History of Pharmacy The main points discussed are: Histories of drugs, pharmacy education, the profession, references, dosage forms, Pharmacopoeias and hospital pharmacy. Pharmacy in modern Egypt, Pharmacy education, development of pharmaceutical industries, It is divided into time lines of the prehistoric, B.C. period (Egyptians, Babylonians, Chinese, Greeks and Romans), and the A.D. period (Persians, Arabs, Indians, Europeans) Ancient Egypt: The Egyptians’ techniques is the main reference from which other copied medical and pharmaceutical sciences They used to cure illnesses using: Dietetics (food and nutrition), Surgery or drug therapy. Drug preparations were conducted by two main categories: Technicians & Specialists. Includes Drug gatherers (collection) Priest herbalists (supervise collection) Drug conservator (preserve gathered drugs in the house of light) Drug preparers (preparation) Chief of fabrication (Supervise preparation) Drugs used by ancient Egyptians were of different origins: animal (honey, beeswax, milk, fats, liver) plant(herbs, leaves, oils, fruits, spices) mineral (alum, copper) Introduced Foreign trade which included new drugs (Punt by Queen Hatshepsut & Syria by Thotmes II) Different non-medical preparations as perfumes and cosmetics (Copper silicate Eye liner, Red ochreLip pigment, Lilly Oilperfume) Medical and pharmacy education: Carried out by priests in schools within the temples (Uhn’s school in Heliopolis) Notable Physicians: Thoth (wrote the ancient formulae), Imhotep (physician of King Zoser) Used excipients in their medical and non-medical preparations (masking taste with milk or honey, water or milk in Liquid preparations, geese fat resins and wax in Ointment preparations) Used different preparation methods: drying, roasting, crushing, squeezing, trituration (dilution), maceration (method of extraction), etc. ** The most important pharmaceutical record are the papyruses : Papyrus Ebers -Papyrus Edwin Smith -Papyrus Kahon -Papyrus Berlin I. Ebers: Contains a collection of 800 prescriptions and 700 drugs, Discovered in 1862 in Luxor by George Ebers. Includes the name of diseases (with symptom descriptions), recommended drugs ( with accurate dosage of each drug), different dosage forms, and real and effective medical formula II. III. IV. Edwin Smith: discovered in 1861 in Luxor by Edwin Smith. Contains full description of 48 bone surgeries Kahon: Discovered in Fayoum. Includes a part containing Gynecology, and the other veterinary medicine Berlin: Discovered in Sakkarah. Its most important content is a test for pregnancy Measurements used in Ancient Egypt: Kite = 140 grain (weight) Tenat (vol) Ro (vol) 9 gm 500 ml 15 ml Ancient Babylonia (currently Iraq) Health practitioners were Priest, Pharmacist, and Physician all in one There was co-operation between the magical healers (spells and magic stones) and empirical healer (natural drugs) Medical texts show the recording of symptoms, prescriptions and directions for compounding. Ancient China Examined many herbs, barks, and roots from fields, swamps, and forests : Rhubarb, Cinnamon, Ephedra, Datura Treated herbs by: Soaking / Boiling / Fermentation Used Ointments, paints, bandages and baths for dosage forms Ancient Greece & Rome Most of their knowledge comes from studying in Ancient Egypt Established many medical schools In Athens and in Egypt (University of Alexandria, Est. 350 B.C. by Ptolmey) Brought scientists from The school of Uhn to teach at the University Famous Graduates: Eklidius, Archemides, Galen Famous Greek Scientists: Hippocrates (Medicine), Theophrastus (Botany), Discorides (Herbal medicines), Galen (Medicine) Persia:Before joining the Islamic Empire: Built hospitals called “Bemaristan” for clinical and educational aims Famous Persian scientists were invited by the Arab rulers to share their knowledge to them, it was easily done due to the minimal language barrier between the two, as the city of El Hira was a bridge between Persian and Arabic After: Arabs and Persians participated in the advancement of science which spread throughout the world India Has influence over the development of science Indians took after the Babylonian scientists Established Hygienic rules (Manno’s Laws): Mouth rinsing after meals, Frequent bathing, Prohibition of easting pungent vegetables such as onions and garlic Important reference called “Susrula”. Includes important info about anatomy and surgery. Describes about 700 drugs of plant, animal and animal origin. Nutrition guidelines, disposing of infected blood, and use of medicinal plants