EX 2015
FROM THE NOTEBOOKS OF A TROUBLED
INVENTOR
&
Moving from the defense industry to the
medical instruments industry
Gavriel J. Iddan, D.SC.
November 11, 2015
I REMEMBER AS A CHILD, THE DOCTOR CARRIED
ALL THE INSTRUMENTS IN
A BLACK CASE……..
FEW URINE AND BLOOD TESTS
IMAGING MENT X-RAY
SURGERY WAS RARE AND COMPLICATED
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MEDICAL KNOWHOW AND SURGERY PROGRESED BY MILITARY
MEDICINE……
FEW DEVICES AND INSTRUMENTS
LAB TEST BASED ON CHEMISTRY AND SIMPLE MICROSCOPY
MEDICATION WAS LIMITED AND INCLUDED ASPIRIN, SULFA…..
NO REGULATION……
November 11, 2015
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ENTERS WW 2 AND THE COLD WAR
MILITARY RESEARCH AND SPENDING WENT
WILD…….(FEAR, BIG SPENDING, NO ATTENTION TO COST…)
NEW TECHNOLOGIES INVENTED INCLUDING:
SEMICONDUCTORS AND ELEC. INSTRIMENTS
POLYMERS CERAMICS, METALS….
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COMPLEX MACHINARY - JETS, ROCKETS,
SUBMARINES, SATELITES,
COMMUNICATIONS…
ADVANCED MANUFACTURING CNC AND
LATELY 3D PRINING
NEW SYSTEMATIC APPROACH TO
MANEGEMENT
WORK BY CODES AND REGULATIONS…….
November 11, 2015
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DEFENSE TECHNOLOGY OF YESTERDAY:




MECHANICS,
BINOCULAR OPTICS,
RADIO AND RADAR ELECTRONICS,
CHEMISTRY OF EXPLOSIVES,
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THE MAGNIFICENT THAT EVOLVED FROM THE
MILITARY/SPACE ACTIVITY :
1. MINIATURIZATION, of electronic circuits and other
components
2. MATERIALS, polymers, ceramics and high quality steels
titanium and other metals that are bio compatible!
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3. System - interdisciplinary engineering
4. Regulation and standards
5. Computer assisted design and manufacturing
6. Computer assisted management.
7. Robotics
THESE MAGNIFICENT 7 SHAPED OUR MODERN MEDICAL INSTRUMENTS INDUSTRY
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IN ADDITION:
LIFE SCIENCE AND MEDICINE ARE CHANGING FROM
EXPERIMENTAL DISCIPLINE INTO A QUANTITATIVE EXACT
SCIENCE
IT LEADS TO OUR ABILITY TO USE ENGINEERING APPROACH
IN THE DESIGN OF MEDICAL INSRUMENTS.
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SOME EXAMPLES:
1. MEDICAL IMAGING INCORPORATING IMAGE PROCESSING
CT, MRI, ULS, OCT – my new initiative….
2. BIOCHEMISTRY (MINIATURE INSULIN PUMPS )
3. MINIATURIZATION (LAPARASCOPY, PCR, DEFIBRILATION)
4. MATERIALS (TOTAL HIP REPLACEMENT…..)
5. ROBOTICS (DA VINCHI…..)
6. TISSUE ENGINEERING
THE LIST GROWS DAILY…..
November 11, 2015
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A PHYSICIAN IDENTIFIED A NEED AND
THE ENGINEER PROPOSED A SOLUTION
SO, YOU HAVE DECIDED TO
BECOME AN INNOVATOR………
TO HAVE A STARTUP………
GOOD LUCK ! YOU ARE GOING
TO NEED IT !
Here are some helpful advises
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OR, AS L. PASTEUR SAID:
“LUCK FAVERS THE PREPERED MIND”
1. ALWAYS, but ALWAYS START WITH TRUE MARKET NEED
2. EXAMINE MANY OPTIONS AND AVOID NIH
3. CHECK CAREFULEY THE IP SCENE
4. PREPARE A CONSERVATIVE WORK PLAN BUT, DO NOT OVER DO
IT
November 11, 2015
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R/D TRIANGLE
Technology
Required spec’s
competitive
edge &
strong IP
R/D cost
Tech. gap
Current
technology
(limited
knowhow)
Tech.
Slope, true
TEAM
knowhow
1st year
launch
2nd year
3rd year
Project time
Ready for
manufacturing
TRUE KNOWHOW REQUIRES INFORMATION ON WHAT’S
COOKING IN LAB’S AND OTHER COMPANIES
*
Iddan G. J. ・From the note books of a troubled inventor・ SPIE Vol.
6083 608301-1 2006
12
Always be on watch for a
DISRUPTIVE TECHNOLOGY * :
IF YOU DON’T YOU MAY BE SURPRIZED AND LOSE
YOUR PROJECT
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REVOLUTION
EVOLUTION
HYBRID CARS14
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TRANSISTOR
EVOLUTION
REVOLUTION
IC CELLULAR
SMART PHONE REVOLUTION
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MY EXAMPLES
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3DV SYSTEMS
GREAT IDEA…….
GENERATE 3D IMAGES BY SENDING A SHORT LASER
LIGHT PULSE
“LIGHT WALL” . THE REFLECTED
WALL HAS IMPRINT OF THE 3D SCENE.
REFLECTD WALL IS CAPTURED BY A CAMERA . BY
CHOPING THE WALL, A BW IMAGE IS CREATED WITH
THE GRAY LEVEL BEING AN INDICATION OF EACH
PIXEL RANGE.
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Laser pulsed illuminator
Light wall
object
gate
Reflected
imprinted wall
imager
Gated
wall
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BUT……..
NO SPECIFIC MARKETING GOAL EXISTED, AND WE WERE SURE THAT EVERYBODY
WILL RCOGNIZE THE BENEFITS……………
OUR FIRT GOAL WAS TO OFFER IT TO TV STUDIOS AS A SMART REPLACEMENT TO
CHROMA - KEY
IT WAS NICE BUT THE IMAGES WERE NOT PERFECT NOT GOOD ENOUGH FOR STUDIO
MONEY WAS RUNNING OUT
WE DECIDED TO GO FOR VIDEO GAME……….TOO LATE
THE COMPANY WAS SOLD TO MICROSOFT WITH MINIMAL RETURN TO THE INVESTORS.
November 11, 2015
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ENDOSCOPIC VIDEO PILL
WHILE TALKING WITH A GASTROENTEROLOGIST
FRIEND I WAS TOLD OF SOME SHORT COMINGS OF
THE ENDOSCOPES AND WAS ENTICED TO FIND A
SOLUTION. THE MARKET NEEDED IT………
R.D.C. HAS BEEN ESTABLISHED BY RUVEN KRUPIK FOR THE PURPOSE OF INVESTING IN
“RAFAEL” TECHNOLOGIES.
G. MERON WAS HIRED AS THE CEO AND FOUNDED “GIVEN IMAGING”
We transformed the world of GI from science fiction to reality
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1st GI Diagnostic Breakthrough in 25 Years
Rigid
Endoscopy
1960
Flexible
endoscopy
1970
1980
Capsule
endoscopy
1990
November 11, 2015
2000
23
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First Generation PillCam SB
1.
Optical dome
2.
Lens holder
3.
Lens
4.
Illuminating LEDs
(light emitting diodes)
5.
CMOS
(Complementary
Metal Oxide
Semiconductor)
imager
6.
Batteries
7.
ASIC (Application
Specific Integrated
Circuit) transmitter
8.
Antenna
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The Given® Diagnostic System
 M2A® Capsule
 Ambulatory
DataRecorder™ on
a belt
 RAPID® application
for image processing
and viewing
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Mouth to Cecum
Teeth
Multiple telangiectasia on
a gastric fold
Epiglottis
Small Intestine
Barret’s Esophagus
Wall of right colon 27
Time Line
10 Years
1981: Gabi Iddan meets Eitan Skapa M.D. and learns
about the need
to examine
the small intestine.
Technology
not available!
1986: small CCD are available.
1990: small transmitters are available.
20 Years
1992: The capsule conceptual design born.
1993: experiments begin, CMOS imager appears.
1994: patent application.
1995: ASIC transmitter appears.
1997: Given Imaging incorporated
2001: FDA granted
November 11, 2015
CHANGES..……
1981
2002
2011
Prof. Eitan Skapa
Dr. Gabi Iddan
First Thoughts
on capsule
Working on Solutions
November 11, 2015
Enjoying
Grandchildren
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WHAT SHALL WE DO IN THE AGE OF
GLOBALIZATION ?????
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ECONOMY AND INDUSTRY WERE BASED ON ADAM SMITH AND HIS UNSEEN HAND AND
THE DEVISION OF LABOR
FOLOWWING WW I JOHN MAYNARD KEYNES INDICATED THE NEED FOR GOVERNMENT
INTERVENSION AND REGULATION
TODAY THAT IS NOT ENOUGH
ENVIRONMENT, FAR EAST AND REGULATIONS ARE GAME CHANGERS WHICH SHOULD BE
DELT WITH WHEN CONCIDERING A NEW PROJECT.
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TRADITIONAL INDUSTRIES HAD TO CLOSE:
IN ISRAEL…ATA TEXTILE, ONE OF THE FLAG SHIPS CLOSED ITS GATES FOLLOWING
MORE THAN 50 YEARS OF ACTIVITY
SIR ARTHUR WAUCHOPE
BRITISH HIGH
COMMISIONER OF
PALESTINE VISITS “ATA”
1937
BUT, OSEM, ISCAR SUCCEDED BY HAVING FINE INNOVATIVE MANEGEMENTS
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OTHER PLAYERS SUCH AS
RAFAEL, ELBIT , AIA AND NETFIM SUCCEDED BY
MANEGEMENT SENSING THE CHANGES AND ENTERED
NEW FIELDS
THE HIGH TECH REVOLUTION SAVED OUR ECONOMY
(AND THE NEW IMMIGRANTS FROM RUSSIA…….)
CHECKPOINT, INTEL AND GIVEN IMAGING TO
NAME A FEW, CHANGED THE NATURE OF OUR
INDUSTRY
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FACTORS EFFECTING THE NEW DESIGNS
(MEDICAL INDUSTRY)
1. TOUGH SAFETY REGULATIONS (FDA…..)
2. HIGH COST OF MEDICAL CARE
3. LOW COST MANUFACTURING IN CHINA, INDIA ETC. EFFECTS THE PRODUCT DESIGN.
4. TOUGH ENVIRONMENTAL LOWS
5. INVESTORS ARE MIXEDUP IN THE COMPANY OPERATION
6. PATENTS ARE CONSUMING FUNDS
7. FUELS ARE EXPENSIVE
8. TERROR IS EFFECTING THE WAY WE WORK
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HOW SHOULD WE SECURE OUR ECONOMICAL
FUTURE UNDER THE CHANGING RULES ???
INNOVATION AND QUALITY
HOW CAN WE DO IT???
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HARD WORK……
INTERDISSPLINARY EDUCATION
DO NOT BE AFRAID IN CASE OF FAILURE
MIND THE ALTERNATIVES
BE RESPONSIBLE WITH EXPENSES.
DO NOT GIVE UP WHEN IN TRUBLE
November 11, 2015
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SOME POSITIVE INDICATIONS:
CSO FUND ARE GREAT FOR STARTUPS
DEMAND FOR NEW TECHNIQUES AND HIGH
TECH PRODUCTS IS ON THE RISE
RAPID TECHNOLOGICAL PROGRESS IS
PROVIDING NEW POSSIBILITIES
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THANK
YOU
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