Today you’ll master control of the cell cycle. 
(Biology In Focus Ch. 9.3)
Watch – a very basic overview:
http://highered.mheducation.com/sites/0072495855/student_view0/chapte
r2/animation__control_of_the_cell_cycle.html
What are the three checkpoints in the cell cycle?
http://outreach.mcb.harvard.edu/animations/checkpoints.swf
Introduction
Normal Cell Division
What is a checkpoint?
What does the G1 checkpoint ensure?
What does the G2 checkpoint ensure?
What does the spindle checkpoint (also called the M checkpoint) ensure?
Is the spindle checkpoint important in mitosis or meiosis?
What two things are spindle fibers attached to?
What does this checkpoint make sure has happened before the sister
chromatids can be separated?
Abnormal Cell Division
What do faulty checkpoints make cells unable to do?
What is likely to happen to cells with faulty checkpoints & these genomic
problems?
What happens if the spindle (M) checkpoint fails? What is the term for this error?
Describe the gamete produced from Meiosis II when the spindle checkpoint is faulty.
What is the term for the phenomenon of getting 3 copies of a given chromosome
(3N) rather than the normal diploid set (2N)?
Down Syndrome results from this type of nondisjunction event. Which human
chromosome occurs in three rather than paired in this disorder?
And now for a more advanced exploration of the signals that constitute these
checkpoints – Read this:
http://www.ncbi.nlm.nih.gov/books/NBK26824/
At each arrow, place the appropriate
name of each checkpoint.
Click on Fig. 17-15. What is the relationship between cyclin and Cdk?
Click on Fig. 17-16. Cdk needs cyclins in order to trigger specific events in
the cell cycle.
What does S-cyclin trigger?
What does M-cyclin trigger?
Stop when you reach the line, “In most cells, a fourth class of cyclins, the G1cyclins, helps promote passage through Start or the restriction point in late G1.”
Read this tutorial:
http://www.biology.arizona.edu/cell_bio/tutorials/cell_cycle/main.html
What does the protein p53 do?
What does the protein p27 do?
How are the levels of p27 correlated with breast cancer prognosis?
Watch the Mitosis animation and complete the quiz.
Now complete the Cellular Communication POGIL and the Signal
Transduction POGIL. You should bring these completed POGILs to
class tomorrow.