Table 1. Data elements present in the real data set.
Data Element
% of visits in model data
Chief Complaint or Reason for Visit
85.16
Sub-syndrome
83.52
Syndrome
54.41
Final diagnosis ICD-9 code
99.72
Table 2. Possible ICD-9 codes associated with the chief complaint “sore throat.” This does
not include misspellings or abbreviations.
ICD-9 Code
Description
034.0
034.0 STREP SORE THROAT
079.99
079.99 VIRAL INFECTION NOS
382.9
382.9 OTITIS MEDIA NOS
462
462 ACUTE PHARYNGITIS
463
463 ACUTE TONSILLITIS
465.9
465.9 ACUTE URI NOS
466.0
466.0 ACUTE BRONCHITIS
473.9
473.9 CHRONIC SINUSITIS NOS
486
486 PNEUMONIA, ORGANISM NOS
528.0
528.0 STOMATITIS
786.07
786.07 WHEEZING
Table 3. Example Analysis Visit Descriptor (for Visit 2307262).
Patient Id
Visit Id
Visit Date
Patient Class
Age Range
Gender
Race
Ethnic Group
Deceased Flag
Deceased Date
Syndrome 1
Syndrome 2
…
Subsyndrome 1
Subsyndrome 2
…
Working Diagnosis 1
Working Diagnosis 2
…
Final Diagnosis 1
Final Diagnosis 2
…
Number Laboratory Orders
Number Laboratory Results
Number Radiology Orders
Number Radiology Results
Number Rx Orders
Botulism Like
Fever
…
Respiratory
…
Abdominal pain
…
Otitis media
…
Blood Culture
MRSA Culture
…
Strep Group A Culture
Urine Culture
DX Chest
DX Sinus Paranasal
…
127151
2307262
12AUG2006:20:15:00.000
E
4-11 Years
F
White
Not Hispanic or Latino
Respiratory
…
Otitis media
…
388.7
382.7
1
1
Table 4. Example Analysis Visit Descriptor (for Visit 3102841).
Patient Id
Visit Id
Visit Date
Patient Class
Age Range
Gender
Race
Ethnic Group
Deceased Flag
Deceased Date
Syndrome 1
Syndrome 2
…
Subsyndrome 1
Subsyndrome 2
…
Working Diagnosis 1
Working Diagnosis 2
…
Final Diagnosis 1
Final Diagnosis 2
…
Number Laboratory Orders
Number Laboratory Results
Number Radiology Orders
Number Radiology Results
Number Rx Orders
Botulism Like
Fever
…
Respiratory
…
Abdominal pain
Abdominal cramps
…
Headache
…
Blood Culture
MRSA Culture
…
Strep Group A Culture
Urine Culture
DX Chest
DX Sinus Paranasal
…
127151
3102841
10JAN2007:08:41:07.000
E
4-11 Years
F
White
Not Hispanic or Latino
Fever
Respiratory
…
Fever
Headache
…
462
462
465.9
1
1
1
1
1
1
1
2
Table 5. Patient Care Descriptor for Patient 127151.
Patient Id
Age Range
Gender
Race
Ethnic Group
Deceased Flag
Number AVisits
Number Laboratory Orders
Number Laboratory Results
Number Radiology Orders
Number Radiology Results
Number Rx Orders
Botulism Like
Fever
GI
Hemorrhagic Illness
Localized Cutaneous Lesion
Neurological
Rash
Respiratory
Severe Illness or Death
Specific Infection
Other
Abdominal pain
Abdominal cramps
…
Headache
…
Otitis media
…
Blood Culture
MRSA Culture
…
Strep Group A Culture
Urine Culture
DX Ankle
DX Chest
…
DX Sinus Paranasal
…
127151
4-11 Years
F
White
Not Hispanic or Latino
2
1
1
1
1
1
1
1
1
2
Table 6. Syndromes assigned to synthetic tularemia injects.
Syndrome
% of 221 visits with
listed syndrome
Fever
92.76
Gastrointestinal
12.22
Hemorrhagic Illness
10.86
Localized Cutaneous Lesion
.45
Lymphadenitis
1.81
Neurological
12.67
Rash
4.52
Respiratory
79.64
Severe Illness or Death
11.76
Specific Infection
7.24
Table 7. Sub-syndromes assigned to synthetic tularemia injects.
Sub-Syndrome
Abdominal Pain
% of 221
visits with
listed SubSyndrome
8.14
Sub-Syndrome
Heart disease, ischemic
% of 221
visits with
listed SubSyndrome
2.26
Alteration of Consciousness
12.67
Hempotysis
7.24
Anemia
10.86
Hypotension
1.81
Asthma
3.62
Influenza-like Illness
8.14
Bronchitis and Bronchiolitis
11.31
Intestinal infections, ill-defined
.45
Cardiac dysrythmias
14.48
Lymphadenopathy
1.81
Chest pain
9.95
Malaise and fatigue
.45
Coagulation defects
.45
Mental disorders
Coma
8.14
Migraine
.45
COPD
1.36
Nausea and vomiting
9.95
Cough
44.34
Pleurisy
.45
Cyanosis and hypoxemia
2.71
Pneumonia and lung abscess
19.00
Death
.45
Pupurae and petechiae
1.36
Dehydration
1.81
Rash
10.41
Diabetes mellitus
1.81
Respiratory failure
12.67
Diarrhea
8.60
Septicemia and bacteremia
4.52
Dizziness
.45
Shock
9.95
Dyspnea
39.82
Skin infection
.45
Edema
2.71
Syncope and collapse
.45
Fever
47.51
Upper respiratory infections
2.26
Gastrointestinal hemorrhage
2.71
Urinary tract infections
1.81
Headache
.90
Viral infection, unspecified
11.31
10.86
Table 8. Laboratory Tests for Synthetic Tularemia Injects. There were 609 tests ordered.
Ordered Test Name Local
(Laboratory Test)
ASO Titer(ASO)
Aerobic
Blood Culture (BLC)
Blood Culture Isolator(BLDC)
Percent of
Tests Ordered
.66
.16
39.90
.66
Ordered Test Name Local
(Laboratory Test)
Influenza Antigen(FLUAG)
Percent of
Tests Ordered
3.45
Legionella Ag Urine Culture
(LEGEIA)
Lyme IgG
.82
Mono Test (MONO)
.16
.66
C Difficile Toxin A
11.33
Ova and Parasite Exam (OVAP)
2.46
C Reactive Protein (CRP)
3.28
Prealbumin (PAB)
1.64
CMV AB IgG (CMVGAB)
.66
Reproductive Culture
.66
CMV AB IgM(CMVMAB)
.66
12.97
Chlamydia/GC by Amplified
Probe(CGPT)
Enteric Pathogen Culture(ENPC)
.66
.16
Epstein Barr Virus Antibody
Screen (EBVSRN)
Gram Smear (GRAS)
.66
Respiratory Culture and Smear
(RTCS)
Respiratory Viral Panel Acute
(RVPA)
Strep Group A Screen Rapid
(RSTREP)
Urine Culture (URC)
.16
Urine Culture and Smear (URCS)
Haptoglobin (HAPT)
1.15
Herpes Virus Six Culture(HHV6Q)
.66
2.46
.66
2.63
10.67
Table 9. Radiology Orders for synthetic tularemia injects.
Ordered Test Name Local
(Radiology Order)
DX Abdomen 2 View
DX Abdomen AP
Percent of Tests Ordered
.64
13.74
DX Abdomen Acute
.64
DX Chest 1 View AP
34.50
DX Chest 1 View NR
1.60
DX Chest 2 View
23.64
DX Chest Special Vi
32
DX Small Bowel Series
.64
PX Abdomen Portable
2.88
PX Chest 1 V Portable
20.77
PX Cholangiogram In
.64
Table 10. Electronic medical records for two synthetic tularemia inject patients. Some
fields have been omitted for clarity; most of the omitted fields are blank.
Table 11. Electronic medical records for two synthetic background patients. Some fields
have been omitted for clarity; most of the omitted fields are blank.
Table 12. Validation of Synthetic background electronic medical records. There were 3272
visit records.
Error
Number of Errors found
Percent of total Records
Care Model did not match ICD-9
codes completely.
80
2.4%
ICD-9 Codes contradictory
8
.24%
Gender or Age ICD-9 mismatch
6
.18%
Sub-syndrome or syndrome
assignment inconsistent with ICD-9 or
chief complaint
4
.12%
Typographical or formatting error
4
.12%
Total
91
2.8%