Lab 6: Schedule
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Lab 7
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Immune response
Ag-Ab reactions
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Return Quiz 2 - urinary system
Quiz 3 next week - lymphatic system
Presentations - in 2 weeks
Due: Ex 35 - lymphatic system #1-18
TODAY
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Identify the structures and
give their functions
Cortex
contains
5
nephrons site of urine
formation
6
Ex 35 - lymphatic system #19-21
Lab 7 worksheet
Skits?
Go over answers at end of lab
Immune System Presentations
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Medulla
contains
7 collecting ducts
- site of water
reabsoprtion
and urine
concentration
Date: Mar 2 or 4
Presentation
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Briefly describe the pathogen and disease
Explain how the immune system responds
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Flowchart that shows nonspecific and specific
defense mechanisms involved
Turn in
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Study guide Quiz 3 lymphatic system
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Identify the components of the lymphatic system
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For a list of structures, see review sheet question #1
Differentiate between the roles of B cells and T cells
in immune responses
Describe the structure and function of lymph nodes
Ex 35 Review sheet: questions #1-21
Histology of a lymph node: capsule, cortex, lymphoid follicle,
medulla, medullary cords, medullary sinuses
What types of lymphocytes are found in lymph nodes?
Antibody-antigen reactions
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Worksheet #1-4
Nonspecific defenses
Cell-mediated immune response
Antibody-mediated immune response
Flowchart - include names of team members
4 reliable references
Components of the Lymphatic
System
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Lymph
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Lymphatic vessels
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Clear, pale yellow fluid
basically the same as
interstitial fluid but in a
different location
transport the lymph
Lymphatic tissues
Red bone marrow

stem cells develop into
lymphocytes and RBCs
1
Lymphatic tissues and organs
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Primary lymphatic organs
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Antibody-mediated immunity
Red bone marrow
Thymus
Sites where B and T cells become
immunocompetent (able to mount
an immune response)
Secondary lymphatic organs
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Sites where most immune
responses occur
Lymph nodes
Spleen
Lymphatic nodules
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Like nodes but not surrounded by
a connective tissue capsule
Vocabulary
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Antigen
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Antibodies (Ab)
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Foreign substance that elicits an immune
response
Shortened from antibody generator
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Antibody
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A protein produced by B cells in response
to a specific antigen
The antibody combines with the antigen to
neutralize, inhibit or destroy it
Bind to foreign antigens
and cells
Combine specifically with
the antigen that triggered
their production
Mark them for destruction
by phagocytes
Copyright 2009, John Wiley &
Sons, Inc.
Clonal selection in B cells
Antibody development
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Activated
B cells
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Plasma
cells
Copyright 2009, John Wiley &
Sons, Inc.
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A B-cell recognizes a target
antigen (a pathogen)
Leads to proliferation by clonal
selection, differentiation into
plasma cells and the production
of numerous antibodies
Memory cells ensure a quick
response in case the target
reappears at a later time.
B-cells which don’t recognize
the target, don’t produce
antibodies.
Image: Max Planck Institute of Neurobiology
2
Antibody structure
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Y-shaped
4 protein chains
connected by disulfide
bonds
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Antibodies agglutinate and
precipitate antigens
Diagnostic uses:
 ABO blood typing
 Pregnancy test
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2 heavy chains
2 light chains
Both constant and
variable regions
Variable regions
construct the antigenbinding site
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Tests for the presence of
hCG, a hormone
produced early in
pregnancy
ELISA tests
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Many uses, including
HIV-1 blood screening
ABO blood typing:
antigens on red blood cells
ABO blood types
Hemagglutination
Antibody-antigen reactions:
the basis of ABO Blood typing
3