Table S1. RNAi phenotypes of lsm genes retrieved from wormmart.
Wormmart is a tool available at wormbase [S1]. RNAi assays represented in this table were
performed following diverse protocols and using distinct genetic backgrounds:
RNAi by feeding starting at L4 [S2], RNAi by feeding starting at L1 [S3], RNAi in RNAi hypersensitive
backgrounds [S4, S5], RNAi by injection [S6], or RNAi by soaking [S7]. Other RNAi screens referred
here were focused in specific phenotypes as aging, cell proliferation, endocytosis, innate immunity or
transgene silencing [S8–13].
Table S2. Yeast lsm phenome.
Table shows all the yeast lsm phenotypes retrieved from the Saccharomyces Genome Database
(SGD) [S13]. All the information available for S. cerevisiae mutant strains for lsm genes is shown. Nonviable phenotypes are highlighted in red.
Table S3. RNA-Seq analyses of lsm-1 mutants.
Sheet 1: Statistical analyses including FPKM (fragments per kilobase of exon per million fragments
mapped) for each gene mapped, and fold change between lsm-1 mutants and wild type animals.
Sheet 2: Genes significantly upregulated (p value ≤ 0.05).
Sheet 3: Genes significantly downregulated (p value ≤ 0.05).
Sheets 4 and 5: Additional information about genes up and down regulated in lsm-1 mutants. Gene
description was retrieved from wormbase using the tool wormmart.
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