Online Supplement
CABG Versus PCI: Greater Benefit in Long-Term Outcomes With Multiple Arterial Bypass
Grafting
Short Title:
Optimal Revascularization of Multivessel CAD
Robert H. Habib1-3, Kamellia R. Dimitrova4, Sanaa A. Badour2, Maroun B. Yammine2,
Abdul-Karim M. El-Hage-Sleiman2, Darryl M. Hoffman4, Charles M. Geller4, Thomas A.
Schwann5, and Robert F. Tranbaugh4
1Department
of Internal Medicine, 2Outcomes Research Unit and 3Vascular Medicine Program,
American University of Beirut, Beirut, Lebanon
4Department of Cardiovascular Surgery, Mount Sinai Beth Israel Medical Center, New York, NY,
USA.
5Department of Surgery, University of Toledo College of Medicine, Toledo, OH, USA.
Corresponding Authors
Robert H. Habib, PhD
American University of Beirut-Medical Center
PO BOX: 11-0236, Riad El Solh, 1107 2020, Beirut, Lebanon
E-mail: rh106@aub.edu.lb
All authors have no conflict of interest to disclose
Research funded by departmental and Institutional funds. Authors SAB, MBY and AME are
funded in part on NIH Training grant 1D43TW009118-01A1 awarded to Scholars in Health
Research Program, American University of Beirut, Beirut - Lebanon.
Presented in part as an oral Plenary Session presentation at the American Association for
Thoracic Surgeons Meeting, April 26-30, 2014, Toronto, Canada
Table S-1. Selected patient demographic, co-morbidity and operative/procedural data
compared shown for BMS-PCI and SA-CABG matched pairs subcohorts.
Patient Factor
Propensity Matched Cohorts
SA-CABG (N=1058)
Categorical Variables
male
BMS-PCI (N=1058)
Count
%
Count
%
682a
64.5%
687a
64.9%
<18
285a
26.9%
296a
28.0%
18-24.99
452a
42.7%
433a
40.9%
25-29.99
218a
20.6%
230a
21.7%
30-34.99
73a
6.9%
68a
6.4%
25-29.99
24a
2.3%
21a
2.0%
BMI Category
>40
Obese
6a
.6%
10a
.9%
315a
29.8%
319a
30.2%
18a
1.7%
27a
2.6%
CCS Classification
1.0
2.0
90a
8.5%
99a
9.4%
3.0
527a
49.8%
514a
48.6%
4.0
423a
40.0%
418a
39.5%
Previous MI
516a
48.8%
486a
45.9%
Hypertension
782a
73.9%
653b
61.7%
COPD
133a
12.6%
128a
12.1%
DIABETES
381a
36.0%
390a
36.9%
Congestive Heart Failure
141a
13.3%
142a
13.4%
Creatinine > 2.5 mg/dL
34a
3.2%
32a
3.0%
Renal Dialysis
22a
2.1%
23a
2.2%
Three Vessel Disease
763a
72.1%
766a
72.4%
Two Vessel Disease
295a
27.9%
292a
27.6%
Left Main Disease
340a
32.1%
68b
6.4%
Off-pump CABG
44a
4.2%
Outcomes
In-hospital death
5a
.5%
12a
1.1%
121a
11.4%
409b
38.7%
Age (yrs)
Mean
68.10a
SD
9.21
Mean
68.29a
SD
11.92
Height (cm)
166.11a
9.75
166.04a
9.80
Weight (kg)
77.55a
15.70
77.23a
16.61
BMI (Kg/m2)
28.08a
5.08
27.96a
5.33
Reintervention
Continuous Variables
BSA (m2)
1.88a
.22
1.88a
.23
Ejection Fraction (%)
49.60a
12.85
49.92a
12.92
Note: Values in the same row and subtable not sharing the same subscript are significantly different
at p < .05 in the two-sided test of equality for column proportions.
Cells with no subscript are not included in the test. Tests assume equal variances. 1
1.
Tests are adjusted for all pairwise comparisons within a row of each innermost subtable
Using the Bonferroni correction.
2.
This category is not used in comparisons because its column proportion is equal to zero
or one.
Table S-2. Selected patient demographic, co-morbidity and operative/procedural data
compared shown for BMS-PCI and MA-CABG matched pairs subcohorts.
Patient Factor
Propensity Matched Cohorts
MA-CABG (N=746)
Categorical Variables
male
BMS-PCI (N=746)
Count
%
Count
%
548a
73.5%
572a
76.7%
<18
171a
22.9%
169a
22.7%
18-24.99
301a
40.3%
289a
38.7%
25-29.99
168a
22.5%
179a
24.0%
30-34.99
74a
9.9%
73a
9.8%
25-29.99
28a
3.8%
31a
4.2%
BMI Category
>40
Obese
4a
.5%
5a
.7%
270a
36.2%
283a
37.9%
18a
2.4%
CCS Classification
1.0
16a
2.1%
2.0
78a
10.5%
91a
12.2%
3.0
367a
49.2%
356a
47.7%
4.0
285a
38.2%
281a
37.7%
Previous MI
320a
42.9%
312a
41.8%
Hypertension
474a
63.5%
464a
62.2%
COPD
89a
11.9%
82a
11.0%
DIABETES
252a
33.8%
263a
35.3%
Congestive Heart Failure
53a
7.1%
55a
7.4%
Creatinine > 2.5 mg/dL
10a
1.3%
11a
1.5%
Renal Dialysis
5a
.7%
8a
1.1%
Three Vessel Disease
607a
81.4%
608a
81.5%
Two Vessel Disease
139a
18.6%
138a
18.5%
Left Main Disease
216a
29.0%
44b
5.9%
Off-pump CABG
21a
2.8%
Outcomes
In-hospital death
2a
.3%
8a
1.1%
Reintervention
83a
11.1%
298b
39.9%
Age (yrs)
Mean
61.10a
SD
8.11
Mean
61.03a
SD
11.46
Height (cm)
168.45a
10.26
168.72a
9.61
Weight (kg)
82.14a
16.64
82.73a
17.69
Continuous Variables
BMI (Kg/m2)
28.95a
5.40
29.05a
5.66
BSA (m2)
1.95a
.23
1.96a
.24
Ejection Fraction (%)
51.33a
12.12
51.19a
12.05
Note: Values in the same row and subtable not sharing the same subscript are significantly different
at p < .05 in the two-sided test of equality for column proportions.
Cells with no subscript are not included in the test. Tests assume equal variances. 1
1.
Tests are adjusted for all pairwise comparisons within a row of each innermost subtable
Using the Bonferroni correction.
2.
This category is not used in comparisons because its column proportion is equal to zero
or one.
Table S-3. Selected patient demographic, co-morbidity and operative/procedural data
compared shown for DES-PCI and SA-CABG matched pairs subcohorts.
Patient Factor
Propensity Matched Cohorts
SA-CABG (N=677)
Categorical Variables
male
DES-PCI (N=677)
Count
%
Count
%
450a
66.5%
449a
66.3%
<18
190a
28.1%
182a
26.9%
18-24.99
274a
40.5%
268a
39.6%
25-29.99
149a
22.0%
173a
25.6%
30-34.99
48a
7.1%
40a
5.9%
25-29.99
12a
1.8%
11a
1.6%
>40
4a
.6%
3a
.4%
209a
30.9%
224a
33.1%
1.0
10a
1.5%
11a
1.6%
2.0
87a
12.9%
74a
10.9%
3.0
499a
73.7%
522a
77.1%
4.0
81a
12.0%
70a
10.3%
Previous MI
273a
40.3%
270a
39.9%
Hypertension
74b
10.9%
BMI Category
Obese
CCS Classification
502a
74.2%
COPD
69a
10.2%
65a
9.6%
DIABETES
272a
40.2%
277a
40.9%
Congestive Heart Failure
62a
9.2%
70a
10.3%
Creatinine > 2.5 mg/dL
25a
3.7%
20a
3.0%
Renal Dialysis
16a
2.4%
13a
1.9%
Three Vessel Disease
524a
77.4%
526a
77.7%
Two Vessel Disease
153a
22.6%
151a
22.3%
Left Main Disease
223a
32.9%
61b
9.0%
Off-pump CABG
28a
4.1%
In-hospital death
3a
.4%
4a
.6%
Reintervention
79a
11.7%
324b
47.9%
Age (yrs)
Mean
68.03a
SD
9.14
Mean
68.50a
SD
12.44
Height (cm)
166.15a
9.80
166.34a
9.23
Weight (kg)
77.43a
15.49
77.99a
16.67
BMI (Kg/m2)
28.02a
4.96
28.09a
5.06
Outcomes
Continuous Variables
BSA (m2)
1.88a
.22
1.89a
.23
Ejection Fraction (%)
51.02a
12.32
51.29a
12.68
Note: Values in the same row and subtable not sharing the same subscript are significantly different
at p < .05 in the two-sided test of equality for column proportions.
Cells with no subscript are not included in the test. Tests assume equal variances.1
1.
Tests are adjusted for all pairwise comparisons within a row of each innermost subtable
Using the Bonferroni correction.
2.
This category is not used in comparisons because its column proportion is equal to zero
or one.
Table S-4. Selected patient demographic, co-morbidity and operative/procedural data
compared shown for DES-PCI and MA-CABG matched pairs subcohorts.
Patient Factor
Propensity Matched Cohorts
SA-CABG (N=546)
Categorical Variables
male
DES-PCI (N=546)
Count
%
Count
%
413a
75.6%
422a
77.3%
<18
127a
23.3%
119a
21.8%
18-24.99
210a
38.5%
211a
38.6%
25-29.99
133a
24.4%
139a
25.5%
30-34.99
53a
9.7%
53a
9.7%
25-29.99
20a
3.7%
19a
3.5%
>40
3a
.5%
5a
.9%
206a
37.7%
211a
38.6%
1.0
9a
1.6%
9a
1.6%
2.0
85a
15.6%
71a
13.0%
3.0
375a
68.7%
402a
73.6%
4.0
77a
14.1%
64a
11.7%
Previous MI
189a
34.6%
184a
33.7%
Hypertension
325a
59.5%
52b
9.5%
BMI Category
Obese
CCS Classification
COPD
33a
6.0%
46a
8.4%
DIABETES
210a
38.5%
202a
37.0%
Congestive Heart Failure
30a
5.5%
30a
5.5%
Creatinine > 2.5 mg/dL
5a
.9%
5a
.9%
Renal Dialysis
3a
.5%
4a
.7%
Three Vessel Disease
455a
83.3%
459a
84.1%
Two Vessel Disease
91a
16.7%
87a
15.9%
Left Main Disease
160a
29.3%
45b
8.2%
Off-pump CABG
12a
2.2%
In-hospital death
1a
.2%
1a
.2%
Reintervention
49a
9.0%
274b
50.2%
Age (yrs)
Mean
60.67a
SD
8.07
Mean
60.07a
SD
12.76
Height (cm)
168.38a
10.20
168.40a
9.08
Weight (kg)
82.18a
17.35
82.63a
18.04
BMI (Kg/m2)
28.95a
5.44
29.05a
5.61
Outcomes
Continuous Variables
BSA (m2)
1.95a
.24
1.96a
.24
Ejection Fraction (%)
53.32a
11.60
53.74a
11.42
Note: Values in the same row and subtable not sharing the same subscript are significantly different
at p < .05 in the two-sided test of equality for column proportions.
Cells with no subscript are not included in the test. Tests assume equal variances. 1
1.
Tests are adjusted for all pairwise comparisons within a row of each innermost subtable
Using the Bonferroni correction.
2.
This category is not used in comparisons because its column proportion is equal to zero
or one.
Figure S-1
Figure S-2