6th Waddensymposium on “Transfusion Medicine and Immune Modulation” This symposium is organized in collaboration with: ` www.waddensymposium.eu Location: Grand Hotel Opduin, Texel, the Netherlands www.opduin.nl This symposium is accredited for 12 points by the Dutch Society for Immunology (N.V.V.I) Final program, 23rd of June till the 26th of June 2013 Sunday 23rd of June 18.00 Arrival Hotel Opduin, Texel 20.00 Dinner Monday 24th of June 07.30 - 08.15 Breakfast 08.15 - 08.30 Welcome, symposium in perspective: Willem Fibbe, Leiden [The Netherlands] Pathophysiology of allo-immunization in blood transfusion Chair: Jaap Jan Zwaginga 08.30 – 09.05 France Noizat- Pirenne [France] “Red blood cell alloimmunization in transfusion” 09.05 – 09.40 Sean. R. Stowell [USA] “Mechanisms and Consequences of Incompatible RBC Transfusion” 09.40 – 10.15 Alexander Vlaar [the Netherlands] “Antibody and non-antibody mediated TRALI” 10.15 – 10.50 Raymond Goodrich [USA] “White cell inactivation as a consequence of pathogen reduction technologies: Exploring the risks and benefits of side effects” 10.50 – 11.20 Coffee break 11.20 – 11.55 Anne Husebekk [Norway] “Platelet immunization” 11.55 – 12.40 Abstracts Robin van Bruggen [the Netherlands] “CD47 functions as a molecular switch for erythrocyte phagocytosis” Anno Saris [the Netherlands] “Alloimmunization and T cell activation in onco-hematological patients transfused with platelets” Dave Roelen [the Netherlands] “HLA mismatches that are identical for the antigen recognition site: An inventory of the functional consequences” 12.40 – 13.30 Lunch 13.30 – 18.00 Informal discussion between young talented scientists / invited speakers (Transfer at 13.30h) 18.00 – 20.00 Dinner 20.00 – 21.00 Keynote lecture Chair: Marian van Kraaij Karina Yazdanbakhsh [USA] “Immune dysregulation in autoimmune cytopenias” Tuesday 25th of June 07.30 – 08.30 Breakfast Immunological consequences of allo-exposure Chair: Frans Claas 08.30 – 09.05 Sarah Robertson [Australia] “Pregnancy and immunomodulation – the latest insights” 09.05 – 09.40 Peter Hordijk [the Netherlands] “Effect of transfusion on endothelial cells” 09.40 – 10.15 Thomas Fehr [Switzerland] “Mixed chimerism and transplantation tolerance” 10.15 – 10.40 Coffee break 10.40 – 11.15 Robert Barker [UK] “T Cell Subsets and Epitopes in Autoimmune Hemolytic Anemia” 11.15 – 11.50 Anita Hill [UK] “The role of complement inhibition in PNH and aHUS” 11.50 – 12.45 Abstracts Henk Schonewille [the Netherlands] “Pregnancy induced red blood cell antibody persistence and feto-maternal chimerism” Lisa Lashley [the Netherlands] “Oocyte donation pregnancies are associated with a higher incidence of HLA alloantibodies” Tess Meuleman [the Netherlands] “The immunomodulating effect of semen on maternal T cells” 12.45 – 13.30 Lunch 13.30 – 18.00 Informal discussion between young talented scientists / invited speakers (Transfer at 13.30h) 18.00 – 20.00 Dinner 20.00 – 21.00 Keynote lecture Chair: Anneke Brand Lee Nelson [USA] “Microchimerism: The Otherness of Self in Autoimmunity and Alloimmunity” Wednesday 26th of June 07.30 – 08.30 Breakfast Cellular therapy Chair: Wim Fibbe 08.30 – 09.05 Edward Geissler [Germany] “Cellular therapy in organ transplantation" 09.05 – 09.40 Katarina Le Blanc [Sweden] “Multipotent mesenchymal stem cells in allogenic stem cell transplantation” 09.40 – 10.15 Bart Roep [the Netherlands] “Tolerogenic dendric cells as immune intervention therapy in clinical type 1 diabetes” 10.15 – 10.50 Hermann Einsele [Germany] “Immunotherapeutic approaches based on DCs/Tcells to improve the outcome of stem cell transplantation” 10.50 – 11.05 Short presentation Liesbeth Oosten [the Netherlands] “Treatment of severe steroid-refractory acute GvHD with mesenchymal stromal cells. A phase III randomized double-blind multi-center HOVON study” 11.05 – 11.25 Coffee break 11.25 – 12.45 General discussion and position paper 12.45 – 13.30 Lunch 13.30 Departure to Harbor (13.15 departure city bus 28 to the harbor) 14.00 Departure boat to Den Helder END OF MEETING