Publications 2011

Publications from TORS.
Agarwal, A.K., Sukumaran, S., Cortes, V.A., Tunison, K., Mizrachi, D., Sankella, S., Gerard, R.D., Horton, J.D.,
Garg, A. 2011. Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical
characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice. J. Biol.
Chem. 286:37676-37691. PMCID: PMC3199511
Bastarrachea, R.A., Veron, S.M., Vaidyanathan, V., Garcia-Forey, M., Voruganti, V.S., Higgins, P.B., Parks,
E.J. 2011. Protocol for the measurement of fatty acid and glycerol turnover in vivo in baboons. J. Lipid
Res. 52:1272-1280. PMCID: PMC3090248
Browning, J.D., Baker, J.A., Rogers, T., Davis, J., Satapati, S., Burgess, S.C. 2011. Short-term weight loss and
hepatic triglyceride reduction: evidence for a metabolic advantage with dietary carbohydrate restriction.
Am. J. Clin. Nutr. 93:1048-1052. PMCID: PMC3076656
Chuang, J.C., Perrello, M., Sakata, I., Osborne-Lawrence, S., Savitt, J.M., Lutter, M., Zigman, J.M. 2011.
Ghrelin mediates stress-induced food-reward behavior in mice. J. Clin. Invest. 121:2684-2692. PMCID:
Cohen, J.C., Horton, J.D., Hobbs, H.H. 2011. Human fatty liver disease: old questions and new insights.
Science. 332:1519-1523. PMCID: PMC3229276
Donato, J., Jr., Cravo, R.M., Renata, F., Gautron, L., Scott, M.M., Lachey, J., Castro, I.A., Margatho, L.O., Lee,
S., Lee, C., Richardson, J.A., Friedman, J., Chua., Jr. S., Coppari, R., Zigman, J.M., Elmquist, J.K., Elias, C.F.
2011. Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not
require signaling in Kiss1 neurons. J. Clin. Invest. 121:355-368. PMCID: PMC3007164
Fukuda, M., Williams, K.W., Gautron, L., Elmquist, J.K. 2011. Induction of Leptin Resistance by Activation of
cAMP-Epac Signaling. Cell Metab. 13:331-339. PMCID: PMC - Journal in Process
Gautron, L., Sakata, I., Udit, S., Zigman, J.M., Wood, J.N., Elmquist, J.K. 2011. Genetic tracing of Nav1.8expressing vagal afferents in the mouse. J. Comp. Neurol. 519:3085-3101. PMCID: PMC3306808
Gautron, L., Elmquist, J.K. 2011. Sixteen years and counting: an update on leptin in energy balance. J.
Clin. Invest. 121:2087-2093. PMCID: PMC3104762
Holland, W. L., Bikman, B.T., Wnag, L.-P., Yuguang, G., Sargent, K.M., Bulchand, S., Knotts, T.A., Shui, G.,
Clegg, D.J., Wenk, M.R, Pagliassotti, M.J., Scherer, P.E., Summers, S.A. 2011. Lipid-induced insulin
resistance mediated by the pro-inflammatory receptor TLR4 requires saturated fatty acid-induced
ceramide biosynthesis in mice. J. Clin. Invest. 121:1858-1870. PMCID: PMC3083776
Holland, W.L., Miller, R.A., Wang, Z.V., Sun, K., Barth, B.M., Bui, H.H., Davis, K.E., Bikman, B.T., Halberg, N.,
Rutkowski, J.M., Wade, M.R., Tenorio, V.M., Kuo, M.-S., Brozinick, J.T., Zhang, B.B.. Birnbaum, M.J.,
Summers, S.A., Scherer, P.E. 2011. Receptor-mediated activation of ceramidase activity initiates the
pleiotropic actions of adiponectin. Nat. Med. 17:55-63. PMCID: PMC3134999
Huang, J., Mirel, D., Pugh, E., Xing, C., Robinson, P., Pertsemlidis, A., Ding, L.H., Kozlitina, J., Maher, J., Rios,
J.J., Story, M., Marthandan, N., Scheurmann, R.H. 2011. Minimum information about a genotyping
experiment (MIGEN). Stand. Genomic Sci. 5:224-229. PMCID: PMC3235517
Huang, Y., Cohen, J.C., Hobbs, H.H. 2011. Expression and characterization of a PNPLA3 isoform (I148M)
associated with nonalcoholic fatty liver disease. J. Biol. Chem. 286:37085-37093. PMCID: PMC3199456
Kim, K.W., Sohn, J.W., Kohno, D., Xu, Y., Williams, K., Elmquist, J.K. 2011. SF-1 in the ventral medial
hypothalamic nucleus: A key regulator of homeostasis. Mol. Cell Endocrinol. 336:219-223. PMCID PMC3057357
Kim, K.W., Zhao, L., Donato, J., Jr., Kohno, D., Xu, Y., Elias, C.F., Lee, C., Parker, K.L., Elmquist, J.K. 2011.
Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the
ventral medial hypothalamic nucleus. Proc. Natl. Acad. Sci. USA. 108:10673-10678. PMCID: PMC3127910
Klöckener, T., Hess, S., Belgardt, B.F., Paeger, L., Verhagen, L.A., Husch, A., Sohn, J.W., Hampel, B., Dhillon,
H., Zigman, J.M., Lowell, B.B., Williams, K.W., Elmquist, J.K., Horvath, T.L., Kloppenburg, P., Brüning, J.C.
2011. High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH
neurons. Nat. Neurosci. 14:911-918. PMCID: PMC3371271
Kozlitina, J., Boerwinkle, E., Cohen, J.C., Hobbs, H.H. 2011. Dissociation between APOC3 variants, hepatic
triglyceride content and insulin resistance. Hepatology. 53:467-474. PMCID: PMC3057507
Mochizuki, T., Arrigoni, E., Marcus, J.N., Clark, E.L., Yamamoto, M., Honer, M., Borroni, E., Lowell, B.B.,
Elmquist, J.K., Scammell, T.E. 2011. Orexin receptor 2 expression in the posterior hypothalamus rescues
sleepiness in narcoleptic mice. Proc. Natl. Acad. Sci. USA. 108:4471-4476. PMCID: PMC3060231
Perello, M., Scott, M.M., Sakata, I., Lee, C.E., Chuang, J.C., Osborne-Lawrence, S., Rovinsky, S.A., Elmquist,
J.K., Zigman, J.M. 2011. Functional implications of limited leptin receptor and ghrelin receptor coexpression in the brain. J. Comp. Neurol. 520:281-294. PMCID: PMC3282302
Ramirez, R., Cohen, J.C., Hobbs, H.H., Browning, J.D. 2011. Hepatic triglyceride content in individuals with
reduced intestinal cholesterol absorption due to variants in NPC1L1. Hepatology. 54:736-737. NIHMSID:
Rossi, J., Balthasar, N., Olson, D., Scott, M., Berglund, E.D., Lee, C.E., Choi, M.J., Lauzon, D., Lowell, B.B.,
Elmquist, J.K. 2011. Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance
and glucose homeostasis. Cell. Metab. 13:195-204. PMCID: PMC3033043
Scott, M.M., Marcus, J.N., Pettersen, A., Birnbaum, S.G., Mochizuki, T., Scammell, T.E., Nestler, E.J.,
Elmquist, J.K., Lutter, M. 2011. Hcrtr1 and 2 signaling differentially regulates depression-like behaviors.
Behav. Brain Res. 222:289-294. PMCID: PMC - Journal in Press
Scott, M.M., Williams, K.W., Rossi, J., Lee, C.E., Elmquist, J.K. 2011. Leptin receptor expression in hindbrain
Glp-1 neurons regulates food intake and energy balance in mice. J. Clin. Invest. 121:2413-2421. PMCID:
Sohn, J.W., Xu, Y., Jones, J.E., Wickman, K., Williams, K.W., Elmquist, J.K. 2011. Serotonin 2C receptor
activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels. Neuron.
71:488-497. PMCID: PMC3184528
Sun, K., Kusminski, C.M., Scherer, P.E. 2011. Adipose tissue remodeling and obesity. J. Clin. Invest.
121:2094-2100. PMCID: PMC3104761
Sunny, N.E., Parks, E.J., Browning, J.D., Burgess, S.C. 2011. Excessive hepatic mitochondrial TCA cycle and
gluconeogenesis in humans with nonalcoholic fatty liver disease. Cell Metab. 14:804-811. PMCID: PMC Journal In Process
Vialou, V., Cui, H., Perello, M., Mahgoub, M., Yu, H.G., Rush, A.J., Pranav, H., Jung, S., Yangisawa, M.,
Zigman, J.M., Elmquist, J.K., Nestler, E.J., Lutter, M. 2011. A role for ΔFosB in calorie restriction-induced
metabolic changes. Biol. Psychiatry. 70:204-207. PMCID: PMC3125466
Wang, J., Grishin, N., Kinch, L., Cohen, J.C., Hobbs, H.H., Xie, X.S. 2011. Sequences in the nonconsensus
nucleotide-binding domain of ABCG5/ABCG8 required for sterol transport. J. Biol. Chem. 286:7308-7314.
PMCID: PMC3044987
Williams, K.W., Scott, M.M., Elmquist, J.K. 2011. Modulation of the central melanocortin system by leptin,
insulin, and serotonin: Co-ordinated actions in a dispersed neuronal network. Eur. J. Pharmacol. 660:212. PMCID: PMC3085544
Williams, K.W., Sohn, J.W., Donato, J., Jr., Lee, C.E., Zhao, J.J., Elmquist, J.K., Elias, C.F. 2011. The acute
effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus. J. Neurosci.
31:13147-13156. PMCID: PMC3319415
Xu, Y., Nedungadi, T.P., Zhu, L., Sobhani, N., Irani, B.G., Davis, K.E., Zhang, X., Zou, F., Gent, L.M., Hahner,
L.D., Khan, S.A., Elias, C.F., Elmquist, J.K., Clegg, D.J. 2011. Distinct hypothalamic neurons mediate
estrogenic effects on energy homeostasis and reproduction. Cell Metab. 14:453-465. PMCID:
***NB These are not directly TORS-related publications and were supported by other funding sources, but
they do test and exploit new non-steady state modeling techniques that are essential to TORS progress.