A randomized prospective trial in 74 patients comparing the ERcap technique and multi-band mucosectomy technique for piecemeal endoscopic resection in Barrett esophagus R.E. Pouw1, L. Alvarez Herrero1,2, F.G. van Vilsteren1, F.J.W. ten Kate3, B.E. Schenk4, E.J. Schoon5, F.T.M. Peters6, R. Bisschops7, B.L. Weusten2, J.J. Bergman1 1 Dept. of Gastroenterology, Academic Medical Center, Amsterdam, Netherlands 2 Dept. of Gastroenterology, St. Antonius Ziekenhuis, Nieuwegein, Netherlands 3 Dept. of Pathology, Academic Medical Center, Amsterdam, Netherlands 4 Dept. of Gastroenterology, Isala Clinics, Zwolle, Netherlands 5 Dept. of Gastroenterology, Catharina Ziekenhuis, Eindhoven, Netherlands 6 Dept. of Gastroenterology, University Medical Center, Groningen, Netherlands 7 Dept. of Gastroenterology, University Hospital Leuven, Leuven, Belgium Endoscopic resection (ER) is an important modality to treat high-grade dysplasia (HGD) or early cancer (EC) in Barrett esophagus (BE). The most widely used ER technique, the ER-cap technique, requires submucosal lifting and prelooping of a snare in a cap making it technically demanding and laborious for piecemeal ER, and a new snare is needed for every resection. The newer multi-band mucosectomy (MBM) technique does not require submucosal lifting or prelooping of a snare and one snare can be used for multiple resections. Aim was to prospectively compare ER-cap and MBM for piecemeal ER in BE. Patients scheduled for piecemeal ER of biopsy-proven HGD/EC in BE, without suspicion on submucosal invasion on endoscopy and EUS, were included. After delineation of the target area patients were randomized to ERcap (16.1mm hard oblique, Olympus) or MBM (Duette, Cook Medical). Assessment criteria were: number of resections/procedure; procedure time; complications; maximum diameter and thickness of specimens; costs of disposables. 74 pts (57M, median 70yrs, median BE 5cm) were randomized: 35 MBM vs 39 ER-cap. Procedure time (34 vs 50min, p=0.03) and costs (€240 vs €322, p=0.001) were significantly less with MBM vs ER-cap. MBM resulted in smaller specimens than ER-cap (17 vs 20mm, p<0.001). Maximum thickness of resected specimens and submucosa of specimens obtained with MBM vs ER-cap was 1.9 vs 2.0mm (p=ns) and 0.8 vs 1.0mm (p=ns), respectively. There were three severe complications: 3 perforations in the ER-cap group, all treated endoscopically. Conclusions: This randomized trial shows that piecemeal ER with MBM is faster and cheaper than with ER-cap and may be associated with fewer complications. MBM results in statistically significantly smaller sized specimens, but the clinical relevance of this may be limited since the depth of resection did not differ. MBM may thus be preferable for piecemeal ER of flattype HGD/EC with a low risk of submucosal invasion.