Chapter 11
Cell Communication
Question?
How
do cells communicate?
Why do cells
communicate?
Cell Communication
Cell Signaling (C.S.)
Is
a relatively “new” topic in
Biology and AP Biology.
Appears to answer many
questions in medicine.
Is a topic you’ll be hearing
more about in your future.
Stages of C.S.
Reception
Transduction
Response
Reception
Direct Contact
Direct Contact
Signal Molecules
Signal Molecules
Receptor Molecules
Receptor Molecules
G-protein linked
G-protein
G-protein
G-protein linked
receptors
G-protein linked
receptors
G-protein linked
receptors
Tyrosine-Kinase
Receptors
Mechanism
Intracellular Proteins
Tyrosine-Kinase
Receptors
Ion-channel Receptors
Ion-channel Receptors
Intracellular Signals
Intracellular Signals
Comment
Signal-Transduction
Pathways
Protein
Phosphorylation
Protein Kinase
Amplification
Secondary Messengers
Secondary Messengers
cAMP
Calcium Ions
Calcium Ions
Inositol Trisphosphate
(IP3)
Start here
Or Start here
Animation Link
http://entochem.tamu.edu/G-
Protein/index.html
Cellular Responses
Cytoplasmic
Regulation
Transcription
Regulation
Question
If
liver and heart cells both
are exposed to ligands, why
does one respond and the
other not?
Alternate explanation
Comment
Chapter
focused only on
activating signals. There are
also inactivation mechanisms
to stop signals.
Don’t
Summary
get bogged down in
details in this chapter.
Use the KISS principle.
Know - 3 stages of cell
signaling.
Know - At least one example
of a receptor and how it
works (in detail).