Problem Duodenal ulcer Desired outcomes of Detailed assessment treatment Heal ulcer Due to naproxen? Prevent relapse H. pylori status Action Follow up and monitoring Anemia Correct Hb ( target) Rheumatoid arthritis Prevent relapses Control symptoms Slow progression of disease Reduce symptoms (shortness of breath , ankle swelling ) Reduce hospital admissions Prevent premature mortality Congestive heart failure Due to blood loss from ulcer? Due to RA? Appears controlled at present Can patient cope without NSAID??? Symptoms appear well controlled at present Is patient's condition stable ?if so could you consider adding a betablocker? Number of hospital Stop naproxen Oral PPI for 4 weeks Eradication therapy if H.pylori positive If iron deficient , start Ferrous sulphate Add ascorbic acid since also on PPI If patient can not cope without NSAID , restart once ulcer healed but add in longterm PPI If stable , consider starting bisoprolol 1.25 mg initially and titrate slowly Consider increasing dose of lisinopril if Bp will allow this Presence of symptoms Rescope to confirm healing Hb after 2-3 months Symptoms of anemia ( fatigue , shortness of breath) Symptom control CRP , ESR Functioning of joints CBC and LFTs since on methotrexate ( risk of toxicity as was on NSAID) Signs of worsening oedema ( e.g. ankle swelling , shortness of breath) Pulse , Bp U + Es ( urea and electrolyte s) Hypertension Control Bp , target < 130/80 mmHg admissions in last year? Could lisinopril dose be titrated further? Bp appears controlled , but is level lower than normal due to bleed? Lisinopril a good choice since patient also has heart failure Continue to monitor Bp No action required Weight Monitor Bp Monitor urea , Cr , K+