Mitosis
Mitosis is the process in which
the nucleus divides to form two
new nuclei. What disease is
mitosis gone wild?
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1
CANCER
In cancer, cells divide and grow uncontrollably,
forming malignant tumors, and invade nearby
parts of the body.
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4
Cancer Video
 Cancer Video 2

How do little elephants grow up to be BIG
elephants?
Your life begins after a
sperm fertilizes an egg,
and you are smaller than a
period in a newspaper
.
Animal Mitosis -- preview
Interphase
Prophase
Metaphase
Anaphase
Telophase
Cytokineses
Animated Mitosis Cycle
http://www.cellsalive.com/mitosis.htm
• Interphase
• Prophase
• Metaphase
• Anaphase
• Telophase
• Cytokinesis
Chromosomes are replicated (amount of
DNA doubles)
• Chromosomes appear as threadlike coils
(chromatin)
•
Nucleus
CELL
MEMBRANE
Cytoplasm
Animal Cell
Plant Cell
Photographs from: http://www.bioweb.uncc.edu/biol1110/Stages.htm
•
•
•
Chromatin condenses into chromosomes
Centrioles (or poles) appear and begin to
move to opposite end of the cell of animal
cells.
Spindle fibers form from centrioles.
Centrioles
Sister chromatids
Spindle fibers
Animal Cell
Plant Cell
Spindle fibers
Photographs from: http://www.bioweb.uncc.edu/biol1110/Stages.htm
Chromosomes line up along the metaphase
plate
• Spindle fibers attach to the centromeres of
each chromosome
•
Centrioles
Spindle fibers
Animal Cell
Plant Cell
Photographs from: http://www.bioweb.uncc.edu/biol1110/Stages.htm
•
Sister chromatids pulled apart by shortening
spindle fibers.
Centrioles
Spindle fibers
Animal Cell
Plant Cell
Photographs from: http://www.bioweb.uncc.edu/biol1110/Stages.htm
Nuclear membranes form around
chromosomes.
• Mitosis ends.
•
Nuclei
Chromatin
Nuclei
Animal Cell
Plant Cell
Photographs from: http://www.bioweb.uncc.edu/biol1110/Stages.htm
•
Cell membrane moves inward to create two
daughter cells – each with its own nucleus
with identical chromosomes.
Plant Mitosis -- Review
Interphase
Prophase
Metaphase
Anaphase
Telophase
Cytokinesis
Interphase
Prophase
Metaphase
IPMATC
Anaphase
Telophase
Cytokinesis
I Pay Money At The Cashier
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Confused?
Here are links to fun resources that
further explain mitosis:
Mitosis, kinetochore animation video (WEHI Movies)
 Mitosis Main Page on the Virtual Cell Biology Classroom of

Science Prof Online.

“Imitosis” music video by Andrew Bird.

DNA Replication

Mitosis & Cytokinesis animated video by McGraw-Hill.

Mitosis animation, step-through and quiz, Sadava, et al., Life: The

Mitosis step through animation from CellsAlive.com.

“That Spells DNA” song by Jonathan Coulton.
step-through animation by John Kyrk.
Science of Biology, 9th Edition, Sinauer Associates.
(You must be in PPT slideshow view to click on links.)
From the Virtual Cell Biology Classroom on ScienceProfOnline.com