赣 南 医 学 院 教 案
教研室：Department of Biochemistry and Molecular Biology
课程名称
授课内容
Biochemistry
授课专业
Chapter 8 Metabolism of Nucleotides
教师姓名： Wu Suzhen
Clinical medicine major
授课学时
6
【Master】
1. De novo synthesis and salvage pathways. The material, site and the
main process of this two pathways.
2. Anti-metabolites of purine nucleotides and pyrimidine nucleotides
and mechanism of their antitumor.
教学目的
3. The similarity and difference of purine catabolism and pyrimidine
catabolism.
【Understand】
The excreted end product of purine catabolism and pyrimidine
catabolism in primates, birds, and some other animals.
【Know】
Hyperuricemia and gout with Disorders of Purine Metabolism.
1. De novo synthesis and salvage pathways. The material, site and the
main process of this two pathways.
教学重点
2. Anti-metabolites of purine nucleotides and pyrimidine nucleotides
and mechanism of their antitumor.
3. The similarity and difference of purine catabolism and pyrimidine
catabolism.
教学难点
Theory of ammonia intoxication.
1. Theaching aid: computer, projector, mike, chalk, ferule, multimedia
courseware
教具和媒
体使用
2. Theaching means: utilize modernization teaching means and
methods, make good courseware, combine pictures with words well;
integrate languge expression, apporiate writing and teaching with
multimedia.
Firstl y give an overview of the source and outlet of nucleotides, and
教学方法
then detail it. Narrating the metabolism of nucleotides on the base of source
and outlet of nucleotides.
Chapter 9 Metabolism of Nucleotides
Section 1 Introduction
Section 2 Synthesis of Purine Nucleotides
2.1 De novo synthesis
2.2 Salvage pathway
2.3 Exchange between purines
教学过程
2. 4 Formation of deoxyribonucleotide
2. 5 Antimetabolites of purine nucleotides
Section 3 Catabolism of Purine Nucleotides
Section 4
Synthesis of Pyrimidine Nucleotides
4.1 De novo synthesis
4. 2 Salvage pathway
4. 3 Antimetabolites of pyrimidine nucleotides
Section 5 Catabolism of Pyrimidine Nucleotides
讲授新进展
内容
Techniqu of gene array，RNA interference and SNPs are the most hot spot
of scientific research at present.
⑴ Berg J M，Tymoczko J L，Stryer L. 2002. Biochemistry. 5th
Edition. New York:W.H. Freeman Publishers.
参考书籍
⑵ Devlin T M.. 2002. Textbook of Biochemisrty with Clinical
Correlations. New York: Wiley-Liss.
⑶ Robert K. Murray, Daryl K. Granner, Peter A. Mayes，et al. 2003.
Harper’s Biochemistry. Stamford：McGraw-Hill.
思考题或/及
作业
Review the content to be mastered.
All students must master De novo synthesis and salvage pathways, the material,
课后总结
site and the main process of this two pathways, anti-metabolites of purine nucleotides
and pyrimidine nucleotides and mechanism of their antitumor, and the similarity and
difference of purine catabolism and pyrimidine catabolism.