CURRICULUM VITAE
of
Professor Richard John POWELL
MBBS, DM, FRCP, FRCPath
Emeritus Professor of Clinical Immunology and Allergy
Academic Division of Immunology, School of Molecular Medical Sciences,
Faculty of Medicine & Health Sciences, University of Nottingham.
R. J. Powell
PERSONAL INFORMATION
Name:
Richard John POWELL
Date of Birth:
19th October 1947
Contact details:
18 West Leake Road, East Leake, Leics.
LE12 6LJ
Tel: 07766 911026
Fax: 01509 856121
E.mail: richard@allergyresolutions.co.uk
Qualifications:
MBBS
LRCP
MRCS
MRCP (UK)
FRCP (UK)
DM
FRCPath (Immunology)
GMC:
Date of Full Registration 25.05.1972
Registration number 1486232
Registered with a licence to practise 16.11.2009
Revalidated Autumn 2014
Medical Protection:
Medical Protection Society 179227
London 1971
London 1971
London 1971
London 1974
London 1992
Nottingham 1995
London 2000
Profile
Having recently retired from the NHS, I now see patients privately in Nottingham,
Leicester, Northampton, Coventry, Derby, Stoke-on-Trent, Leamington Spa, Harley
Street, London and when required at my home address. I am Professor Emeritus at
Nottingham University and remain actively involved in research.
Medico-Legal work
I have 30 years experience of preparing reports involving clinical negligence and
personal injury.
My clinical expertise resides within Allergy including food, venom, drugs, occupational
(including latex), Immunodeficiency (not HIV), Inflammatory joint/connective tissue
conditions, Chronic Fatigue Syndrome/Fibromyalgia and related disorders. I also have
expertise using immuno-modulatory therapies in many inflammatory disorders including
the eye.
The proportion of work for Plaintiff is 45%, Defendant 45% and 10% Joint Instruction.
Recently attended BMA Medico-Legal Expert Witness course 2013.
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R. J. Powell
Committees and Working Groups
Current and most recent -:
 Member of Royal College of Physicians Working Group on improving Clinical
Allergy in the UK, 2001-2003
 Member of Trent Regional Immunology Education Committee 1997-2008
 Member of Medical Advisory Panel for Lupus UK 2000-2012
 Member of International Society for Behcet’s Disease 2000-2010
 Chairman of Data Monitoring Committee, Multicentre Study of Interferon alpha
in Behcet’s Disease, Moorfields Hospital, London 2006-present
 Lead Clinician for Clinical Immunology at QMC Nottingham from 2000-2008
 Member of Standards of Care Committee, BSACI 2003-present
 Medicines Management Committee at University Hospital 2004-2007
 Member of the Commission on Human Medicines’ Respiratory and Allergy
Advisory Group 2006-present
 Clinical Advisor to the Healthcare /Care Quality Commission from 2006-2011
 Member of BSACI Education Subcommittee 2008 -present
Learned Society Membership
International Fellow in the American Academy of Allergy, Asthma and Immunology
Member of European Academy of Allergology and Clinical Immunology
Member of British Society of Allergy and Clinical Immunology (Treasurer 2008-2011)
Fellow Royal College of Physicians
Fellow Royal College of Pathologists (registered with CME scheme at RC Pathologists)
Member of Royal Society of Medicine
Previously regular Reviewer for the following Journals
Clinical and Experimental Allergy
Lupus
British Journal of Rheumatology
Arthritis and Rheumatism
Postgraduate Medical Journal
Senior Associate Editor for Annals of the Rheumatic Diseases, 1992-1996
Examinations Board
Member of Panel of Examiners in Immunology at Royal College of Pathologists 20022007
External Examiner to Imperial College, London for the Faculty of Medicine
Examinations 2003-2007
Previous recent appointments
01.09.1981-05.11.2007
Consultant Clinical Immunologist and Allergist,
Queens Medical Centre Campus, Nottingham University Hospitals NHS Trust,
(Then Locum Consultant in similar post 26.01.08-31.08.08)
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R. J. Powell
01.09.1981-05.11.2007
Professor (initially Senior Lecturer then Reader), Division of Molecular and Clinical
Immunology School of Molecular Medical Sciences, University of Nottingham
Original Peer Reviewed Articles
“SLE with widespread subcutaneous fat calcification”
Proc Roy Soc Med 67:215 (1974)
RJ Powell, BM Ansell & EGL Bywaters
“Benorylate in management of Still’s Disease”
BMJ 1:145 (1974)
RJ Powell & BM Ansell
“Double blind clinical trial of 5 hydroxytryptophan in a case of Lesch Nyhan syndrome”
J Neurol Neurosurg Psychiat 39:656 (1976)
CD Firth, EC Johnstone, MH Joseph, RJ Powell & RWE Watts
“Evidence for a subset of rheumatoid factors which cross react with DNA-histone and
have a distinct cross idiotype”
JEM 151:1514-1527 (1980)
V Agnello, A Arbetter, C Ibanez de Kasep, RJ Powell, EM Tan &F Joslin
“Characterisation of complement fixing activity and cross idiotypes of rheumatoid factors
in idiopathic mixed cryoglobulinaemia”
Clin Immunol Immunopathol 29:146-151 (1983)
RJ Powell & V Agnello
“Effect of Thalidomide in orogenital ulceration”
BMJ 287:799-800 (1983)
PW Bowers &d RJ Powell
“C-reactive protein levels in neonates: determined by latex enhanced immunoassay”
J Clin Pathol 37:1027-1028 (1984)
C O’Callaghan, P Franklin, TS Elliott, I Deverill, N Richards & RJ Powell
“Thalidomide in severe orogenital ulceration’
The Lancet (ii) 1424-1426 (1984)
JS Jenkins, RJ Powell, BR Allen, S Littlewood, PD Maurice & NJ Smith
“Can the rapid semi-quantitative estimation of serum CRP be adapted for the
management of bacterial infections?”
J Clin Pathol 38:464-467 (1985)
NP Richards, TS Elliott, RJ Powell, C O’Callaghan & P Franklin
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R. J. Powell
“Immunological tests and the diagnosis of dementia in elderly women”
Age and Ageing 14:91-95 (1985)
NJ Smith & RJ Powell
“An improved assay for IgG rheumatoid factor: its value in the diagnosis of rheumatoid
arthritis (RA)’
J Rheumatol 12:427-431 (1985)
RJ Powell, AM Leyland, JD Pound & DH Bossingham
“Class specific rheumatoid factors in rheumatoid arthritis: response to chrysotherapy and
relationship to disease activity’
J Rheumatol 12:434 (1985)
S Rudge, JD Pound, DH Bossingham & RJ Powell
“Investigation and treatment of orogenital ulceration: studies on a possible mode of
action of Thalidomide”
B J Dermatol 113(38): 141-144 (1985)
RJ Powell, BR Allen, JS Jenkins, L Steele, I Honeyball, PD Maurice & S Littlewood
“C-reactive protein levels in neutropenic patients with pyrexia”
Clin Lab Haematol 7:307-315 (1985)
D Gozzard, EA French, TE Blecher & RJ Powell
“Thalidomide, orogenital ulceration and risk of teratogenicity”
The Lancet 1:5111 (1985)
S Jenkins, RJ Powell, BR Allen, S Littlewood, PD Maurice & NJ Smith
“Skin immunofluorescence in the diagnosis of primary bullous disease -a review of 279
cases”
Clin Exp Dermatol 11:352-364 (1986)
PD Maurice, BR Allen, DW Marriott, RJ Powell & WG Reeves
“Rheumatoid factor tests in the diagnosis and prediction of rheumatoid arthritis”
Ann Rheum Dis 45:684-690 (1986)
DJ Walker, JD Pound, ID Griffiths & RJ Powell
“µ Heavy chain and monoclonal IgG kappa paraproteinaemia in systemic lupus
erythematosus”
Brit J Rheum 26:460-462 (1987)
IH Leach, JS Jenkins, CF Murray-Leslie & RJ Powell
“C3 degradation products (C3d) in normal pregnancy”
J Clin Pathol 40:1362-1363 (1987)
JS Jenkins & RJ Powell
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R. J. Powell
“Novel C3 Nephritic factor activity in the glomerulonephritis of staphylococcal
endocarditis”
QJM 246:895-898 (1987)
CF Craddock, NP Richards, RJ Powell & AG Morgan
“Relationship between synovial fluid C3 degradation products and local joint
inflammation in rheumatoid arthritis, osteoarthritis and crystal associated arthropathy”
Ann Rheum Dis 47:190-197 (1988)
M Doherty, N Richards, J Hornby & RJ Powell
“Radioimmunoassay artefact associated with circulating anti-rabbit antibodies”
Clin Endocrin 28:39-43 (1988)
WJ Jeffcoate, C Selby & RJ Powell
“Is inosine pranobex contraindicated in autoimmune diseases?”
BMJ 269:646 (1988)
AJ Chuck, RJ Powell, N Dunn & JK Lloyd Jones
“Abnormal fibrinolytic activity in SLE and its possible mechanisms”
Brit J Rheum 27:436-439 (1988)
P Chu, NH Russell, RJ Harris, DR Cater & RJ Powell
“Epoprostenol in systemic capillary leak syndrome”
The Lancet 2:1143 (1988)
IW Fellows, RJ Powell, PJ Toghill, TJ Williams & GF Cohen
“Frequency resolving ability in systemic lupus erythematosus”
B J Audiology 23:69-72 (1989)
AA Narula, RJ Powell & A Davies
“Defective fibrinolysis in Behcet’s syndrome - significance and possible mechanisms”
Ann Rheum Dis 48:590-593 (1989)
R Aitchison, P Chu, DR Cater, RJ Harris & RJ Powell
“Anticardiolipin Antibodies: A risk factor in peripheral arterial thrombosis?”
Surg Res Comm 6:119-122 (1989)
JJ Ernshaw, NC Armitage, NP Richards, RJ Powell, BR Hopkinson & GS Makin
“Toxoplasmosis and systemic lupus erythematosus”
Ann Rheum Dis 49:254-257 (1990)
M Wilcox, RJ Powell, SF Pugh & AH Balfour
“Dermatomyositis following chronic staphylococcal joint sepsis”
Ann Rheum Dis 49(6): 405-406 (1990)
RJ Powell, M Doherty & S Lane
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R. J. Powell
“Post-streptococcal reactive arthritis”
Ann Rheum Dis 49(4): 270-271 (1990)
RJ Powell & JS Jenkins
“Hypothesis - Nodal generalised osteoarthritis is an autoimmune disease”
Ann Rheum Dis 49:1017-1020 (1990)
M Doherty, M Patrick & RJ Powell
“Complement activation during low-dose peripheral arterial thrombolysis”
Surg Res Comm 8(1): 81-85 (1990)
DC Berridge, RJ Powell, BR Hopkinson & GS Makin
“Estimating the incidence of SLE”
Brit J Rheum 29(6): 498 (1990)
N Hopkinson, M Doherty & RJ Powell
“Nailfold Capillary Density. As a possible indicator of pulmonary capillary loss in
Systemic Lupus Erythematosus but not Mixed Connective Tissue Disease”
J Rheumatol 18/10:1532-1536 (1991)
M Pallis, ND Hopkinson & RJ Powell
“Classical complement activation induced by normal pregnancy; implications for the
management of connective tissue disease”
J Clin Path 47(1): 66-67 (1992)
ND Hopkinson & RJ Powell
“Autoantibodies in pet dogs owned by patients with Systemic Lupus Erythematosus
(SLE)”
The Lancet 339:1378-1380 (1992)
DRE Jones, ND Hopkinson & RJ Powell
“Screening of acute psychiatric admissions for previously undiagnosed systemic lupus
erythematosus”
Brit J Psych 161:107-110 (1992)
ND Hopkinson, P Bendall & RJ Powell
“Selective activation of circulating CD4+ lymphocytes in severe adult atopic dermatitis”
Brit J Dermatol 127:228-232 (1992)
JM Sowden, RJ Powell & BR Allen
“Auto-antibodies, immunoglobulins and Gm allotypes in nodal generalised osteoarthritis”
Brit J Rheum 31:605-608 (1992)
ND Hopkinson, RJ Powell & M Doherty
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R. J. Powell
“Respiratory involvement in systemic lupus erythematosus: correlation with results of
laboratory tests and histological appearance of muscle biopsy specimens”
Thorax 47(11): 957-960 (1992)
SA Evans, ND Hopkinson, WJM Kinnear, L Watson, RJ Powell & IDA Johnston
“Pneumocystis carinii pneumonia following immunosuppressive therapy in Systemic
Lupus Erythematosus”
Brit J Rheum 31:643-648 (1992)
K Lim, RJ Powell & IDA Johnston
“The prevalence and incidence of systemic lupus in Nottingham, U.K. 1989-90”
Brit J Rheumatol 32:110-115 (1993)
ND Hopkinson, M Doherty & RJ Powell
“Prevalence of rheumatoid arthritis and rheumatoid factor in women: evidence for a
secular decline”
Ann Rheum Dis 52:254-257 (1993)
TD Spector, DJ Hart & RJ Powell
“Inclusion body myositis: an under-diagnosed condition?”
Ann Rheum Dis 52:147-151 (1993)
ND Hopkinson, C Hunt, RJ Powell & J Lowe
“Urine neopterin is the best parameter of disease activity in patients with SLE comparisons with serum sIL-2R and anti-dsDNA, ESR and plasma C3, C4 and C3
degradation products”
Ann Rheum Dis 52:429-435 (1993)
KL Lim, AC Jones, NS Brown & RJ Powell
“Distribution of cell adhesion molecules in skeletal muscle from patients with systemic
lupus erythematosus”
Ann Rheum Dis 52:667-671 (1993)
M Pallis, DK Robson, DO Haskard & RJ Powell
“Relapsing eosinophilic myositis causing acute muscle compartment syndrome”
BJR 32(5): 436-437 (1993)
CF Murray-Leslie, RC Quinnell, RJ Powell & J Lowe
“Focal myositis: an unusual cause of bilateral upper eyelid swellings”
Postgrad Med J 69:876-878 (1993)
KL Lim, K Robson & RJ Powell
“Quantitative analysis by flow cytometry of lymphocyte CD11a using standardised flow
cytometry”
Scand J Immunol 38:559-564 (1993)
M Pallis, A Robins & RJ Powell
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R. J. Powell
“Muscle biopsy abnormalities in systemic lupus erythematosus: correlation with clinical
and laboratory parameters”
Ann Rheum Dis 53:178-182 (1994)
KL Lim, R Abdul-Wahab, J Lowe & RJ Powell
“Human anti-fibronectin antibodies in Systemic Lupus Erythematosus: occurrence and
antigenic specificity”
Clin & Exp Immunol 96:20-25 (1994)
MS Atta, RJ Powell, ND Hopkinson & I Todd
“The influence of anti-fibronectin antibodies on interaction involving extracellular matrix
components and cells: a possible pathogenetic mechanism”
Clin & Exp Immunol 96:26-30 (1994)
MS Atta, RJ Powell & I Todd
“Complement activation by cellulosic dialysis membranes”
Clin Pathol 47(2): 155-158 (1994)
A Innes, AM Farrell, RP Burden, AG Morgan & RJ Powell
“Yellow nails, bronchiectasis and low circulating B cells”
Respiratory Medicine -88:475-476 (1994)
C Parry, RJ Powell & IDA Johnston
“An electron microscopic study of muscle capillary wall thickening in systemic lupus
erythematosus”
Lupus 3:401-407 (1994)
M Pallis, ND Hopkinson, J Lowe & RJ Powell
“Urine neopterin: A new parameter for serial monitoring of disease activity in patients
with systemic lupus erythematosus”
Ann Rheum Dis 53:743-748 (1994)
KL Lim, K Muir & RJ Powell
“Guideline for the clinical use and dispensing of thalidomide”
PGMJ 70(830): 901-904 (1994)
RJ Powell & JM Gardner-Medwin
“Clinical features and race-specific incidence/prevalence rates of systemic lupus
erythematosus in a geographically complete cohort of patient”
Ann Rheum Dis 53:675-680 (1994)
ND Hopkinson, M Doherty & RJ Powell
“Fever as an unusual presentation of a common condition”
Ann Rheum Dis 53:711-713 (1994)
JMM Gardner-Medwin, K Lim & RJ Powell
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R. J. Powell
“Clinical experience with thalidomide in the management of severe oral and genital
ulceration in conditions such as Behçet’s disease: the use of neurophysiological studies to
detect thalidomide neuropathy”
Ann Rheum Dis 53:828-832 (1994)
JM Gardner-Medwin, NJ Smith & RJ Powell
“C3 nephritic factor and SLE: report of four cases and review of the literature”
Quart J Med 87:609-615 (1994)
MJ Walport, KA Davies, M Botto, DA Isenberg, RJ Powell, NT Cheung & GR
Struthers
“Investigation of the prevalence and clinical associations of antibodies to human
fibronectin in Systemic Lupus Erythematosus”
Ann Rheum Dis 54:117-124 (1995)
MS Atta, K Lim, DA Ala’Aldeen, RJ Powell & I Todd
“Skeletal muscle lymphocytic vasculitis in Systemic Lupus Erythematosus: relation to
disease activity”
Lupus 4:148-151 (1995)
KL Lim, J Lowe & RJ Powell
“Enhanced expression of MHC class I molecules on cultured human thyroid follicular
cells infected with reovirus through induction of Type 1 interferons”
Clin Exp Immunol 101:121-126 (1995)
MS Atta, WL Irving, RJ Powell & I Todd
“Interferonperiodic fever syndrome”
Eur J Clin Invest 25:683-686 (1995)
JPH Drenth, RJ Powell, NS Brown & J Van der Meer
“Distribution of cases of Systemic Lupus Erythematosus at time of first symptom in an
urban area”
Ann Rheum Dis 54:891-895 (1995)
ND Hopkinson, KR Muir, MA Oliver, M Doherty & RJ Powell
“Diagnostic and management problems in a complex case of connective tissue disease”
Postgrad Med J 71:751-752 (1995)
SS Yeap, CM Deighton, RJ Powell, R Read & RG Finch
“Arthropathy, leucopenia and recurrent infection associated with a TcR 
Brit J Rheum 34:978-983 (1995)
E Hodges, C Quin, AM Farrell, S Christmas, HF Sewell, M Doherty, RJ Powell &JL
Smith
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R. J. Powell
“Incidence of ovarian failure in Systemic Lupus Erythematosus following treatment with
pulse cyclophosphamide”
Ann Rheum Dis 55:224-229 (1996)
EM McDermott & RJ Powell
“One patient, two unusual conditions and three basic lessons”
Ann Rheum Dis 55:350-352 (1996)
JM Gardner-Medwin & RJ Powell
“A post-traumatic leg ulcer”
Ann Rheum Dis 55:214-215 (1996)
MR Holbrook, RJ Powell & M Doherty
“Restrictions of T cell receptor  chain repertoire in the peripheral blood of patients with
systemic lupus erythematosus”
Ann Rheum Dis 55(9):627-631 (1996)
MR Holbrook, PJ Tighe & RJ Powell
“Peripheral blood lymphocyte adhesion molecule deployment in the immune response”
Scan J Immunol 43:304-313 (1996)
M Pallis, RA Robins & RJ Powell
“Clinical spectrum of Familial Hibernian Fever: A 14 year follow up study of the index
and extended family”
Mayo Clin Proc 72, 806-817 (1997)
EM McDermott, DM Smillie & RJ Powell
“Soft tissue involvement in systemic lupus erythematosus”
BJR 36 703-704 (1997)
EM McDermott & RJ Powell
“Correlation between CD29 density on CD8+ lymphocytes and IgG in Systemic Lupus
Erythematosus”
Lupus 6, 379-384 (1997)
M Pallis, KL Lim, JM Gardner-Medwin, RA Robins & RJ Powell
“Peripheral Blood Lymphocyte Binding to a Soluble FITC-Fibronectin Conjugate”
Cytometry 28 157-164 (1997)
M Pallis,RA Robins & RJ Powell
“An investigation into variability in microvascular skin blood flow and the responses to
transdermal delivery of acetylcholine at different sites in the forearm and hand”
BJ Clin Pharmacol 43 391-397 (1997)
JM Gardner-Medwin, JY Taylor, IA Macdonald & RJ Powell
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R. J. Powell
“The treatment of severe and difficult cases of systemic lupus erythematosus with
tacrolimus - a report of three cases”
Ann Rheum Dis 56, 690-692(1998)
M Duddridge & RJ Powell
“Basaloid follicular hamartoma, total body hair loss and SLE”
Lupus 7, 207-209 (1998)
SJ Morton, A Stevens & RJ Powell
“Linkage of Familial Hibernian Fever to Chromosome 12p13”
Am J Hum Genet 62, 1446-1451 (1998)
MF McDermott, BW Ogunkolade, EM McDermott, LC Jones, Y Wan, KA Quane, J
McCarthy, M Phelan, MG Molloy, RJ Powell, CI Amos and GA Hitman
“Exclusion of the Familial Mediterranean fever locus as a susceptibility region for
autosomal dominant familial Hibernian fever”
J Med Genetics 35, 432-434 (1998)
MF McDermott, EM McDermott, K Quane, LC Jones, W Ogunkolade, D Curtis, F
Waldron-Lynch, GA Hitman, MG Molloy, RJ Powell
“Cyclosporin in the treatment of Churg Strauss Syndrome”
Ann Rheum Dis 57,258-259 (1998)
EM McDermott & RJ Powell
“Smoking history, alcohol consumption, and systemic lupus erythematosus: a case
control study ”
Ann Rheum Dis 57,451-455 (1998)
CJ Hardy, BP Palmer, KR Muir, AJ Sutton & RJ Powell
“IgE and non IgE mediated allergic disorders in SLE”
Ann Rheum Dis 57,660-663 (1998)
SJ Morton, B Palmer, K Muir & RJ Powell
“Wegener’s Granulomatosis: a review of Diagnosis and Treatment in 53 subjects”
Rhinology 36,188-191(1998)
CR Jennings, NS Jones, J Dugar, RJ Powell & J Lowe
“Germline Mutations in the Extracellular Domains of the 55kDa TNF Receptor, TNFR1,
Define a Family of Dominantly Inherited Autoinflammatory Syndromes”
Cell 97, 133-144 (1999)
MF McDermott, I Aksentijevich, J Galon, EM McDermott, BW Ogunkolade, M
Centola, E Mansfield, M Gadina, L Karenko, T Pettersson, J McCarthy, DM Frucht,
M Aringer, Y Torosyan, AM Teppo, M Wilson, HM Karaaslan, Y Wan, I Todd, G
Wood, R Schlimgen, TR Kumarajeewa, SM Cooper, JP Vella, CI Amos, J Mulley,
KA Quane, MG Molloy, A Ranki, RJ Powell, GA Hitman, JJ O’Shea, & DL Kastner
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R. J. Powell
“Tacrolimus (FK506) in the Treatment of Posterior Uveitis Refractory to Cyclosporin”
Ophthalmology 106, 723-728 (1999)
CML Sloper, RJ Powell & HS Dua
“Antibodies from SLE sera define differential release of autoantigens from cell lines
undergoing apoptosis”
Clin.Exp Imm 118, 322-328 (1999)
ML Huggins, I Todd & RJ Powell
“Systemic Lupus Erythematosus (SLE) and hair treatment: a large community based
control study”
Lupus 8, 541-544 (1999)
C Hardy, B Palmer, KR Muir & RJ Powell
“Systemic vasculitis or not? That is the question”.
Annals Rheum Dis 58, 591-594 (1999)
V Kontogiannis, M Havlat, JS Lowe, RJ Powell
“Cladribine in the treatment of Systemic Lupus Erythematosus Nephritis”
Annals Rheum Dis 58, 653 (1999)
V Kontogiannis, PC Lanyon, RJ Powell
“Pregnancy outcome and family size in Systemic Lupus Erythematosus: a case-control
study”
Rheumatology 38, 559-563 (1999)
CJ Hardy, BP Palmer, S J Morton, KR Muir, and RJ Powell
“Racial group Socio-economic Status, and the Development of Persistent Proteinuria in
Systemic Lupus Erythematosus”
Annals Rheum Dis 59:116-119(2000)
ND Hopkinson, C Jenkinson, KR Muir, M Doherty, RJ Powell
“An audit of Cyclosporin for Systemic Lupus Erythematosus and related overlap
syndromes: limitations of its use”
Ann Rheum Dis 59; 487-489(2000);
SJ Morton and RJ Powell
“Papulonecrotic Tuberculide and Stenosis of the Abdominal Aorta”
Rheumatology 39: 205-208 (2000)
V Kontogiannis, K L Dalziel and RJ Powell
“Etoposide in Wegener’s granulomatosis”
Rheumatology 39;810-811 (2000)
SJ Morton, PC Lanyon & RJ Powell
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R. J. Powell
“Cyclosporin and Tacrolimus: their use in a routine clinical setting for scleroderma”
Rheumatology 39:865-869 (2000)
SJ Morton & RJ Powell
“Treatment of the Nephrotic Syndrome with Etanercept in Patients with Tumor Necrosis
Factor Receptor - Associated Periodic Syndrome ”
NEMJ 343:1044-1045 (2000)
E Drewe, E McDermott and R J Powell
“Tacrolimus (FK506) in the management of high-risk corneal and limbal grafts”
Ophthalmology 108:1838-1844 (2001)
C Sloper, R J Powell and H Dua
“Seasonal differences in finger skin temperature and microvascular blood flow in men
and women are exaggerated in women with primary Raynauds phenomenom.”
British Journal of Clinical Pharmacology 52: 17-23 (2001)
J M Gardner-Medwin, IA Macdonald, JY Taylor, PH Riley, RJ Powell
“Limited Efficacy of Thalidomide in the treatment of febrile attacks of the Hyper-IgD
and periodic fever syndrome. A Randomised, Double-Blind, Placebo-Controlled Trial”.
Journal of Pharmacology and Experimental Therapeutics 298:1221-1226 (2001)
JPH Drenth, AG Vonk, A Simon, RJ Powell & JWM van der Meer
“Quantitative and Qualitative analysis of the balance between type 1 and type 2 cytokineproducing t helper and T cytotoxic cells in Systemic Lupus Erythemaotosus”
Journal of Autoimmunity 17:155-163 (2001)
MR Amel-Kashipaz, ML Huggins, P Lanyon, A Robins, I Todd & RJ Powell
“Retroviral activity in Behcet’s syndrome and Systemic Lupus Erythematosus detected
by a PCR based reverse transcriptase assay”
Rheumatology International 1-9 (2002)
RS MacIntosh, ML Huggins, V Kontogiannis, PJ Tighe & RJ Powell
“Recurrent fevers in the presence of multiple autoimmune diseases and antibody
deficiency”
Ann Rheum Dis. 61:676-677 (2002)
E Drewe, AP Huissoon, MJ Thomas, PC Lanyon & RJ Powell
“Prospective study of anti-tumour necrosis factor receptor superfamily 1B fusion protein,
and case study of anti-tumour necrosis factor receptor superfamily 1A fusion protein, in
tumour necrosis factor receptor associated periodic syndrome (TRAPS): clinical and
laboratory findings in a series of seven patients”
Rheumatology, 42: 1-6 (2002)
E Drewe, EM McDermott, PT Powell, JD Isaacs & RJ Powell
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R. J. Powell
“Human autologous mixed lymphocyte reaction as an in vitro model for autoreactivity to
apoptotic antigens”
Immunology 107:358-365 (2002)
MR Amel-Kashipaz, ML Huggins, RJ Powell & I Todd
“Normal production of inflammatory cytokines in chronic fatigue and fibromyalgia
syndromes determined by intracellular cytokine staining in short in short-term cultured
blood mononuclear cells”
Clin Exp Immunol 132:360-365 (2003)
MR Amel-Kashipaz, D Swinden, I Todd & RJ Powell
“Assessment of Be1 and Be2 cells in systemic lupus erythematosus indicates elevated
interleukin-10 producing CD5+ B cells”
Lupus 12:356-363 (2003)
MR Amel-Kashipaz, ML Huggins, P Lanyon, A Robins, RJ Powell & I Todd
“A rare case of shock”
Ann Rheum Dis 62:705-6 (2003)
TW Felton, E Drewe, S Jivan, RI Hall & RJ Powell
“Immune deficiency secondary to protein losing enteropathy after Fontan procedure for
tricuspid atresia”
CPD Bulletin in Immunology and Allergy 3:23-24 (2003)
R Chee, MJ Thomas & RJ Powell
“Heterogeneity among patients with Tumour Necrosis Factor Receptor- Associated
Periodic Syndrome Phenotypes”
Arth Rheum 48:2632-2644 (2003)
E Aganna, L Hammond, PN Hawkins, A Aldea, SA McKee, HKP van Amstel, C
Mischung, K Kusuhara, FT Saulsbury, HJ Lachmann, A Bybee, EM McDermott,
M La Regina, JI Arostegui, JM Campistol, S Worthington, KP High, MG Molloy,
N Baker, JL Bidwell, JL Kastaner, ML Whiteford, PL Janssens-Korpola, R
Manna, RJ Powell, P Woo, P Solis, K Minden, J Frenkel, J Yague, RM Mirakian,
GA Hitman & MF McDermott
“Infliximab in the treatment of Refractory Posterior Uveitis”
Amer Acad Ophthalmology 110:1449-1453 (2003)
A Joseph, D Raj, HS Dua, PT Powell, PC Lanyon & RJ Powell
“Polymorphism at the C-reactive protein locus influences gene expression and
predisposes to systemic lupus erythematosus”
Hum Mol Genetics 13:137-47 (2004)
AI Russell, DS Cunninghame Graham, C Shepherd, CA Robertson, J Whittaker, J
Meeks, RJ Powell, DA Isenberg, MJ Walport & TJ Vyse
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R. J. Powell
“Treatment of Erdheim-Chester Disease with Cladribine – a rational approach”
Brit J Ophthalmology 88:844-7 (2004)
CML Sloper, RS McIntosh, RHS Gregson, SE Stevens, PJ Tighe, M Sokal, AP
Haynes & RJ Powell
“Simvastatin improves inflammatory attacks in the hyper-IgD and periodic fever
syndrome”
Clin Pharmacol Therapeutics 75:476-83 (2004)
A Simon, E Drewe, JWM van der Meer, RJ Powell, RI Kelley, AFH Stalenhof &
JPH Drenth
“Shedding of mutant Tumour Necrosis Factor Receptor 1 (TNFRSF1A), associated with
TNF Receptor Associated Periodic Syndrome (TRAPS), differs between cell types”.
Arth and Rheum 50:2651-2659 (2004)
ML Huggins, PM Radford, RS McIntosh, SE Bainbridge, P Dickinson, KA
Draper-Morgan, PJ Tighe, RJ Powell & I Todd
“Mutant forms of tumour necrosis factor receptor 1 that occur in TNF receptor-associated
syndrome retain signalling functions but show abnormal behaviour”.
Immunology 113:65-79 (2004)
I Todd, PM Radford, KA Draper-Morgan, R McIntosh, S Bainbridge.
P Dickinson, L Jamhawi, M Sansaridis, ML Huggins, PJ Tighe & RJ Powell
“Treatment of renal amyloidosis with etanercept in tumour necrosis factor receptorassociated periodic syndrome”.
Rheumatology 43;1405-8 (2004)
E Drewe, ML Huggins, AG Morgan, MJD Cassidy & RJ Powell
“Reactivation of Epstein-Barr Virus in patients with Systemic Lupus Erythematosus”
Rheum. International 25:183-187 (2005)
ML Huggins, I Todd & RJ Powell
“Efficacy of Sirolimus (Rapamune) in the treatment of patients with refractory uveitis”
British Journal of Ophthalmology 89;666-9 (2005)
VA Shanmuganathan, E M Casely, D Raj, RJ Powell, A Joseph, WM Amoaku,
HS Dua.
“The role of ciclosporin in steroid responsive sensineural hearing loss”
Acta Otolaryngol 125:1356-60 (2005)
L McClelland, RJ Powell & J Birchall
“Systemic cytokine levels and the effects of etanercept in TNF receptor-associated
periodic syndrome (TRAPS) involving a C33Y mutation in TNFRSF1A”
Rheumatology 45:31-37 (2006)
ML Nowlan, E Drewe, H Bulsara, N Esposito, PJ Tighe, RJ Powell & I Todd
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“Efficacy and safety of specific immunotherapy with SQ-allergen extract in treatmentresistant seasonal allergic rhinoconjunctivitis”
Journal of Allergy and Clinical Immunology 117:319-325(2006)
AJ Frew, RJ Powell, CJ Corrigan & SR Durham
“Modelling of Tumour Necrosis Factor Superfamily 1A mutants associated with Tumour
Necrosis Factor Receptor-Associated Periodic Syndrome indicates misfolding consistent
with abnormal function”
Arthritis and Rheumatism 54:2674-2687 (2006)
SL Rebelo, SE Bainbridge, MR Amel-Kashipaz, PM Radford, RJ Powell, I Todd
& PJ Tighe
“BSACI guidelines for the management of chronic urticaria and angioedema”
Clinical and Experimental Allergy 37:631-50 (2007)
Powell RJ, Du Toit GL, Siddique N, Leech SC, Dixon TA, Clark AT, Mirakian R,
Walker SM, Huber PAJ & Nasser SM
“Tacrolimus immunosuppression in high–risk corneal grafts”
British Journal of Ophthalmology 91:51-5 (2007)
A Joseph, D Raj, V Shanmuganathan, RJ Powell & HS Dua
“Disseminated Mycobacterium tuberculosis infection due to IFN gamma deficiency.
Response to replacement therapy”
Thorax 62:97-9(2007)
SL Seneviratne, R Doffinger, J Macfarlane, L Ceron-Gutierrez, MR Amel
Kashipaz, A Robbins, T Patel, PT Powell, DS Kumararatne & RJ Powell
“ Effect of Grass Pollen immunotherapy with Alutard SQ on quality of life in seasonal
allergic rhinitis”
Allergy 62;1335-133 (2007)
RJ Powell, AJ Frew, CJ Corrigan & SR Durham
“Mutant Tumour Necrosis Factor Receptor associated with Tumour Necrosis Factor
Receptor-Associated Periodic Syndrome is altered antigenically and is retained within
patients’ leucocytes”
Arthritis and Rheumatism 56;2765-2773(2007)
I Todd, PM Radford, N Daffa, SE Bainbridge, RJ Powell and PJ Tighe
“Elevated CD16 Expression by Monocytes from patients with Tumour Necrosis Factor
Receptor –Associated Periodic Syndrome”
Arthritis and Rheumatism 56;4182-4188 (2007)
Ian Todd, Paul M Radford, Loems Zeigler-Heitbrock, Amir M Ghaemmaghami,
Richard J Powell and Patrick J Tighe
“GUIDELINES - Suspected Anaphylactic Reactions Associated with Anaesthesia”
Anaesthesia 64; 199-211(2009)
Working Party members included RJ Powell
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R. J. Powell
“Novel Markers of Inflammation Identified in Tumor Necrosis Factor ReceptorAssociated Periodic syndrome (TRAPS) by Transcriptomic Analysis of Effects of
TRAPS-Associated Tumor Necrosis Factor Receptor Type 1 Mutations in an Endothelial
Cell Line”
Arthritis and Rheumatism 60;269-280 (2009)
Susana L Rebelo, Mohammad R Amel-Kashipaz, Paul Radford, Susan
Bainbridge, Roel Fiets, Johnny Fang, Elizabeth McDermott, Richard Powell, Ian
Todd & Patrick Tighe
“A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF
receptor-associated periodic syndrome (TRAPS)”
Immunology 44.7: 2096-110 (2014)
O. H Negm, H.A Mannsperger, E.M McDermott, E Drew, R Powell
“BSACI guidelines for the management of chronic urticaria and angioedema”
Clinical and Experimental Allergy 45:547-565 (2015)
R.J Powell, S.C Leech, S. Till, P.A.J Huber, S.M Nasser and A.T Clark
Recent Reviews/Editorials
“The TNF Receptor-Associated Periodic Syndrome (TRAPS) - emerging concepts of an
autoinflammatory Disorder”
Medicine 81:349-368 (2002)
KM Hull, E Drewe, I Askentijich, HK Singh, K Wong, EM McDermott, J Dean,
RJ Powell & DL Kastner
“The Eye in Systemic Inflammatory Disease”
Lancet 364:2125-33 (2004)
P McCluskey & RJ Powell
“NOD2 and inflammatory disease”
CPD Bulletin Immunology and Allergy 4(1): 20-22 (2004)
E Drewe and RJ Powell
“A treatment for allergic rhinitis: a view on the role of levocetirizine”
Current medical Research and Opinion 21:1099-1106 (2005)
Holgate S, Powell RJ, Jenkins M & Ali O
“TNF and TNF receptors in TRAPS ”
Current Medicinal Chemistry- anti-inflammatory and allergy agents 4:577-585(2005)
I Todd, PJ Tighe & RJ Powell
“Thalidomide. Treat with caution!”
Netherlands Journal of Medicine 64:391-2 (2006)
Powell RJ
Recent Book Chapters
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R. J. Powell
“Defence Mechanisms”
Scott-Brown’s Otorhinolaryngology: Head and Neck Surgery, 7th Edition
Hodder Arnold May 2008
I Todd & RJ Powell
“Evaluation of the Immune System”
Scott-Brown’s Otorhinolaryngology: Head and Neck Surgery, 7th Edition
London, Hodder Arnold May 2008
E Drewe & RJ Powell
“Immunodeficiencies”
Scott-Brown’s Otorhinolaryngology: Head and Neck Surgery, 7th Edition
London, Hodder Arnold May 2008
E Drewe & RJ Powell
Recent Presentations by Invitation
“Pharmo-economics of SLIT for Hayfever”
Royal Society of Medicine London - November 2009
“Sublingual Immunotherapy, its place in Therapy”
World Allergy Congress Buenos Aires Argentina - December 2009
“Urticaria and Angioedema”
European Meeting of Allergy Nurses, London - June 2010
“Angioedema in the Clinic”
European Academy of Allergy and Clinical Immunology, London - June 2010
“Food Allergies”
Fibromyalgia Conference, Chichester – April 2012
“Allergies – Myths and Connections”
Allergy NI, Belfast – April 2012
“Urticaria – the Allergist”
Royal Society of Medicine – May 2012
“Invigorating your practice – Angioedema & Urticaria’
BSACI Annual meeting, Telford - July 2013
“Allergy tests can only be interpreted with a good clinical history”
Biomedical Science Congress, Birmingham – Sept 2013
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R. J. Powell
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