Publications from TORS. 2009 Cortés, V.A., Curtis, D.E., Sukumaran, S., Shao, X., Parameswara, S., Rashid, S., Smith, A.R., Ren, J., Esser, V., Hammer, R.E., Agarwal, A.K., Horton, J.D., Garg, A. 2009. Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2 deficient mouse model of congenital generalized lipodystrophy. Cell Metab. 9:165-176. PMCID: PMC2673980 Grefhorst, A., Parks, E.J. 2009. Reduced insulin-mediated inhibition of VLDL secretion upon pharmacological activation of the liver X receptor in mice. J. Lipid Res. 50:1374-1383. PMCID: PMC2694336 Halford, R.W., Russell, D.W. 2009. Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer’s disease, but does extend lifespan. Proc. Natl. Acad. Sci. USA. 106:35023506. PMCID: PMC2651246 Khuu, A., Ren, J., Dimitrov, I., Woessner, D., Murdoch, J., Sherry, A.D., Malloy, C.R. Orientation of lipid strands in the extracellular compartment of muscle: effect on quantitation of intramyocellular lipids. Magn. Reson. Med. 2009. 61:16-21. PMCID: PMC2775057 Kim, K.W., Zhao, L., Parker, K.L. 2009. Central nervous system-specific knockout of steroidogenic factor 1. Mol. Cell Endocrinol. 300:132-136. NIHMSID: NIHMS99070 Lee, S., Lee, C.E., Elias, C.F., Elmquist, J.K. 2009. Expression of the diabetes-associated gene TCF7L2 in adult mouse brain. J. Comp. Neurol. 517:925-39. PMCID: PMC Journal in Process ***Melnick, M., Phair, R.D., Lapidot, S.A., Jaskoll, T. 2009. Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkB paradigm. BioMed Central Developmental Biology. 9:32. PMCID: PMC2700095 Potthoff, M.J., Inagaki, T., Sapati, S., Ding, X., He, T., Goetz, R., Mohammadi, M., Finck, B.N., Mangelsdorf, D.J., Kliewer, S.A., Burgess, S.C. 2009. FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc. Natl. Acad. Sci. USA. 106:10853-10858. PMCID: PMC2705613 Ramadori, G., Gautron, L., Fujikawa, T., Vianna, C.R., Elmquist, J.K., Coppari, R. 2009. Central administration of resveratrol improves diet-induced diabetes. Endocrinology. 150:5326-5333. PMCID: PMC2795706 Romeo, S., Yin, W., Kozlitina, J., Pennacchio, L.A., Boerwinkle, E., Hobbs, H.H., Cohen, J.C. 2009. Rare lossof-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans. J. Clin. Invest. 11:70-79. PMCID: PMC2613476 Russell, D.W. 2009. 50 Years of advances in bile acid metabolism. J. Lipid. Res. 50:S120-S125. PMCID: PMC2674696 Russell, D.W., Halford, R.W., Ramirez, D.M.O., Shah, R., Kotti, T. 2009. Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain. Annu. Rev. Biochem. 78:1017-1040. PMCID: PMC2837268 Sakata, I., Yang, J., Lee, C.E., Osborne-Lawrence, S., Rovinsky, S.A., Elmquist, J.K., Zigman, J.M. 2009. Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells. Am. J. Physiol. Endocrinol. Metab. 297:E134-41. PMCID: PMC2711663 Scott, M.M., Lachey, J.L., Sternson, S.M., Lee, C.E., Elias, C.F., Friedman, J.M., Elmquist, J.K. 2009. Leptin targets in the mouse brain. J. Comp. Neurol. 514:518-532. PMCID: PMC2710238 Seo J., Fortuno, E.S., Suh, J.M., Stenesen, D., Tang. W., Parks, E.J., Adams, C.M., Townes, T., Graff, J.M. 2009. Atf4 regulates obesity, glucose homeostasis, and energy expenditure. Diabetes. 58:2565-2573. PMCID: PMC2768187 Stiles, A.R., McDonald, J.G, Bauman, D.R., Russell, D.W. 2009. CYP7B1: one cytochrome P450, two human genetic diseases, and multiple physiological functions. J. Biol. Chem. 284:28485-28489. PMCID: PMC2781391 Yin, W, Romeo, S., Chang, S., Grishin, N.V., Hobbs, H.H., Cohen, J.C. 2009. Genetic variation in ANGPTL4 provides insights into protein processing and function. J. Biol. Chem. 284:13213-13222. PMCID: PMC2676053 ***NB These are not directly TORS-related publications and were supported by other funding sources, but they do test and exploit new non-steady state modeling techniques that are essential to TORS progress.