Publications from TORS Investigators - 2010
Browning, J.D., Cohen, J.C., Hobbs, H.H. 2010. Patatin-Like phosppholipase domaincontaining 3 and the pathogenesis and progression of pediatric nonalcoholic fatty liver
disease. Hepatology. 52:1189-1192. PMCID: PMC Journal-In Process.
Browning, J.D. , Horton, J.D. 2010. Fasting reduces plasma proprotein convertase,
subtilisin/kexin type 9 and cholesterol biosynthesis in humans. J. Lipid Res. 51:33593363. PMCID: PMC2952577.
Chavez-Jauregui, R.N., Mattes, R.D., Parks, E.J . 2010. Dynamics of fat absorption and
impact of sham feeding on postprandial lipema. Gastroenterology. 139:1538-1548.
PMCID: PMC2948783.
Chuang, J.C., Cui, H., Mason, B.L., Mahgoub, M., Bookout, A.L., Yu, H.G., Perello, M.,
Elmquist, J.K., Repa, J.J., Zigman, J.M., Lutter, M. 2010. Chronic social defeat stress
disrupts regulation of lipid synthesis. J. Lipid Res. 51:1344-1355. PMCID: PMC3035497.
Chuang, J.C., Krishnan, V., Yu, H.G., Mason, B., Cui, H., Wilkinson, M.B., Zigman, J.M.,
Elmquist, J.K., Nestler, E.J., Lutter, M. 2010. A beta(3)-adrenergic-leptin-melanocortin
circuit regulates behavioral and metabolic changes induced by chronic stress. Biol.
Psychiatry. 67:1075-1082. PMCID: PMC2868111.
Fon Tacer, K., Bookout, A.L., Kurosu, H., John, G., Wang, L., Kuro-o, M., Mangelsdorf, D.J
., Kliewer, S.A. 2010. Comprehensive expression atlas of the fibroblast growth factor
system in adult mouse. Mol. Endocrinol. 24:2050-2064. PMCID: PMC2954642.
Gautron, L., Lee, C., Funahashi, H., Friedman, J., Lee, S., Elmquist, J.K. 2010.
Melanocortin-4 receptor expression in a vago-vagal circuitry involved in postprandial
functions. J. Comp. Neurol. (1):6-24. PMCID: PMC2857345.
Gautron, L., Lazarus, M., Scott, M.M., Saper, C.B., Elmquist, J.K . 2010. Identifying the
efferent projections of leptin-responsive neurons in the dorsomedial hypothalamus
using a novel conditional tracing approach. J. Comp. Neurol. 2010. 518(11):2090-108.
PMCID: PMC Journal-In Process.
He, S., McPhaul, C., Li, J.Z., Garuti, R., Kinch, L.N., Grishin, N.V., Cohen, J.C. , Hobbs, H.H.
2010. A sequence variation (I148M) in PNPlA3 associated with nonalcoholic fatty liver
disease disrupts triglyceride hydrolysis. J. Biol. Chem. 285:6706-15 PMCID:
PMC2825465.
Hill, J.W., Elias, C. F., Fukuda, M., Williams, K.W., Berglund, E.D., Holland, W.L., Cho, Y.R., Chieh Chuang, J., Xu, Y., Choi, M., Lauzon, D., Lee, C.E., Coppari, R , Richardson, J. A.,
Zigman, J.M., Chua, S., Scherer, P.E., Lowell, B.B., Brüning, J.C., Elmquist, J.K. 2010.
Direct insulin and leptin action in pro-opiomelanocortin neurons is required for normal
glucose homeostasis and fertility. Cell Metabl. 11:286-97. PMCID: PMC2854520.
Huang, Y., He, S., Li, J., Seo, Y.K., Osborne, T.F., Cohen, J.C. , Hobbs, H.H. 2010. A feedforward loop amplifies nutritional regulation of PNPLA3. Proc. Natl. Acad. Sci. USA.
107:7892-7897. PMCID: PMC2867902.
Kim, K.W., Li, S., Zhao, H., Peng, B., Tobet, S. A., Elmquist, J.K., Parker, K.L., Zhao, L. 2010.
CNS-Specific ablation of steroidogenic factor 1 results in impaired female reproductive
function. Mol. Endocrinol. 24:1240-50. PMCID: PMC2875803.
Kliewer, S.A., Mangelsdorf, D.J. 2010. Fibroblast growth factor 21: from pharmacology to
physiology. Am. J. Clin. Nutr. 91:254S-257S. PMCID: PMC2793111.
***Lippincott-Schwartz, J., Phair, R.D. 2010. Lipids and cholesterol as regulators of
traffic in the endomembrane system. Annu. Rev. Biophys. 39:559-578. PMCID: PMC
Journal in Process.
Musunuru, K., Pirruccello, J.P., Do, R., Peloso, G.M., Guiducci, C., Sougnez, C., Garimella,
K.V., Fisher, S., Abreu, J., Barry, A.J., Fennell, T., Banks, E., Ambrogio, L., Cibulskis, K.,
Kernytsky, A., Gonzalez, E., Rudzicz, N., Engert, J.C., DePristo, M.A., Daly, M.J., Cohen,
J.C., Hobbs, H.H. , Altshuler, D., Schonfeld, G., Gabriel, S.B., Yue, P., Kathiresan, S. 2010.
Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia. N. Engl.
J. Med. 363:2220-2227. PMCID: PMC3008575.
Perello, M., Sakata, I., Birnbaum, S., Chuang, J.-C., Osborne-Lawrence, S., Rovinsky, S.A.,
Woloszyn, J., Yanagisawa, M. , Lutter. M. *, Zigman, J.M. *. 2010. Ghrelin increases the
rewarding value of high fat diet in an orexin-dependent manner. Biol. Psych. 67:880-6.
PMCID: PMC2854245.
Ren, J., Sherry, D., Malloy, C.R. 2010. 1H MRS of intramyocellular lipids in soleus muscle
at 7 T: spectral simplification by using long echo times without water suppression.
Magn. Reson. Med. 64:662-671. PMCID: PMC3022418.
Rios, J., Stein, E., Shendure, J, Hobbs, H.H. , Cohen, J.C. . 2010. Identification by wholegenome resequencing of gene defect responsible for severe hypercholesterolemia.
Hum. Mol. Genet. 19:4313-4318. PMCID: PMC2957323.
Sunny, N.E. , Satapati, S., Fu, X., He, T., Mehdbeigi, R., Spring-Robinson, C.L., Duarte, J.,
Potthoff, M., Browning, J. , Burgess, S.C. 2010. Progressive adaptation of ketogenesis in
mice fed a high fat diet. Am. J. Physiol. Endocrinol. Metab. 298:E1226-E1235. PMCID:
PMC2886525.
Tolson, K.P., Gemelli, T., Gautron, L., Elmquist, J.K , Zinn, A.R., Kublaoui, B.M. 2010.
Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin
expression. J. Neurosci. (10):3803-12. NIHMSID: NIHMS186604.
Vernochet, C., Davis, K.E., Scherer, P.E., Farmer, S.R. 2010. Mechanisms regulating
repression of haptoglobin production by peroxisome proliferator-activated receptorgamma ligands in adipocytes. Endocrinology. 151: 586-94. PMCID: PMC2817616.
Williams, K.W., Margatho, L.O., Lee, C.E., Choi, M., Lee, S., Scott, M.M., Elias, C.F.,
Elmquist, J.K. 2010. Segregation of acute leptin and insulin effects in distinct populations
of arcuate proopiomelanocortin neurons. J. Neurosci. (7):2472-9. PMCID: PMC2836776.
Xing, C., Cohen, J.C., Boerwinkle, E. 2010. A weighted false discovery rate control
procedure reveals alleles at FOXA2 that influence fasting glucose levels. Am. J. Hum.
Genet. 86;440-6. PMCID: PMC2833364.
Xu, Y., Berglund, E.D. , Sohn, J.-W., Holland, W.L. , Chuang, J.-C., Fukuda, M., Rossi, J.,
Williams, K.W., Jones, J.E., Zigman, J.M., Lowell, B.B., Scherer, P.E., Elmquist, J.K. 2010.
5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in
liver. Nat. Neurosci. 13:1457-1459. PMCID: PMC3059249.
Xu, Y., Hill, J.W., Fukuda, M., Gautron, L., Sohn, J-W., Kim, K-W., Lee, C.E., Choi, M.J.,
Lauzon, D., Dhillon, H., Lowell, B.B., Zigman, J.M. , Zhao, J.J., Elmquist, J.K. 2010. PI3K
signaling in the ventromedial hypothalamic nucleus is required for normal energy
homeostasis. Cell Metabl. 12:1-8. PMCID: PMC2919367.
Xu, Y., Jones, J.E., Lauzon D.A., Anderson, J.G., Balthasar, N., Heisler, L.K., Zinn, A.R.,
Lowell, B.B., Elmquist, J.K. 2010. A serotonin and melanocortin circuit mediates dfenfluramine anorexia. J. Neurosci. 30: 14630-14634. PMCID: PMC - Journal in Process.
Zhao, T.J., Liang, G., Li, R.L., Xie, X., Sleeman, M.W., Murphy, A.J., Valenzuela, D.M.,
Yancopoulos, G.D., Goldstein, J.L. , Brown, M.S. 2010. Ghrelin O-acyltransferase (GOAT)
is essential for growth hormone-mediated survival of calorie-restricted mice. Proc. Natl.
Acad. Sci. USA. 107:7467-72. PMCID: PMC2867684.
Zhao ,T.J., Sakata, I., Li, R.L., Liang, G., Richardson, J.A., Brown, M.S., Goldstein, J.L.,
Zigman, J.M. 2010. Ghrelin secretion stimulated by {beta}1-adrenergic receptors in
cultured ghrelinoma cells and in fasted mice. Proc. Natl. Acad. Sci. USA. 2010 Sep
7;107(36):15868-73. Epub 2010 Aug 16. PMCID: PMC2936616.