DIPARTIMENTO DI BIOSCIENZE
A.Pellicioli and F. Marini laboratory, Department of Life Sciences, University of Milan
Post-Doc position
Dipartimento di Bioscienze
Università degli Studi di Milano
Project title: Processing of DNA Double Strand Breaks and genome instability
Beginning and duration: June/September 2014 - 2 years
Description: The ability of cells to detect and properly repair double stranded DNA breaks
(DSBs) is essential for maintaining genome stability and preventing cancer development.
Indeed, DSBs are the most cytotoxic forms of DNA damage, because inaccurate DSB
repair leads to mutations and/or gross chromosomal rearrangements. A critical step in
regulating DSB repair is the processing of its DNA ends. Several factors are involved in
this mechanism, which are conserved in all eukaryotes. Mutations in most of these factors
lead to genome instability, cancer and severe human inherited diseases. The candidate will
characterize the functional role of some of these factors in human cell lines, in term of
DNA repair and checkpoint response.
Requirements: Good theoretical knowledge and possibly practical experience in genetics,
biochemistry, molecular and cell biology. Experience in mammalian cell culturing.
Previous experience with DNA damage response and cell cycle is a plus. High motivation
and dedication. Good knowledge of English.
Reference letters required.
Contact:
Achille Pellicioli, PhD
Dipartimento di Bioscienze
Università degli Studi di Milano
Via Celoria 26, 20133 MILANO
Ph: 02 50315033
e-mail: achille.pellicioli@unimi.it
Dipartimento di Bioscienze
Via Celoria 26 – 20133 Milano, Italy
Tel 02503 15042 - Fax 02503 15044 – direzione.bioscienze@unimi.it