Additional file 2 Outcomes reflecting care processes Outcome Definition Feeding = Head of bed elevated at 30° Adequate prevention of venous thromboembolism Rate of antibiotic use When we assessed How we assessed ππ’ππππ ππ πππ‘ππππ‘ − πππ¦π ππππππ£πππ πππ‘ππππ ππ ππππππ‘ππππ πππππππ πππ‘ππππ‘ − πππ¦π Every 3 three days from ICU day 2 to 17. Checked prescription = ππ’ππππ ππ πππ‘ππππ‘ − πππ¦π π€ππ‘β βπππ ππ πππ ππππ£ππ‘ππ ππ‘ ≥ 30° ππππππππ πππ‘ππππ‘ − πππ¦π Every 3 three days from ICU day 2 to 17. Bed observation We considered only patients with indication of head of the bed at 30° (MV, enteral feeding or altered level of consciousness) = ππ’ππππ ππ πππ‘ππππ‘ − πππ¦π π€ππ‘β πππππ’ππ‘π π·ππ ππππ£πππ‘πππ πππ‘ππππ‘ − πππ¦π Every 3 three days from ICU day 2 to 17. Checked prescription Every 3 three days from ICU day 2 to 17. Checked prescription Adequate prevention of VTE is defined as: Dalteparin 5.000U 1x a day SC, enoxaparin 40mg 1x a day SC or heparin 5.000U 12/12hs SC or fondaparinux 2.5 mg 1x a day SC. A higher dose can be used if the patient has indication of anticoagulation therapy. If heparin is contraindicated: compression stockings ± pneumatic compression ππ’ππππ ππ πππ‘ππππ‘ − πππ¦π π€ππ‘β πππ‘πππππ‘ππ ππππ πππππ‘πππ = X 100 πππ‘ππππ‘ − πππ¦π = ππ’ππππ ππ πππ‘ππππ‘ − πππ¦π π’ππππ πππππ’ππ‘π π ππππ‘πππ πππ‘ππππ‘ − πππ¦π ππ ππ Every 3 three days from ICU day 2 to 17. We assessed RASS of patients on invasive mechanical ventilation = ππ’ππππ ππ πππ‘ππππ‘ − πππ¦π π€ππ‘β πππππππ ππ ππππ πππππ‘πππ X 100 πππ‘ππππ‘ − πππ¦π Every 3 three days from ICU day 2 to 17. Checked prescription Tidal volume ≤ 8mL/kg of predicted weight = πππ‘ππππ‘ − πππ¦π ππ ≤ 8ππΏ πππ πΎπ πππππππ‘ππ π€πππβπ‘ × 1000 πππ‘ππππ‘ − πππ¦π ππ ππ Every 3 three days from ICU day 2 to 17. Checked mechanical ventilator data Central line-associated bloodstream infection (CLABSI) rate = ππ’ππππ ππ πΆπΏπ΄π΅ππΌ × 1000 ππ’ππππ ππ πππ‘ππππ‘ − πππ¦π π€ππ‘β ππππ‘πππ ππππ Daily from ICU day 2 to 17. Blood cultures and clinical data Patients under adequate sedation Patient-days under moderate, mild sedation, or alert and calm (RASS -3 to 0) Rate of analgesic use Bloodstream infection defined according to the CDC criteria Rate of ventilator-associated pneumonia (VAP) = ππ’ππππ ππ ππ΄ππ × 1000 ππ’ππππ ππ πππ‘ππππ‘ − πππ¦π ππ ππ Daily from ICU day 2 to 17. Laboratory and clinical data Rate of urinary tract infection associated with catheter (UTI) = ππ’ππππ ππ πππΌπ × 1000 ππ’ππππ ππ πππ‘ππππ‘ − πππ¦π π€ππ‘β ππππ€ππππππ π’ππππππ¦ πππ‘βππ‘ππ Daily from ICU day 2 to 17. Urine culture and clinical data Rate of mechanical ventilation Rate of use of central line catheter Rate of use of indwelling urinary catheter = ππ’ππππ ππ πππ‘ππππ‘ − πππ¦π ππ ππ × 100 ππ’ππππ ππ πππ‘ππππ‘ − πππ¦π Daily from ICU day 2 to 17. Patients’ inspection = ππ’ππππ ππ πΆππΆ − πππ¦ × 100 ππ’ππππ ππ πππ‘ππππ‘ − πππ¦π Daily from ICU day 2 to 17. Patients’ inspection = ππ’ππππ ππ πΌππΆ − πππ¦ π₯ 100 ππ’ππππ ππ πππ‘ππππ‘ − πππ¦π Daily from ICU day 2 to 17. Patients’ inspection