Health Canada Santé Canada STATUS DECISION OF CONTROLLED AND NON-CONTROLLED SUBSTANCE(S) Substance: Benzobarbital HCl Based on the current information available to the Office of Controlled Substances, it appears that the above substance is: Controlled X Not Controlled ☐ under the schedules of the Controlled Drugs and Substances Act (CDSA) for the following reason(s): The substance is a barbiturate and is captured under item 1 of Schedule IV to the CDSA. Prepared by: _______________________________________ Vincent Marleau Date: _______________ Verified by: Date: ________________ _______________________________________ Mark Kozlowski Approved by: _______________________________________ Date: ________________ DIRECTOR, OFFICE OF CONTROLLED SUBSTANCES This status was requested by: Melissa Tristani, OCS 2 Drug Status Report Drug: Benzobarbital HCl Drug Name Status: Benzobarbital HCl is the common name. Chemical Name: 1-Benzoyl-5-ethyl-5-phenylpyrimidine-2,4,6-trione hydrochloride Other Names: 1-Benzoyl-5-ethyl-5-phenylbarbituric acid HCl; Benzobarbitone HCl; Benzonal HCl. Chemical structure: Molecular Formula: C19H16N2O4HCl CAS-RN: N/A Pharmacological class / Application: Barbiturate International status: US: Benzobarbital HCl is not listed specifically in the Schedules to the US Controlled Substances Act and is not mentioned anywhere on the DEA website. United Nations: The substance is not listed on the Yellow List - List of Narcotic Drugs under International Control, the Green List - List of Psychotropic Substances under International Control, nor the Red List - List of Precursors and Chemicals Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances under International Control. Canadian Status: Benzobarbital HCl is not listed specifically in the Schedules to the CDSA. The substance is a salt of benzobarbital, which contains the core structure of the barbiturates. Currently, “Barbiturates, their salts and derivatives including” are listed as item 1 in Schedule IV to the CDSA. Given that benzobarbital is a barbiturate, the substance is captured, along with its salt, under item 1 of Schedule IV to the CDSA. Recommendation: Benzobarbital HCl is included under item 1 of Schedule IV to the CDSA and is a controlled substance. Date: June 18th, 2013.