th 5 Waddensymposium on “Modulating and monitoring alloreactivity” This symposium is organized in collaboration with: ` www.waddensymposium.eu Location: Grand Hotel Opduin, Texel, the Netherlands www.opduin.nl Preliminary program, 24th of June till the 27th of June 2012 Sunday 24th of June 18.00 Arrival Hotel Opduin, Texel 20.00 Dinner Monday 25th of June 07.30 - 08.15 Breakfast 08.15 - 08.30 Welcome, symposium in perspective: Willem Fibbe, Leiden [The Netherlands] The players Chair: Cees van Kooten 08.30 – 09.05 Jean Paul Soulillou [France] ”The role of B cells in transplantation and tolerance” 09.05 – 09.40 Andrew Bushell [UK] “Regulatory T cells for controlling alloreactivity:- Is mouse to man a logical step?” 09.40 – 10.15 Loredana Ruggeri [Italy] “Role of alloreactive NK cells in allogeneic transplantation” 10.15 – 10.50 Francesco Dazzi [UK] “Mesenchymal stroma: innate tolerance and tissue repair” 10.50 – 11.20 Coffee break 11.20 – 11.55 Marcus Saemann [Austria] “Professional Antigen Presenting Cells: the role of mTOR” 11.55 – 12.55 Short abstracts Nicolle Litjens, Anne Bouvy, Carla Baan, Eyten Breman, Marlies Reinders 13.00 – 13.45 Lunch 14.00 – 18.00 Informal discussion between young talented scientists / invited speakers (Transfer at 14.00h) 18.00 – 20.00 Dinner 20.00 – 21.00 Keynote lecture Chair: Wim Fibbe Robert Lechler [UK] “Is alloimmunity manageable without drugs” Tuesday 26th of June 07.30 – 08.30 Breakfast The responses Chair: Frans Claas 08.30 – 09.05 Ineke ten Berge [the Netherlands] “Interplay between viral and alloimmunity” 09.05 – 09.40 Will Burlingham [USA] “The role of chimerism in transplantation tolerance” 09.40 – 10.15 Stephen Sacks [UK] “Complement and innate immunity in transplant rejection” 10.15 – 10.40 Coffee break 10.40 – 11.15 Caner Süsal [Germany] “Clinical relevance of HLA specific antibodies” 11.15 – 11.50 Craig Taylor [UK] ”Determining HLA epitope immunogenicity using comparative protein modelling” 11.50 – 13.00 Short abstracts Pieter vd Pol, Michael Eikmans Dave Roelen, Sebastiaan Heidt, Moshe Israeli, Cornelis van der Torren 13.00 – 13.30 Lunch 13.45 – 18.00 Informal discussion between young talented scientists / invited speakers (Transfer at 13.45h) 18.00 – 20.00 Dinner 20.00 – 21.00 Keynote lecture Chair: Jaap Jan Zwaginga Phil Halloran [Canada] “Molecular Diagnosis of Kidney Allograft Rejection” Wednesday 27th of June 07.30 – 08.30 Breakfast Clinical implementation Chair: Willem Weimar 08.30 – 09.05 Robert Montgomery [USA] “Desensitization” 09.05 – 09.40 Claudio Brunstein USA] “Double cord blood transplantation” 09.40 – 10.15 Teun van Gelder [the Netherlands] “Immunosuppressive therapy” 10.15 – 10.50 Silvia Gregori [Italy] “Treg-based cell therapy in transplantation” 10.50 – 11.15 Coffee break 11.15 – 12.45 General discussion and position paper 12.45 – 13.30 Lunch 13.35 Departure by bus to Harbour 14.00 Departure boat to Den Helder END OF MEETING