Daily Lesson Planning Tool
Course/Grade: 10th
Lesson Topic:
School: Hampton HS
Immune response
Teacher C. Flinchum
Evolution Module
Date of Lesson: Day 2
Pd:
Learning Goal
Students will understand how antibodies work to protect us from pathogens
Immunology virtual lab from HHMI, laptop cart, handout on immune response, video on immune response,
Materials:
lab notebooks, writing utensil.
Context & Background: Components of the immune system called antibodies are found in the liquid portion of blood and help
protect the body from harm. Antibodies can be used also outside the body in a laboratory-based assay to help diagnose disease
caused by malfunctions of the immune system or by infections.
Explanation of Technology Use: The virtual lab allows for students to see how immune assays work, and the practical application
of immunology work.
Lesson
Component
Engage
& Hook
Explain
& Model
Teacher
Student
“Why is it that once we get chicken pox,
we never get it again?”
“How does our immune system learn to
recognize pathogens, and protect us
from them?”
Teacher leads class in discussion on
pathogens, activating prior knowledge.
Teacher writes responses on board.
Students will be participating in a discussion
with each other about what we know about
pathogens and immune response. They will
offer responses, and the teacher will write them
on the board/doc camera. The students will take
notes for their interactive lab notebook.
Provide a brief introduction to the
immune system including:
1.General definition of the immune
system
2.Summary of the first, second, and
third lines of defense in the human
immune system
3.First line of defense (skin, mucous
membranes, and secretions)
4.Second line of defense (phagocytosis,
phagocytic white blood cells, and the
inflammatory response)
Students will write down notes in their lab notebook.
They will have the opportunity to ask questions and
answer them as well. I will have questions
embedded into the ppt. We will draw the diagrams
out in our lab notebooks to help clarify the process.
Students will watch the Viral Outbreak 10 minute
video on antibodies and viruses, “The Virus Hunter’s
Toolkit.”
Steps:
1.Macrophage endocytosis of pathogen
2.Antigen presentation
3.Helper T cell (TH) activated
4.Release of chemical signals to various
immunological cells
This video will serve as a segway to the
ELISA virtual lab.
1
I will have all the students write down
the steps in their interactive notebook as
well, just as they would in a research
lab. This will force them to pay attention
instead of just clicking through. There is
a worksheet as well, which they will
paste into their notebook and fill out.
Explore
& Apply
I will circulate and answer questions, as
well as prompt discussions.
Students will get out the laptops and use the HHMI
Immunology Virtual lab to see how an ELISA assay
is done. This will highlight how antibodies work, as
well as give them a practical application of
immunology work.
Students will work in pairs to efficiently work through
the lab and answer the questions on the worksheet,
including drawing diagrams of what is happening.
“How would you mix the serial
dilutions?”
“Why do we discard the tip each time?”
“How would you make a 1:25 dilution?”
Students will turn in their lab
notebooks. Students will be graded
mostly on completion of their
worksheet.
Evaluate
& Close
Students will discuss what worked and what didn’t
for them. We will tie in Nature of Science as well.
Students will fill out an exit ticket.
We will close by talking about what
they found difficult about the lab, and
what they were surprised by.
Exit Ticket: “Name two types of
information an ELISA assay could be
used to gain about a patient.”
Sara Brandt
July 2011