Publications from TORS Investigators - 2008
Bingham, N.C., Anderson, K.K., Reuter, A.L., Stallings, N.R., and Parker, K.L. 2008.
Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in
increased adiposity and a metabolic syndrome. Endocrinology. 149:2138-2148.
PMCID:PMC 2329259.
Browning, J.D., Weis, B., Davis, J., Satapati, S., Merritt, M., Malloy, C.R., Burgess, S.C.
2008. Alterations in hepatic glucose and energy metabolism as a result of calorie and
carbohydrate restriction. Hepatology. 48(5):1487-96. PMCID: PMC2701295.
Inagaki, T., Lin, V.Y., Goetz, R., Mohammadi, M., Mangelsdorf, D.J., Kliewer, S.A. 2008.
Inhibition of growth hormone signaling by the fasting-induced hormone FGF21. Cell
Metabl. 8:77-83. PMCID: PMC2575072.
Kim, K.W., Jo, Y.H., Zhao, L., Stallings, N.R., Chua, S.C., Jr., Parker, K.L. 2008.
Steroidogenic factor 1 regulates expression of the cannabinoid receptor 1 in the
ventromedial hypothalamic nucleus. Mol. Endocrinol. 22:1950-1961.
PMCID:PMC2505330.
Kotti, T., Head, D. D., McKenna, C.M., Russell, D. W. 2008. Biphasic requirement for
geranylgeraniol in hippocampal long-term potentiation. Proc. Natl. Acad. Sci. USA.
105:11394-11399. PMCID: PMC2516227.
Kublaoui, B.M., Gemelli, T., Tolson, K.P., Wang, Y., Zinn, A.R. 2008. Oxytocin deficiency
mediates hyperphagic obesity of Sim1 haploinsufficient mice. Mol. Endocrinol. 22:17231734. PMCID: PMC2453606.
Lutter, M. , Krishnan, V., Russo, S.J., Jung, S., McClung, C.A., Nestler, E.J. 2008. Orexin
signaling mediates the antidepressant-like effect of calorie restriction. J. Neurosci.
28:3071-3075. PMCID: PMC2713756.
Lutter, M. , Sakata, I., Osborne-Lawrence, S., Rovinsky, S.A., Anderson, J.G., Jung, S.,
Birnbaum, S., Yanagisawa, M. , Elmquist, J.K. , Nestler, E.J.,Zigman, JM. 2008. The
orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nat.
Neurosci. 11:752-753. PMCID: PMC2765052.
Ren, J., Dimitrov, I., Sherry, A.D . , Malloy, C.R . 2008. Composition of adipose
triglycerides by 1H NMR. J. Lipid Res. 49: 2055-62. PMCID: PMC2515528.
Romeo, S., Kozlitina, J., Xing, C., Pertsemlidis, A., Cox, D., Pennacchio, L.A., Boerwinkle,
E., Cohen, J.C. , Hobbs, H.H. 2008. Genetic variation in PNPLA3 confers susceptibility to
nonalcoholic fatty liver disease. Nat. Genet. 40;1461-5. PMCID: PMC2597056.
Satapati, S., He, T., Inagaki, T., Potthoff, M,. Merritt ,M., Esser, V., Mangelsdorf, D.J. ,
Kliewer, S.A. , Browning, J.D. , Burgess, S.C. 2008. Partial resistance to PPARalpha
agonists in Zucker diabetic fatty (ZDF) rats is associated with impaired hepatic
mitochondrial function. Diabetes. 57(8):2012-21. PMCID: PMC2494699.
Xu, Y., Jones, J.E., Kohno, D., Williams, K.W., Lee, C.E., Choi, M.J., Anderson, J.G., Heisler,
L.K., Zigman, J.M., Lowell, B.B. Elmquist, J.K . 2008. 5-HT2CRs expressed by proopiomelanocortin neurons regulate energy homeostasis. Neuron. 60:582-589. PMCID:
PMC2631191.
Yang, J., Brown, M.S., Liang, G. Grishin, N.V., Goldstein, J.L. 2008. Identification of the
acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone.
Cell. 132:387-396. PMCID: PMC2631191.
Yang, J., Zhao, T. J., Goldstein, J. L. , Brown, M.S. 2008. Inhibition of ghrelin Oacyltransferase (GOAT) by octanoylated pentapeptides. Proc. Natl. Acad. Sci. USA.
105:10750-10755. PMCID: PMC2504781.
Zhao, L., Kim, K.W., Ikeda, Y., Anderson, K.K., Beck, L., Chase, S., Tobet, S.A., Parker, K.L.
2008. Central nervous system-specific knockout of steroidogenic factor 1 results in
increased anxiety-like behavior. Mol. Endocrinol. 22:1403-1415. PMCID: PMC2422821.