THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY CHAPTER I 1. Introduction The evolution and development of mankind began thousands and thousands of years before, and today our intelligence, our brain is a resultant of this long developmental phase. Technology also has been on the path of development since when a man appeared. It is man that gave technology its present form. But today, technology is entering a phase where it will out with man in intelligence as well as efficiency. Man has now to find a way in which he can keep in pace with technology, and one of the recent developments in this regard, is the brain chip technology. Brain chips are made with a view to enhance the memory of human beings, to help paralyzed patients, and are also intended to serve military purposes. It is likely that implantable computer chips acting as sensors, actuators, may soon assist not only failing memory, but even bestow fluency in a new language, or enable “recognition” of previously unmet individuals. The progress already made in therapeutic devices, in prosthetics and in computer science indicates that it may well be feasible to develop direct interfaces between the brain and computers. The study of the human brain is, obviously, the most complicated area of research. It will be several years before we see a practical application of the technology we've discussed. Let's hope such technologies will be used for restoring the prosperity and peace of the world and not to give the world a devastating end. 1.1 Rationale for this research This research is made for us know what are the advantages and disadvantages of the brain chip technology, how does this chip works and what are the possible effects to our body when it is implemented. 1.2 Statement of the problem This research entitled “Brain Chip Technology” was conducted to know the results of the past experiments done by the recent researcher. General Problem The study intended to develop and evaluate brain chip technology. Specifically, it sought to answer the following questions: 1. How do the respondents assess the current technical support system in terms of the following THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY 1.1 accuracy 1.2 effectiveness 1.3 efficiency 2. Is it helpful to our brain? 3. Is this chip helps the brain to manage well? 4. Does this technology essential to our life? To find this out, this research uses survey, books, internet and interviews to the people who are related on this technology. 1.3 Objectives To know what are the components of the brain chip. To inform other people about this technology. To find the possible outcomes, results and effects of the brain chip. 1.4 Research Method In order to perform a study entitled “Brain Chip Technology”, the researcher thought that it is proper and appropriate to make use of the descriptive type of research. The Descriptive Method is a fact-finding approach with adequate interpretation. This method allows the researchers to collect data and to report from the point of view of some objectives and basic assumption of the study. It also analyses and interprets the status of the system currently in use. This method of research focuses on process, analysis, and interpretation of data being collected. It involves the interpretation of the significance of what is being described. This process of research goes beyond simple gathering and tabulation of data. The methods involved range from the survey, which describes the status quo, the correlation study that investigate the relationship between variables, to test and assess mobile game application. The main goal of this descriptive research is to test and assess a mobile game application in terms of its portability, functionality and accuracy. THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY CHAPTER II RELATED LITERATURE AND STUDIES This chapter presents the local literature, local studies, foreign literature and foreign studies along the present line of this study considered pertinent or relevant by the researcher. FOREIGN STUDIES (Based on the studies of Richard Larin, Ray Wu, Haven Eichleay, Olga Belomestnykh, & Jonathan Go) On July 3rd 2001, what started as an innocent Massachusetts fireworks show became the crime scene that changed one man’s life forever. At 6’2” and 180 pounds, Matthew Nagle was a star football player at Weymouth High. When he was leaving the show, one of Nagle’s friends entered into a heated argument. The dispute quickly escalated to blows and Nagle rushed to his friend’s aid. During the struggle Nagle was stabbed in the neck by an 8-inch knife that severed his spinal cord. When he awoke in a hospital, he was paralyzed from the neck down. Despite his grim situation, Nagle was determined to find a way to walk again. A ray of hope appeared two years later when he read an article in The Boston Globe about cutting-edge brain chip research at Cyberkinetics Inc. He pleaded with his doctors to contact Cyberkinetics, and shortly after he was selected to participate in a clinical trial. In 2004 he became the first person to be implanted with a Cyberkinetics’ BrainGate® chip. Young, physically fit and confident, Nagle was the perfect subject."I learned to use it in two or three days - it's supposed to take 11 months," he stated proudly. "I totally knew THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY this was going to work." Three years after his accident Nagle gained the ability to perform basic computer tasks, control a TV, and even operate a prosthetic hand through thought alone. This accomplishment laid the foundation to find a cure for paralysis. “I learned to use it in two or three days - it's supposed to take 11 months" -Matthew Nagle BRAIN FUNCTION The human brain is the command center of the nervous system. It is composed of 100 billion highly specialized cells called neurons. Through the complex networking of these cells, the brain sends and receives signals that manage biological processes within the body and direct voluntary movement. In a healthy person, sensory neurons carry signals from the body through the spinal cord to the brain, while motor neurons carry signals from the brain through the spinal cord to all other parts of the body. Nagle’s severed spinal cord effectively disconnected his brain from his limbs. Currently, there are no cures for paralyzed people. However, research concerning the development of brain-computer interfaces (BCIs) presents a potential solution. Successful trials using BCIs in subjects, such as Nagle, provide hope that brain chip technology will one day enable paralyzed people to control computers, wheelchairs, and even their own limbs. Fifty Years of Progress Brain chips have been a far - fetched dream ever since Jose Delgado began his research in the early 1950s. Known as the pioneer of brain chip technology, he THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY implan ted primitive devices in animal and human brains. Delgado was able to control his subject’s emotions by stimulating different areas of the cortex. In his most famous experiment in 1963, Delgado implanted a miniature electrode, called a stimoceiver, into the brain of a fighting bull. This stimoceiver received and transmitted signals over FM radio waves, and could be controlled remotely. By stimulating a specific part of the charging bull’s brain, Delgado was able to stop the bull in its tracks. This and e xperiments like it, were the earliest forms of BCI research. The Chip Brain chips often fail because of pinholes in their insulation coat. These pinholes allow chemicals and fluid to come in direct contact with the sensitive circuitry of the chip, which results in immediate failure of the chip. Thus the coating material of Nagle’s brain chip was of utmost importance. Because of the size constraint, encapsulating the chip in a thick layer of insulation was not a viable option. Instead, the chip implanted in Nagle was coated in monolithic silicone. Its electrodes were coated with Paralyn e C, topped with platinum tips and insulated with thin glass. The combination of these materials allowed the chip to be small, durable, and efficient. Nagle’s chip recorded brain signals using integrated CMOS circuitry, which is an array of recording electrodes. Just like repeating an experiment ensures statistically significant results, using multiple electrodes improved the reliability of the recorded data. The Comparing the Chip to a Dime [CyberkineticsInc] In 1998 the first BCI was implanted into a human brain. However, this primitive design had limited functionality. It read neural signals, but produced an THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY impractical output; the p erson with this chip could “type” only three characters per minute on a virtual keyboard. Three years later, John Donoghue and a group of researchers established Cyberkinetics: Neurotechnology Systems, a public company to commercially develop BCIs. Matthew Nagle’s brain chip was designed to provide a balance between safety, durability, and functionality. The chip had to be small enough to not hinder normal brain function and non- disruptive to neural communication to avoid brain damage. At the same time, the chip had to be resistant to corrosion caused by brain chemicals. While fulfilling these safety requirements, the primary function of the chip was to record and transmit the delicate signals of Nagle’s brain. Brain chip was equipped with 96 recording electrodes spaced 0.4mm apart. It received data at the rate of 10,000 signals per second per electrode. The end size of the chip was 4mm x 4mm x 1.5mm and was implanted a little over 1mm into Nagle’s brain. Implementation In developing the BCI, researchers implanted a brain chip in subjects with full neural and motor capacity. The subjects performed elementary actions, such as raising an arm, and the neuron activity was recorded using the chip. These experiments allowed for the s imultaneous recording of both hand motion and neural activity. Later in the trial, Nagle developed the ability to open and close a prosthetic hand. All of his accompli shments were exciting not only because of the physical successes, but also because of the manner in which he was able to control the BCI. Like a THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY healthy person, Nagle was able to do other things, such as whistling or talking, while voluntarily “moving” and this exact location. After recovering from surgery, doctors thought that it would take 11 months for Nagl e to learn how to control a computer cursor using the BrainGate® system. However, Nagle surprised everyone when he began to have success on just his second day of training with the implanted BCI. The BrainGate Neural Interface created a direct link between Nagle’s brain and a computer in the following way: when he thought “move cursor down,” his cortical neurons fired in a distinctive pattern. The brain chip sensed these electrical signals The researchers were then able to create a relational model using the two data sets. In addition, researchers discovered that although there are multiple sets of neurons that determine the force and direction of motor action, the data from a small sample of neurons can be reconstructed into full three-dimensional arm trajectories using simple multiple linear regression. Researchers found that the placement of the brain chip did not matter as much as originally thought. The chip was able to pick up neural signals not only from the neurons that it directly touched, but also from important nearby neural clusters. This suggests that users of the chip were able to learn how to use the BCI through signals generated by the BCI itself. With prolonged use, the neurons in contact with the chip became increasingly compatible and responsive in performing desired tasks. In Nagle’s inaugural clinical trial, doctors first pinpointed the exact location in Nagle’s primary motor cortex that once controlled his dominant hand. The chip was then implanted at and transmitted them to a pedestal plug that was directly attached to his skull. The signal was then sent through a wire to an amplifier, where it was converted into optical data and sent to a THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY computer through fiber-optic cables. The BrainGate® system decoded the data associated with Nagle’s thoughts into the specified movement of the computer cursor. Thus Nagle was able to play computer games, check email, and draw using BrainGate. In his case a cursor or a prosthetic hand. In other words, the BCI did not require single-focus concentration. Furthermore, using the BrainGate® system became intuitive for Nagle. Rather than thinking about the process of moving a cursor by moving his hand, he eventually started moving the cursor by simply imagining the cursor going from place to place. The cursor became as much a part of Nagle as his arms and legs once were. Researchers removed Nagle’s brain chip after one year of observation. B ecause of the brevity of his trial, it is unknown whether transmitting signals from an implanted chip causes brain damage. Brain experimentation is a risky procedure where minor errors or mechanical malfunctions can lead to permanent damage or even death. Extended research beyond the scope of Nagle’s study is necessary to determine the long-term effects of the chip. A Look into the Future Despite all the uncertainties, Nagle’s success provides hope and motivation for what researchers envision in the n ear future of brain chip technology—paralyzed people gaining the ability to fully control prosthetic limbs. Doctors hypothesize that with training and improved technology, the brain can control a prosthetic limb as if it were a part of the body itself. This is supported by research revealing that the adult cortex shows significant functional reorganization after nervous system injuries, changes in sensory experience, or learning of new motor skills. THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY Bold researchers are even optimistic about the ultimate goal of brain chip technology: to give paralyzed people control of their own limbs. Theoretically, one could bypass the broken motor pathway by hooking up BrainGate® to stimulators that activate muscle tissue. Researchers are currently planning larger clinical trials in order to accomplish this far-off, though seemingly reachable, goal. Donoghue comments, "These are the first steps. The goal is, one day you'd be sitting there with a person who was sipping coffee, typing on a computer, and he'd say, `Oh, by the way, I was a paraplegic but they wired me back together.' The promise is terrific. I think these things will happen. But it will take time." Rats Communicate Through Brain Chips Pairs of rats can communicate through brain chips and collaborate to perform a task, reportresearchers in today’s Scientific Reports. Brain activity recorded in one rat was translated into a pattern of electrical pulses that were then transmitted to another rat that had been trained to push a particular lever in response to one of two patterns of electrical stimulation in its brain. The rats also worked together, say the researchers. If the second rat chose the wrong lever, then the first rat would change its THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY brain function and behavior in the next trial so that the receiving rodent was more likely to get it right, claim the scientists. The research was led by Miguel Nicolelis, a neuroscientist at Duke University Medical Center, who has previously described a brain-computer interface through which a monkey could control a walking robot (see “The Power of Thought”) and another setup in which a virtual sense of touch was fed into a monkey’s brain through an electrical stimulating array (see “Giving Prosthetics a Sense of Touch”). A handful of labs have been making impressive progress in reading and writing to the brain in recent years with the aim of helping paralyzed people regain mobility via thought-controlled robotics. Last year, two research teams reported that quadriplegic patients could use brain implants to control robot limbs (see “Brain Chip Helps Quadriplegics Move Robotic Arms with Their Thoughts” and “Patient Shows New Dexterity with a Mind-Controlled Robot Arm”). But today’s study, says Nicolelis, was not about improving brain-computer interface technology for patients but rather exploring new frontiers. “We observed the emergence of physiological properties that we could not predict before we did this,” he says, pointing to what he calls collaboration between the two animals’ brains. In the experiment, Nicolelis and his team trained a rat to choose between a right-side or left-side lever to push depending on which of two LEDs lit up. If the rat pushed the correct lever, it got a rewarding sip of water. The researchers recorded the electrical activity of the rat’s motor cortex, the region of the brain that controls movements, and translated the activity involved in pushing the right-side lever into THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY many pulses and pushing the left-side lever into fewer pulses. These pulses were then sent to the implant in the brain of another rat in a separate chamber. That rat had been trained to respond to pulse patterns in a similar way—more pulses meant push the right-side lever. With no cue from the LEDs in its cage, the second rat was able to choose the correct lever 64 percent of the time, at which point both rats would get a water reward (the information-sending rat would thus get two; the information receiving rat would get only one). When the second rat got it wrong, the first rat noticed, says Nicolelis, because it did not get a second reward. So in the next trial, the first rat would respond more quickly to the LED cue and produce a greater amount of task-related neuron firing compared to background brain noise, he says, which made the second rat more likely to choose the correct lever. This is what Nicolelis refers to as collaboration. The researchers also demonstrated the brain-to-brain communication with whisker stimulation in the first rat. Like a cat, rats use their whiskers to determine how wide an opening is, and the rodents can be trained to turn their head to the left or right depending on whether a hole in their cage is narrow. Similar to the first experiment, the brain activity of the first rat was translated into a particular pattern of pulses sent to the second rat, which had been trained to poke its head left in response to electrical pulses, and right in the absence of pulses. With these tests, the second rat chose the correct side about 62 percent of the time. With the whisker test, the team demonstrated that the rats need not be in the same building—or even on the same continent—to collaborate. A rat in Brazil at THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY the Edmond and Lily Safra International Institute of Neuroscience of Natal sent brain signals to a rat on the Duke campus in Durham, North Carolina. However, the binary decisions made in the rat tests are not up-to-speed with what brain-computer interfaces can do these days, wrote University of Pittsburgh’s Andrew Schwartz, a pioneer in patient brain-computer interfaces, in an e-mail to MIT Technology Review. “It may sound like ‘mental telepathy’ and therefore seem exciting, but when looked at more carefully, it is very simplistic,” he wrote. “As a communication channel, you could think of a locked-in patient trying to communicate by blinking, where a blink means yes and no blink mean no. This kind of information could be conveyed by recording from a single neuron in one rat and buzzing electrical current in the receiver rat. If the rat feels the buzz, it means yes, no buzz means no.” But Nicolelis sees this demonstration as the beginning of a new line of research that could lead to a new form of computing. He says his lab is working on “swarms” of rats that could share motor and sensory information via brain-to-brain interfaces. “If you put brains together, you could create a more powerful non-Turing machine, an organic computer that computes by experience, by heuristic,” he says. “That could be a very interesting architecture to explore.” Brain Chip Helps Quadriplegics Move Robotic Arms with Their Thoughts THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY A paralyzed patient equipped with an implanted brain chip has been able to use a robotic arm to reach for and pick up a bottle of coffee, bring it close enough to her face so she could drink from a straw, and then place the bottle back on the table. The quadriplegic patient was outfitted with an electronic brain implant that can drive a robotic arm to reach and grasp objects (see video). A study published today in the journal Nature shows that people with the brain chips can use the devices to perform complex three-dimensional tasks that could be helpful in daily life. Furthermore, the implanted electrodes can record neuronal signals for as long as five years—longer than had been suspected. In previous studies, patients using brain implants have been able to move a cursor on a screen, but not perform complicated movements with objects in the real world. The results are the latest announcements from a team led by John Donoghue, a neuroscientist at Brown University. Donoghue and collaborators hadreported in 2006 that patients paralyzed by spinal-cord injuries could use brainmachine interfaces to drive the movement of cursors on a screen and do simple openand-close movements with a robotic hand. Now the researchers have shown that a brain-machine interface can direct more complicated tasks. “Not only can people control a computer cursor, they can control really complex devices like a robotic arm that can carry out the functions that our own arm can do,” says Donoghue. The brain implant is a small array that’s four millimeters on each side (“about the size of a baby aspirin,” says Donoghue) with 96 hairlike electrodes extending from one side. The device sits on the surface of the brain, and the THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY electrodes penetrate the arm-controlling region of the motor cortex by one millimeter. The implant records the impulses of dozens of neurons. A patient’s intent to move generates these impulses, which are then transmitted to a computer that translates the patterns of electrical activity into commands that can control a robotic arm. “What’s striking to me about this study is that it’s nicely showing, for the first time in human patients, that you can use these signals to control a robot of importance for activities of daily living for a patient,” says Andrew Jackson, a neuroscientist at Newcastle University. The researchers say that algorithmic improvements in picking up patterns of activity in the brain and interpreting those patterns were key to the advance. The goal of the pilot clinical trial is to develop technologies that can restore the ability to communicate and move and to give independence to people with neurological disease or injury. So far, seven patients have enrolled in the trial. The two participants in this latest work both suffered from brain-stem strokes that left them unable to speak or move their limbs. At the time of the study, one patient had the implant for five months, the other for more than five years. The longevity of the implants demonstrates that the device can pick up usable signals from the brain for years, a point of concern in the field. “When you put something into the brain, there’s a reaction to the presence of that device,” says Donoghue. Cells are damaged or displaced by the electrodes, and the brain can form scar tissue around them. But “it doesn’t seem that the reaction of the brain is a barrier to recording,” says Donoghue. THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY Still, the signal deteriorated over time. “Even though they are recording signals five years after the array was put in, the signals aren’t that stable day to day,” says Jackson. He points out that the jellylike tissue of the brain moves within our skull, and a rigid, fixed implant may force the brain to deform around it. “If the signals are changing day to day, would [a patient] need to recalibrate the system day to day?” For now, the implant must be plugged into an external setup, but the Brown researchers and researchers at Blackrock Microsystems in Utah (which manufactures the implants) are working on wireless versions that are being tested in animals. Donoghue hopes that the implants can eventually drive electrical stimulation of a patient’s own muscles, circumventing the need for robotic arms. Such experiments have shown promise in nonhuman primates (for example, see a recent study from Northwestern University). This paper defines and discusses the break-through technology of brain implants. Brain implants, often referred to as neural are technological devices that connect directly to a biological subject's brain. The paper explains how the link between the computer chip and the human brain is established, and how things that used to be in the science fiction movies has now become reality such as controlling movements through thought only and giving orders to the computer through the brain directly without any other interference from the human body. The paper also discusses the vital implication of this technology in the healthcare industry and the hope that this technology gives to paralyzed patients interact with their environments THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY and perhaps, ultimately, to bypass damaged spinal cords and restore movement to lifeless limbs. Brain implants, often referred to as neural implants, are technological devices that connect directly to a biological subject's brain--usually placed on the surface of the brain, or attached to the brain's cortex. . Some brain implants involve creating interfaces between neural systems and computer chips, which are part of a wider research field called brain-computer interfaces. Another common purpose of modern brain implants and the focus of much current research is establishing a biomedical prosthesis circumventing areas in the brain, which became dysfunctional after a stroke or other head injuries. This includes sensory substitution, e.g. in vision. Other brain implants are used in animal experiments simply to record brain activity for scientific reasons. A typical neural implant consists of an array of electrodes that works with the nervous system, either by recording neuronal activity (recording) or by electrically stimulating them. Electrodes connect the electrochemical functions within the tissue and the electronic system. A circuit chip with site selection, amplifiers, and multiplexers works with some form of signal processing/embedded computing. Finally, a wireless link usually handles bidirectional data and power input. Implanting neural implants in the brain itself generally requires electrode sites every 200 [micro]m or so for recording, and perhaps every 400 [micro]m for stimulation. In cochlear electrodes, sites are on 250-[micro]m centers, consistent with about 128 sites in the human cochlea. THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY Generally, neural implants either record brain signals or stimulate the brain, but scientists are developing implants that could do both. A wide variety of high-density microelectrode structures are used in the central-nervous system. Most have a silicon substrate. Others use metal foils and polymers. The nervous system has similarities to microelectronics. Neurons, which are specialized nervous-tissue cells, form complex networks that perform sensory and other physiological functions. Neuronal-cell bodies take inputs from other cells, launching spike discharges to stimulate other cells. Closely placed artificial electrodes sense voltages generated near the cell body during depolarization (a decrease in potential absolute value) of the cell's membrane. To explore changes over time, as in the case of neural prostheses, it is important to record simultaneously from dozens or possibly hundreds of cells over a period of years or even decades. Other devices in the pipeline include retinal implants for the blind, cortical implants for paralysis, and implants for managing epilepsy. Driven by solid-state imagers, retinal implants stimulate the optic nerve. Human volunteers have identified simple objects using only 4 4-site arrays. Larger arrays are in development. Implants that record signals from the motor cortex could provide a front end for functional neuromuscular stimulation, offering hope to the paralyzed. Someday, electrode arrays could detect developing seizures and suppress them even before the patient senses them. All these wireless, implantable microsystems could come in the next decade. THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY In the neuron-to-chip experiment, the current generated by the neuron has to flow through the thin electrolyte layer between cell and chip. This layer's resistance creates a voltage, which a transistor inside the chip can pick up as a gate voltage that will modify the transistor current. In the reverse signal transfer, a capacitative current pulse is transmitted from the semiconductor through to the cell membrane, where it decays quickly, but activates voltage-gated ion channels that create an action potential. Direct interfaces between small networks of nerve cells and synthetic devices promise to advance our understanding of neuronal function and may yield a new generation of hybrid devices that exploit the computational capacities of biological neural networks. There are several research teams in the U.S. and Europe that are currently working on so-called neural-silicon hybrid chips. One of the most celebrated researchers in the field is Ted Berger at the Center for Neural Engineering at University of Southern California in Los Angeles. Berger is also a key player in the newly established National Science Foundation Engineering Research Center devoted to biomimetic microelectronics. Berger has set his sights on building artificial neural cells, initially to act as a cortical prosthesis for individuals who have lost brain cells to neurological diseases such as Alzheimer's. But eventually, his lab's efforts may usher in a new era in biologically inspired computing and information processing. THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY 2. HOW DOES BRAIN/NUERAL IMPLANTS WORK? Neural signals usually run from tens to hundreds of micro-volts in amplitude, with frequencies extending to about 10 kHz. There is no way of knowing in advance where to position electrode sites near neurons of interest. Probes with onchip electronics interface with sites through selectors that let the user choose a subset of sites to monitor or stimulate. Concentrations of eight or so are common. This compensates for any probe movement in tissue over time. Selected channels are fed to amplifiers that are usually coupled. They boost signal levels by 60 dB, operate from 60 to 80 um in <0.1 mm2, and have significantly less noise than the thermal noise from the site itself. In some cases, the lower cutoff frequency is programmable to record of low-frequency waves in addition to recording neural spikesOutput multiplexers are sometimes used to time-multiplex the signals from several channels onto a single output lead, reducing the number of leads from dense multi-channel arrays. Lead count is one of the biggest problems in such systems. Output buffers are also important in making signals immune to leakage and noise externally coupled onto the output leads. The use of dozens or hundreds of sites can quickly exhaust the available bandwidth in inductively coupled stimulation/recording systems. This, and the development of totally implantable microsystems, will require in-vivo interpretation of neural events and proper responses. And in-vivo neural processing chips for spike recognition are already here. Wireless microsystems may be getting under our skin but millions of disabled persons aren't complaining. [8] THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY The BrainGate Neural Interface creates a direct link between a person's brain and a computer, translating neural activity into action. A person without use of his limbs but fitted with a BrainGate, can now play a videogame or change channels on TV using only his mind. This is how they did it: 1. The chip: A 4-millimeter square silicon chip studded with 100 hair-thin microelectrodes is embedded in a person's primary motor cortex--the region of the brain responsible for controlling movement. 2. The connector: When the person thinks "move cursor up and left" (toward email icon), his cortical neurons fire in a distinctive pattern; the signal is transmitted through the pedestal plug attached to his skull. 3. The converter: The signal travels to a shoebox-sized amplifier mounted on the wheelchair, where it's converted to optical data and bounced by fiber-optic cable to a computer. 4. The computer: BrainGate learns to associate patterns of brain activity with particular imagined movements--up, down, left, right--and to connect those movements to a cursor. Electrical signals are responsible for communication in both the brain and computers. Current research is hoping to use this similarity to get nerve cells and silicon chips interacting directly. Two-way transmission--as shown in Figure 1- of THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY electrical signals between chips and neurons can already be achieved on a small scale without invasive connections or damage to either transmitter Combining technology and biology could lead to devices to restore vision, hearing and limb control and equipment for many applications in the computer industry. The Max Planck Institute in Germany is a center of research working on neural-silicon hybrids. Recently, RA Kaul and P. Fromhertz from the Institute and NI Syed from the University of Calgary reported in Physical Review Letters on direct interfacing between a silicon chip and a biological excitatory synapse. The team constructed a silicon-neuron hybrid circuit by culturing a presynaptic nerve cell atop a capacitor and transistor gate and a postsynaptic nerve cell atop a second transistor gate. They applied a voltage to the capacitor, which excited the presynaptic neuron, and this activity was recorded with the first transistor. When the presynaptic neuron fired, it generated excitation of the postsynaptic neuron, presumably via an excitatory synapses, and the activity in the postsynaptic neuron was recorded with the second transistor. Further, short trains of activity in the presynaptic neuron appeared to increase the strength of the excitatory synapse between the cells, creating a memory trace within the circuit. THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY 3. CONTROLLING MOVEMENT THROUGH THOUGHT ALONE Systems that allow a brain to control a computer are inching ever closer to reality, but their most important applications may be different from those envisaged by science fiction. Information processing in the brain involves the coordinated activity of large networks of neurons. Over the past 15 years we have developed and utilized technologies for extracting this information from neuronal populations in behaving animals. This involves chronically implanting multi-electrode arrays in functionally connected areas of the motor and somatosensory systems of the brain. Multiprocessor computer systems are used to simultaneously discriminate and record the spiking activity of large numbers of single neurons within those systems. Mathematical techniques are used to decode the information processed by these neuronal populations while the animals perform specific behavioral tasks involving somatosensory perception and/or trained limb movement. It was recently shown that electronic decoding of neuronal population activity could be used to extract and utilize "comm" for forelimb movement from the motor cortex of rats. The rats were initially trained to use their forelimbs to press down a lever to a certain position. The lever movement controlled movement of a robot arm to obtain a drop of water from a dropper. When the rat released the lever the robot arm delivered the water to the rat's mouth. Next we suddenly switched the control of the robot arm away from this lever- THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY press, and replaced it with the electronic signal carrying decoded movement commands from the motor cortex. Four of the six rats were able to use this motor command signal to control the robot arm with sufficient accuracy to reliably and repeatedly retrieve water drops. After a few days of this training, the animals were increasingly able to move the robot arm and retrieve water without the concomitant lever pressing. This suggests that motor cortical control of limb movement is modifiable. Thus, paraplegic patients might be able to use their motor cortex activity to directly control a robot arm, or their own arm using functional stimulation of the paralyzed muscles. Monkeys can control a robot arm as naturally as their own limbs using only brain signals, a pioneering experiment has shown. The macaque monkeys could reach and grasp with the same precision as their own hand. "It's just as if they have a representation of a third arm," says project leader Miguel Nicolelis, at Duke University in Durham, North Carolina. Experts believe the experiment's success bodes well for future devices for humans that are controlled solely by thought. One such type of device is a neurally-controlled prosthetic--a brain-controlled false limb. Nicolelis says his team's work is important because it has shown that prosthetics can only deliver precision movements if multiple parts of the brain are monitored and visual feedback is provided. Gerald Loeb, a biomedical engineer at the University of Southern California in Los Angeles, says the new experiment already has some parallels in everyday life. For example, he says, when you drive a car it becomes an extension of your body. The core of the new work is the neuronal model created by THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY the researchers. This translates the brain signals from the monkey into movements of the robot arm. It was developed by monitoring normal brain and muscle activity as the monkey moved its own arms. The task involved using a joystick to move a cursor on a computer screen. While the monkey was doing this, readings were taken from a few hundred neurons in the frontal and parietal regions of the brain. The activation of the biceps and wrist muscles was monitored, as was the velocity of the arms and the force of the grip. Once the neuronal model had developed an accurate level of prediction the researchers switched the control of the cursor from the joystick to the robotic arm, which in turn was controlled by the monkey's brain signals. At first the monkeys continued moving their own arms whilst carrying out the task, but in time they learned this was no longer necessary and stopped doing so. A big brown cockroach crawls across the table in the laboratory of Japan's most prestigious university. The researcher eyes it nervously, but he doesn't go for the bug spray. He grabs the remote. This is no ordinary under-the-refrigerator type bug. This roach has been surgically implanted with a micro-robotic backpack that allows researchers to control its movements. This is Robo-roach. "Insects can do many things that people can't, " said Assistant Professor Isao Shimoyama, head of the bio-robot research team at Tokyo University. "The potential applications of this work for mankind could be immense." Within a few years, Shimoyama says, electronically controlled insects carrying mini-cameras or other sensory devices could be used for a variety of sensitive missions--like crawling through earthquake rubble to search for victims, or slipping under doors on espionage surveillance. Far-fetched as that might THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY seem, the Japanese government has deemed the research credible enough to award $5 million to Shimoyama's microrobotics team and biologists at Tsukuba University, a leading science center in central Japan. Money from the five-year grant started coming in this month, and young researchers are lining up for a slot on Shimoyama's team. The team breeds its own supply of several hundred cockroaches in plastic bins. Not just any roach will do. Researchers use only the american cockroach (Perplaneta americana) because it is bigger and hardier than most other species. From that supply, they select roaches to equip with high-tech "backpacks"--tiny microprocessor and electrode sets. Before surgery, researchers gas the roach with carbon dioxide. Wings and antennae are removed. Where the antennae used to be researchers fit pulseemitting electrodes. With a remote, researchers send signals to the backpacks, which stimulate the electrodes. The pulsing electrodes make the roach turn left, turn right, scamper forward or spring backward. [13] University of Reading scientists have developed a robot controlled by a biological brain formed from cultured neurons. And this is a world's premiere. Other research teams have tried to control robots with 'brains,' but there was always a computer in the loop. This new project is the first one to examine 'how memories manifest themselves in the brain, and how a brain stores specific pieces of data.' As life expectancy is increasing in most countries, this new research could provide insights into how the brain works and help aging people. In fact, the main goal of this project is to understand better the development of diseases and disorders which affect the brain such as Alzheimer or Parkinson diseases. It's interesting to note that this project is being led by Professor Kevin Warwick, who became famous in 1998 when THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY a silicon chip was implanted in his arm to allow a computer to monitor him in order to assess the latest technology for use with the disabled. These robots are developed at the Cybernetic Intelligence Research Group, part of the School of Systems Engineering at the University of Reading. The team has been led by Kevin Warwick, Professor of Cybernetics (please also check his personal home page. He worked with two lecturers in his group, Dr Victor Becerra and Dr Slawomir Nasuto, as well as with Dr Ben Whalley, another lecturer in the School of Pharmacy. The robot's biological brain is made up of cultured neurons which are placed onto a multi electrode array (MEA). The MEA is a dish with approximately 60 electrodes which pick up the electrical signals generated by the cells. This is then used to drive the movement of the robot. Every time the robot nears an object, signals are directed to stimulate the brain by means of the electrodes. In response, the brain's output is used to drive the wheels of the robot, left and right, so that it moves around in an attempt to avoid hitting objects. The robot has no additional control from a human or a computer, its sole means of control is from its own brain. THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY 4. HEALTHCARE INDUSTRY APPLICATIONS The development of electronic brain implants, called neuroprostheses, that can translate the intention to move into the actual movement of a robotic device, or of a cursor on a computer screen. The hope is to give paralyzed patients greater ability to interact with their environments and perhaps, ultimately, to bypass damaged spinal cords and restore movement to lifeless limbs. The concept of using thought to move a robotic device, a wheelchair, a prosthetic, or a computer was once strictly the stuff of science fiction, but no longer. BrainGate[TM] collects and analyzes the brainwaves of individuals with pronounced physical disabilities, turning thoughts into actions. The potential to better communicate, interact, and improve people's way of life is about to explode. Years of advanced research by world-renowned experts at prestigious universities--including Brown, Harvard, Emory, MIT, Columbia, and the University of Utah--has resulted in the development of BrainGate[TM], a life-changing technology and device that gives renewed hope to paraplegics, quadriplegics and others suffering from spinal cord injuries and strokes. Eventually, it has the potential to revolutionize the way all of our brains work. BrainGate has been featured on broadcasts such as 60 Minutes and in publications including Popular Mechanics, Nature and Wired. A pacemaker-like device that uses high-frequency electrical currents to block brain signals to the stomach and pancreas through the vagus nerves helps patients lose excess weight, without the aid of dietary or other lifestyle interventions THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY and with no significant adverse effects on heart rate or blood pressure, according to results of a new open-label study. Patients who had the device implanted for 6 months lost an average of almost 15% of their excess body weight, while about one-quarter lost about 25%. Three patients lost more than 30% of their excess weight. The new therapy, called intra-abdominal vagal blocking (VBLOC), has several advantages over existing weight-loss strategies, said Michael Camilleri, MD, professor of medicine and physiology at the Mayo Clinic in Rochester, Minnesota, and co-lead author of the study. "First, it's minimally invasive and in fact can be done entirely with the laparoscope or keyhole surgery; second, it doesn't produce any change to the anatomy or the routing of the food through the upper digestive organs; and third, it is completely reversible. "The study, which appears in the June issue of Surgery, is the first of its kind in humans. The device works much like a pacemaker, which sends electrical signals to the heart to ensure optimal rhythms. "The principle here is quite similar," said Dr. Camilleri. "In some respects, it's like sending a scrambling message into the vagus nerves to stop them from doing what they would normally do after we eat. "Blocking the vagus nerve achieves 3 major goals, Dr. Camilleri explained to Medscape Neurology & Neurosurgery. "The first is to stop the contractions of the stomach and therefore prevent the efficient and rapid breakdown of food; second, by blocking those contractions, we also slow down the emptying of food from the stomach, and third, we block the production of enzymes that are necessary to digest the food. "Researchers followed the subjects weekly for 4 weeks, every 2 weeks until 12 weeks, and then monthly, assessing body weight; physical parameters, including electrocardiograms (ECG); and adverse events. THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY Matthew Nagle played the video game Tetris yesterday simply by thinking, controlling the on-screen action through a tiny chip implanted in his brain, as his paraplegic body sat limp. The 24-year-old former Weymouth High School football star, his spinal cord shredded during a knife attack three years ago, is a oneman experiment that may one day help to bring movement and a small dose of freedom to thousands of patients trapped by full-body paralysis. Researchers released promising data yesterday on the BrainGate device implanted in Nagle's head, finding that their sole test subject was able to control an onscreen cursor using brain waves in seven of eight test sessions. But much has happened since scientists recorded that feat: Nagle has drawn computer art, opened e-mail and played Pong as well as Tetris, he said in an interview yesterday. Next up, Super Mario Brothers. Researchers at Foxborough-based Cyberkinetics hope that, one day, they will be able to connect BrainGate to patients' arms and legs, permitting movement. "I don't care if I have to use a cane. I'm going to walk. I'm going to do this," said Nagle, speaking softly between gasps and gulps as a ventilator pumped oxygen into his lungs. "I know God has a plan for me." This is a far-off future: Researchers must still test BrainGate on dozens more patients and then reconfigure it to control limb-moving devices, a complex endeavor that could take years. Nonetheless, the experiment on Nagle, publicized at a research conference in Phoenix yesterday, offers a wondrous example of progress in helping paralyzed patients. It is the first time a product made by a privately owned firm has produced such a result. Nagle's journey to this frontier of science began in a moment of tragic chaos on July 4, 2001, at Wessagussett Beach in Weymouth. Nagle recalls a brawl breaking out, his friend under attack, fists flying, THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY someone screaming about a knife. Then everything went black. He had been stabbed in the neck. The tip of the curved, 8-inch knife remains lodged in Nagle's spine. Nicholas Cirignano, 23, was arrested and charged with assault with intent to murder and assault with a deadly weapon. Nagle plans to be there. His anger fuels his quest to walk: "I'm not going to let (someone) with a knife do this to me." Though Nagle is feeble and under constant care at his home, a room at New England Sinai Hospital and Rehabilitation Center in Stoughton, he retains the gruff manner of his football days, his words pointed and occasionally profane. Nagle says he can scarcely describe the experiment in which he is taking part. "It's unbelievable," he said. BrainGate was invented by Dr. John Donoghue, a Brown University professor who is also chief scientific officer at Cyberkinetics. In 2002, Donoghue's lab published a paper in Nature, a scientific journal, demonstrating that unique chips he designed, when implanted in monkeys' brains, allowed the primates to move an on-screen cursor. A device just like the ones put in monkeys is now in Nagle's brain, and Cyberkinetics is seeking four more patients to gather enough data to persuade the Food and Drug Administration to approve BrainGate for wider testing. The company estimates that it will have to carry out tests on up to 60 patients before winning approval. A hole was drilled in Nagle's head and the aspirin-sized BrainGate chip was put into his primary motor cortex, the part of the brain that controls movement. A hundred ultra-thin electrodes attached to the chip pierced his brain, able to detect the electrical signals generated by thoughts and then relay them through wires into a computer. After a three-week recovery, Nagle was shown a cursor moving on screen and told to think about the direction it moved. The computer attached to the THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY chip recorded the impulses he had when thinking about the cursor moving left, right, up and down. Each direction was associated with a characteristic pattern of signals from his brain. Then the computer was programmed to recognize each pattern and move the cursor accordingly. He thought up; it moved up. "We're essentially providing a way of connecting his brain to the outside world," said Tim Surgenor, chief executive officer of Cyberkinetics. The data released yesterday show that Nagle had control in seven of eight tests, moving a cursor to a designated spot, represented during the tests as a bag of money. He also navigated the cursor around obstacles-bank robbers--on his way to the money. Nagle was also able to turn off and on a television and control its volume using his thoughts. What came after, unreported as yet by the scientists, involved more elaborate control on Nagle's part. He was able to manipulate an imaginary paddle up and down in the Pong video game. Just two days ago, he first played with the fast stream of falling puzzle pieces in Tetris. A series of surgeries restored his ability to speak, and he is hoping that another set of procedures will allow him to breathe on his own. Nagle said that participation in the BrainGate experiment will one day help those like him and that his current predicament will remind others of their good fortune to be healthy. "God uses some people's body to show what life can be like," he said. THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY CHAPTER III ANALYSIS AND FINDINGS This chapter presents the analysis and findings along the present line of this study considered pertinent or relevant by the researcher. I. Analysis What happens when you place the equivalent of 1024 neurons in parallel on a chip? Well, you get a new form of computing for cloud computing and sensor networks as well as toys that can recognize cue cards, better artificial intelligence and pattern recognition. Imagine a chip that worked like our brains and could do everything from make our cloud services better, give sensor networks sensibility, make toys interact with the kids and give cameras the power to track, count and spot people in a crowded mall. Meet the CM1K, the silicon marketed by Folsom, Calif.-based start-up CogniMem, that is going to give artificial intelligence, sensor networks and lower-power predictive computing a big boost. THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY CogniMem, a blending of Cognitive Memory, was created this year to market the CM1K and will sell it to you in units of 1,000 for $80 a chip. The chip was developed based on technology from IBM. It’s not the cheapest chunk of silicon out there, nor is it really ready for most high-end applications. But the promise is that its way of creating chips that can handle massively parallel memory functions could lead to breakthroughs in the way computing is done, making it greener and more efficient for certain kinds of problems. Much like IBM, CogniMem is trying to build out chips that model the human brain, and has a license from IBM to make its products. “Based on multiple generations of IBM-patented ZISC technology, we have perfected this approach for practical commercial use, providing unmatched performance at low power, and made it available now.” said Bruce McCormick, co-founder, president and CEO of CogniMem, noted in the press release. The CM1K contains 1024 neurons, which can be daisy-chained together to make giant systems. The company says the chips are good for massively parallel jobs such as determining closest vectors in video searching, real-time surveillance and analytics, data mining, fingerprint matching, hyperspectral image analysis, financial services, weather forecasting, and a wide range of scientific computational tasks. THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY Here’s where it gets technical Late last week, CogniMems announced a way to group its chips called the CogniBlox system. From the release: “It’s composed of four CM1K chips or a total of 4,096 cognitive memory processing elements per board in a trainable 3-layer network, each having 256 programmable 1-byte connections to the input. Systems of 1 million elements can be configured allowing for 256 million connections every 10 microseconds with a typical power consumption of 500 watts and 0.13 petaops of performance.” From the point of the average consumer, this type of advance in silicon may not mean much, but it opens up an entirely new world of computing that relies on sensors and compute everywhere. Right now, we are tied to our machines, but as we evolve new ways of helping chips process information in a more distributed system that uses THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY lower power, we can create entirely new applications and move a step closer to taking the computers out of computing. II. Findings There is no computer that works as efficiently as the human brain. The scientists' goals are to build an artificial brain that will work just like the human brain. University of Zurich, Neuroinformatics researchers have made a breakthrough on this goal. They are now understanding how to configure neuromorphic chips that can replicate the brain’s information processing capabilities in real-time. Researchers validate this by creating a synthetic sensory processing system that demonstrates cognitive abilities. Most methods to neuroinformatics are restricted to the progress of neural network replicas on computers that aim to incite complex nerve networks or supercomputers. Only a select few researchers will follow the Zurich researchers’ method to develop electronic circuits that are similar to the brain in terms of size, speed, and energy consumption. A professor at the Institute of Neuroinformatics, GiacomoIndiveri said, "Our goal is to emulate the properties of biological neurons and synapses directly on microchips." The core challenge for researchers is how to construct networks made of completely artificial, i.eneuromorphic, neurons in a way that will execute the specified tasks. Lately, researchers have been effectively developing a neuromorphic structure that can perform complex sensorimotor tasks in real time. This network can also perform tasks that require short-term memory along with decision making traits THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY that are essential for cognitive tests. With this being said researchers can combine neuromorphic neurons into the network that implemented neural processing modules parallel to the “finite-state machines.” Researchers demonstrate for the first time how a real-time hardware neuralprocessing coordination where the user can dictate the behavior can be fabricated. Indiveri explains that thanks to their findings, neuromorphic chips can be designed for a large class of behavior modes. Their findings are pivotal for the progression of the new brain- stimulated technologies. Today’s computing chips are incredibly complex and contain billions of nanoscale transistors, allowing for fast, high-performance computers, pocket-sized smartphones that far outpace early desktop computers, and an explosion in handheld tablets. Despite their ability to perform thousands of tasks in the blink of an eye, none of these devices even come close to rivaling the computing capabilities of the human brain. At least not yet. But a Boise State University research team could soon change that. Electrical and computer engineering faculty Elisa Barney Smith, Kris Campbell and Vishal Saxena are joining forces on a project titled “CIF: Small: Realizing Chipscale Bio-inspired Spiking Neural Networks with Monolithically Integrated Nanoscale Memristors.” THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY Team members are experts in machine learning (artificial intelligence), integrated circuit design and memristor devices. Funded by a three-year, $500,000 National Science Foundation grant, they have taken on the challenge of developing a new kind of computing architecture that works more like a brain than a traditional digital computer. “By mimicking the brain’s billions of interconnections and pattern recognition capabilities, we may ultimately introduce a new paradigm in speed and power, and potentially enable systems that include the ability to learn, adapt and respond to their environment,” said Barney Smith, who is the principal investigator on the grant.The project’s success rests on a memristor – a resistor that can be programmed to a new resistance by application of electrical pulses and remembers its new resistance value once the power is removed. Memristors were first hypothesized to exist in 1972 (in conjunction with resistors, capacitors and inductors) but were fully realized as nanoscale devices only in the last decade. One of the first memristors was built in Campbell’s Boise State lab, which has the distinction of being one of only five or six labs worldwide that are up to the task.The team’s research builds on recent work from scientists who have derived mathematical algorithms to explain the electrical interaction between brain synapses and neurons. “By employing these models in combination with a new device technology that exhibits similar electrical response to the neural synapses, we will design entirely new THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY computing chips that mimic how the brain processes information,” said Barney Smith. Even better, these new chips will consume power at an order of magnitude lower than current computing processors, despite the fact that they match existing chips in physical dimensions. This will open the door for ultra-low-power electronics intended for applications with scarce energy resources, such as in space, environmental sensors or biomedical implants. Once the team has successfully built an artificial neural network, they will look to engage neurobiologists in parallel to what they are doing now. A proposal for that could be written in the coming year. Barney Smith said they hope to send the first of the new neuron chips out for fabrication within weeks. CHAPTER IV DISCUSSIONS ABOUT THE RESEARCH This chapter presents the discussions along the present line of this study considered pertinent or relevant by the researcher. THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY III. Discussions A. Rats Communicate Through Brain Chips Pairs of rats can communicate through brain chips and collaborate to perform a task, report researchers in today’s Scientific Reports. Brain activity recorded in one rat was translated into a pattern of electrical pulses that were then transmitted to another rat that had been trained to push a particular lever in response to one of two patterns of electrical stimulation in its brain. The rats also worked together, say the researchers. If the second rat chose the wrong lever, then the first rat would change its brain function and behavior in the next trial so that the receiving rodent was more likely to get it right, claim the scientists. The research was led by Miguel Nicolelis, a neuroscientist at Duke University Medical Center, who has previously described a brain-computer interface through which a monkey could control a walking robot (see “The Power of Thought”) and another setup in which a virtual sense of touch was fed into a monkey’s brain through an electrical stimulating array (see “Giving Prosthetics a Sense of Touch”). A handful of labs have been making impressive progress in reading and writing to the brain in recent years with the aim of helping paralyzed people regain mobility via thought-controlled robotics. Last year, two research teams reported that quadriplegic patients could use brain implants to control robot limbs (see “Brain Chip Helps Quadriplegics Move Robotic Arms with Their Thoughts” and “Patient Shows New Dexterity with a Mind-Controlled Robot Arm”). THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY But today’s study, says Nicolelis, was not about improving braincomputer interface technology for patients but rather exploring new frontiers. “We observed the emergence of physiological properties that we could not predict before we did this,” he says, pointing to what he calls collaboration between the two animals’ brains. In the experiment, Nicolelis and his team trained a rat to choose between a right-side or left-side lever to push depending on which of two LEDs lit up. If the rat pushed the correct lever, it got a rewarding sip of water. The researchers recorded the electrical activity of the rat’s motor cortex, the region of the brain that controls movements, and translated the activity involved in pushing the right-side lever into many pulses and pushing the left-side lever into fewer pulses. These pulses were then sent to the implant in the brain of another rat in a separate chamber. That rat had been trained to respond to pulse patterns in a similar way—more pulses meant push the right-side lever. With no cue from the LEDs in its cage, the second rat was able to choose the correct lever 64 percent of the time, at which point both rats would get a water reward (the information-sending rat would thus get two; the information receiving rat would get only one). When the second rat got it wrong, the first rat noticed, says Nicolelis, because it did not get a second reward. So in the next trial, the first rat would respond more quickly to the LED cue and produce a greater amount of taskrelated neuron firing compared to background brain noise, he says, which made the THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY second rat more likely to choose the correct lever. This is what Nicolelis refers to as collaboration. The researchers also demonstrated the brain-to-brain communication with whisker stimulation in the first rat. Like a cat, rats use their whiskers to determine how wide an opening is, and the rodents can be trained to turn their head to the left or right depending on whether a hole in their cage is narrow. Similar to the first experiment, the brain activity of the first rat was translated into a particular pattern of pulses sent to the second rat, which had been trained to poke its head left in response to electrical pulses, and right in the absence of pulses. With these tests, the second rat chose the correct side about 62 percent of the time. With the whisker test, the team demonstrated that the rats need not be in the same building—or even on the same continent—to collaborate. A rat in Brazil at the Edmond and Lily Safra International Institute of Neuroscience of Natal sent brain signals to a rat on the Duke campus in Durham, North Carolina. However, the binary decisions made in the rat tests are not up-to-speed with what brain-computer interfaces can do these days, wrote University of Pittsburgh’s Andrew Schwartz, a pioneer in patient brain-computer interfaces, in an e-mail to MIT Technology Review. “It may sound like ‘mental telepathy’ and therefore seem exciting, but when looked at more carefully, it is very simplistic,” he wrote. “As a communication channel, you could think of a locked-in patient trying to THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY communicate by blinking, where a blink means yes and no blink mean no. This kind of information could be conveyed by recording from a single neuron in one rat and buzzing electrical current in the receiver rat. If the rat feels the buzz, it means yes, no buzz means no.” But Nicolelis sees this demonstration as the beginning of a new line of research that could lead to a new form of computing. He says his lab is working on “swarms” of rats that could share motor and sensory information via brain-to-brain interfaces. “If you put brains together, you could create a more powerful non-Turing machine, an organic computer that computes by experience, by heuristic,” he says. “That could be a very interesting architecture to explore.” B. The Human Brain on a Chip Even though computers have yet to rival the power of the human brain, a recent breakthrough in chip design may prove promising in recreating the power and efficiency of meatware. Called neuromporphic chips, the new processors, developed in collaboration between the University of Zurich and ETH Zurich, are about the same THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY size as a neuron, and are capable of performing the same tasks a human brain can accomplish. One the main hurdles in developing their new processors was configuring the processor network to simulate human neural activity. To do this the team in Zurich built a network of artificial neurons which could be joined together to create a processing module. In their test, which asked the chip to identify which way a series of bar was moving across a computer screen, the neuromorphic chip’s processing modules successfully identified the bars’ movement. Bully for them, they managed to identify visual input. What’s impressive, however, is that the chip successfully calculated a solution in real-time, demonstrating its ability to merge both visual processing with memory and context dependent decision-making, all of which are believe to be elements of cognition. "Thanks to our method, neuromorphic chips can be configured for a large class of behavior modes. Our results are pivotal for the development of new braininspired technologies" says Giacomo Indiveri, a professor of Neuroinformatics at the University of Zurich and ETH Zurich. While the chips only contain 4000 “neurons,” a pittance when compared to the billions in our own brains, everything has to start somewhere, and the chip THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY could prove instrumental in developing technology capable of mimicking or even surpassing human neuroprocessing. If neuromorphic chips could be scaled up, and artificial neurons be built to contain millions of connections apiece, I wonder if chips like these could be used to create true artificial intelligence systems, or even electronic repositories for own brains? In the future it just might be possible to download your own brain into a neuromorphic computing environment, where your consciousness might continue well beyond its usual expiration date. If you’d like to get away from my sci-fi rambling and look deeper into this subject, the Zurich team’s work was recently published in the Proceedings of the Nation Academy of Sciences of the US. C. Intel: Chips in brains will control computers by 2020 Computerworld - By the year 2020, you won't need a keyboard and mouse to control your computer, say Intel Corp. researchers. Instead, users will open documents and surf the Web using nothing more than their brain waves. Scientists at Intel's research lab in Pittsburgh are working to find ways to read and harness human brain waves so they can be used to operate computers, television sets and cell phones. The brain waves would be harnessed with Intel-developed sensors implanted in people's brains. The scientists say the plan is not a scene from a sci-fi movie -- Big Brother won't be planting chips in your brain against your will. Researchers expect that consumers will want the freedom they will gain by using the implant. THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY "I think human beings are remarkable adaptive," said Andrew Chien, vice president of research and director of future technologies research at Intel Labs. "If you told people 20 years ago that they would be carrying computers all the time, they would have said, 'I don't want that. I don't need that.' Now you can't get them to stop [carrying devices]. There are a lot of things that have to be done first but I think [implanting chips into human brains] is well within the scope of possibility." Intel research scientist Dean Pomerleau told Computerworld that users will soon tire of depending on a computer interface, and having to fish a device out of their pocket or bag to access it. He also predicted that users will tire of having to manipulate an interface with their fingers. Instead, they'll simply manipulate their various devices with their brains. "We're trying to prove you can do interesting things with brain waves," said Pomerleau. "Eventually people may be willing to be more committed ... to brain implants. Imagine being able to surf the Web with the power of your thoughts." To get to that point Pomerleau and his research teammates from Intel, Carnegie Mellon University and the University of Pittsburgh, are currently working on decoding human brain activity. Pomerleau said the team has used Functional Magnetic Resonance Imaging (FMRI) machines to determine that blood flow changes in specific areas of the brain based on what word or image someone is thinking of. People tend to show the same brain patterns for similar thoughts, he added. THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY For instance, if two people think of the image of a bear or hear the word bear or even hear a bear growl, a neuroimage would show similar brain activity. Basically, there are standard patterns that show up in the brain for different words or images. Pomerleau said researchers are close to gaining the ability to build brain sensing technology into a head set that culd be used to manipulate a computer. The next step is development of a tiny, far less cumbersome sensor that could be implanted inside the brain. D. Brain chip Essences Everyone must become aware of the covert implantation program of these horrible devices that connect your thoughts to the implant control agency. Yes, the mind/brain/computer interface is far beyond what most can imagine. The most targeted individuals (TIs) would likely be the outspoken activists. They would be eventually classified as schizophrenic while undergoing electronic torture and used as an unwitting spy against their associates. Eventually, they will be conditioned through dreams and subliminal brain-chip communications to turn them into a patsy for some fascist scheme. Organized crime can use these brain-chips to induct TIs into their organization, control and punish electronically or economically/socially until he or she complies or dies. Brain chip technology as of 2008 can be a self contained, passively powered supercomputer… wireless… (hopefully satellites require too much power to communicate) which monitors and THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY interacts with brain synapses. They may also contain some kind of nano-microwave camera technology as well. Not only can this technology decrypt your synaptic patterns for each thought… it can be turned around so the computer brain simulator program creates auditory sounds and sentences with distinct directions and distances. Further, the chip can control the body to walk around while it induces the mind into unconsciousness. This type of brain-chip can interface with the visual centers of the brain to play your favorite movie while your eyes are closed. You can also have a menu placed in your visual center so you can mentally select your choice of… movies to watch in darkness and silence (for example). It’s all in your head. Brain Chip: Biological Kohonen’s Chip The human brain contains more than one hundred billion neurons and 1014 synapses. Even without regard to the size of the genome, it can be easily concluded that a deterministic blueprint for connectivity of such an enormous number of networks is unrealistic. Therefore, as in the case of structure formation, self-organizing processes must play a significant role in developing functional connectivity of neurons. Among the many algorithms in neural net models, the concept generally referred to as Kohonen’s self-organizing map, provides the most plausible self-organization processes for creating associative memories, the configuration of which are virtually identical to that found in neurophysiological studies (7). THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY Vortex waves in the brain chip play the equivalent role of climbing fibers in the cerebellar chip with one notable difference. The physics of a wave gives the brain chip a two dimensional property. At the same time, the vortex wave fulfills the condition necessary for the distance dependent learning weighting of Kohonen’s map The CEO-LGS system fills the missing role of the climbing fibers equivalent in the cerebral cortex. The single column unit CEO, as schematically depicted in Figure 16, has the configuration of a two dimensional cerebellar chip. Instead of one to one activation of a Purkinje cell by a linearly connected climbing fiber as in the cerebellar chip, spatially graded activation through the ELDER system of a group of pyramidal cells within a single brain chip can be effectively achieved by the CEO-LGS system. This configuration is highly compatible with the self-organizing neural net of Kohonen type for effectively creating associative memory, the configuration of which has been repeatedly validated by neurophysiological studies. The Legacy of Linus C. Pauling Double Nobel Price laureate (Chemistry and Peace), Linus Carl Pauling, was deeply intrigued by the fact that the inert gas, Xenon, was an excellent general anesthetic. He concluded that the only property common to all anesthetic agents, including Xenon, was their effect on water crystallization (8). The hydrate-microcrystal (aqueous-phase) theory did not receive significant attention. Nevertheless, as Pauling himself stated (9), “the hydrate-microcrystal idea should be an important part of the accepted theory of general anesthesia when the theory is finally formulated.” One of the main reasons why the hydrate-microcrystal theory THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY did not receive nod of approval from scientific society was because Pauling incorrectly implied the effect of water condensation on neuronal membrane potentials. Had Pauling known the Vortex Model and brain chip theory, he would immediately have realized that water condensation within CEO and ELDER to be the critical factor. Under the Vortex Theory/Brain Chip concept, the consciousness can be defined as the steady, random, spontaneous discharges of cortical pyramidal cells through ELDER mediated electron flow triggered by the steady flow of the CEOLGS system. Establishment of a steady state within the LGS of the brain requires a certain thermodynamic steady state or homeostasis. The thermal gradients required to produce a convective force are dependent on the presence of an appropriately heated solid body core. In the context of the free convective self-organization schema, the reticular activation system (RAS), or reticular formation, and its connectivity within the thalamus likely play the primary role of a solid body with steady temperature for generating convective flow. The state of consciousness is dependent on the establishment of the requisite thermodynamics, and, resultant establishment of steady state cortical activities through the ELDER system. A highly plausible explanation for the basic mechanism of anesthetic agents is, as Pauling anticipated, their effect on the kinetic viscosity (Reynold’s number) of a fluid or gas involved in propagating an essential steady flow because of water microcrystal formation. Such an alteration in kinetic viscosity produces alteration in the kinetics of the steady flow and, hence, ELDER activities. Pauling’s microcrystal theory also provides an answer to the long unsolved mystery in anesthesia: Why anesthetic effect is enhanced when the subject is placed in an environment of lower atmospheric pressure. Pauling had shown that THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY hydrate microcrystal formation due to admixture with anesthetic agents, including alcohol, is dependent on atmospheric pressure. At lower atmospheric pressure, the identical concentration of an anesthetic agent results in more ready microcrystal formation. Implication for functional MRI: Aquaporin as a mediator of autoregulation One of the regional phenomena known to occur in association with brain activities is the phenomenon generally referred to as autoregulation, the main feature of which is an increase in regional blood flow (11). Although the exact controlling mechanisms of autoregulation are not known, there have been many unambiguous observations of the coupling of physiological increase in regional blood flow and regional brain activities. In 1961 Sokoloff introduced autoradiograpic images of the primary visual cortex exhibiting an increase in regional blood flow well corresponding to retinal stimulation (12). This observation became the world first “functional image”, and established the concept of brain activation study. The revolutionary advances in computer technology made possible for autoregulation based functional imaging, pioneered by Sokoloff, to be performed routinely in humans non-invasively. The first representative technology was positron emission tomography (PET), especially the one based on infusion of O15 labeled water (H2O15-PET). Figure 17 This simplified hypothesis states that oxygen supply in relation to an increase in activation-induced perfusion (flow in Figure) exceeds oxygen consumption associated with neuronal activities. As a result, regional deoxy-Hb levels paradoxically decrease in association with neuronal activities (brain activation). THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY However, that regional deoxy-Hb decline associated with increase in regional blood flow can simply be explained by the well-known Munro-Kellie doctrine without additionally introducing the concept of oxygen consumption (see Figure 18). Accordingly, fMRI should be considered to be a blood flow based functional imaging method virtually identical to H2O15-PET. Widely adopted fMRI methodologies detect pixels which show a statistically significant increase (not decrease) in signal intensity on T2* weighted images. In other words, the technique detects a decline in relative deoxy-Hb concentrations in a given voxel. Since an increase in oxygen consumption associated with regional neural activities results in an increase in deoxy-Hb concentrations and, hence, a decline in signal intensity on T2 weighted images, fMRI in fact detects a phenomenon totally opposite to that predicted based on oxygen consumption. The reverse observed phenomenon is generally attributed to an “oversupply of oxygen“ brought about by an increase in regional blood flow (Figure 17) (13). Therefore, the majority of, if not all, fMRI studies detect regional brain activities based on regional blood flow. It is well known that an increase in regional blood flow results in spontaneous reduction in venous blood volume in accordance with the MunroKellie doctrine (Figure 18) (14). It is clear that a decline in relative deoxy-Hb concentrations in a given voxel, the basis of fMRI, is readily explainable as a physiological epiphenomenon accompanying increase in regional blood flow, without the need to invoke changes in blood oxygenation. Like its sister methods, such as THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY H2O15-PET, fMRI is another functional imaging method based on regional blood flow. Figure 19 Typical time series of an activated pixel in the primary motor cortex. Red: raw data. Blue: boxcar type model function. Note the delay in activation signal changes compared to actual task performance. Figure 20: Subdivision of primary motor cortex Representative independent component fMRI images within the right primary sensorimotor cortex (SMI) obtained by independent component-cross correlation-sequential epoch (ICS) analysis. The entire right SMI was covered by two consecutive 5 mm thick axial slices placed 2.5 mm apart. ICS analysis identifies functionally independent, spatially discrete components (independent component fMRI images). Activated areas are quantitatively color-coded according to the magnitude of activation using a differential color schema for each functionally discrete independent component. Red graphs indicate representative time series of independent components corresponding to the accompanying fMRI image. Blue lines represent the 6 second delayed boxcar model function applied to cross correlation analysis. The abscissa indicates time in seconds and the ordinate indicates percent mean intensity changes. MI-4a, 4 anterior area of the primary motor cortex; MI-4p, 4 posterior area of the primary motor cortex; 3a, 3a area of the primary sensory cortex; SI, the “classical” primary sensory cortex (Brodmann areas 1, 2 and 3b). To provide better visualization of the three dimensional (3D) relationship, part of the activation map of slice 1 is placed over that of slice 2 (upper left). The schematic gray block (upper right) shows the 3D spatial THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY position of SMI and the localization of the independent areas of activation. CS: central sulcus. MI-4a, 4 anterior area of the primary motor cortex; MI-4p, 4 posterior area of the primary motor cortex; 3a, 3a area of the primary sensory cortex; SI, the “classical” primary sensory cortex (Brodmann areas 1, 2 and 3b). What is the mechanism of neural activities associated increase in regional blood flow? Again, the vortex theory gives a highly plausible hypothesis of the molecular mechanisms of autoregulation, namely, temporal and spatial coupling of neural activity and blood flow. It is well known that the response in regional blood flow corresponding to neural activities shows a delay of four to six seconds (Figure 19). Nevertheless, once activated, increases in blood flow has a relatively low time constant consonant with flow changes associated with caliber changes in blood vessels. This indicates that the molecular mechanisms responsible for blood flow change possess at least two cascades of processes the final result of which is an increase in vessel caliber7. Vessels within the region of cortex which is the target of this discussion do not possess a muscular layer that controls vessel caliber. Therefore, theoretically, vessel caliber change can be accomplished by either: 1) increase in inflow controlled by the proximal arterial component resulting in increase vessel caliber due to passive changes in the flexible vessel walls; or 2) physical structure, as yet to be defined. One’s intuition may accept the former. Several studies, however, indicate that regional flow changes coupled with given neural activities occur in the order of less than 1 mm3 (Figure 20), clearly indicating that the former possibility is not the case. Accordingly, one has to accept the latter, requiring identification of non-muscular structures responsible for caliber changes. The best THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY candidate is aquaporin-4 (assembly) regulated water contents of the structures surrounding vessels. Such a structure is astrocyte feet (Figure 8). According to the Vortex Theory (1), one of the main constituents of the fluid flowing within the COE and LGS is likely to be CO28 (REF). Following arrival of input, an entropy-vortex wave is created and travels along the CEO (Figure 12). If CO2 content within the fluid is at near saturation, this perturbation results in release of CO2 from the fluid analogous to champagne stirred by a bubble cutter (Figure 21). How aquaporin-4 (assembly) will be activated is not totally understood at this point. Nevertheless, accumulating data suggest two potential candidates, namely, water molecules and Figure 21: Champagne and bubble cuter Women often carried a bubble cutter for drinking champagne at social functions in order to be spared the embarrassment of eructating, or burping, in public. CO2. Carbon dioxide (CO2), rather than oxygen (O2), is believed to have an important role in regional blood flow alteration (11,15). Should aquaporin-4 surrounding vessels indeed be regulated by CO2, the physical pressure imposed on vessels by astrocyte feet could be reduced resulting in increased blood flow (Figure 22). This can effectively explain the observed spatial and temporal coupling of neural activities and blood flow (autoregulation). THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY Figure 22 Similar to the release of bubbles into the air effected by stirring champagne using a bubble cutter, an entropy-vortex wave (solid arrow) can release CO2 (red) from extracellular fluid where CO2 is under near saturation. While the entropyvortex wave introduces activation of ELDER, CO2 can also affect aquaporin channels of surrounding vessels, thereby effectively producing coupling of neural activities and blood flow with spatial as well as temporal concordance. CHAPTER V CONCLUSION AND RECOMMENDATION THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY This chapter presents the conclusions and recommendations along the present line of this study considered pertinent or relevant by the researcher. I. Conclusions Brain implants, often referred to as neural implants, are technological devices that connect directly to a biological subject's brain--usually placed on the surface of the brain, or attached to the brain's cortex. . Some brain implants involve creating interfaces between neural systems and computer chips, which are part of a wider research field called brain-computer interfaces. A typical neural implant consists of an array of electrodes that works with the nervous system, either by recording neuronal activity (recording) or by electrically stimulating them. Electrodes connect the electrochemical functions within the tissue and the electronic system. A circuit chip with site selection, amplifiers, and multiplexers works with some form of signal processing/embedded computing. Finally, a wireless link usually handles bidirectional data and power input. Implanting neural implants in the brain itself generally requires electrode sites every 200 um or so for recording, and perhaps every 400 um for stimulation. The BrainGate Neural Interface creates a direct link between a person's brain and a computer, translating neural activity into action. A person without use of his limbs but fitted with a BrainGate, can now play a videogame or change channels on TV using only his mind. The components of the neural interface are: 1. The chip: A 4millimeter square silicon chip studded with 100 hair-thin microelectrodes is THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY embedded in Nagle's primary motor cortex--the region of the brain responsible for controlling movement, 2. The connector: When Nagle thinks "move cursor up and left" (toward email icon), his cortical neurons fire in a distinctive pattern; the signal is transmitted through the pedestal plug attached to his skull, 3. The converter: The signal travels to a shoebox-sized amplifier mounted on Nagle's wheelchair, where it's converted to optical data and bounced by fiber-optic cable to a computer, and 4. The computer: BrainGate learns to associate patterns of brain activity with particular imagined movements--up, down, left, right--and to connect those movements to a cursor. Applications of chip brain implant include controlling movements through thought alone. Systems that allow a brain to control a computer are inching ever closer to reality, but their most important applications may be different from those envisaged by science fiction. Monkeys can control a robot arm as naturally as their own limbs using only brain signals, a pioneering experiment has shown. University of Reading scientists have developed a robot controlled by a biological brain formed from cultured neurons. Other application of brain implants are already in use in the healthcare industry. The hope is to give paralyzed patients greater ability to interact with their environments and perhaps, ultimately, to bypass damaged spinal cords and restore movement to lifeless limbs. For the researcher, he concluded the following: THE EFFECTS IF BRAIN CHIP TECHNOLOGY TO THE HUMAN BODY - Brain implants enhance capability of human organs and senses. - It has a significant role to play in future genetic engineering fields and neuroscience. - The implants may enhance your capabilities, but they will expire when you do. - It will enhance memory. - It might enable “cyberthink”- invisible communication. - Enable consistent and constant access to information where and when needed. - It will increase the dynamic range of senses, enabling, for example, seeing IR, UV, and chemical spectra. - It will increase the dynamic ranging of senses. - Giving light to blind and giving paralyzed patients full mental control of limbs. - No genetic modifications in the next generation. - Rescue missions(remote controlled rat). - The advantage of implants is that they take the decision making power away from the addict. Chips take away one's free will. It enables a person to make a better choice not to take drugs at all. II. Recommendations