Cardiovascular and Pulmonary Research: A Year in Review Combined Sections Meeting 2016 Anaheim California February 17-20, 2016 Paul Ricard, PT, DPT, CCS Johns Hopkins Hospital, Baltimore, MD Lawrence Cahalin, PT, PhD, CCS University of Miami, Miller School Of Medicine Disclosures • Paul Ricard has no disclosures regarding material presented in this course. • Lawrence Cahalin has no disclosures regarding material presented in this course. Speaker’s Note • This year’s format will consist of each presenter speaking on a limited number of articles (bold/underlined in the following references) to allow for a more in depth presentation in areas that have been determined to be of most interest based on the literature review. • Participants and authors are welcome to join in the conversation in the time allotted for each article. • Please note that the following references are up to date as of December 2015. Articles from January, and February may be included in the final presentation and may supersede chosen articles to be discussed at the discretion of the presenters prior to the presentation. Objectives 1. Report and interpret new literature surrounding the examination of or treatment for cardiovascular and pulmonary health conditions. 2. Compare their prior knowledge and practice to ideas and concept in current literature. 3. Discuss with peers the application and impact these studies may have on current and future practice. Cystic Fibrosis (16) 1. 2. 3. 4. 5. 6. 7. Swisher AK, Pepe A, Weckesser J, Orenstein D, Hebestreit H. Peak Aerobic Capacity in Adults With Cystic Fibrosis Stratified by Lung Disease Severity: A Retrospective Chart Review. Cardiopulm Phys Ther Journal.26(3):78-82. Swisher AK, Hebestreit H, Mejia-Downs A, Lowman JD, Gruber W, Nippins M, Alison J, Schneiderman J. Exercise and Habitual Physical Activity for People with Cystic Fibrosis: Expert consensus, Evidence-Based Guide for Advising Patients. Cardiopulm Phys Ther Journal;26(4):85-98. Bongers B, Werkman MS, Arets HGM, Takken T, Hulzebos HJ. A Possible Alternative Exercise Test for Youths with Cystic Fibrosis: The Steep Ramp Test. Med Sci in Sports Exercise. March 2015: 47(3);485-492. Ong T, Ramsey BW. Update in Cystic Fibrosis 2014. Amer J Respir Crit Care Med. 2015; 192(6);669675. Zlosnik JEA, Zhou G, Brant R, et al. Burkholderia Species Infections in Patient with Cystic Fibrosis in British Columbia, Canada. 30 Years’ Experience. Ann Am Thorac Soc. 2015; 12(1):70-78. Habib AR, Manji J, Wilcox PG, et al. A Systematic Review of Factors Associated with Health-Related Quality of Life in Adolescents and Adults with Cystic Fibrosis. Ann Am Thorac Soc. 2015; 12(3):420428. Grossoehme DH, Szczesniak RD, Britton LL, et al. Adherence Determinants in Cystic Fibrosis: Cluster Analysis of Parental Psychosocial, Religious, and/or Spiritual Factors. Ann Am Thorac Soc. 2015; 12(6):838-846. Pulmonary Rehabiliation (16) 1. 2. 3. 4. 5. 6. 7. 8. 9. Spruit MA, Pitta F, McAuley E, et al. Pulmonary Rehabilitation and Physical Activity in Patients with Chronic Obstructive Pulmonary Disease. Amer J Respir Crit Care Med. 2015; 192(8);924-933. Rochester CL, Vogiatzis I, Holland AE, et al. An Official American Thoracic Society/European Respiratory Society Policy Statement: Enhancing Implementation, Use, and Delivery of Pulmonary Rehabilitation. AJRCCM. 2015; 192(11);1373-1386. Au DH, Macaulay DS, Jarvis JL, et al. Impact of a Telehealth and Care Management Program for Patients with Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2015; 12(3):323-331. Evans RA, Dolmage TE, Mangovski-Alzamora S, et al. One-Legged Cycle Training fo Chronic Obstructive Pulmonary Disease. A Pragmatic Study of Implementation to Pulmonary Rehabilitation. Ann Am Thorac Soc. 2015; 12(10):1490-1497. Chaplin E, Gibb M, Sewell L, et al. Response of the COPD Assessment Tool in Stable and Postexacerbation Pulmonary Rehabilitation Populations. JRCP; 35(3);214-218. Atabaki A, Fine J, Haggerty M, et al. Effectiveness of Repeated Courses of Pulmonary Rehabilitation on Functional Exercise Capacity in Patients with COPD. JRCP; 35(4);272-277. Mkacher W, Mekki M, Chaieb F, et al. Balance Training in Pulmonary Rehabilitation: Effects On Psychosocial Outcomes. JRCP; 35(4);278-285. Nguyen H, Harrington A, Liu I-UA, et al. Impact of Pulmonary Rehabilitation on Hospitalizations for Chronic Obstructive Pulmonary Disease Among Members of an Integrated Health Care System; JRCP; 35(5);356-366. Kirkham A, Pauhl K, Elliott R, et al. Utility of Equations to Estimate Peak Oxygen Uptake and Work Rate From a 6-Minute Walk Test in Patients With COPD in a Clinical Setting. JRCP; 35(6):431-438. COPD (16) 1. 2. 3. 4. 5. 6. Langer D, Charususin N, Jacome C, Hoff M, McConnell A, Decramer M, Gosselink R. Efficacy of a Novel Method for Inspiratory Muscle Training in People With Chronic Obstructive Pulmonary Disease. Phys Ther. February 2015;95:1264-1273. Nyberg A, Saey D, Maltais F. Why and How Limb Muscle Mass and Function Should Be Measured in Patients with Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. Sep 2015;12(9):1269-77. Robles PG, Sussman MS, Naraghi A, et al. Intramuscular Fat Infiltration Contributes to Impaired Muscle Function in COPD. Med Sci in Sports Exercise July 2015; 47(7):1334-1341. Zainuldin R, Mackey MG, Alison JA. Prescription of Walking Exercise Intensity From the 6Minute Walk Test in People With Chronic Obstructive Pulmonary Disease. January/February 2015; 35(1):65-69. De-Torres JP, Wilson DO, Sanchez-Salcedo P, et al. Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease. Development and Validation of the COPD Lung Cancer Screening Score. Amer J Respir Crit Care Med. 2015; 191(3):285-291. Casaburi R, Rennard SI. Exercise Limitation in Chronic Obstructive Pulmonary Disease. The O’Donnell Threshold. Amer J Respir Crit Care Med. 2015;191(8):873-875. COPD (16) 1. 2. 3. 4. 5. 6. 7. Elbehairy AF, Ciavaglia CE, Webb KA, et al. Pulmonary Gas Exchange Abnormalities in Mild Chronic Obstructive Pulmonary Disease. Implications for Dyspnea and Exercise Intolerance. Amer J Respir Crit Care Med. 2015; 191(12);1384-1394. Greening NJ, Harvey-Dunstan TC, Chaplin EJ, et al. Bedside Assessment of Quadriceps Muscle by Ultrasound After Admission for Acute Exacerbations of Chronic Respiratory Disease. Amer J Respir Crit Care Med. 2015; 192(7);810-816. Rennard SI, Locantore N, Delafont B, et al. Identification of Five Chronic Obstructive Pulmonary Disease Subgroups with Different Prognosis in the EXLIPSE Cohort Using Cluster Analysis. Ann Am Thorac Soc. 2015; 12(3); 303-312. Durheim MT, Smith PJ, Babyak MA, et al. Six-Minnute-Walk Distance and Accelerometry Predict Outcomes in Chronic Obstructive Pulmonary Disease Independent of Global Initiative for Chronic Obstructive Lung Disease 2011 Group. Ann Am Thorac Soc. 2015; 12(3):349-356. Iepsen UW, Jorgensen KJ, Ringbaek T, et al. A Systematic Review of Resistance Training Versus Endurance Training in COPD. JRCP; 35(3):163-172. Saglam M, Arikan H, Vardar-Yagli N, et al. Inspiratory Muscle Training in Pulmonary Arterial Hypertension. JRCP; 35(3):198-206. Zambom-Ferraresi F, Cebollero P, Gorostiaga E, et al. Effects of Combined Resistance and Endurance Training Versus Resistance Training Alone on Strength, Exercise Capacity, and Quality of Life in Patients with COPD. JRCP; 35(6);446-453. Orthotopic Lung Transplant (16) • Wickerson L, Mathur S, Singer LG, Brooks D. Physical Activity Levels After Early Lung Transplantation. Phys Ther. February 2015;95:517-525. • van Adrichem EJ, Reinsma GD, van den Berg S, van der Bij W, Erasmus MR, Krijnen WP, Dijkstra PU, van der Schans CP. Predicting 6-minute Walking distance in Recipients of Lung Transplantation: Longitudinal Study of 108 Patients. Phys Ther. February 2015;95:720-729. • Bain JC, Turner DA, Rehder KJ, Eisenstein EL, Davis RD, Cheifetz IM, Zaas DW. Economic Outcomes of Extracorporeal Membrane Oxygenation With and Without Ambulation as a Bridge to Lung Transplantation. Respir Care. 2015. respcare-03729. • Castleberry AW, Englum BR, Snyder LD, et al. The Utility of Preoperative Six-Minute-Walk Distance in Lung Transplantation. Amer J Respir Crit Care Med. 2015; 192(7);843-852. • Singer LG, Chowdhury NA, Faughnan ME, et al. Effects of Recipient Age and Diagnosis on Health-related Quality-of-Life Benefit of Lung Transplantation. Amer J Respir Crit Care Med. 2015; 192(8);965-973. Research/Teaching (NEW 16) 1. 2. 3. 4. 5. 6. 7. 8. 9. Harward LM, Greenwood KC, Mippins M, Canali A. Student Perceptions and Understanding of ClientTherapist Interactions Within the Inpatient Acute Care Environment: Qualitative Study. Phys Ther. February 2015;95:249-256. LeFebvre K, Wellmon R, Ferry D. Change in Attitudes Toward Interprofessional Learning and Collaboration Among Physical Therapy Students Following a Patient Code Simulation Scenario. Cardiopulm Phys Ther Journal.26(1):8-14. Ricard PEH, Cahalin LP. Cardiovascular and Pulmonary Research: They Year (2014) in Review. Cardiopulm Phys Ther Journal.26(2):42-50. Bartlo P, Brooks G, Cohen M. Toward Entry-Level Competencies in Cardiovascular and Pulmonary Physical Therapy. Cardiopulm Phys Ther Journal;26(4):99-107. Tudor-Locke C, Barreira TV, Schuna JM. Comparison of Step Outputs for Waist and Wrist Accelerometer Attachment Sites. Med Sci in Sports Exercise. April 2015; 47(4):839-842. Burchard EG, Oh SS, Foreman MG, et al. Moving toward True Inclusion of Racial/Ethnic Minorities in Federally Funded Studies. A Key Step for Achieving Respiratory Health Equality in the United States. Amer J Respir Crit Care Med. 2015; 191(5):514-521. Pinkerton KE, Harbaugh M, Han MK. Women and Lung Disease. Sex Differences and Global Health Disparities. Amer J Respir Crit Care Med. 2015; 192(1);11-16Leone FT, Evers-Casey S, Graden S, Schnoll R. Behavioral Economic Insights into Physician Tobacco Treatment Decision-Making. Ann Am Thorac Soc. 2015; 12(3):364-369. Kershaw KN, Osypuk TL, Do DP, et al. Neighborhood- Level Racial/Ethnic Residential Segregation and Incident Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis. Circulation. 2015;131:141-148. Collins GS, Reitsma JB, Altman DG, Moons KGM. Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD): The TRIPOD Statement. Circulation. 2015;131:211-219. Heart Failure (16) 1. 2. 3. 4. 5. 6. Collins S, Dias K. Year in Review- Heart Failure: Stability, Decompensation, and Readmission. Cardiopulm Phys Ther Journal.26(3):58-72. Panizzolo FA, Maiorana AJ, Naylor LH, et.al. Is the Soleus a Sentinel Muscle for Impaired Aerobic Capacity in Heart Failure. Med Sci in Sports Exercise. March 2015; 47(3):498-508. Kraljevic J, Hoydal MA, Ljubkovic M, et al. Role of KATP Channels in Beneficial Effects of Exercise in Ischemic Heart Failure. Med Sci in Sports Exercise December 2015; 47(12):2504-2512. Zamani P, Rawat D, Shiva-Kumar P, et al. Effect of Inorganic Nitrate on Exercise Capacity in Heart Failure With Preserved Ejection Fraction. Circulation. 2015;131:371-380. Pal N, Sivaswamy N, Mahmod M, et al. Effect of Selective Heart Rate Slowing in Heart Failure With Preserved Ejection Fraction. Circulation. 2015;131:1719-1725. Pandey A, Garg S, Khunger M, et al. Dose-Response Relationship Between Physical Activity and Risk of Heart Failure: Meta-Analysis. Circulation. 2015;131:1786-1794. Cardiac Rehabilitation (16) 1. 2. 3. 4. 5. 6. 7. ter Hoeve N, Huisstede BMA, Stam HJ, van domburg RT, Sunamura M, van den Berg-Emons RJG. Does Cardiac Rehabilitation After an Acute Cardiac Syndrome Lead to Changes in Physical Activity Habits? Systematic Review. Phys Ther. February 2015;95:167-179. Seeron P, Lanas F, Rios E, et al. Evaluation of the Quality of Clinical Guidelines for Cardiac Rehabilitation: A Critical Review. JRCP; January/February 2015;35(1):1-12. Pinto B, Dunsiger SI. Mediators of Exercise Maintenance After Cardiac Rehabilitation. JRCP. January/February 2015; 35(1):13-20. Ramadi A, Haennel RG, Stone JA, et al. The Sustainability of Exercise Capacity Changes in Home Versus Center-Based Cardiac Rehabilitation. JRPC. January/February 2015: 35(1):21-28. Najafi F, Nalini M. Hospital-based Versus Hybrid Cardiac Rehabilitation Program in coronary Bypass Surgery Patients in Western Iran: Effects On Exercise Capacity, Risk Factors, Psychological Factors, and Quality of Life. JRCP. January/February 2015; 35(1):29-36. Lalonde R, Poirier P, Arvisais D, Curnier D. Exercise-Induced Ischemic Preconditioning and the Potential Application to Cardiac Rehabilitation: A Systematic Review. JPRC; 35(2);93-102. Beckie T, Fletcher G, Groer M, Kip K, Ji M. Boipsychosocial Health Disparities Among Young Women Enrolled in Cardiac Rehabilitation. JRPC; 35(2):103-113. Cardiac Rehabilitation (16) 1. 2. 3. 4. 5. 6. Kowal T, Chessex C, Lee D, Grace S. Integrated Cardiovascular Rehabilitation: How Do Noncardiac And Polyvascular Disease Patients Fare? JRCP; 35(2):114-123. Sangster J, Furber S, Allman-Farinelli M, et al. Effectiveness of a PedometerBased Telephone Coaching Program on Weight and Physical Activity for People Referred to a Cardiac Rehabilitation Program: A Randomized Controlled Trial. JRCP; 35(2):124-129. Choi JH, Kim BR, Joo S, et al. Comparison of Cardiorespiratory Responses During Aquatic and Land Treadmill Exercise in Patients with Coronary Artery Disease. JRCP; 35(2):140-146. Savage P, Rengo J, Menzies K, et al. Cardiac Rehabilitation After Heart Valve Surgery: Comparison With Coronary Artery Bypass Graft Patients. JRCP; 35(4):231-237. Chamosa S, Alarcon JA, Dorronsoro M, et al. Predictors of Enrollment in Cardiac Rehabilitation Programs in Spain. JRCP; 35(4):255.262. Pack Q, Squires R, Valdez-Lowe C, et al. Employment Status and Participation in Cardiac Rehabilitation: Does Encouraging Earlier Enrollment Improve Attendance? JRCP; 35(6):390-398. Peripheral Vascular (16,NEW) 1. 2. 3. 4. 5. 6. 7. Liu Z, Tao X, Chen Y, Fan Z, Li Y. Bed rest versus early ambulation with standard anticoagulation in the management of deep vein thrombosis: a meta-analysis. PLoS One. 2015 Apr 10;10(4):e0121388. Cucato GG, Da Rocha Chehuen M, Ritti-Dias RM, et. al. Post-Walking Exercise Hypotension in Patients with Intermittent Claudication. Med Sci in Sports Exercise. March 2015;47(3):460-467. Farah BQ, Ritti-Dias RM, Cucato GG, et.al. Clinical Predictors of Ventilatory Threshold Achievement in Patients with Claudication. Med Sci in Sports Exercise. March 2015; 47(3):493497 Boss HM, Kappelle LJ, Van Der Graaf Y. et al. Physical Activity and Vascular Events and Mortality In Patients with Vascular Disease. Med Sci in Sports Exercise November 2015; 47(11):2359-2365. Tagougui S, Leclair E, Fontaine P, et al. Muscle Oxygen Supply Impairment during Exercise in Poorly Controlled Type 1 Diabetes. Med Sci in Sports Exercise. February 2015; 47(2):231-239. Rissanen A-Pe, Tikkanen HO, Koponen AS, et al. Central and Peripheral Cardiovascular Impairments Limits V*O2peak in Type 1 Diabetes. Med Sci in Sports Exercise. February 2015: 47(2):223-230. Armstrong MEG, Green J, Reeves GK, et al. Frequent Physical Activity May Not Reduce Vascular Disease Risk as Much as Moderate Activity: Large Prospective Study of Women in the United Kingdom. Circulation. 2015;131:721-729. Cardiac Potpourri (16) 1. 2. 3. 4. 5. 6. 7. 8. Jette DU, Stilphen M, Ranganathan VK, Passek S, Frost FS, Jette AM. Interrater Reliability of AMPAC “6-Clicks” Basic Mobility and Daily Activity Short Forms. Phys Ther. February 2015;95:758766. Nelson GA, McNaught-Mitchell M, Roopchand-Martin S, Gordon C. Wii Fit Plus Exercise Training for Persons With Cardiac Disease. Cardiopulm Phys Ther Journal.26(3):73-77. Schnell F, Riding N, O’Hanlon R, et al. Recognition and Significance of Pathological T-Wave Inversions in Athletes. Circulation. 2015;131:165-173. O’Donnell CJ, Beiser AS, Himali JJ, et al. Low Cardiac Index Is Associated With Incident Dementia and Alzheimer Disease: The Framingham Heart Study. Circulation. 2015;131:1333-1339. Marijon E, Uy-Evanado A, Reinier K, et al. Sudden Cardiac Arrest During Sports Activity in Middle Age. Circulation. 2015;131:1384-1391. McIlvennan CK, Eapen ZJ, Allen LA. Hospital Readmission Reduction Program. Circulation. 2015;131:1796-1803. Dougherty CM, Glenny RW, Burr RL, et al. Prospective Randomization Trial of Moderately Strenuous Aerobic Exercise After an Implantable Cardioverter Defibrillator. Circulation. 2015;131:18.5-1842. Dreyer RP, Wang Y, Strait KM, et al. Gender Difference in the Trajectory of Recovery in Health Status Among Young Patients With Acute Myocardial Infarction: Results From the Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) Study. Circulation. 2015;131:1971-1980. Critical Care (16) 1. 2. 3. 4. 5. 6. 7. Waters A, Hill K, Jenkins S, Johnston C, Mackney J. Discordance Between Distance Ambulated as Part of Usual Care and Functional Exercise Capacity in Survivors of Critical Illness Upon Intensive Care Discharge: Observational Study. Phys Ther. February 2015;95:1254-1263. Malone D, Ridgeway K, Nordon-Craft A, Moss P, Schenkman M, Moss M. Physical Therapist Practice in the Intensive Care Unit: Results of a National Survey. Phys Ther. February 2015;95:1335-1344. Sottile PD, Nordon-Craft A, Malone D, Schenkman M, Moss M. Patient and family perceptions of physical therapy in the medical intensive care unit. J Crit Care. May 2015;pii.S08839441(15)00266-X. Cottereau G, Dres M, Avenel A, Fichet J, Jacobs FM, Prat D, Hamzaoui O, Richard C, Antonello M, Sztrymf B. Handgrip Strength Predicts Difficult Weaning But Not Extubation Failure in Mechanically Ventilated Subjects. Respir Care. Aug 2015;60(8):1097-1104. Sommers J, Engelbert RHH, Dettling-Ihnenfeldt D, Gosselink R, Spronk PE, Nollet F, van der Schaaf M. Physiotherapy in the intensive care unit: an evidence-based, expert driven, practical statement and rehabilitation recommendations. Clin Rehabil. Feb 2015. 0269215514567156. Parry SM, Granger CL, Berney S, Jones J, Beach L, El-Ansary D, Koopman R, Denehy L. Assessment of impairment and activity limitations in the critically ill: a systematic review of measurement instruments and their clinimetric properties. Intensive Care Med. May 2015;41(5):744.62 Connolly B. MacBean V, Crowley C, Lunt A, Moxham J, Rafferty GF, Hart N. Ultrasound for the assessment of peripheral skeletal muscle architecture in critical illness: a systematic review. Crit Care Med. Apr 2015;43(4):897-905. Critical Care (16) 1. 2. 3. 4. 5. 6. Dirks ML, Hansen D, Van Assche A, Dendale P, Van Loon LJ. Neuromuscular electrical stimulation prevents muscle wasting in critically ill comatose patients. Clin Sci (Lond). Mar 20`5;128(6):357-365. Collings N, Cusack R. A repeated measures, randomised cross-over trial, comparing the acute exercise response between passive and active sitting in critically ill patients. BMC Anesthesiol. Jan 2015;15:1. Peterson ML. The Impact of Low Hemoglobin on the Percentage of Adverse Events During Physical Therapy in the Acute Care Setting: A Retrospective Study. JACPT. April 2015;6(1):29-34. Fields C, Trotsky A, Fernandez N, Smith BA. Mobility and Ambulation for Patients With Pulmonary Artery Catheters: A Retrospective Descriptive Study. JACPT. August 2015;6(2):64-70. Felten-Barentsz KM, Haans AJC, Slutsky AS, et al. Feasibility and Safety of Hydrotherapy in Critically Ill Ventilated Patients. Amer J Respir Crit Care Med. 2015;191(4):476-477. Goligher EC, Fan E, Herridge MS, et al. Evolution of Diaphragm Thickness during Mechanical Ventilation. Impact of Inspiratory Effort. Amer J Respir Crit Care Med. 2015; 192(9);1080-1088. Cardiac Surgery (16 NEW) 1. 2. 3. 4. 5. 6. 7. 8. Humphrey R, Malone D. Effectiveness of Preoperative Physical therapy for Elective Cardiac Surgery. Phys Ther. February 2015;95:160-166. Wilson CM, Kostsuca SR, McPherson SM, Warren MC, Seidell JW, Colombo R. Preoperative 5Meter Walk Test as a Predictor of Length of Stay After Open Heart Surgery. Cardiopulm Phys Ther Journal.26(1):2-7. Shumock KM, Appel J, Toonstra A. Axillay Intra-Aortic Balloon Pump Placement as a Means for Safe Mobility in a Patient Awaiting Left Ventricular Device Implantation: A Case Report. Cardiopulm Phys Ther Journal.26(3):53-57. Smulter N, Lingehall HC, Gustafson Y, Olofsson B, Engstrom KG. Patients Validation of the Confusion Assessment Method in Detecting Postoperative Delirium in Cardiac Surgery. Am J Crit Care. 2015 Nov;24(6):480-487. Ciolac EG, Castro RE, Greve JM, et al. Prescribing and Regulating Exercise with RPE after Heart Transplant: A Pilot Study. Med Sci in Sports Exercise. July 2015; 47(7):1321-1327. Albany K, Bibi KW, Greenwood KC. Walking Speed Difference Following Open Heart Surgery Vary With Discharge Destination. JACPT. August 2015;6(2):56-63. Kilic A, Higgins RSD, Whitcon BA, Kilic A. Racial Disparities in Outcomes of Adult Heart Transplantation. Circulation. 2015;131:882-889. Wasfy JH, Borden WB, Secemsky EA, et al. Public Reporting in Cardiovascular Medicine: Accountability, Unintended consequences, and Promise for Improvement. Circulation. 2015;131:1518-1527. Cardiovascular & Pulmonary Potpourri 1. 2. 3. 4. 5. 6. Liao L-R, Ng GYF, Jones AYM, Pang MYC. Cardiovascular Stress Induced by WholeBody Vibration Exercise in Individuals With Chronic Stroke. Phys Ther. February 2015;95:966-977. Falvey JR, Crankshaw A. Application of ICF Model to a Patient With Home Mechanical Ventilation: A Case Report With 1-Year Follow-up. Cardiopulm Phys Ther Journal.26(1):15-21. Irons S, Brusola GA, Buster TW, Burnfield JM. Novel Motor-Assisted Elliptical Training Interventino Improves 6-Minute Walk Test and Oxygen Cost for an Individual With Progressive Supranuclear Palsy. Cardiopulm Phys Ther Journal.26(2):36-41. Cohen S, Nathan JA, Goldberg AL. Muscle wasting in disease: molecular mechanisms and promising therapies. Nat Rev Drug Disc. Jan 2015;14(1):58-74 Fournier S, Donley DA, Bonner DE, Devallance E, Olfert IM, Chantler PD. Improved Arterial-Ventricular Coupling in Metabolic Syndrome after Exercise Training: A Pilot Study. Med Sci in Sports Exercise. Jan 2015;47(1):2-11. Malenfant S, Potus F, Mainguy V, et al. Impaired Skeletal Muscle Oxygenation and Exercise Tolerance in Pulmonary Hypertension. Med Sci in Sports Exercise November 2015; 47(11):2273-2282. Cardiovascular & Pulmonary Potpourri 1. 2. 3. 4. 5. Keyser RE, Woolstenhulme JG, Chin LMK, et al. Cardiorespiratory Function Before and After Aerobic Exercise Training in Patients With Interstitial Lung Disease. January/February 2015; 35(1): 47-55. Vainshelboim B, Fox D, Saute M, et al. Limitations in Exercise and Functional Capacity in Long-Term Postpneumonectomy Patients. January/February 2015; 35(1):56-64. Degens H, Gayan-Ramirez G, van Hees HWH. Smoking-induced Skeletal Muscle Dysfunction. From Evidence to Mechanisms. Amer J Respir Crit Care Med. 2015:191(6):620-625. Ramani M, Bradley WE, Dell-Italia LJ, Ambalavanan N. Early Exposure to Hyperoxia or Phyoxia Adversely Impacts Cardiopulmonary Development. Amer J Respir Cell Mol Biol. 2015; 12(5):594-602. Lee AL, Cecins N, Holland AE, et al. Field Walking Tests Are Reliable and Responsive to Exercise Training in People With Non-Cystic Fibrosis Bronchiectasis. JRCP; 35(6);439-445.