CH 107 Exam 3 Mock Exam
1. ____ will react with an amine to form an amine salt.
a) HCl
b) H2O
c) NH4+
d) Ammonia
e) -COOH
2. The reaction of hexanoic acid and dimethylamine will form
a) 2, 2-dimethylhexanamide
b) N,N-dimethylhexanamide
c) N-ethylhexanamide
d) N, N-dimethylhexanamide
e) N, 2-dimethylhexanamide
3. The reaction between an amine and _____ forms an amide.
a) Ketone
b) Alcohol
c) Carboxylic Acid
d) Aldehyde
e) Ester
4. The amine ethyl propanamine is a ______.
a) Secondary amine
b) Secondary amide
c) Tertiary amine
d) Tertiary amide
e) Primary amine
5. Ethyl propanamine will react with propanoic acid to form
a) N-ethyl-N-propyl propanamide
b) N, N-dipropyl ethanamide
c) Ethyl propyl propanamide
d) N, ethyl propanamide
e) N, B-dipropyl propanamide
6. A quarternary ammonium compound has a nitrogen bonded to ___ carbons and
has a ___ charge.
a) Four, positive
b) Four, negative
c) Three, positive
d) Three, negative
e) Five, positive
7. Amides are considered to be:
a) Basic
b) Acidic
c) Neither acidic or basic
d) Both acidic and basic
e) Hydrophobic
8. In amidation, a secondary amine will yield:
a) A primary amide
b) A secondary amide
c) A tertiary amide
d) No reaction
e) A primary amine
9. In what form are amine-containing drugs administered?
a) Amine salt
b) Free base
c) Pumiliotoxin
d) Polyamides
e) None of the above
10. Alkaloids are derived from
a) Plants
b) Animals
c) Fungi
d) All of the above
e) A and B
11. Amines are considered to be
a) Acidic
b) Basic
c) Neither acidic or basic
d) Nonpolar
e) Hydrophobic
12. In the peptide Glu-Ala-Gln-Gly, _____ is the C-terminal residue and ______ is the N
terminal residue.
a) Glycine, Glutamic acid
b) Glycine, glycine
c) Glutamic acid, glycine
d) Glutamic acid, glutamic acid
e) None of the above
13. The bonds between strands in a Beta sheet are:
a) Hydrogen bonds
b) Disulfide bonds
c) Peptide bonds
d) Intramolecular
e) None of the above
14. The type of interaction between the sidechains of valine and leucine is expected
to be
a) Disulfide bond
b) Hydrophobic interaction
c) Peptide bond
d) Hydrogen bond
e) Intramolecular bond
15. The ____ is the overall protein structure while the ____ is the spatial arrangement
of neighboring residues
a) Tertiary, secondary
b) Tertiary, primary
c) Quaternary, primary
d) Quaternary, tertiary
e) Quaternary, secondary
16. Globular proteins are ____ while fibrous proteins are____.
a) Structural, functional
b) Functional, structural
c) Not water soluble, water soluble
d) Disulfide bonds, hydrogen bonds
e) Hydrogen bonds, disulfide bonds
17. The bond between two cysteine molecules is called
a) Peptide bonds
b) Disulfide bonds
c) Hydrogen bonds
d) Hydrophobic interactions
e) Hydrophilic interactions
18. Gly-Met-Asn-Arg-Lys-Trp is a ____ that has ____peptide bonds.
a) Hexapeptide, six
b) Hexapeptide, five
c) Pentapeptide, six
d) Pentapeptide, five
e) None of the above
19. Amino acids that are not synthesized in the body and must be obtained from the
diet are called
a) Incomplete
b) Essential
c) Basic
d) Polar
e) easily synthesized
20. A ____ is a molecule with both positive and negative charges.
a) Zymogen
b) Heterocyclic amine
c) Free base
d) Zwitterion
e) Polyamide
21. Which of the following have no affect on enzyme activity.
a) Temperature
b) pH
c) Hydrogen bonds
d) Enzyme concentration
e) Substrate concentration
22. An enzyme in a bacteria is no longer active due to the mechanism of action of the
anti-biotic. This anti-biotic binds to RNA polymerase in a bacterium and prevents
RNA synthesis from occurring. What type of inhibitor is this?
a) Competitive
b) Non-competitive
c) Irreversible
d) Allosteric
e) None of the above
23. In ________, the production of the final product controls the overall activity of the
enzyme.
a) Feedback control
b) Competitive inhibition
c) Zymogen activation
d) Cofactor activation
e) None of the above
24. An enzyme in it’s non-active form is a ______.
a) Cofactor
b) Zymogen
c) Protease
d) All of the above
e) A and C
25. In order to bond, the substrate must have the correct:
a) Shape
b) Size
c) Interactions
d) All of the above
e) A and B
26. The following is what step in an enzyme reaction
ES EP
a) 1
b) 2
c) 3
d) 4
e) 5
27. Substrate binding is _______. After the product is formed, the enzyme _______
undergo another reaction.
a) Irreversible, cannot
b) Irreversible, can
c) Reversible, cannot
d) Reversible, can
e) Depends on how it is feeling.
28. Which of the following is an isoenzyme?
a) Lactate dehydrogenase
b) Sucrase
c) Chymotrypsin
d) Pepsin
e) Insulin
29. Reversible inhibitors bind to the active site in what way?
a) Hydrophobic interaction
b) Hydrogen bonding
c) Covalent bonding
d) A and B
e) B and C
30. Cofactors are:
a) Large molecules
b) Not required for enzyme activity
c) Necessary for enzyme function
d) Destabilize the active site
e) None of the above
Short answer
31.Draw a pentapeptide with arg-ser-glu-ala-phe. Number the residues; give the one
letter code, indicate all peptide bonds, carboxy terminus and the amino terminus.
32. Compare and contrast globular and fibrous proteins (at least 3 items) and give
an example of each.
33. Draw and name 2 primary, 2 secondary and 2 tertiary amines for C6H15N.
34. Explain both the lock and key model and the induced fit model of enzyme
substrate interactions.