Nature22Feb2007Vol445Number7130pp795p950
Nature 22 February 2007 Volume 445 Number 7130, pp795-950
Usage of Human Famsbase for Nature 22 February 2007 Volume 445 Number 7130,
pp795-950
APOBEC3 inhibits mouse mammary tumour virus replication in vivo p927
Chioma M. Okeoma, Nika Lovsin, B. Matija Peterlin and Susan R. Ross
10.1038/nature05540
First paragraph | Full Text | PDF
2: P60705 Reports
BLink, Conserved Domains, Links
Probable DNA dC->dU-editing enzyme APOBEC3
gi|48474723|sp|P60705|ABEC3_RAT[48474723]
: P60705. Reports Probable DNA dC->...[gi:48474723] BLink, Conserved Domains,
Links
CommentFeaturesSequenceLOCUS
linear
P60705
429 aa
ROD 12-DEC-2006
DEFINITION Probable DNA dC->dU-editing enzyme APOBEC3.
ACCESSION
VERSION
DBSOURCE
P60705
P60705 GI:48474723
swissprot: locus ABEC3_RAT, accession P60705;
class: standard.
created: Mar 29, 2004.
sequence updated: Mar 29, 2004.
annotation updated: Dec 12, 2006.
COMMENT
[FUNCTION] Probable human APOBEC3G ortholog. Is not able to
prevent
HIV-1 infectivity in the presence and absence of HIV-1 VIF (virion
infectivity factor) in vitro. May have DNA deaminase (cytidine
deaminase) activity.
[COFACTOR] Zinc (By similarity).
[SUBCELLULAR LOCATION] Cytoplasm (By similarity). Nucleus (By
similarity). Note=Mainly cytoplasmic, small amount are found in the
nucleus (By similarity).
[SIMILARITY] Belongs to the cytidine and deoxycytidylate deaminase
family.
FEATURES
source
Location/Qualifiers
1..429
/organism="Rattus norvegicus"
/db_xref="taxon:10116"
gene
1..429
/gene="Apobec3"
Protein
1..429
/gene="Apobec3"
/product="Probable DNA dC->dU-editing enzyme APOBEC3"
/EC_number="3.5.4.-"
ORIGIN
1 mgpfclgcsh rkcyspirnl isqetfkfhf knlryaidrk dtflcyevtr kdcdspvslh
61 hgvfknkdni haeicflywf hdkvlkvlsp reefkitwym swspcfecae qvlrflathh
121 nlsldifssr lynirdpenq qnlcrlvqeg aqvaamdlye fkkcwkkfvd nggrrfrpwk
181 klltnfryqd sklqeilrpc yipvpsssss tlsnicltkg lpetrfcver rrvhllseee
241 fysqfynqrv khlcyyhgvk pylcyqleqf ngqaplkgcl lsekgkqhae ilfldkirsm
301 elsqviitcy ltwspcpnca wqlaafkrdr pdlilhiyts rlyfhwkrpf qkglcslwqs
361 gilvdvmdlp qftdcwtnfv npkrpfwpwk gleiisrrtq rrlhrikesw glqdlvndfg
421 nlqlgppms
//
1: P60705. Reports Probable DNA dC->...[gi:48474723] BLink, Conserved Domains,
Links
>gi|48474723|sp|P60705|ABEC3_RAT
Probable
DNA
dC->dU-editing
enzyme
APOBEC3
MGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLRYAIDRKDTFLCYEVTRKDCDSPV
SLHHGVFKNKDNI
HAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQVLRFLATHHNLSLDI
FSSRLYNIRDPENQ
QNLCRLVQEGAQVAAMDLYEFKKCWKKFVDNGGRRFRPWKKLLTNFRYQDSKLQ
EILRPCYIPVPSSSSS
TLSNICLTKGLPETRFCVERRRVHLLSEEEFYSQFYNQRVKHLCYYHGVKPYLCYQL
EQFNGQAPLKGCL
LSEKGKQHAEILFLDKIRSMELSQVIITCYLTWSPCPNCAWQLAAFKRDRPDLILHIY
TSRLYFHWKRPF
QKGLCSLWQSGILVDVMDLPQFTDCWTNFVNPKRPFWPWKGLEIISRRTQRRLHRI
KESWGLQDLVNDFG
NLQLGPPMS
6: Q99J72 Reports
BLink, Conserved Domains, Links
DNA dC->dU-editing enzyme APOBEC-3 (Apolipoprotein B mRNA-editing complex 3)
(Arp3) (CEM15) (CEM-15)
gi|46395954|sp|Q99J72|ABEC3_MOUSE[46395954]
1: Q99J72. Reports DNA dC->dU-editin...[gi:46395954] BLink, Conserved Domains,
Links
CommentFeaturesSequenceLOCUS
linear
Q99J72
429 aa
ROD 20-FEB-2007
DEFINITION
DNA
dC->dU-editing
enzyme
APOBEC-3
(Apolipoprotein
B
mRNA-editing
complex 3) (Arp3) (CEM15) (CEM-15).
ACCESSION
VERSION
DBSOURCE
Q99J72
Q99J72 GI:46395954
swissprot: locus ABEC3_MOUSE, accession Q99J72;
class: standard.
extra accessions:Q8C7L0,Q8C8V7
created: Apr 13, 2004.
sequence updated: Apr 13, 2004.
annotation updated: Feb 20, 2007.
COMMENT
[FUNCTION] Probable human APOBEC3G ortholog. Has DNA
deaminase
(cytidine deaminase) activity. Mediates G-to-A hypermutation in
newly synthesized HIV-1 viral DNA and is thus able to prevent HIV-1
infectivity in vitro, in the presence and absence of HIV-1 VIF
(virion infectivity factor).
[COFACTOR] Zinc (By similarity).
[SUBCELLULAR LOCATION] Cytoplasm (By similarity). Nucleus (By
similarity). Note=Mainly cytoplasmic, small amount are found in the
nucleus (By similarity).
[ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named
isoforms=4; Name=1; IsoId=Q99J72-1; Sequence=Displayed; Name=2;
IsoId=Q99J72-2; Sequence=VSP_009832; Name=3; IsoId=Q99J72-3;
Sequence=VSP_009831, VSP_009833; Name=4; IsoId=Q99J72-4;
Sequence=VSP_009831; Note=Lacks exon V. Also active in inhibiting
HIV-1 in vitro.
[TISSUE SPECIFICITY] Expressed in spleen, node and lung.
[POLYMORPHISM] Polymorphism seems to be an important factor for the
ability of the protein to prevent HIV-1 infectivity in vitro. The
protein derived from MDTF and EL4 cell lines are unable to reduce
HIV-1 infectivity, while the protein derived from L1.2, 3T3 and
splenocytes are able to do it, in the presence and absence of HIV-1
VIF (virion infectivity factor).
[MISCELLANEOUS] HIV-1 VIF (virion infectivity factor) does not bind
to mouse APOBEC3.
[SIMILARITY] Belongs to the cytidine and deoxycytidylate deaminase
family.
FEATURES
source
Location/Qualifiers
1..429
/organism="Mus musculus"
/db_xref="taxon:10090"
gene
1..429
/gene="Apobec3"
Protein
1..429
/gene="Apobec3"
/product="DNA dC->dU-editing enzyme APOBEC-3"
/EC_number="3.5.4.-"
1: Q99J72. Reports DNA dC->dU-editin...[gi:46395954] BLink, Conserved Domains,
Links
>gi|46395954|sp|Q99J72|ABEC3_MOUSE DNA dC->dU-editing enzyme APOBEC-3
(Apolipoprotein B mRNA-editing complex 3) (Arp3) (CEM15) (CEM-15)
MGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLGYAKGRKDTFLCYEVTRKDCDSP
VSLHHGVFKNKDNI
HAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQIVRFLATHHNLSLDIF
SSRLYNVQDPETQ
QNLCRLVQEGAQVAAMDLYEFKKCWKKFVDNGGRRFRPWKRLLTNFRYQDSKLQ
EILRPCYIPVPSSSSS
TLSNICLTKGLPETRFCVEGRRMDPLSEEEFYSQFYNQRVKHLCYYHRMKPYLCYQ
LEQFNGQAPLKGCL
LSEKGKQHAEILFLDKIRSMELSQVTITCYLTWSPCPNCAWQLAAFKRDRPDLILHI
YTSRLYFHWKRPF
QKGLCSLWQSGILVDVMDLPQFTDCWTNFVNPKRPFWPWKGLEIISRRTQRRLRRI
KESWGLQDLVNDFG
NLQLGPPMS
9: NP_055323 Reports
BLink, Conserved Domains, Links
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C [Homo sapiens]
gi|22907039|ref|NP_055323.2|[22907039]
10: NP_004891 Reports
BLink, Conserved Domains, Links
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B [Homo sapiens]
gi|22907025|ref|NP_004891.3|[22907025]
13: NP_001006667 Reports
BLink, Links
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F isoform b [Homo
sapiens]
gi|54873619|ref|NP_001006667.1|[54873619]
14: NP_660341 Reports
BLink, Conserved Domains, Links
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F isoform a [Homo
sapiens]
gi|22907044|ref|NP_660341.2|[22907044]
15: NP_068594 Reports
BLink, Conserved Domains, Links
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G [Homo sapiens]
gi|13399304|ref|NP_068594.1|[13399304]
Foxp3 occupancy and regulation of key target genes during T-cell stimulation p931
Alexander Marson et al.
10.1038/nature05478
First paragraph | Full Text | PDF
Here we identify Foxp3 target genes and report that many of these are key modulators
of T-cell activation and function. Remarkably, the predominant, although not exclusive,
effect of Foxp3 occupancy is to suppress the activation of target genes on T-cell
stimulation. Foxp3 suppression of its targets appears to be crucial for the normal
function of Treg cells, because overactive variants of some target genes are known to be
associated with autoimmune disease.
Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T
cells p936
Ye Zheng et al.
Foxp3-mediated regulation unique to the thymus affects, among others, genes encoding
nuclear factors that control gene expression and chromatin remodelling. In contrast,
Foxp3 target genes shared by the thymic and peripheral TR cells encode primarily
plasma membrane proteins, as well as cell signalling proteins. Together, our studies
suggest that distinct transcriptional sub-programmes implemented by Foxp3 establish
TR lineage during differentiation and its proliferative and functional competence in the
periphery.
/gene="FOXP3"
Foxp3 Homo sapiens
1:
AAI13404. Reports
Forkhead box P3 [...[gi:109731678]
BLink, Conserved
Domains, Order cDNA clone, Links
CommentFeaturesSequenceLOCUS
linear
AAI13404
431 aa
PRI 29-JUN-2006
DEFINITION Forkhead box P3 [Homo sapiens].
ACCESSION
VERSION
AAI13404
AAI13404.1 GI:109731678
DBSOURCE
accession BC113403.1
KEYWORDS
MGC.
SOURCE
Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE
AUTHORS
1 (residues 1 to 431)
Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM
TITLE
Mammalian Gene Collection Program Team
Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL
PUBMED
REFERENCE
CONSRTM
TITLE
Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
12477932
2
(residues 1 to 431)
NIH MGC Project
Direct Submission
JOURNAL
Submitted (21-FEB-2006) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK
COMMENT
NIH-MGC Project URL: http://mgc.nci.nih.gov
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Mike Brownstein, NIMH
cDNA Library Preparation: British Columbia Cancer Research Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRCB Plate: 5 Row: b Column: 21.
Method: conceptual translation.
FEATURES
source
Location/Qualifiers
1..431
/organism="Homo sapiens"
/db_xref="taxon:9606"
/clone="MGC:141963 IMAGE:8322455"
/tissue_type="Pooled, bladder, uterus, PCR rescued clones"
/clone_lib="NIH_MGC_358"
/lab_host="DH10B"
/note="Vector: pCR4-TOPO with reversed insert; Clone
identification sequence tag: ACGGTGCG"
Protein
1..431
/product="forkhead box P3"
Region
337..409
/region_name="FH"
/note="Forkhead (FH), also known as a 'winged helix';
cd00059"
/db_xref="CDD:28941"
CDS
1..431
/gene="FOXP3"
/coded_by="BC113403.1:31..1326"
/db_xref="GeneID:50943"
/db_xref="HGNC:6106"
/db_xref="MIM:300292"
1:
AAI13404. Reports
Forkhead box P3 [...[gi:109731678]
BLink, Conserved
Domains, Order cDNA clone, Links
>gi|109731678|gb|AAI13404.1| Forkhead box P3 [Homo sapiens]
MPNPRPGKPSAPSLALGPSPGASPSWRAAPKASDLLGARGPGGTFQGRDLRGGAHA
SSSSLNPMPPSQLQ
LPTLPLVMVAPSGARLGPLPHLQALLQDRPHFMHQLSTVDAHARTPVLQVHPLESP
AMISLTPPTTATGV
FSLKARPGLPPGINVASLEWVSREPALLCTFPNPSAPRKDSTLSAVPQSSYPLLANGV
CKWPGCEKVFEE
PEDFLKHCQADHLLDEKGRAQCLLQREMVQSLEQQLVLEKEKLSAMQAHLAGKM
ALTKASSVASSDKGSC
CIVAAGSQGPVVPAWSGPREAPDSLFAVRRHLWGSHGNSTFPEFLHNMDYFKFHN
MRPPFTYATLIRWAI
LEAPEKQRTLNEIYHWFTRMFAFFRNHPATWKNAIRHNLSLHKCFVRVESEKGAV
WTVDELEFRKKRSQR
PSRCSNPTPGP