Health Canada
Santé Canada
STATUS DECISION OF CONTROLLED
AND NON-CONTROLLED SUBSTANCE(S)
Substance: N-(1-Methyl-1-phenylethyl)-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indazole-3carboxamide
Based on the current information available to the Office of Controlled Substances, it appears that
the above substance is:
Controlled
Not Controlled
☐
X
under the schedules of the Controlled Drugs and Substances Act (CDSA) for the following
reason(s):

The efficacy of N-(1-methyl-1-phenylethyl)-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1Hindazole-3-carboxamide as a cannabinoid receptor agonist has not been established and
therefore the substance cannot be included under item 1 of Schedule II to the CDSA.
Prepared by: _______________________________________
Vincent Marleau
Date: _______________
Verified by:
Date: ________________
_______________________________________
Manager, NCED, OCS
Approved by: _______________________________________
Date: ________________
DIRECTOR, OFFICE OF CONTROLLED SUBSTANCES
This status was requested by: “third party information removed as per agreement with applicant”
Drug Status Report
Drug: N-(1-Methyl-1-phenylethyl)-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indazole-3carboxamide
Drug Name Status: N-(1-Methyl-1-phenylethyl)-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1Hindazole-3-carboxamide is the common name.
Chemical Name: N-(2-Phenylpropan-2-yl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-indazole3-carboxamide
Chemical structure:
Molecular Formula: C23H27N3O2
CAS-RN: 1400742-50-8
Pharmacological class / Application: Synthetic cannabinoid
International status:
US: N-(1-Methyl-1-phenylethyl)-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indazole-3carboxamide is not listed specifically in the Schedules to the US Controlled Substances Act and
is not mentioned anywhere on the DEA website.
United Nations: The substance is not listed on the Yellow List - List of Narcotic Drugs under
International Control, the Green List - List of Psychotropic Substances under International
Control, nor the Red List - List of Precursors and Chemicals Frequently Used in the Illicit
Manufacture of Narcotic Drugs and Psychotropic Substances under International Control.
Canadian Status: N-(1-Methyl-1-phenylethyl)-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1Hindazole-3-carboxamide is not listed in the Schedules to the CDSA. The substance is a synthetic
cannabinoid but there are currently no reports in the scientific literature on the efficacy of the
substance as a cannabinoid receptor agonist. Cannabinoid receptor agonists are captured under
item 1 of Schedule II to the CDSA by virtue of being “similar synthetic preparations” while
cannabinoid receptor antagonists are excluded from item 1 of Schedule II to the CDSA. Since it
cannot be established whether N-(1-methyl-1-phenylethyl)-1-[(tetrahydro-2H-pyran-4yl)methyl]-1H-indazole-3-carboxamide is an efficient cannabinoid receptor agonist, the
substance cannot be included under item 1 of Schedule II to the CDSA.
Recommendation: N-(1-Methyl-1-phenylethyl)-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1Hindazole-3-carboxamide is not included in the schedules to the CDSA and is not a controlled
substance.
Date: November 12th, 2013.