ดร. เพ็ญนภา ชลปฐมพิกุลเลิศ (Dr. Pennapa Chonpathompikunlert)
ACADEMIC QUALIFICATIONS AND PROFESSIONAL EXPERIENCE
2000-2003
2005-2009
05/2009-05/2011
06/2011-05/2012
B.Sc. (Physical Therapy), Second Honour.
Faculty of Associated Medical Sciences, Khon Kaen University,
Thailand.
Ph.D. (Neuroscience Program)
Faculty of Medicine, Khon Kaen University, Thailand.
Post-doctoral fellow in TIMS (Tsukuba Research Center for
Interdisciplinary Materials Science), University of Tsukuba, Japan
Research scientist in Graduate School of Pure and Applied Science
of Tsukuba, University of Tsukuba, Japan
Visiting for Research
28 July -11 August 2010, lecture and laboratory in the field of Biomedical
Engineering& Environmental Science at Department of Biomedical Engineering&,
Environmental Science, National Tsing Hua University.
25 October-20 November 2010, lecture and laboratory in the field of Biomedical
Engineering& Environmental Science at Department of Biomedical Engineering&,
Environmental Science, National Tsing Hua University.
28-31 August 2010, visiting researcher at laboratory of Molecular Neurobiology,
Department of Biochemistry and Molecular Biology of the School of Biology of the
University of Barcelona, Spain to perform experiments on the use of techniques of
BRET (Bioluminescence resonance energy transfer) and FRET (Fluorescence
resonance energy transfer) to study protein interaction.
1-4 September 2010, visiting researcher at the Institute of Molecular Cancer
Research of the University of Zurich, Switzerland.
ผลงานทางวิชาการ
ผลงานทางวิชาการทีต่ พี มิ พ์ เผยแพร่
1. Chonpathompikunlert P, Fan CH, Ozaki Y, Yoshitomi T, Yeh CK,
Nagasaki Y. (Epub ahead of print). Redox nanoparticle treatment protects
against neurological deficit in focused ultrasound-induced intracerebral
hemorrhage. Nanomedicine.
2. Chonpathompikunlert P, Yoshitomi T, Han J, Isoda H, Nagasaki Y.
(2011). The use of nitroxide radical-containing nanoparticles coupled with
piperine to protect neuroblastoma SH-SY5Y cells from Aβ-induced
oxidative stress. Biomaterial., 32: 8605-8612.
3. Chonpathompikunlert P, Yoshitomi T, Han J, Toh K, Isoda H, Nagasaki
Y. (2011). Chemical nanotherapy: nitroxyl radical-containing nanoparticle
protects neuroblastoma SH-SY5Y cells from Aβ-induced oxidative stress.
Ther Deliv., 2(5): 585-597.
4. Chonpathompikunlert P, Han J, Toh K, Isoda H, Nagasaki Y. (2011).
TEMPOL protects human neuroblastoma SH-SY5Y cells against βamyloid-induced cell toxicity. Eur J Pharmacol., 650: 544-549.
5. Priprem A, Chonpathompikunlert P, Sutthiparinyanont S, Wattanathorn J.
(2011). Antidepressant and cognitive activities of intranasal piperine-
encapsulated liposomes. Advances in Bioscience and Biotechnology., 2(2):
107-115.
6. Chonpathompikunlert P, Wattanathorn J, Muchimapura S. (2010).
Piperine, the main alkaloid of Thai black pepper, protects against
neurodegeneration and cognitive impairment in animal model of cognitive
deficit like condition of Alzheimer’s disease. Food Chem Toxicol.,
48(3):798-802.
7. Wattanathorn J, Chonpathompikunlert P, Muchimapura S, Priprem A,
Tankamnerdthai O. (2008). Piperine, the potential functional food for mood
and cognitive disorders. Food Chem Toxicol ., 46(9): 3106-3110.
ผลงานทางวิชาการทีน่ าเสนอในทีป่ ระชุมวิชาการ
1. Chonpathompikunlert P, Yoshitomi T, Nagasaki Y. (2012). Effects of
Nitroxide radical-containing nanoparticles suppress inflammation-induced
edema and pain behavior in mice. MANA International Symposium, Epochal
Tsukuba, Japan. (oral presentation)
2. Chonpathompikunlert P, Yoshitomi T, Han J, Toh K, Isoda H, Nagasaki Y.
(2011). Nitroxyl radical-containing nanoparticle protects neuroblastoma SHSY5Y cells from Aβ-induced oxidative stress. TJIA 2011 Thailand Japan
International Academic Conference. Tokyo, Japan. (oral presentation)
3. Chonpathompikunlert P, Fan CH, Ozaki Y, Yoshitomi T, Yeh CK, Nagasaki
Y.(2011). Antioxidant-Nanocarier Attenuates intracerebral hemorrhage induced
by Focused Ultrasound. 8th IBRO World Congress of Neuroscience in
Florence, Italy.
4. Chonpathompikunlert P, Yoshitomi T, Han J, Toh K, Isoda H, Nagasaki Y.
(2011).Combination Nanotherapy - Drug Delivery by Antioxidative
Nanocarrier. MANA International Symposium, Epochal Tsukuba, Japan, p. 131.
(oral presentation)
5. Chonpathompikunlert P, Yoshitomi T, Han J, Toh K, Isoda H, Nagasaki Y.
(2011). Antioxidant effect of Radical-Containing Nanoparticle (RNP)
combination piperine against Alzheimer’s amyloid beta-peptide (1-42)-induced
oxidative stress in SH-SY5Y cells. International Conference on Biomaterials
Science (ICBS), Tsukuba, Japan.
6. Chonpathompikunlert P, Yoshitomi T, Han J, Toh K, Isoda H, Nagasaki Y.
(2011). Combination Nanotherapy for Drug Delivery by Antioxidative
Nanocarrier. International Symposium on Free Radical Research: Contribution
to Medicine. Hyatt Regency Kyoto, Japan, p. 124.
7. Chonpathompikunlert P, Yoshitomi T, Han J, Toh K, Isoda H, Nagasaki Y.
(2010). Comparison of the effects of TEMPO, Radical containing Nanoparticle
and Radical containing Nanoparticle combination Piperine on Aβ Amyloid
Toxicity. The 3 rd International NanoBio Conference, ETH Zurich,
Switzerland. (Published online in a special supplement of the Cells and
Materials (eCM) Journal).
8. Chonpathompikunlert P, Yoshitomi T, Han J, Toh K, Isoda H, Nagasaki Y.
(2010). Neuroprotective effect of Radical-containing Nanoparticle (RNP)
against Alzheimer’s amyloid beta-peptide (1-42)-induced oxidative stress in
SH-SY5Y cells. The 63th National conference of Society for free radical
research, Yokohama, Japan, p. 74. (oral presentation)
9. Chonpathompikunlert P, Wattanathorn J, Muchimapura S, Priprem A. (2009).
Nasal administration of liposome encapsulated piperine attenuates the memory
deficit and neuronal loss in Alzheimer’s model induced by AF64A. The 27th
Hong Kong Society of Neurosciences Annual Meeting, The University of
Science and Technology, Hong Kong, p. 170-171.
10. Chonpathompikunlert P, Wattanathorn J, Muchimapura S. (2008). Effect of
piperine on cognition and oxidative stress in animal model of Alzheimer’s
disease. The 3rd Sino-Thai International Conference on Traditional Medicine
and Natural Health Products. Guangxi Traditional Chinese Medical University,
China, p. 358-364. (oral presentation)
11. Chonpathompikunlert P, Wattanathorn J, Muchimapura S, Priprem A,
Tankumnerdthai O. (2008). Piperine Reduces Hippocampal Neuronal Loss in
Animal Model of Alzheimer’s Disease. First National Neuroscience
Conference. Science Park Convention Center, Thailand, p. 78.
12. Chonpathompikunlert P, Wattanathorn J, Muchimapura S, Priprem A.
(2007). Piperine, the main alkaloid of piper nigrum, enhances cognitive function
in rats. The 2nd Sino-Thai International Conference on Traditional Medicine
and Natural Products. Kosa Hotel, Khon Kaen, Thailand, p. 420-425.
13. Chonpathompikunlert P, Wattanathorn J, Muchimapura S, Priprem A. (2007).
Nasal administration of liposome encapsulated piperine enhances cognitive
function in young adult rats. The 3rd International Conference on Polyphenols
and Health. Kyoto, Japan, p. 230.
14. Chonpathompikunlert P, Wattanathorn J, Priprem A. (2007). Study of the
Effect of piperine on Cognitive Enhancing Property and Lipid Peroxidation in
Hippocampus Area of Healthy Adult Rats. Asian Association of Schools of
Pharmacy (AASP), Makati City, Philippines, p. 94.
15. Chonpathompikunlert P, Wattanathorn J, Muchimapura S, Priprem A, Tongun T. (2006). Neuropharmacological profile of piperine. The 4th Congress of
Federation of Asian-Oceanian Neuroscience Societies, Hong Kong, p. 128-129.
16. Chonpathompikunlert P, Wattanathorn J, Muchimapura S, Banchonglikitkul
C, Suntorntanasas T, Singhara S. (2006). Screening the effect of KKU1 on the
central nervous system. Collegium Internationale NeuroPsychopharmacologicum (CINP) Asia Pacific Regional Meeting NeuroPsychopharmacology: Challenging for Better Health, Pataya, Thailand, p. 115.
รายงานการวิจยั หนังสื อ ตาราและ book chapter –
สิทธิบัตร RESEARCH EXPERIENCES
Scavenging enzyme action pathways, Cognitive deficit condition,
Neurodegenerative disease, free radical, Neuropharmacology, Nanotechnology for drug
delivery system.
RESEARCH OF INTEREST
Overall research goal focuses on the role of nanotechnology for drug delivery to
treatment various pathological conditions that related with free radical pathway.
Specifically, we are interested in
(1) Neurodegenerative disease
(2) Brain tumor
(3) Inflammatory disease
(4) Stroke condition
SCIENTIFIC PRESENTATION AWARDS
1. Attendance in the 11th International Brain Research Organisation (IBRO)
Associate School of Neuroscience in Kuala Lumpur, Malaysia, 2007
2. Attendance in Tsukuba Research Center for Interdisciplinary Materials Science
(TIMS) University of Tsukuba, Japan for two month about nanoparticle of drug
delivery system, 2008
3. Attendance in the 7th IBRO school of neuroscience, Hong Kong, 2009
4. The Outstanding Oral Presentation Award from The 3rd Sino-Thai International
Conference on Traditional Medicine and Natural Health Products, 31/10/2008