BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Hu, Xiaoping Philip
Professor of Biomedical Engineering
eRA COMMONS USER NAME (credential, e.g., agency login)
xiaopinghu
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and
residency training if applicable.)
DEGREE
INSTITUTION AND LOCATION
MM/YY
FIELD OF STUDY
(if applicable)
University of Sci. & Tech. of China, Hefei, China
University of Chicago, Chicago, Illinois
University of Chicago, Chicago, Illinois
University of Chicago, Chicago, Illinois
B.S.
M.S.
Ph.D.
Post-doc
07/82
06/84
06/88
07/88
Physics
Physics
Medical Physics
Medical Imaging
A. Personal Statement
I have extensive expertise and experience in neuroimaging, both in terms of methods and applications. As a
faculty member at the University of Minnesota, I initially worked on developing new methods for magnetic
resonance spectroscopic imaging and imaging at high magnetic fields. Upon the birth of functional MRI in early
1990s, I shifted my focus to methodological developments, mechanistic investigations, and applications of
fMRI. As PI or co-Investigator on a number of previous NIH-funded grants, I laid the groundwork for the
proposed research by developing effective methods for neuroimaging data acquisition and analysis and by
validating and successfully applying these techniques in a number of applications. In addition, I successfully
administered these projects (e.g. staffing, research protections, budget), collaborated with other researchers,
and produced scores of peer-reviewed publications from these collaborations. The current application builds
logically on my prior work with Drs. Lynch, Li and Coles. I will work closely with them, providing intellectual
inputs to experimental design, data acquisition, analysis and interpretation. In short, I have a demonstrated
record of successful and productive research in neuroimaging, and my expertise and experience have
prepared me to play my role successfully on the proposed project.
B. Positions and Honors
Positions and Employment
1988 - 1990 University of Chicago: (Department of Radiology) Research Associate
1990 - 1994 University of Minnesota: (Department of Radiology) Assistant Professor
1994 - 1998 University of Minnesota: (Department of Radiology) Associate Professor
1998 - 2003 University of Minnesota: (Department of Radiology) Professor
2002 - Present Emory University: (Georgia Tech/Emory University Biomedical Engineering) Professor
Other Experience and Professional Memberships
1990Member, International Society for Magnetic Resonance in Medicine
1990Member, Institute of Electronic and Electrical Engineers
1994 Associate Editor, IEEE Transactions on Medical Imaging
1996-1998 Member, Clinical Neuroscience and Biological Psychopathology Review Committee, NIMH, NIH
1997-2000 Member, Student Award Committee, International Society for Magnetic Resonance in Medicine.
1998-2000 Member, Brain Disorders and Clinical Neuroscience 6, CSR, NIH
2001- 2004 Editorial Board, Magnetic Resonance in Medicine
2002Member of the Canada Research Chair Review College
2003
Ad hoc reviewer of the Board of Scientific Councilor of Laboratory of Brain and Cognition at NIMH
2004-2006 President, Oversea Chinese Magnetic Resonance Imaging Society
200420042005200720072007-
Senior Member, Institute of Electronic and Electrical Engineers
Member, Board of Advisors, Southwest Medical Devices Association
Deputy Editor, Magnetic Resonance in Medicine
Chartered Member, Biomedical Computing and Health Informatics, CSR, NIH
Member, Organization for Human Brain Mapping
Member of the Council, World Association of Chinese Biomedical Engineers
Honors
1982 M.-R. Kou Scholarship for best senior in physics, University of Science and Technology of China
1991 Research Scholar, Radiological Society of North America
2004 Fellow, International Society for Magnetic Resonance in Medicine
2009 Fellow, Institute of Electronic and Electrical Engineers
2009 Fellow, American Institute of Medical and Biological Engineers
C. Selected Peer-reviewed Publications (Selected from 198 peer-reviewed publications)
Most relevant to the current application
1. Li L, Coles CD, Lynch ME, and Hu X. Voxelwise and skeleton-based region of interest analysis of fetal
alcohol spectrum disorders in young adults. Human Brain Mapp 30:3265–3274, 2009. PMID 19278010.
2. Li Z, Coles CD, Lynch ME, Hamann S, Peltier S, LaConte SM, and Hu X. Prenatal cocaine exposure alters
emotional arousal regulation and its effects on working memory. Neurotox Terat 31 342–348, 2009. PMID
19699795
3. Coles CD, Goldstein FC, Lynch ME, Chen X, Kable JA, Johnson KC, and Hu X. Memory and brain volume
in adults prenatally exposed to alcohol. Brain and Cognition 75(1): 67-77, 2011. PMID 21067853.
4. Chen XC, Coles CD, Lynch ME, and Hu X. Understanding specific effects of prenatal alcohol exposure on
brain structure in young adults, Human Brain Mapp (accepted). PMID 21692145.
5. Santhanam P, Li Z, Lynch ME, Coles CD, and Hu X, Default Mode Network Dysfunction in Adults with
Prenatal Alcohol Exposure. Psych Res: Neuroimaging (accepted).
Additional recent publications of importance to the field (in chronological order)
6. Li Z, Coles CD, Lynch ME, Ma X, Peltier S, and Hu X. Occipital-temporal reduction and sustained visual
attention deficit in prenatal alcohol exposed adults. Brain Imag Behav 2:38-48; 2008. PMID 19112522.
7. Rilling JK, Glasser MF, Preuss TM, Ma X, Zhao T, Hu X, and Behrens TEJ. The evolution of the arcuate
fasciculus revealed with comparative DTI. Nature Neurosci 11: 426-428, 2008. PMID 18344993
8. Nana R. Zhao TJ, and Hu X. Single-shot multi-echo parallel EPI for DTI with improved SNR and reduced
distortion. Magn Reson Med 60(6); 1512-1517, 2008. PMID 19025894
9. Santhanam P, Li Z, Hu X, Lynch ME, and Coles CD. Effects of prenatal alcohol exposure on brain
activation during an arithmetic task: an fMRI study. Alcoholism: Clinical and Experimental Research 33(11),
1901-1908, 2009. PMID 19673738.
10. Deshpande G, LaConte SM, James GA, Peltier S and Hu X. Multivariate Granger causality analysis of
fMRI data. Human Brain Mapp 30(4):1361-1373, 2009. PMID 18537116
11. Glielmi C, Schuchard RA, and Hu X. Estimating cerebral blood volume with expanded vascular space
occupancy slice coverage. Magn Reson Med 61(5): 1193-1200, 2009. PMID: 1925336
12. Li L, Preuss T, Rilling J, Hopkins W, Glasser MF, Kumar B, Nana R, Zhang X, and Hu X. Chimpanzee (Pan
troglodytes) precentral corticospinal system asymmetry and handedness: a diffusion magnetic resonance
imaging study. PLoSOne 5(9): e12886, 2010. PMID 20877630.
13. Deshpande G, Santhanam P, and Hu X. Instantaneous and causal connectivity in resting state brain
networks derived from functional MRI data. NeuroImage 54(2): 1043-1052, 2011. PMID 21151556.
14. Li L, Rilling JK, Preuss TM, Glasser MF and Hu X. The effects of connection reconstruction method on the
interregional connectivity of brain networks via diffusion tractography. Human Brain Mapp (accepted).
15. Poplawsky A, Dingledine R and Hu X. The direct detection of a single evoked action potential with
magnetic resonance spectroscopy in lumbricus terrestris. NMR Biomed (accepted). PMID 21728204.
D. Research Support
Ongoing Research Support
NIH PO1AG026423, Herndon (PI)
4/2007-3/2012
Evolution of Aging and Dementia in Female Primates
To study the effects of aging with behavioral, biological and imaging markers.
Role: PI on Imaging Core
NIH R01-MH056120-08A2
Bremner (PI)
7/2007 - 6/2012
Neural Circuits in Women with Abuse and PTSD
To study neurobiological basis of effects of abuse in women with post-traumatic stress disorder.
Role: Co-PI
NIH T32EB005969, Hu (PI)
9/2007 – 8/2012
Interdisciplinary Training in Biomedical Imaging
To provide interdisciplinary training in biomedical imaging to graduate students.
Role: PI
NIH P50 CA128301 Goodman, Hu, Meltzer (PIs)
9/2008 – 8/2013
Emory Molecular and Translational Imaging Center
To develop and validate molecular imaging methods for oncological applications and to translate them to
clinical settings.
Role: PI
NIH 1 U01 MH081988-01A1 Walker (PI)
9/2008 – 4/2013
Predictors and Mechanisms of Conversion to Psychosis.
The work intends to identify findings that will enhance our ability to identify persons at high risk for imminent
psychosis, by refine predictors of conversion, and expanding our understanding of the underlying neural
mechanisms.
Role: Co-I.
NIH/NIMH 1 P50 MH078105 (Gunnar, PI; Sanchez, PI Proj.3) 3/2009-2/2014
Early Experience, Stress and Neurobehavioral Development Center
Goal of this project: To examine the effects of early adverse care on neurobehavioral development, both in
humans and nonhuman primates.
Role: Co-I.
NCI/NIH 1 R21 CA 141836-01A2 (PIs: Hu, Shim, Olsen)
4/2010 – 3/2012
Using Proton MRS to Predict Response of SAHA Treatment in Glioblastoma
To identify proton MR metabolites that can predict the response of SAHA treatment in an orthotopic brain
tumor rat model; To evaluate MRS biomarkers in SAHAtreated glioblastoma patients at 3 Tesla; To implement
three dimensional CSI to obtain information of whole brain and determine the combined measures of the
metabolites to predict treatment response by using bioinformatics.
Role: PI
Georgia Institute of Tech. NHLBI-HV-10-08 (PI: Taylor)
8/2010 – 7/2015
Center for Translation Cardiovascular Nanomedicine
Establish the Center for Translational Cardiovascular Nanomedicine, a highly collaborative and
multidisciplinary Program of Excellence in Nanotechnology (PEN) at Georgia Institute of Technology, Emory
University and University of California, Davis. The vision of this PEN is to develop and apply nanotechnology
and biomolecular engineering tools and approaches to address compelling medical needs in the detection and
treatment of atherosclerosis and the repair of damaged vasculature and heart tissue.
Role: Co-I.
Completed Research Support (in past 3 years)
NIH R01EB002009 Hu (PI)
5/2000-3/2010
Improvement and Application of fMRI
Develop a technique for the monitoring and compensation of physiology related fluctuation in fMRI data.
Role: PI
NIH R01DA17795 Hu (PI)
4/2004-04/2010
Assessing Developmental Effects of Prenatal Cocaine Exposure
To ascertain developmental changes in the brain as a consequence of prenatal cocaine exposure.
Role: PI
NIH P20CA134223 Goodman, Hu, Meltzer (PIs)
9/2007 – 8/2008
Emory Molecular and Translational Imaging Center
To develop and validate molecular imaging methods for oncological applications and to translate them to
clinical settings.
Role: PI
NIH U01 HL080711-01
Bao (PI)
5/2005-4/2010
Nanotechnology: Detection & Analysis of Plaque Formation
Detection and analysis of plaque formation.
Role: Co-PI
R21 HD055255-01 Sanchez (PI)
4/2007 – 3/2010
NIH
Understanding Neurodevelopment in Macaques with Different Rearing Experiences
Build upon previous finding on the impace of early maltreatment on behavior and neuroendocring function of
rhesus monkeys during their first two years of life, and extends the study to the adolescent and adult ages.
Coulter Foundation (PI: Hu, Fei)
7/2010 – 6/2011
MRI-based Attenuation Correction for Combined MRI/PET
Further develop and evaluate MRI/PET technology, making it acceptable for routine applications for
quantitative MRI/PET imaging in both clinical and research studies.
Coulter (PI: Hu, Martin)
7/2010 – 6/2011
Multiparametric Non-Invasive Evaluation of Liver Disease: Hepatic Lipid Quantification Using
Combined Magnetic Resonance Spectroscopy and Imaging
Develop non-invasive MR imaging methodology to significantly improve diagnostics and treatment of fatty liver
disease and hepatitis.
Role: PI.
NIH 1 P50 MH077083-01 (PI: Mayberg)
7/2006 – 6/2011
Predictor of Antidepressant Treatment Response: Emory CIDAR Grant
Predictor of antidepressant treatment response.
Role: Co-I.