Every Breath You Take Part II
Pneumonia Noninvasive Ventilation & Oxygen Availability Edward Anthony Oppenheimer, M.D. With an
introduction by June Price
Every Breath You Take Part II
Pneumonia Noninvasive Ventilation & Oxygen Availability
Edward Anthony Oppenheimer, M.D.
With an introduction by June Price
Pneumonia is our number one nemesis.
People with SMA don't usually die of old age or from skiing accidents. They die from respiratory failure often initiated
by pneumonia. More than anything, we need to keep ourselves our lungs strong and healthy if we expect to outlive
the tuna salad in the refrigerator.
But good health doesn't just happen. We must take an active role in our health care: learn as much as we can about
it, document our findings, then share this information with our physicians.
One reader was recently hospitalized with pneumonia. She was concerned because her critical oxygen saturation
levels (the amount of oxygen in the blood) remained low despite being placed on a BiPAP to aid in ventilation. In an
effort to better understand what happens when we get pneumonia, Living SMArt asked Dr. Tony Oppenheimer to
offer an explanation. Dr. Oppenheimer is a pulmonologist specializing in noninvasive ventilation for people with motor
neuron diseases.
Normally with respiratory muscle weakness, without pneumonia, noninvasive ventilation achieves improved gas
exchange in the alveoli of the lungs. When alveolar ventilation is satisfactory, CO2 is eliminated and oxygen is
provided. The arterial oxygen saturation then is usually a good guide to adequate ventilation. However, when
pneumonia occurs the situation is different and more difficult. Areas of pneumonia have the alveolar air exchange
units filled with inflammatory fluid (pus) that has to resolve before gas exchange is possible in those areas.
Neither room air nor added oxygen can get into those alveolar units (air sacs), but the blood channels (capillaries)
remain open due to mechanical distention and the effect of the inflammatory by-products that cause vasodilatation.
The result is that venous (blue) blood low in oxygen "shunts" past these alveolar units which are filled with
pneumonia, and no gas exchange occurs.
Thus, venous blood returns to the heart from the lung without oxygen uptake, and this is circulated to the body. This
is a temporary "shunt" effect which will decrease as the pneumonia clears. The mechanical ventilation cannot
overcome the shunt (this is true for both noninvasive ventilation and tracheostomy ventilation). Added oxygen only
has a minor effect because it never reaches the air sacs that are filled with pneumonia.
Fortunately, adults without heart disease can usually manage despite low oxygen saturation if they are getting the
right antibiotics and if the CO2 and pH are good. So, it is not a mechanical ventilation problem; it is related to the
amount of the lung with pneumonia. Mechanical ventilation provides enough ventilation so that gas exchange in the
remainder of the lungs achieves a satisfactory CO2 and pH.
It is very important to assist effective cough to remove any bronchial secretions. Manually assisted cough techniques,
and sometimes even using a mechanical "In-Exsufflator cough machine" [J.H. Emerson Co., Cambridge, MA (800)
252-1414], has been helpful for some people. Dr. John Bach has written two articles about this in the medical journal
CHEST in 1994.
One way to prepare for potential respiratory problems down the road is to start noninvasive ventilation earlier, when
there are some symptoms related to breathing and the vital capacity has fallen to 50% or less. Starting noninvasive
ventilation means learning how to use the equipment, getting some comfort and practice with it, and obtaining better
sleep at night without having to sit up. And then when a respiratory infection occurs it is more likely that pneumonia
can be avoided because ventilation stays stronger and the assisted ventilation provides a bigger breath in, so that a
better cough is possible to eliminate excess secretions.
Pneumonia creates severe problems, regardless of whether you are breathing independently or on a ventilator.
Fortunately, most people recover in time and can survive a period of poor arterial oxygen saturation (SaO2). The
heart compensates by increasing heart rate and cardiac output in order to deliver more oxygen to the tissues.
The circulation of blood is somewhat like a train. When it is loaded with less oxygen the train circulates more often
around the circuit in order to deliver enough oxygen to each point on the way, by making extra trips with a smaller
load of oxygen each time. Most people can provide the extra heart work to increase circulation without a problem.
Older people or those with heart disease may not do as well. The larger the percent of the lung involved with
pneumonia the greater the problem of course. Unfortunately, giving a person more oxygen is not very effective when
the decreased SaO2 is due to pneumonia.
It is always better to avoid pneumonia by:
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staying healthy
being experienced with noninvasive assisted ventilation if breathing is borderline
getting a Pneumovax immunization at least once and yearly Flu immunization, and
keeping away from people with respiratory infections (particularly children).
While some people have difficulty with Influenza immunizations, most people do not and definitely will benefit from
them if there is an influenza epidemic. They do not give protection from other cold virus and "flu" illnesses.
Key Points:
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Oxygen saturation levels will remain low, even when using a ventilator, if pneumonia is present.
Learn to use noninvasive ventilation (such as a BiPAP) before problems occur when vital capacity is 50% or less.
Learn assistive cough techniques, either manual or mechanical, to remove secretions.
Prevent illness both by avoiding contact with affected individuals and by immunization.
Edward Anthony Oppenheimer, M.D.
Pulmonary & Critical Care Medicine
Southern California Permanente Medical Group
4950 Sunset Boulevard
Los Angeles, CA 90027-5822
FAX: (213) 667-5725
Reprinted with permission from Living SMArt, Vol. 2, Issue 6; December 1995 - January 1996, for "Celebrate," Spring
1996.