February 2010
Toxicologic and Exploratory Pathology
Specialty Section, Society of Toxicology
TEPSS, the Toxicologic and Exploratory Pathology Specialty Section
of the Society of Toxicology, is an organization to promote the use of
pathology methods and approaches in toxicology research. We
develop and propose symposia and workshops for the SOT annual
meeting, promote high-quality scholarship by selecting top students
for travel awards, provide networking opportunities for pathologists
at the SOT meeting, and provide pathologists’ perspective to the SOT
leadership.
Current members have varied educational backgrounds and hold
positions in universities, industry and government. Our membership
is actively engaged in research and product development for which
specialized knowledge in the application of experimental pathology,
tissue evaluation and whole animal response to toxicants is a critical
component of the safety evaluation process.
President’s Message from Charles Qualls
Officers
President
Charles W. Qualls, Jr.
chuck.qualls@amgen.com
President-Elect
Glenn Cantor
glenn.cantor@bms.com
Past President
Karen Regan
kregan@zoominternet.net
Vice President
Doug Wolf
wolf.doug@epa.gov
Treasurer and Secretary
Sandra Eldridge
sandra.eldridge@crl.com
Councilors
Another Society of Toxicology Meeting is fast approaching. I hope
that you will be able to join us for the Toxicology and Exploratory
Pathology Specialty Section lunch meeting which will be held during
the SOT meeting on Wednesday 7 March from noon till 1:30 PM in
Room 255E. During this meeting, student travel award recipients
will present their research, a general business meeting will be
conducted, outgoing and incoming officers will be announced, and
camaraderie over a free lunch will be enjoyed by all!
Norm Barlow
norman.barlow
@sanofi-aventis.com
Brian Day
DayB@NJHealth.org
Student Representative
Lu Wang
lwang3@u.washington.edu
Postdoctoral
Representative
One of TEPSS major functions is to sponsor continuing education
Chidozie Amuzie
courses and various forms of sessions. In 2010, we are the sponsor of amuziech@cvm.msu.edu
two continuing education courses and one workshop; in addition, we
Website Liaison
are endorsers of 6 other sessions.
One of the most influential things that TEPSS can do to increase the
visibility of TEPSS and pathology at the SOT is presenting
continuing education courses or other types of sessions at the SOT.
Continued on Page 6
Table of Contents
Doug Wolf
wolf.doug@epa.gov
Award Contact
Norm Barlow
norman.barlow@sanofiaventis.com
________________________
Membership Information….....……………………….…….2
TEPSS and the Annual SOT Meeting ………………….…..2
Student Travel Awards……………………………………4
Page 1
Membership Information, Dues Reminder
If you are currently a member of SOT, you may join or renew your
membership in the Toxicologic and Exploratory Pathology Specialty
Section for $15 annually by using the SOT on-line membership form.
Students may join one specialty section for no additional cost.
TEPSS and the SOT Annual Meeting
A major function of SOT specialty sections is to propose the symposia and
Your
Text Herefor the SOT annual meeting. In a field as diverse as toxicology,
workshops
there are so many proposals that only portions are selected each year.
TEPSS, the Toxicologic and Exploratory Pathology Specialty Section, has
been successful in sponsoring a variety of high-quality sessions each year.
At the 2010 annual meeting in Salt Lake City, TEPSS-sponsored sessions
are:
 Segment Specific Renal Pathology for the Non-Pathologist
(continuing education course)
 Assessment of Ocular Toxicity in Toxicology Studies
Conducted for Regulatory Purposes (continuing education
course)
 Novel Research Approaches, Animal Models, and Clinical
Examples in Translational Toxicology (workshop)
In planning for the 2011 meeting programs SOT has areas of emphasis for
thematic approach. Other areas are covered but the following themes are
being emphasized by the educational committee:
 Global Air Quality and Human Health
 Novel Approaches to Preclinical Safety Assessment: Bridging the
Gap Between Discovery and the Clinic Through Translational
Toxicology
 Environment and Disease
 Toxicity Testing: State of Science and Strategies to Improve Public
Health
 Integration of Toxicological and Epidemiological Evidence to
Understand Human Risk
 Emerging Global Public Health Issues
Continuing Education (CE) Target Areas for 2011 are:
 Cardiovascular Toxicology
 Epigenetic Mechanisms
 Systems Biology
Page 2
For additional information about TEPSS
For additional information regarding TEPSS please go to our
website at http://www.toxicology.org/ISOT/SS/TEP/index.html or
contact any of the officers/councilors listed in the newsletter.
TEPSS-sponsored sessions in 2009 included:

Strategies to Integrate Systems Biology into in vitro
Screening in Early Nonclinical Safety Assessment;
Workshop

Stress as a Confounding Factor in Toxicology Studies; CE
Basic

Devils Lie in the Details: Practices and Problems in
Neuropathology-Significance
for
Neurotoxicology;
Roundtable

Kinase Inhibitors as Targeted Therapeutics in
Inflammation and Oncology- Approaches to Predict and
Manage Clinical Toxicities; Informational Session

The Role of Inflammation During Metabolic Liver Disease
and Drug-Induced Liver Toxicity: Novel Insights;
Symposium

Biomarkers for Assessing the Systemic Inflammatory
Response Syndrome in Toxicology Studies; Workshop

How Similar is Similar and How Relevant is Relevant?
Considerations in the Design of a Predictive Development
Program for Biotherapeutics; CE Basic

Improved Safety Biomarkers for Monitoring Kidney
Injury; Workshop
Page 3
Student Travel Awards
Student travel awards are more than an opportunity for talented students to
receive financial assistance to attend the annual meeting. The TEPSS
reception, held each year at the SOT annual meeting, is an excellent
opportunity for students to meet prospective mentors and employers in a
relaxed and congenial atmosphere. Our top student awardees provide a short
presentation to the assembled membership on their award-winning research.
Past Awardees:
2006 Student Award Winners:
TEPSS Awards
Sharmilee Sawant, University of Louisiana, Monroe (advisor: Harihara M.
Mehendale). Type 2 diabetic mice are protected from acetaminophen
hepatotoxicity
Steven Cooper, University of Arkansas for Medical Sciences and FDA
National Center for Toxicological Research (advisor: K Barry Delclos). Dietary
effects on cell proliferation and apoptosis in para-nonylphenol (NP) induced
polycystic kidney Disease (PKD) in male Sprague-Dawley rats.
Merck Award
Xiaomin Deng, Michigan State University (advisor: Robert A. Roth). Modest
inflammation enhances diclofenac hepatotoxicity in rats: A potential animal
model for idiosyncratic drug reaction
2007 Student Award Winners:
TEPSS Award
Jaya Chilakapati, University of Louisiana, Monroe (advisor: Harihara M.
Mehendale). CYP2E1 knockout mice are protected from thioacetamide-induced
liver injury
Merck Award
Shashikiran Donthamsetty, University of Louisiana, Monroe (advisor:
Harihara M. Mehendale). Hepatotoxicity sensitivity of nonalcoholic
steatohepatic (NASH) mice to acetaminophen is due to low PPAR-alpha
Page 4
2008 Student Award Winners:
TEPSS Awards
Atrayee Banerjee, Texas A&M University, College Station (advisor: S.K.
Ramaiah). Osteopontin-mediated β1 and β2 integrin signaling: A mechanism
for higher hepatic neutrophil infiltration and liver injury in female alcoholic
liver disease
Christine M. Dugan, Michigan State University (advisors: Robert Roth and
Patty Ganey). Determinants of sensitivity to halothane-induced
hepatotoxicity in mice.
2009 Student Award Winners:
TEPSS Award
Lu Wang, University of Mississippi (advisor: Kristine Willett). Histologic
and immunohistochemical characterization of CYP1C1 and CYP1A
expression in PAH-induced Fundulus hepatic lesions.
McClellan Award
Chidoze J. Amuzie, Michigan State University (James Pestka). SOC3 and
IGF-1 are potential biomarkers for deoxynivalenol-induced growth inhibition
in the mouse.
Roger McClellan Student Award
The Roger McClellan Student Award was initiated in 2009. The award,
funded by an endowed fund established by Roger McClellan, is given to a
student who is enrolled in a program leading to a DVM degree or in postDVM residency or graduate program. Special consideration will be given to
abstracts that exemplify the role of comparative medicine in evaluating the
safety or risk of exposure to chemicals or physical agents. The research must
be hypothesis driven. The awardee is selected by TEPSS, together with the
Comparative and Veterinary Specialty Section.
Charles Capen Student Travel Award
This is the first year for this new award. The International Academy of
Toxicologic Pathology (IATPFellows.org) funds an award in the amount of
$750 USD which can be used by the successful student for costs to attend the
Society of Toxicology Annual Meeting. The Charles Capen Student Travel
Award is a memorial in recognition of Dr. Charles Capen and his legacy as a
researcher, teacher, and mentor to the veterinary and toxicologic pathology
communities.
Page 5
President’s Message
continued from page 1
TEPSS is currently in discussions with the STP Education Committee
regarding co-sponsoring a session at the 2011 SOT meeting. I hope
that you will consider putting together a continuing education course
or other session for the 2011 SOT meeting. I must warn you that
proposals with a finalized list of speakers and abstracts must be
submitted in April. Now is the time to start putting your ideas
together. Feel free to contact me or any of the TEPSS leadership team
for help if you would like to consider putting a session together or
working on a session.
If you are engaged in TEPSS, thank you, if not, please consider getting
involved. Working through TEPSS is a special way to increase the
knowledge, impact and stature of pathology throughout the SOT.
Feel free to contact any of the leadership team for ideas of how you
can get involved.
I hope that I see you in Salt Lake City!
Chuck Qualls
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