E.
Noninvasive assessment of coronary artery ectasia using multidetector
computed tomography.
Coronary Artery Disease 2007;18(3):175-180.
35.
Zeina AR, Rosenschein U, Barmeir E.
Dimensions and anatomic variations of left main coronary artery in
normal population:multidetector computed tomography assessment.
Coronary Artery Disease 2007;18(6):477- 482.
36.
Goldhammer U, Biniamini Y, Maor I ,Rosenschein U, Lanir A.
The Early Anti-Oxidant Effect of Carvedilol Predicts Clinical Course in
Congestive Heart Failure Patients.
J. Cardiovasc Med 2007;8(6):453-456.
37.
Zeina AR, Odeh M, Rosenschein U, Zaid G, Barmeir E.
Coronary artery disease among asymptomatic diabetic and nondiabetic
Patients undergoing coronary computed tomography angiography.
Coronary Artery Disease 2008;19 (1):37-41
38.
Lubovich A, Rosenschein U
PCI vs CABG in Patients with Multivessel and Left Main Coronaries
Artery Disease:Lessons from the SYNTAX Trial.
Harefua Cardiology, 2009;7-9
39.
Allah S , Rivlin Y , Shnizer S , Rosenschein U , Goldhammer E.
Serum oxidizability potential of ischemic heart disease patients is
associated with exercise test results and disease severity.
World Journal of Cardiology, 2009;31(1):46-50
40.
Shanati A, Rivlin Y, Rosenschein U, Goldhammer E.
Oxidizability Potential IS Associated with Exercise Test Results and
Coronary Artery Disease Severity in IHD Patients.
World J Cardiol 2009;1(1):26-30.
16
41.
Goldhammer E, Rivlin Y, Shnizer S, Shanati A, Sagiv M, Rosenschein U.
Serum Oxidizability Potential is Associated with Age and Exercise Test
Results.
Eur Rev Aging Phys Act 2010;7:37-41.
42.
Zaid G, Yehudai D, Rosenschein U, Zeina AR.
Coronary artery disease in an asymptomatic population undergoing a
multidetector computed tomography (MDCT) coronary angiography.
The Open Cardiovascular Medicine Journal, 2010;4:7-13.
43.
Kobo O, Hammoud M, Makhoul N, Hatem O, Rosenschein U.
Screening, diagnosis, and treatment of renal artery stenosis by
percutaneous transluminal renal angioplasty with stenting.
IMAJ 2010;12(3):140-143
44.
E. Goldhammer, Y. Ben Moshe, A. Lubovich, Y. Rivlin, I. Maor, R. Zeina,
Rosenschein U.
Serum Endothelin-1, MMP-9, and Myeloperoxidase and Coronary Artery
Morphology as Detected by Multi-Slice CT Angiography in Intermediate
and High Risk Asymptomatic Subjects.
The Open Biomarkers Journal, 2010;3:7-12.
45.
Lubovich A, Hatem H, Behar S, Rosenschein U.
Bypassing the Emergency Room to Reduce Door-to-Balloon Time and
Improve Outcomes of Patients with ST Elevation Myocardial Infarction:
The Acute Coronary Syndrome Israeli Survey Experience.
IMAJ 2011;13:216-219
46.
4.
Sharif D, Radzievsky N, Samniah N, Hassan A, Kushnir A, Rosenschein U.
Palpography Detects Mechanical Dyssnchrony and Worsens with Right
Ventricular Pacing and Reduced Left Ventricular Ejection Fraction.
PACE 2011;34(7):875-83
Case Reports
1.
Rosenschein U, Kuretz A, Schneider M, Klajman A.
Thrombocytosis and renal abscess.
Nephron 1998;48:246 (letter).
2.
Rosenschein U, Ellis SG.
Pre-procedural warfarinization and brachial approach for elective coronary
17
stent placement – a possible strategy to decrease cost and duration of
hospitalization.
Catheterization and Cardiovascular Diagnosis, 1992; 25: 290-292.
3.
Rassin T, Desmet W, Piessens J, Rosenschein U.
Ultrasound Thrombolysis in Stent Thrombosis.
Catheter Cardiovasc Interven 2000; 51: 332-334.
4.
Zeina AR, Orlov I, Blinder J., Hassn A, Rosenschein U, Barmeir E.
Atypical Presentation of Acute Myocardial Infarction in a Young Man
diagnosed by Multidetector Computed Tomography.
IMAJ 2006; 8(1):69-70.
5.
Zeina AR, Zaid G, Sharif D, Rosenschein U, Barmeir E.
Huge Pericardial Hemangioma Imaging.
Circulation 2007;115:315-317.
6.
Zeina AR, Rosenschein U, Barmeir E.
Giant coronary-pulmonary artery fistula with multiple saccular
aneurysms: multidetector computed tomography evaluation.
Heart 2008;94:277
7.
Zeina AR, Shefer A, Sharif D, Rosenschein U, Barmeir E.
Acute myocardial infarction in a young woman with normal coronary
arteries and myocardial bridging.
The British Journal of Radiology, 2008;81(965):e141-4
8.
Sharif D, Radzievsky N, Rosenschein U.
Recurrent Pericardial Constriction: Vibrations of the Knock, the
Calcific Shield, and the Evoked Constrictive Physiology
Circulation. 2008;118:1685-1688.
4.
Review papers
1.
Rosenschein U, Rassin T.
Ultrasound thrombolysis
Science & Medicine, January/February,1997; 36-43.
2.
Elisha Bar-Meir, Abd-El-Rauf Zeina, Jorge Blinder, Rosenschein U.
Assessment of Coronary Artery Bypass Grafts by Cardiac Computed
Tomography Angiography.
IMAJ 2005;7:275-276.
18
5.
Books and Book Chpters
1.
Rosenschein U.
Ultrasound Angioplasty.
In: Strategic Approaches in Coronary Interventions.
Eds: SG Ellis and DR Holmes.
Williams and Wilkins 1996: 150-158.
2.
Agmon Y, Miller HI, Rosenschein U.
Ultrasound angioplasty using the angiosonics system.
In: Ultrasound Angioplasty.
Ed: RJ Siegel.
Kluwer Academic Press.1996: 151-170.
3.
Rosenschein U, Alter A, Rozenszajn LA.
Therapeutic ultrasound inhibits smooth muscle cells migration: a potential role
in the prevention of restenosis.
In: Endoluminal Stenting.
Ed: U Sigwart.
WB Saunders 1996: 129-133.
5. Rosenschein U.
Coronary ultrasound thrombolysis: state-of-the-art and clinical perspective
. In: Strategic Approaches in Coronary Interventions.
Eds: SG Ellis and DR Holmes.
Williams and Wilkins 2000: 164-171.
Others
Images in Medicine
1.
Rosenschein U.,MD, Kaganovitch N. MD, Machoul N. MD, Storch S. MD.
Treatment of Hypertension by Renal Artery Stenting.
IMAJ 2004; 6(7):445.
2.
Zeina AR, J Blinder, Rosenschein,U. E Barmeir.
Coronary-pulmonary artery fistula diagnosed by multidetector computed
tomography.
Postgraed.Med. J. 2006;82:15.
19
Editorials related to published manuscripts:
1.
Yock PG, Fitzgerald PJ. Catheter-based ultrasound thrombolysis: shake, rattle
and reperfuse. Circulation 1997; 95:1360-1362.
2.
Holmes DR, Berger PB. Percutaneous revascularization of occluded vein
grafts: is it still a temptation to be resisted?. Circulation 1999; 99: 8-11.
3.
de Feyter PJ. Percutaneous Treatment of Saphenous Vein Bypass
Obstruction- A continuing obstinate problem. Circulation 2003;107:2285-2286
“Meeting highlights” related to published manuscripts:
1. Ferguson JJ. ACUTE Trial.
Circulation,1998, Vol 97,pp 1217-1220.
2. Alexander JH, Kong DF, Cantor WJ. Highlights from the 71 st American Heart
Association Scientific Sessions: November 8 to 11,1998.
Am Heart J 1999, Vol 137,pp 555-574.
Press release by professional societies (related to published manuscripts):
1. Scientists employ sound method of dissolving clots in blood vessels.
American Heart Association, March 1997.
2. New Minimally Invasive Ultrasound Technique Restores Blood Flow in
Blocked Coronary Bypass Grafts.
European Society Cardiology, August 1998.
Interviewees by the American College of Cardiology
(related to published manuscripts):
1.
American College of Cardiology (ACCEL)
Taped during the AHA
Washington, DC, November 13-17,1988
2.
American College of Cardiology (ACCEL)
Taped during the AHA Anaheim CA, November 2001
(Vol. 54, No 2, Feb 2002)
Patents
20
1.
1989
In vivo Ultrasonic System for Angioplasty and Ultrasound
Contrast Imaging.
US Patent No. 5,163,421
2.
1992
Ultrasonic Transmission Apparatus
US Patent No 5,269,297
3.
1996
Ablation of blood thrombi by means of acoustic energy
US Patent No. 5,524,620
4.
1997
Method of inhibiting restenosis by applying ultrasonic energy.
US Patent No. 5,836,896.
5.
1997
Methods for prevention and treatment of
cancer and other proliferative diseases with
ultrasound energy.
US Patent No. 5,984,882
6.
1997
Ultrasound transmission apparatus and method of using same.
US Patent No. 5,971,949
7.
2000
Pulsed Mode Lysis Method
US Patent No. 6,113,558
8.
2005
Embolism Filter with Self-Deployable Guidewire Stop
US Patent No. 7,479,151 B2
9.
2007
Guidewire Stop
US Patent No. 7,819,844
10.
2009
Embolism Filter with Self-Deployable Guidewire Stop
US Patent No. 0149806-A1
11. 2009
Retrieval Catheter and Methods of Retrieving Deployed Medical
Devices.
US Patent No. 0254116-A1
12. 2009
Dual-Lumen Retrieval Catheters and Methods of Retrieving
Deployed Medical Device
US Patent No 2265223
13. 2009
Delivery Catheter with Constraining Sheath and Methods of
Deploying Medical Device Into a Body Lumen
US Patent No. 0254169-A1
21
15.
CONFERENCES
International
Plenary or invited talks
1.
Ultrasound Angioplasty.
In: Application of New Coronary Devices Mini-course.
The American College of Cardiology 42nd Annual Scientific Meeting,
Anaheim, California. March 14, 1993.
2.
Ultrasonic Ablation of Intracoronary Thrombus.
Transcatheter Cardiovascular Therapeutics.
Washington DC. February 24-27, 1994.
3.
Ultrasound Thrombolysis.
Transcatheter Cardiovascular Therapeutics.
Washington DC. February 24-27, 1995.
4.
New Experience with Ultrasound Thrombolysis
Moderne endovaskulare Katheterverfahren bei arteriellen Thrombosen.
Munich, Germany, 1995.
5.
Analysis of coronary ultrasound thrombolysis endpoints in acute
myocardial infarction (ACUTE Trial): results of the feasibility phase
Transcatheter Cardiovascular Therapeutics.
Washington DC. February 28 – March 3, 1996.
6.
Therapeutic Ultrasound in Cardiovascular Medicine – From Conception of
Idea to Clinical Trial.
1st European Workshop on Therapeutic Ultrasound Thrombolysis.
Essen, Germany. May 18, 1996.
7.
Thrombolysis and Peripheral Thrombectomy
Endovascular Therapy Course Coronary and Peripheral
Paris, France, May 20-23, 1997
8.
The Dark Side of Coronary Stenting
Endovascular Therapy Course Coronary and Peripheral
Paris, France, May 20-23, 1997.
9.
PTCA and Acute MI: Tips and Tricks
Endovascular Therapy Course Coronary and Peripheral
Paris, France, May 20-23, 1997
22
10.
Therapeutic Coronary Ultrasound
45th Annual Scientific Meeting of the Cardiac Society of Australia and New
Zealand
11.
Melbourne, Australia, August 9, 1997.
Clinical studies in Coronary Ultrasound Thrombolysis
45th Annual Scientific Meeting of the Cardiac Society of Australia and New
Zealand Melbourne, Australia, August 9, 1997.
12.
Non-invasive ultrasound thrombolysis is safe and effective – in vitro
results Tran catheter Cardiovascular Therapeutics.
Washington DC. February 24-27, 1997.
13.
The broad spectrum of ultrasonic angioplasty: a device for all seasons?
(thrombus, atheroma and total occlusions)
Transcatheter Cardiovascular Therapeutics.
Washington DC. February 24-27, 1997.
14. Coronary Ultrasound Thrombolysis – update
The 11th Annual Meeting of the Japanese Coronary Association,
Kobe, Japan. December 19-29, 1997.
15. Ultrasound Thrombolysis
7th Live Demonstration Course in Interventional Cardiology
Singapore, February 16-19, 1998.
16.
Ultrasound
Myocardial reperfusion XI: concepts and controversies
Atlanta, Georgia, March 28, 1998
17. Thrombus-containing lesions
Endovascular Therapy Course
Paris, France May 5-8, 1998
18. Therapeutic ultrasound thrombolysis experimental results: methods and
analysis 10 Jahre Koronare Stentimplantation und Rotoblation in
Deutschland Essen, Germany, May 14-16, 1998.
19. Ultrasound thrombolysis: basic aspects of a novel concept
Nuove Modalita di Trattamento dei Trombi Coronarici
Milan, Italy, 12 June, 1998.
20. Mechanical Coronary Thrombectomy: Ultrasound Atheroablation for Acute
MI’s (ACUTE study final results) and Thrombus-Containing SVG’s (ATLAS
update) Transcatheter Cardiovascular Therapeutics Washington DC, USA
October 1998.
23
21. Ultrasound Thrombolysis.
Myocardial reperfusion XII: concepts and controversies.
New Orleans, USA March 1999.
22. Lesions with Thrombus
American College of Cardiology 1999
New Orleans, USA March 1999.
23. An Update of Vascular Ultrasound Thrombolysis
Essener Gefasstage
Essen, Germany, June 1999.
24. Transcatheter ultrasound thrombolysis – from AMI to saphenous vein
grafts and beyond.
8th Annual Meeting of the Japanese Society of Interventional Cardiology
Yokohama, Japan July 1999
25. Ultrasound thrombolysis in AMI: The ACUTE and ATLAS Studies
Transcatheter Cardiovascular Therapeutics,
Washington DC, USA October 1999
26. Progress with ultrasound thrombolysis: interim observations from ATLAS
Transcatheter Cardiovascular Therapeutics,
Washington DC, USA October 1999
27.
Transcatheter ultrasound thrombolysis – from AMI to saphenous vein
grafts and beyond 9th PTCA Live Demonstration Course Kurashiki, Japan,
February 2000
28. Current PCI in thrombus-rich lesions: facts and fantasies
9th PTCA Live Demonstration Course Kurashiki.
Japan, February 2000
29. Thrombus-containing lesions
American College of Cardiology 49th Annual Session (ACCIS2000)
Anaheim, CA, March 2000
30. eData Collection and Management in the eMillenium.
Vascular Interventions 2000 Milan, Italy, May 2000
31. Pathophysiology of PCI in intracoronary thrombosis
PCI in Thrombus Rich Lesions Symposium.
PCR Paris, France, May 2000
32. Devices avoid complications
2nd International Congress on Complications during Coronary Intervention:
Management and Prevention Lausanne, Switzerland, June 2000
24
33. Therapeutic ultrasound – Acolysis
Transcatheter Cardiovascular Therapeutics.
Washington DC October 17-21, 2000
34. The case for ultrasound thrombo-ablation in AMI intervention (Acolysis)
Transcatheter Cardiovascular Therapeutics.
Washington DC October 17-21, 2000
35. Ultrasound-induced apoptosis: implications for restenosis and cancer
2nd International Symposium on Sonodynamic Therapy
Yokohama, Japan, March 30, 2001
36. Therapeutic ultrasound can induce apoptosis in smooth muscle cells – a
potential role for restenosis prevention.
American College of Cardiology
Orlando, FL, March 18-21, 2001
37. Therapeutic ultrasound – possible role in coronary interventions – from,
thrombolysis to restenosis.
4th International Meeting on Interventional Cardiology: Frontiers in
Interventional Cardiology June 24-28, 2001.
38. External ultrasound for thrombolysis
In: Symposium entitled: Therapeutic Ultrasound – the new frontier
European Society of Cardiology
Stockholm, Sweden September 1-5, 2001
39. Aspirate or Dissolve: The challenges too mechanical treatment in primary
PTCA In: Symposium entitled: Optimal Reperfusion Strategies for Acute
Myocardial Infarction European Society of Cardiology Berlin, Germany
September , 2002.
40.
My Worst Complications
Transcatheter Cardiovascular Therapeutics.
Washington DC, September, 2003
41.
Using bioeffects of ultrasound for therapeutic purposes.
Euro-Echo Barcelona.
Spain, December,2003.
42.
Embolic Protection Devices-Limitation Novel Ideas.
5th International Meeting on Interventional Cardiology: Frontiers in
Interventional Cardiology.
Tel-Aviv, Israel, December , 2003.
43. Therapeutic Ultrasound –The new frontier
Grand Rounds-Department of Cardiology University of Erlangen.
Erlangen, Germany, April 2004.
25
44. Therapeutic Ultrasound Past Present and Future Grand Rounds,
University of Essen.
Essen Germany. February 2005.
45. Cardiogenic Shock Revisited:Ongoing Frustration or New Hopes?
Innovations in Cardiovascular Interventions (ICI) Meeting.
Tel-Aviv, Israel, December 2006.
46. "Therapeutic ultrasound" Main Session on "New developments in
echocardiography and their clinical relevance".
73 Annual Scientific Meeting of the German Cardiac Society Mannheim,
Germany, April 2007.
47. Use of extraction devices during primary percutaneous coronary
intervention-prevention versus salvage approach.
PCR, Barcelona. Spain, May 2007
48. The Gardia Concept Integrating Everyday Guidewires with A Modular
Embolic Protection Device-In novative Devices and Futuristic Concepts II
Non stent Based Technologies.
TCT, Washington DC ,October 2007.
49. Bypassing the ER to Reduce DoortoBalloon Time the Israeli ExperienceInterventional Strategies and Adjunct Pharmacology in ACS and AMI.
TCT, Washington DC ,October 2007.
50. My Worst Complications coronary Intervention,
TCT, Washindgon DC,October 2007.
51. Perspectives on the role of ultrasound in clinical trials of thrombolysis
International Sonothrombolysis Conference,Mannheim,
Germany, July 2008.
52. Embolic Protection and Thrombectomy-The GARDIA Embolic Protection
Device: Standard Guidewires Coupled to a Modular Filter.
TCT, Cardiovascular Therapeutics. Washington DC, October 2008.
53. The Challenges in Embolic Protection
ICI Meeting, Tel-Aviv, December 2008.
54. Ultrasound Thrombolysis - Waves, Bubbles and Clots.
The First D. Dan and Betty KahnUniversity of Michigan-Technion,
Collaborative Cardiovascular Research Symposium.
Ann Arbor, Michigan; October 4, 2011.
26
27
Abstracts
1. Mayevsky A, Zarchin N, Rosenschein U.
The effect of anesthesia on the metabolic response to cortical spreading
depression in the gerbil.
Society for Neuroscience, Cincinnati, Ohio, Vol. 1, p. 261, 1981.
2.
Rosenschein U, Radnay J, Shoham D, Shainberg A, Klajman A, Rozenszajn
LA.
Tissue-specific T-lymphocytes in polymyositis.
7th European Immunology Meeting, Jerusalem, Israel, p. 208, 1985.
3.
Rosenschein U, Bernstein J, Bakst A, DiSegni E, Kaplinsky E, Bernhein J,
Rozenszajn LA.
Ultrasonic angioplasty device: experimental in vivo thrombolysis and in vitro
atherosclerotic plaque disruption.
Circulation, Vol. 78(II), p. 270, 1988.
4.
Rosenschein U, Kraus L, Marboe CC, Bernstein J, Rozenszajn LA, Rose EA,
Barr ML, Weinstein JS.
Ultrasonic angioplasty: Initial clinical results in peripheral vascular disease.
Circulation, Vol. 80(II), p. 306, 1989.
5.
Rosenschein U, Kraus L, Rozenszajn LA, David D, Marboe CC, Rose EA,
Watkins JF, Weinstein JS.
Clinical experience with ultrasonic angioplasty in totally occluded peripheral
arteries.
J Am Coll Cardiol, Vol. 15 (Suppl A), p. 104A, 1990.
6.
Rosenschein, U, Rozenszajn LA, David D, Marboe CC, Rose EA, Watkins
JF, Cannon PJ.
Ultrasonic angioplasty in peripheral vascular disease.
Eur Heart J, Vol 11 (Suppl), p. 191, 1990.
7.
Rosenschein U, Rozenszajn LA, Rose EA, Watkins JF, Marboe CC,
Cannon PJ, Weinstein JS.
Ultrasonic angioplasty in totally occluded peripheral arteries.
Circulation, Vol. 82(III), p. 871, 1990.
8.
Watkins, JF, Rose EA, DetWiler P, Fong JC, Sanchez JA, Coppey LJ,
Cannon PJ, Rosenschein U.
Mechanism of ultrasonic angioplasty.
Circulation, Vol. 82(III), p. 869, 1990.
9.
Rosenschein U, Dick JLR, Haudenschild CC, Topol EJ.
Does coronary arteriography morphology indicate plaque content?
J Am Coll Cardiol, Vol. 17 (Suppl A), p. 239A, 1991.
28
10.
Rosenschein U, DetWiler P, Rose EA, Watkins JF.
Ultrasonic angioplasty displays elasticity-dependent ablation.
Eur Heart J, Vol. 12 (Suppl), p. 7, 1991.
11.
Rosenschein U, Guberinich D, Yakubov SJ, Bach DS, Abrams GD, Sonda
PL, Topol EJ.
Shock wave thrombus ablation: a promising non-invasive method for
mechanical thrombolysis.
Circulation, Vol. 84, pp. 11-269, 1992.
12.
Nath CF, Rosenschein U, Muller DWM, Hacker JA, Guberinich D, Ellis SG.
Heparin monitoring during PTCA: ACT or APTT?
Circulation, Vol. 84, pp. 11-592, 1992.
13.
Yakubov SJ, Dick RJ, Haudenschild CC, Rosenschien U.
Deep tissue retrieval with coronary atherectomy is paradoxically associated
with less restenosis.
Circulation, Vol. 84, pp. 11-529, 1992.
14.
Hartnell GG, Saxson FS, Abela GSA, Rosenschein U.
Coronary ultrasonic thrombus ablation: assessment of a new transcatheter
device for coronary thrombolysis.
Eur Heart J, Vol. 13 (Suppl), p. 14, 1992.
15.
Lincoff AM, Ellis SG, Galeana A, Sigmon KN, Lee KL, Rosenschein U, for
the TAMI study group.
Is a coronary artery with TIMI grade 2 flow “patent”? Outcome in the
Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) trial.
Circulation, Vol. 86, pp. 11-268, 1992.
16.
Rosenschein U, Rozenszajn LA, Bernheim J, Frimerman, A, Keren G,
Roth D, Laniado S, Miller HI.
A new Coronary Ultrasound Angioplasty device: Study of acute effects invivo.
Eur Heart J, Vol. 14 (Suppl), pp. Ii-iv, 1993.
17.
Roller M, Perry C, Sutton JM, Grambow D, Kandalwal M, Palacios I,
Rosenschein U.
Urokinase therapy in the Catheterization Laboratory is associated with high
rate of bleeding.
Circulation, Vol. 88, pp. 1-252, 1993.
18.
Rosenschein U, Bernheim J, Frimerman A, Keren G, Roth A, Laniado S,
29
Miller HI.
Coronary Ultrasound Angioplasty: Study of acute effects in vivo.
Circulation, Vol. 88, pp. 1-546, 1993.
19.
Koifman B, Baron J, Frimerman A, Keren G, Rosenschein U, Laniado S,
Miller HI
Technetium-99m MIBI during PTCA: a new method to assess myocardium
at rest.
Isr J Med Sci Vol. 30, pp188, 1994
20.
Frimerman A, Miller HI, Rosenschein U, RothA, Laniado S, Keren G.
Mechanism of PTCA in acute coronary syndromes assessed by
intravascular ultrasound.
J Am Coll Cardiol, Vol. 21, p. 404A, 1994.
21.
Miller HI, Frimerman A, Rosenschein U, Laniado S, Keren G.
Prolonged dilatation improves the results of PTCA – an intravascular
ultrasound and angiography study.
J Am Coll Cardiol, Vol. 21, p. 404A, 1994.
22.
Frimerman A, Miller HI, Rosenschein U, Roth A, Laniado S, Keren G.
Intravascular ultrasound characteristic as determinant of long term
PTCA results in patients with acute myocardial infarction.
J Invasive Cardiol, Vol. 7, (Suppl C), p. 11C, 1995.
23.
Rosenschein U, Alter A, Rozenszajn LA, Miller HI
Therapeutic ultrasound inhibits smooth muscle cell migration and
adhesion.
Eur Heart J, Vol 16 (Suppl), p. 229, 1995.
24.
Rosenschein U, Miller HI.
Three years of the coronary ultrasound angioplasty experience: from bench
testing to clinical trial.
J Invas Cardiol, Vol. 7 (Suppl C), p. 37C, 1995.
25. Rosenschein U, Alter A, Rozenszajn LA, Miller HI.
Therapeutic ultrasound inhibits smooth muscle cells migration and
adhesion.
J Invas Cardiol, Vol. 7 (Suppl C), p. 40C, 1995.
30
26. Miller HI, Luchansky M, Rosenschein U, Frimerman A, Shefer A,
Laniado S.
Changes in stroke volume during acute occolusion of a coronary artery in
man.
J Invas Cardiol, Vol. 7 (Suppl C), p. 44C, 1995.
27. Rosenschein U, Roth a, Laniado S, Bassan S, Shefer A, Frimerman A, Miller
HI.
Ultrasound thrombolysis in acute myocardial infarction: initial results.
J Am Coll Cardiol, Vol. 27 (Suppl A), p. 81A, 1996.
28.
Rosenschein U, Roth A, Laniado S, Rassin T, Shefer A, Frimerman A,
Miller HI.
Ultrasound thrombolysis in acute myocardial infarction: initial results from
first clinical experience.
Israel J Med Sci, Vol. 32 (Suppl), p. S6, 1996.
29. Blum A, Vardinon N, Rosenschein U, Frimerman A, Shefer A,
Laniado S,
Miller HI. Coronary artery inflammation – a prolonged phenomenon after
successful revascularization.
Israel J Med Sci, Vol. 32 (Suppl), p. S3, 1996 (Abstr).
30. Blum A, Vardinon N, Rosenschein U, Frimerman A, Shefer A, Laniado S,
Miller HI.
Characterization of the angina pectoris (AP) syndrome by inflammatory
markers.
Israel J Med Sci, Vol. 32 (Suppl), p. S3, 1996 (Abstr).
31. Rassin T, Rosenschein U, Frimerman A, Shefer A, Miller HI.
The utility of rotational atherectomy in complex coronary stenosis
unsuitable for balloon angioplasty.
Israel J Med Sci, Vol. 32 (Suppl), p. S22, 1996 (Abstr).
32. Rosenschein U, Roth A, Laniado S, Rasin T, Basan S, Miller HI.
Coronary ultrasound thrombolysis in myocardial infarction: results of the
feasibility phase study.
Circulation (Suppl) 1996; Vol. 94(8):I-86 (Abstr.).
33. Rosenschein U, Roth A, Laniado S, Rasin T, Basan S, Shefer A, Miller HI.
Analysis of coronary ultrasound thrombolysis (ACUTE trial) in myocardial
infarction: Results of the feasibility phase.
Eur Heart J, Vol. 17, p.181, 1996.
31
34. Alter A, Kinor N, Savion N, Rosenschein U, Rozenszajn LA.
Immune modulation of vascular SMC proliferation and migration in an invitro system.
J Vascular Res, Vol. 33, p. S1-3, 1996.
35. Rosenschein U, Rozenszajn LA, Miller HI, Alter A.
Therapeutic ultrasound induces disorganization of the cytoskeleton and
inhibition of smooth muscle cell adhesion and migration.
J Vascular Res, Vol. 33, p. S1-85, 1996.
36. Rosenschein U, Eshel, Y, Furman, V, Kerner, E, Laniado, S, Miller HI.
Focused therapeutic ultrasound is a safe and effective method for noninvasive thrombolysis: results of in vitro studies.
J Invasive Cardiol, Vol. 9, Suppl C, p 17C, 1997.
37. Blum A, Weinberg G, Giladi U, Rosenschein U, Pasternak S, Laniado S,
Miller HI.
Anticytomegalovirus (CMV) antibodies – a marker of restenosis.
J Invasive Cardiol, Vol. 9, Suppl C, p 32C, 1997
38. Blum A, Weinberg G, Giladi U, Rosenschein U, Pasternak S, Laniado S,
Miller HI.
Anticytomegalovirus (CMV) antibodies and coronary artery disease.
J Invasive Cardiol, Vol. 9, suppl C, p 35C, 1997.
39. Blum A, Vardinon N, Kaplan G, Keren G, Rosenschein U, Laniado S, Yust I,
Burke M, Miller HI.
Serum amyloid type A (SAA) – a marker of restenosis.
J Invasive Cardiol, Vol. 9, Suppl C, p 48C, 1997.
40. Rosenschein U, Thuesen L, Andersen HR, Laniado S, Miller HI, Hertz I,
Haude H, Erbel R.
Coronary ultrasound thrombolysis in acute myocardial infarction: results
from the ACUTE study.
Circulation Vol. 96, (Suppl), p I-206, 1997.
41. Agmon Y, Miller HI, Roth A, Rassin T, Frimerman A, Keren G, Laniado S,
Rosenschein U.
Coronary ultrasound thrombolysis in acute myocardial infarction (ACUTE
Study): 6 month follow-up of the feasibility phase patients.
Eur. Heart J, Vol.18, p. 271, 1997.
42. Rosenschein U, Hertz I, Tenenbaum-Koren E, Thuesen L, Andersen HR,
Laniado S, Miller HI, Erbel R.
Coronary ultrasound thrombolyis in acute myocardial infarction: Results
from the ACUTE Study
J Am Coll Cardiol Vol. 31,pp 192A, 1998.
32
43. Muller DWM, Moncur J, Rosenschein U ,Nicklas J.
Ultrasound Thrombolysis: Ablated Thrombus Does Not Impede
Microcirculatory Flow or Impair Regional Left Ventricular Wall Motion.
Aust NZ Med, Vol. 28, pp 128, 1998.
44. Miller HI, Rosenschein U, Herz I, Thuesen L, Anderson HR, Laniado S, Erbel.
Coronary ultrasound thrombolysis in acute myocardial infarction: results
from the ACUTE study.
Eur Heart J Vol. 19, pp 398, 1998.
45. Fajadet J, Erbel R, Rosenschein U. For the Acolysis Registry Group
Coronary ultrasound thrombolysis in occluded saphenous vein grafts:
preliminary results.
Eur Heart J Vol.19, pp 393, 1998.
46. Rosenschein U, Eshel Y, Furman V, Kerner E, Laniado S, Miller HI. Focused
non-invasive therapeutic ultrasound thrombolysis is safe and effective in
experimental settings.
Eur Heart J Vol. 19, pp 659, 1998.
47. Rozenszajn LA, Gozdanker N, Ashush H, Shapira H, Rosenschein U, Radnay
J.
Ultrasound irradiation induces apoptosis in HL-60 cells and in normal and
pathological blood mononuclear cells.
British J Haematol Vol. 102, pp 327, 1998.
48. Fajadet J, Calderon L, Thomas M, Amann F, Desmet W, Ozman F, Gasper J,
Erbel R, Hertz I, Gaul G, Miller HI, Rosenschein U.
Coronary Ultrasound in Acute Coronary Syndromes: the first 100 patients
from the Acolysis Registry.
Circulation Vol. 98, pp I-87, 1998.
49. Ashush H, Rozenszajn LA, Gozdanker N, Radnay J, Shapira H, Rosenschein
U.
High intensity focus ultrasound induces apoptosis in human leukemic cells.
Meeting of the Federation of the Israeli Society of Experimental Biology Vol.
105, 1998.
50. Rosenschein U
Transcatheter ultrasound thrombolysis – from AMI to saphenous vein grafts
and beyond.
Jap J Interven Cardiol, Vol. 14(1), pp 106, 1999.
33
51. Brosh D, Herz I, Laniado S, Miller HI, Rosenschein U
Percutaneous transluminal ultrasound thrombolysis in native coronaries in
the setting of acute coronary syndromes.
Int J Cardiol Interven, Vol. 2, pp 39, 1999
52.
Frimerman A, Rosenschein U, Finkelstein A, Bazan S, Keren G, Miller HI
Follow-up angiography for clinical indicatons of patients after stenting
reveals patent stent site in most cases
Int J Cardiol Interven, Vol. 2, pp 35, 1999
53.
Herz I, Erbel R, Miller HI, Gilula Z, Thuesen L, Andersen HR, Laniado S,
Agmon Y, Rosenschein U
Improvement of left ventricular function after percutaneous trasnluminal
coronary ultrasound thrombolysis in acute myocardial infarction
Int J Cardiol Interven Vol. 2, pp 35, 1999.
54.
The Acolysis Registry Study Group
Percutaneous transluminal therapy of occluded saphenous vein grafts:
Can the challenge be met with ultrasound thrombolysis?
Int J Cardiol Interven Vol. 2, pp 17, 1999
55.
Rosenschein U
Ultrasound-guided focused ultrasound thrombolysis-The power of bubbles
Int J Cardiol Interven Vol. 2, pp 15, 1999.
56.
Rosenschein U
Coronary ultrasound thrombolysis-“From Concept to Clinical Reality
Int J Cardiol Interven Vol. 2, pp 15, 1999.
57.
Alter A, Rozenszajn LA, Salzberg S, Hacohen D, Rosenschein U,
Savion N.
Changes in smooth muscle cells associated with 2-5A synthetase activity in
response to immune system cell signals.
Thromb Haemost (Aug Suppl); 626, 1999.
58.
Rosenschein U for the ATLAS Trial Investigators.
Ultrasound thrombolysis and high risk vein graft disease: preliminary core
lab data from the ATLAS trial.
J Isr Heart Soc (Suppl);58, 2000
59.
Ashush H, Blass M, Barda-Saad M, Azimov D, Rozenszajn LA,
Rosenschein U.
Therapeutic ultrasound can induce apoptosis in vitro – a potential role for
restenosis prevention?.
J Isr Heart Soc (Suppl); 60, 2000
34
60.
Frimerman A, Keren G, Rosenschein U, Finkelstein A, Basan S, Miller HI.
Clinical parameters and functional tests are not predictive for in-stent
restenosis.
J Cardiovasc Intervent, (Suppl);3, 2003
61.
Ashush H, Firestein F, Elimelech R, Barda-Saad M, Radnay J,
Rosenschein U, Rozenszajn LA.
Therapeutic ultrasound: new strategy of apoptosis induction in malignant
hemopoietic cells.
Acta Hematologica, Vol. 103 (Suppl 1), pp 34, 2000.
62.
Shemesh L, Ashush H, Firestein F, Barda-Saad M, Rosenschein U,
Rozenszajn LA.
Apoptosis induction in human p53 positive cancer cells treated with
therapeutic ultrasound.
Acta Hematalogica, Vol. 103 (Suppl 1), pp 58, 2000.
63.
Miller HI, Frimmerman A, Bazan S, Rosenschein U, Shalman E, Barak C,
Dgany E, Leibowitz M.
Assessment of the distal coronary bed: online analysis using intracoronary
pressure measurements.
Am J Cardiol, pp 106i, 2000
64.
Erbel R, Kuechler R, Miller HI, Herz I, Rosenschein U.
Ultrasound thrombolysis has a positive effect on restenosis rates in AMI
patients.
Am J Cardiol, pp 95i, 2000
65.
Erbel R, Kuechler R, Miller HI, Herz I, Rosenschein U.
Therapeutic ultrasound reduces restenosis rates in primary PCI in AMI
patients.
J Am Coll Cardiol, Vol. 37 (suppl), pp70A, 2001.
66.
Rosenschein U, Ashush H, Blass M, Barda-Saad M, Alter A, Firestein F,
Rozenszajn LA.
Therapeutic ultrasound can induce apoptosis in smooth muscle cells: a
potential role for restenosis prevention.
J Am Coll Cardiol, Vol. 37 (Suppl), pp26A, 2001.
67.
Rosenschein U, Ashush H, Blass M, Barda-Saad M, Alter A, Firestein F,
Rozenszajn LA, Rechavi G.
Therapeutic ultrasound and smooth muscle cell functions – a potential role
for restenosis prevention.
J Isr Heart Soc (Suppl), p1, 2001
35
68.
Rosenschein U, Herz I, Kuechler R, Miller HI, Erbel R.
Therapeutic ultrasound reduces restenosis rates in primary PCI in AMI
patients
J Isr Heart Soc (Suppl), p18, 2001
69.
Ashush, H., Firestein, F., Shemesh, L., Elimelech, R., Aran, Y., Radnay, J.,
Shapiro, H., Rosenschein, U. and Rozenszajn, L.A. Ceramide signaling
pathway involvement in ultrasound-induced apoptosis.
Exp. Hematol. Vol , pp 29, 2001.
70.
Firestein, F., Elimelech, R., Ashush, H., Shemesh, L., Aran, Y., Radnay, J.,
Schickler, R., Rosenschein, U. and Rozenszajn, L.A. Apoptosis induction
of p53 positive malignant lymphoid cells by ultrasound application.
Exp. Hematol. Vol 29, pp 67, 2001.
71.
Firestein F, Rozenszajn LA,, Shemesh-Darvish L, Elimelech R, Radnay J,
Rosenschein U. Apoptosis induction of human malignant lymphoid cells by
ultrasound application. Role of mitochondria – caspase pathway
activation. “Apoptosis 2003, from signaling pathway to therapeutic tools”
Luxemburg, February 2003.
72.
Singh M, Rosenschein U, Kalon KH, Berger PB, Kuntz R, Holmes DR
Treatment of Saphenous Vein Bypass Grafts with Ultrasound Trombolysis:
A Randomized Trial
J Am Coll Cardiol. Vol 41 (Supp A), pp 43A, 2003
73.
Goldhammer E, Biniamini Y,Rosenschein U, Maor I, anchilevitch A.
Paraoxonase serum activity is reduced by aerobic exercise.
The Annual Meeting of the ESC 8/2004 Munich, Germany.
European Heart Journal. Vol. 25, suppl., p.357-358, 2004.
74.
Bar-Meir E, Zeina AR, Blinder J , Rosenschein U
Assessment of Coronary Artery Bypass Grafts by Cardiac Computed
Tomography Angiography.
IMAJ ;Vol 7:275-276, 2005.
75.
Goldhammer E, Maor I, Rosenschein U, Lanir A, Sagiv M.
B-Type Natriuretic Peptide Response to Aerobic Exercise Test Compared
to Strength Testing in Patients with Left Ventricular Dysfunction.
Spring Meeting Leuven ,April 7-10, 2005.
36
76.
Sharif D, Sharif-Rasslan A, Shefer A, Makhoul N, Hassan A, Rosenschein
U.
Left Anterior Descending Coronary Artery Velocity Profiles Change During
Follow up After Primary Angioplasty in Acute Anterior Myocardial Infarction
and Predict Recovery of Left Ventricular Function.
Circulation; Vol 112:17,2005.
77.
Zaid G, Tanchilevitch A, Gropper A, Rivlin E, Lanir A, Rosenschein U,
Goldhammer E.
Diagnostic accuracy of Serum B-type Natriuretic Peptide for Myocardial
Ischemia Detection During Exercise Testing with Spect Perfusion Imaging.
Int J Cardiol, Vol 25;117(2):157-164,2007
78.
Hammoud M, Makhoul N, Sharif D, Shefer A, Hassan A ,Storch S,
Loberman Z, Rosenschein U.
Screening, diagnosis and treatment of renal artery stenosis by
Percutaneous Transluminal Renal Angioplasty (PTRA) with stenting, the
Haifa experience.
WCC- Barcelona,September 2006.
79.
M. Hammoud, D. Sharif, Rosenschein U.
Risk factors, psychosocial factors, clinical manifestation and outcome of
very young adults presented with acute myocardial infarction, a single
center experience.
WCC-Barcelona, September 2006.
80.
Zeina AR., Blinder J.,Rosenschein U.,Makhoul N., Barmeir E.
Left main coronary artery disease: Should patients undergo coronary CT
Angiography befor bypass grafting surgery?
ISRA, Nov.Tel-Aviv, 2006.
81.
Goldhammer E, Zaid G, Rivlin E, Gropper R, Lanir A, Rosenschein U.
The contribution of serum B-type natriuretic peptide to the diagnostic
accuracy of myocardial ischemia detection during exercise testing with
SPECT perfusion imaging.
Journal of Nuclear Cardiology, Vol 14:2,2007
82.
Goldhammer E, Zeina AR, Ben Moshe Y, Zaid G, Rivlin E, Maor I,
Bar Meir E, Rosenschein U.
Endothelin-1 is associated with the presence of soft plaques in
asymptomatic subjects, as diagnosed by 64-row multidetector computed
tomography.
Journal of Nuclear Cardiology, Vol 14:2,2007
37
83.
Hammoud H, Sharif D, U Rosenschein.
Percutaneous Renal Artery Angioplasty for Renal Artery Stenosis
Reduces the Incidences of Flash Pulmonary Edema and Hospitalization
Rate for Acute Heart Failure.
European Society of Cardiology, Vienna September 2007
84.
Scheinert D, Rosenschein U, Ulrich M, Bräunlich S, Schmidt A,
A New Modular Embolic Protection System; First In Man Experience.
PCR, Barcelona 2009.
38
Participation in organizing conferences
Session Panel Member
Transcatheter Cardiovascular Therapeutics
Washington, DC, September 1997
Interviewee
American College of Cardiology (ACCEL)
Taped during the AHA
Washington, DC, November 13-17, 1988
Session Chairman
Endovascular Therapy Course Coronary and
Peripheral
Paris, France, May 1998
Session Guest Animator
Endovascular Therapy Course Coronary and
Peripheral
Paris, France, May 1998
Course Co-Organizer &
Co Chairman
New treatment modalities of coronary thrombus
Milan, Italy, June 1998.
Case Moderator
Transcatheter Cardiovascular Therapeutics,
Washington DC, USA, Oct 1998
Discussant
Transcatheter Cardiovascular Therapeutics,
Washington DC, USA, Oct 1998
Case Moderator
Transcatheter Cardiovascular Therapeutics,
Washington DC, USA, October 1999
Discussant
Transcatheter Cardiovascular Therapeutics,
Washington DC, USA, October 1999
Case Moderator
American College of Cardiology 49th Annual
Session (ACCIS 2000)
Anaheim, CA, March 2000
Chairman & Organizer
PCI in Thrombus-Rich Lesions Symposium
PCR Paris, France, May 2000
Case Moderator
Transcatheter Cardiovascular Therapeutics,
Washington DC, USA, October 2000
39
Discussant
Transcatheter Cardiovascular Therapeutics,
Washington DC, USA, October 2000
Co- Chair
4th International Meeting on Interventional
Cardiology: Frontiers in Interventional Cardiology
London, June 2001
Chairman
4th International Meeting on Interventional
Cardiology: Frontiers in Interventional Cardiology
Discussant
Transcatheter Cardiovascular Therapeutics,
Washington DC, USA, October 2001
Live Case Discussant
Transcatheter Cardiovascular Therapeutics,
Washington DC, USA, October 2001
Interviewee
American College of Cardiology (ACCEL)
Taped during the AHA Anaheim CA, November
2001(Vol. 54, No 2, Feb 2002)
Session Chairman
European Society of Cardiology
Embolic Protection Devices
Berlin, Germany September, 2002
Session Chairman
Transcatheter Cardiovascular Therapeutics,
Washington DC, USA September 2002
Founder & Co Chairman
Yearly debate Meeting
“Point Counter Point”,
Tel Aviv University. 2002-Present.
Symposia Chairman
Embolic Protection Devices
European Society of Cardiology
Berlin, Germany September, 2002
Session Chairman
Complication- my worst nightmare
Transcatheter Cardiovascular Therapeutics,
Washington DC, USA September 2002
Symposia Chairman
Evolving Role of Distal Protection
American College of Cardiology
Chicago USA March 2003
Poster Abstract Moderator
Transcatheter Cardiovascular Therapeutics,
Washington DC, USA, September, 2003
40
Symposia-Chairman
Hematopoiesis:From Basic Research to Tissue
Engineering.
February 2004. Bar-Ilan University.
Symposia-Co-Chair
Adjunctive Mechanical Therapy
American College of Cardiology
New-Orleans USA March 2004.
Co-Chair
The 53rd Annual Meeting of Israel Heart
Association, Tel-Aviv, April 2006.
Chairman
Technology parade
Interventional Accessory
Devices
ICI Tel-Aviv, December 2006.
Scientific Committee
International Sonothrombolysis Conference
Mannheim/Heidelberg Germany,July 4-5,2008
Discussant
Symposia.
Embolic Protection and Thrombectomy
Transcatheter Cardiovascular Therapeutics
Washington, October 2008.
Chairman & Organizing Committee
The first D.Dan and Betty Kahn
University of Michigan– Technion, Collaborative Cardiovascular Research
Symposium, Ann Arbor, Michigan; October 4, 2011.
Chairman and organizing committee The T2Med meetings
41