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SUPPLEMENTAL MATERIAL: SEARCH PROTOCOLS
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Medline search
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1. *Bacteria, Aerobic/ip
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2. *Bacteria, aerobic/ch
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3. *Bacteria, aerobic/cl
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4. *Bacteria, Anaerobic/ch
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5. *Bacteria, anaerobic/cl
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6. *Bacteria, anaerobic/ip
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7. *Gram-Negative Bacteria/ip
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8. *Gram-Negative Bacterial Infections/mi
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9. *Gram-Negative Bacterial Infections/di
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10. *Gram-Negative Bacterial Infections/dt
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11. *Gram-Negative Bacterial Infections/ec
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12. *Gram-Positive Bacteria/ip
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13. *Gram-Positive Bacterial Infections/di
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14. *Gram-Positive Bacterial Infections/mi
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15. *Gram-Positive Bacterial Infections/ec
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16. *Gram-Positive Bacterial Infections/dt
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17. *Gram-Positive Cocci/ch
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18. *Gram-Positive Cocci/cl
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19. Bacteremia/ep
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20. Bacteremia/bl
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21. Bacteremia/di
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22. Bacteremia/dt
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23. Bacteremia/ec
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24. Bacteremia/mi
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25. Bacteria/ch
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26. Bacteria/cl
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27. Bacteria/ge
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28. Bacteria/ip
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29. Bacterial infections/di
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30. Bacterial infections/mi
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31. Bacterial proteins/an
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32. Bacterial Proteins/ip
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33. Bacterial typing techniques/ec
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34. Bacterial typing techniques/mt
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35. Bacteriological techniques/
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36. Bacteriological techniques/ec
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37. Bacteriological techniques/mt
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38. Gram-Negative Bacteria/cl
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39. Gram-Negative Bacteria/ge
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40. Gram-negative bacteria/ip
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41. Gram-Positive Bacteria/cl
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42. Gram-Positive Bacteria/ge
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43. Gram-positive bacteria/ip
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44. Gram-Positive Cocci/ip
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45. Microbial Sensitivity Tests/ec
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46. Microbiological techniques/ec
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47. Microbiological techniques/mt
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48. Specimen handling/mt
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49. or/1-48
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50. maldi.mp. or Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/
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51. 49 and 50
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52. limit 51 to (english language and humans)
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DARE, NHS EED, HTA and Cochrane
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The search term used was ‘MALDI’ mapped to MeSH at the York CRD website, 1 as
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follows:
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MeSH DESCRIPTOR Spectrometry, Mass, Matrix-Assisted Laser Desorption-
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Ionization EXPLODE ALL TREES
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This search encompassed DARE2, NHS EED3, and ‘HTA in Progress’ and ‘HTA
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Published’. This produced two hits, of which one article had already been captured in
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Medline/EMBASE searches. A separate search of the Cochrane systematic review
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database4, using ‘MALDI’ as the search term, did not identify any relevant sources.
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The EMBASE search was related to the Medline search and is available on request.
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http://www.crd.york.ac.uk/crdweb/
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DARE: Database of Abstracts of Reviews of Effects is focused primarily on systematic reviews that evaluate the effects of
health care interventions.
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NHS EED: NHS Economic Evaluation Database
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Search was undertaken here: http://onlinelibrary.wiley.com/cochranelibrary/search
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A systematic review of matrix assisted laser
desorption/ionization time-of-flight mass spectrometry
compared to routine microbiological methods for time taken
to identify microbial organisms from positive blood cultures
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Padraig Dixon1*, Philippa Davies1, William Hollingworth1, Margaret Stoddart1,
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Alasdair MacGowan3
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1 School of Social and Community Medicine, University of Bristol, UK
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2 North Bristol NHS Trust, Department of Medical Microbiology, Southmead Hospital,
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Bristol, UK
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3 Bristol Centre for Antimicrobial Research & Evaluation, University of Bristol and
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North Bristol NHS Trust, Department of Medical Microbiology, Southmead Hospital,
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Bristol, UK
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* Corresponding author
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Email: padraig.dixon@bristol.ac.uk
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Fax of corresponding author: +44 (0)117 928 7325
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Key words: MALDI-TOF, bloodstream infection, identification time.
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Journal name: European Journal of Clinical Microbiology and Infectious Diseases.
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