DESIGNER GENES: PLYM A PRESENTATION BY MEGAN HINES BRITTANY DANIEL, ACTRESS WHAT IS NON-HODGKIN’S LYMPHOMA? • A cancer of lymph tissue • No initial cause • Affects those of any age but almost half that are affected are over age 65 • Symptoms- swollen lymph nodes on neck, armpits, groin; abdominal pain or swelling; chest pain, coughing or trouble breathing; fatigue, fever, night sweats, weight loss • Treatment depends on the symptoms, stage/location of the disease, and the age/health of the patient. HOW DOES PLYM SAVE LIVES? • Vector: The pLym is inserted into the retrovirus (aka deadened cell). • Den-ase: The operon will be turned on in the presence of intestinal microbiota to trigger transcription. • GLP: Growing Lymph Protein, begins transcription in the presence of Den-ase. GLP ORI pLym Den-ase • *Intestinal Microbiota – the bacteria that lives in the human gut; cancer of white blood cells EARLY DETECTION (THE PILL) This pill will be taken with the bacteria in it where the GLP will glow. LYMPHOMA AWARENESS FDA COMPLIANCE GUIDELINES • http://www.fda.gov/iceci/compliancemanuals/compliancepolicyguidancemanual/ucm074396.htm WORK CITED • "Result Filters." National Center for Biotechnology Information. U.S. National Library of Medicine, 15 July 2013. Web. 24 Mar. 2014. • "Swollen Lymph Nodes: Causes, Symptoms, and Treatment." WebMD. WebMD, 6 Dec. 2012. Web. 24 Mar. 2014.