Abstract “Synthesis and Optimization of Hybrid Membrane Desalination Processes” Ahmed AlNouss, Sabla Alnouri and Patrick Linke Texas A&M University at Qatar, P.O.Box: 23874, Education City, Doha, Qatar Membrane desalination technology has become a valuable advanced water treatment process to purify difficult water sources for potable use. The most common desalination technologies are membrane processes; Reverse Osmosis (RO) and Nanofiltration (NF). The studies of hybrid RO-NF desalination systems have shown potential advantages of higher overall availability, low power demand, and improved water quality. Under the proposed title, a systematic network synthesis approach is to be developed to evaluate the performance of a hybrid membrane desalination plant consisting of NF and RO process in order to determine the optimal process design and operating conditions for a given water production. This work is done by the use of process superstructure representations and global optimization taking into account desired process conditions and constraints that are associated with the hybrid RO-NF system. The superstructure that captures all the structural and operational options is systematically generated aiming to enable the extraction of the multiple different optimal designs using the global optimization and giving a better visualization of the hybrid design network. The optimization problems is formulated accounting for all the design decisions that are supported by superstructure representation, based on numbers and types of units, flow rates, pressures, and post treatment requirements and an economic objective function is utilized so as to provide efficient of economical desirable configuration that capture all the significant capital and operating costs, such as intake, pre and post treatment, along with the revenue from the value extraction. The solution obtained by the proposed mathematical model would provide an optimized design of the hybrid RO-NF desalination plant and this is illustrated using a case study of sea water desalination with 35 ppt salinity. Keywords: Optimization, Reverse Osmosis, Nanofiltration, Hybrid, Superstructure, Desalination