Guidelines for the Management of Paediatric Surgical Patients with Insulin Dependent Diabetes Mellitus. Liaise with the diabetes team Liaise with the Anaesthetist All Major Elective Surgery and Elective day-case surgery on Morning List Children who are first on the list, undergoing a quick day-case procedure, and likely to be able to eat by lunchtime might require only a small reduction in the morning insulin dose without any further fluid administration i.e the children who have a short anaesthetic on Disney ward. Discuss with anaesthetist and diabetes team. Otherwise: Day before o normal insulin and diet o admit the child on the afternoon/evening prior to surgery o insert an IV cannula and take FBC, U&Es and do a capillary blood glucose Morning of operation o the child should be first on the list o omit usual morning insulin dose o nothing to eat 6 hours before surgery o can drink clear fluids until 2 hours before theatre o start IV fluids and insulin at 06:00 on morning of operation (see appendix). Perform a capillary blood glucose just before commencing IV fluids o capillary blood glucose hourly (including theatre) until the IV infusion comes down, unless agreed with a paediatric diabetes consultant o adjust insulin to keep the blood glucose between 5 and 12 mmol/l o IF the blood glucose is >15mmol/l at the time they are sent for theatre, postpone or cancel the operation 40 After the operation o if eating normally post-op refer to the appendix for restarting insulin: stop IV infusion of insulin 60 minutes after subcutaneous insulin started if not eating, or vomiting post-op continue IV fluids and IV insulin infusion until ready to start s/c insulin leave IV cannula in until discharge Day cases on Afternoon list: Day before o normal insulin and diet Morning of the operation o For patients on multiple dose injection regimen (ie glargine at night, and novorapid with meals), give usual novorapid bolus with breakfast o For insulin pumps give normal bolus with breakfast and normal basal rate until theatre o For twice daily regimens, give 20% of the usual morning insulin dose as soluble insulin eg Novorapid. Do not give long acting insulin, so NO insulin mixture o This will need to be conveyed to parents as this is likely to happen at home. o Fast after breakfast o admit by 10:00 on the morning of admission o on arriving, site cannula o no insulin at lunchtime for those on multiple injection regimen o nothing to eat 6 hours before the operation o can drink clear fluids up to 2 hours before the operation o start IV fluids and insulin at 11:00 pm at the latest, see appendix. Perform capillary blood glucose just prior to commencing IV fluids o capillary glucose hourly (including theatre) until the IV infusion comes down, unless agreed with a paediatric diabetes consultant o adjust insulin to keep blood glucose between 5 and 12mmol/l o if the capillary blood glucose is >15mmol at the time they are sent for theatre, cancel/postpone the operation 41 After the operation o o if eating normally by tea-time give usual evening insulin for every type of insulin regimen o stop IV insulin 60 minutes after subcutaneous insulin started o if not eating or vomiting post-op continue IV fluids and IV insulin until ready to start s/c insulin o see appendix for changing back to s/c insulin o leave IV cannula in until discharge Emergency Surgery: on arriving, measure blood glucose, venous blood gases, check urine for ketones if ketoacidotic, consult DKA guidelines and inform paediatric diabetes team if not ketoacidotic o establish when likely to go to theatre, and when they will become nil by mouth then o start on maintenance fluids and insulin (0.05u/kg/hour) o measure capillary blood glucose before starting IV fluids, and then hourly and check urine for ketones at every sample o adjust insulin to maintain blood glucose between 5 and12mmol/l o continue IV fluids and insulin infusion until ready to eat Appendix(diabetes and surgery) NB These guidelines are NOT the same as DKA guidelines USE PRE-PREPARED FLUID CHART. 1. Maintenance fluid guide: 0.45%saline and 5% dextrose with 10mmol added potassium per 500ml bag Body weight Fluid requirement 1st 10kg 2nd 10kg 3rd 10kg 100mls/kg/day 50mls/kg 20mls/kg eg for 32kg child 10 x 100 = 1000 42 10 x 50 = 500 12 x 20 = 240 total = 1740mls for 24 hour period Run fluids at 73 mls/hour per-operative fluids will be determined by the anaesthetists some post-operative patients may need less fluids, e.g post-op appendix, and we should aim for 2/3rds maintenance and on-going losses, in which case reduce maintenance fluids and add ongoing losses where appropriate. 2. Insulin infusion Add 50units of actrapid to 50mls of 0.9% saline, making a solution of 1unit/ml Start infusion at 0.025u/kg/hour (i.e 0.025mls/kg/hour) Aim to maintain blood glucose levels between 5 and 12 mmol/l o If blood glucose above 12mmol/l, increase infusion by 50%, i.e 0.025 to 0.05mls/kg/hour o If blood glucose below 5 mmol/l, stop insulin and call a doctor, although it is preferable to reduce the rate of the infusion rather than to stop the insulin altogether as this will cause rebound hyperglycaemia 3. Restarting insulin: If ready to eat breakfast: o twice/three injection regimen – give usual insulin in the morning o multiple injection regimen – give usual short acting insulin, plus half of the usual evening dose of long-acting insulin before breakfast, then usual short acting insulin doses before the other meals o usual long acting dose that evening If ready to eat lunch o twice/three injection regimen – 1/3rd of usual morning insulin before lunch, then normal insulin from then on o multiple injection regimen – give usual short acting insulin before lunch plus ¼ of the usual long acting insulin, usual insulin that evening If ready to eat evening meal o usual insulin for all types of regimen FOR ALL REGIMENS Stop IV insulin 60 minutes after s/c insulin has started FMA, ALS, Anaesthetists August 2004 Updated May 2008, review 2010 43 44