Structured Clinical Scenarios in Penile/ Scrotal Trauma Matthew Liew Milan Thomas Ann Crump June 2014 Thanks to Arie Parnham and Ben Grey Overview Traumatic injuries of the genitourinary tract are seen in 2-10% of patients admitted to hospitals Of these 30-60% are associated with injuries to the external genitalia Males>Females Anatomical differences Increased environmental risk Most common 15-40 years old (5% <10 yrs old) 70% have associated injuries Risk Factors Sports Off-road cycling In-line hockey skating Rugby Psychiatric patients Blunt Trauma Penile 60% during intercourse Rare in flaccid penis as tunica 2mm (erect: 0.25mm) Scrotal Rupture- 50% Need 50kg of force Testicular dislocation- rare Penetrating Trauma Associated with complex injuries of other organs. Always consider tetanus Missiles Trauma/ extent of injuries in guns related to calibre and velocity of missile Low velocity High velocity 200-300 m/s permanent cavity 800-1000m/s temporary cavity +permanent cavity and tissue vapourisation Penetrating Trauma Animal bites Rare Dog Pasturella Multicida 50% Also E.coli, Strep viridans, Staph aureus and Bacteroides Treatment Augmentin followed by doxycycline, cephalosporin/ erythromycin for 10-14 days local wound management Clean with warm running water/disinfectant, conservative debridement in the scrotum Consider rabies treatment • human rabies immunoglobulin & human diploid cell vaccine Penetrating Trauma Human Bites Rare Streptococci, Staphylococcus aureus, Haemophilus spp., Bacteroides spp Treatment Although transmission rare consider HIV, Hep B/C and appropriate prophylaxis Wound management Augmentin/ clindamycin Diagnosis ATLS protocol (not in the scope of this talk) Thorough history Consider abuse (genital injury is seen frequently after sexual abuse) If weapon, is it: Close/far range Calibre Type of weapon Physical examination Gynaecological examination Investigations Urinalysis If haematuria Male Retrograde urethrogram Female Cystoscopy Investigations Penile Fracture MRI may be useful Blunt testicular trauma USS with a high resolution probe (7.5MHz or greater) Accuracy 56%-94% some studies show poor specificity 78% and sensitivity 28% for differentiating rupture Colour doppler-duplex may provide useful information on testicular perfusion In case of inconclusive USS CT/MRI Investigations Blunt female genital trauma USS/CT/MRI as additional injuries and extensive intra-pelvic haematoma frequently found Penetrating genital trauma urethrography irrespective of urinalysis Female may need laparotomy Associated pelvic or abdominal injury (usually) require CT. CT cystography should be performed in pelvic injuries associated with non-visible haematuria Male Treatment Blunt Penile Trauma Penile fracture Absorbable/non-absorbable sutures ASAP gives good long-term outcome and potency Post op complications 9% Wound infection and impotence 1.3% Conservative management NOT recommended Increases risk of penile abscesses, missed urethral disruption, persistent haematoma, fibrosis and angulation 35% and impotence 62% Orvis and McAninch. Penile rupture. 1989 Treatment Blunt Testicular Trauma Haematocoeles <3x size of contralateral testis conservative management >3x size of contralateral testis with or without rupture Delayed surgery >3days higher rate of orchidectomy even in non-ruptured Prolonged hospital stay Early surgery gives >90% preservation If tunica (‘testicular’) rupture exploration and excision of necrotic tubular tissue and closure of tunica (Vicryl). High rate of testicular preservation and normal endocrine function Treatment Blunt Testicular Trauma Extensive disruption of tunica albuginea Mobilisation of free tunica vaginalis flap for testis closure If unable to reconstruct then orchidectomy Traumatic dislocation Rare (usually MVA) Manual replacement and secondary orchidopexy unless unable to manually reposition then primary orchidopexy Complete disruption of cord Realignment without vaso-vasotomy Staged secondary microsurgical vaso-vasostomy after rehab (only few case reports) Treatment Penetrating Penile Trauma Surgical exploration with conservative debridement of non- viable tissue Primary reconstruction where possible Prophylactic abx although evidence poor Superficial injuries with intact Buck’s fascia Conservative management Extended injuries of penis Primary alignment In non-alignable tissue then split-thickness graft of at least 0.4mm to reduce contraction See Viva questions Case 1 Penile Fracture presents at 2am Case 1 28 male Sudden onset of penile pain swelling and bruising preceded by popping noise and immediate loss of erection What else do we want to know? Case 2 When did it happen? 6hrs ago How did it happen? Rigid penis slipped out of vagina hitting the mons pubis of female partner Has he passed urine yet? Is he in retention? No and No What Next? Case 2 Patient underwent immediate surgery with no further investigation as signs of complex penile trauma were obvious Anything you would do differently? Urethrogram A Foley catheter (8 to 16 French) is inserted into the fossa navicularis, and the balloon is inflated with 1 to 2 mL.Thirty to 50 percent aqueous contrast solution is gently injected while films are obtained. The patient is typically positioned 300 obliquely, to allow visualization of the entire urethra. Findings After penile degloving and NVB mobilization, a very large ventral albuginea tear involving both cavernosal bodies with urethral rupture is seen After urethral mobilization, complete urethral rupture is obvious Now What? What happened Buccal mucosa graft is used both to cover the cavernosal defect and to augment urethral anastomotic repair as a dorsal roof Remaining cavernosal defect is grafted with saphenous vein Penile Fracture Disruption of the tunica albuginea with rupture of the corpus cavernosum. Usually occurs during vigorous sexual intercourse as penis slips out of vagina and strikes the perineum or pubic bone (faux pas du coit) Taghaandan most common cause in Middle East Tunica made from bilaminar structure (inner circular, outer longitudinal). The outer layer determines the strength and thickness. Tunica can resist rupture up to 1500mmHg. Diagnosis Can be made more often than not through history and examination. Buck’s fascia intact penile haematoma is contained between skin and tunica. Buck’s fascia disrupted haematoma in perineum, scrotum and suprapubically. The phallus deviates to the opposite side of the tunical tear because of haematoma and mass effect Rolling sign blood clot felt against the fracture site Concomitant injury 20% of fractures have urethral injury Associated with visible haematuria, blood at the meatus, inability to void. Given that urethral injury occurs not infrequently and that urethrography is a simple and reliable study, clinicians should have a low threshold for urethral evaluation in all cases Imaging MRI to be used in atypical presentation. Management Prompt exploration Distal circumcising incision Closure of tunical defect with interrupted 2-0/3-0 absorbable sutures. Partial urethral injury should be oversewn with fine absorbable suture over a urethral catheter Complete urethral injuries should be debrided, mobilised and repaired tension free over a catheter 1 month sexual abstinence Outcomes and Complications Immediate reconstruction <8hrs Faster recovery Reduced morbidity Lower complications Lower incidence of long-term penile curvature Summary Clinical diagnosis in most part MRI imaging of choice if diagnosis in dispute Suspect urethral injury Early repair essential Case 2 24 year old male presents with amputated penis in a bag of ice and psychiatric nurse in tow Known Schizophrenic Hasn’t been taking antipsychotic medications Smells of alcohol Matthew 18:9 And if your eye causes you to stumble, gouge it out and throw it away. It is better for you to enter life with one eye than to have two eyes and be thrown into the fire of hell. What is the initial management? What to do with the penis?? Initial assessment and Treatment Airway C-spine Breathing Circulation Disability Exposure Clear Clear RR 25, O2 sats 95%, Bilateral equal air entry Cool peripheries, Cap refill 4 sec, BP 100/50 AVPU, GCS 14/15, PEARL Penis amputated. Actively bleeding What to do with the penis? The amputated penis must be regarded as a free flap. Survival with cold ischaemia 6-24hrs Patient stabilises and with pressure bleeding slows but doesn’t stop What next? See Viva questions Penile Anatomy Tell me about the blood and nerve supply to the penis (both skin, urethra and erectile tissue) Penile Reimplantation Patient to be well hydrated and warm to keep peripherally vasodilated 2 layer spatulated urethral anastomosis over catheter Urethral urothelium polyglycolic acid sutures PETCRYL(synthetic absorbable monofiliament) Corpus spongiosum PDS Erectile bodies are coaptedPDS Structures to be re-anastomosed are Dorsal arteries11-0 nylon Deep dorsal vein10-0 nylon Dorsal nerves Epineurium 10-0 nylon Catheter removed and soft silicone silastic stent placed SPC Bed rest 1 week SPC 2-3 weeks Penile re- implantation If no microsurgical capability then macroscopic anastomosis of the urethra and corporal bodies can be performed with good erectile results albeit with reduced sensation and greater skin loss Penile Amputation Most evidence is poor level III or IV Western cultures most common cause is psychiatric illness or assault. Many of those psychiatric patients have domineering older mother with no father figure. Klingsor syndrome god or messenger telling the to amputate penis. Often do it on notion that promised great things denied the individual because of sexual thoughts/indiscretion Summary Stabilise patient Consider mental health issues particularly consent Transfer to centre with microsurgical abilities Case 3 38 year old Persistent painful erection for 8 hours What would you ask for in the history? Risk factors for priapism? Case 3 History Time of onset- 8 hrs No sexual stimulation for 6 hours No trauma playing football trauma to perineum Well in the evening ‘Woke up with erection that wouldn’t settle’ PMHx No previous episodes FHx No sickle cell, haematological malignancies or bleeding dyscrasias Case 3 History: Duration Association with pain- severity Previous history Risk factors sickle cell or cancer Medications: viagra, injections, some antipsychotics Illicit drugs e.g. cocaine, marijuana, ETOH XS Trauma (pelvic/genital or perineal): e.g. bicycle Neurological: SCI, anaesthesia, or cauda equina Infection: mycoplasma (hypercoagualable), malaria Rare: black widow spider bite, CO poisoning Case 3 What are the features on examination? How would you investigate priapism? Case 3 What are the features on examination? Erect or semierect penis. Ventral glans or corpus spongiosum rarely rigid Look for features or underlying cause Piesus sign: perineal compression in young children causes immediate detumescence in high flow How would you investigate priapism? FBC – rare cause leukaemia ABG of cavernous to differentiate high and low flow If similar to venous blood then usually low flow. Imaging? Colour flow penile doppler Case 3 How do you manage priapism? Priapism. Corporeal relaxation causes external pressure on the emissary veins exiting the tunica albuginea, trapping blood in the penis and causing erection. Case 3 How do you manage priapism? Conservative measures Aspiration/injection of corpus cavernosum Penile nerve block e.g. 1% lignocaine 19G needle to large syringe into cavernosum Where do you puncture? Aspirate 20-30mls only need to aspirate from one side 30% success If successful, place bandage around penis to ensure continued emptying and compression May need instillation of phenylephrine Dilute solution of phenylephine 100μg (alpha adrenergic sympathomimetic) injected into corpus cavernosum and then aspirate every 10 minutes What is the diagnosis? What next? What issues need to be discussed? Case 3 Diagnosis?: Ischaemic Priapism What needs to be discussed?: Risk of future erectile dysfunction What next?: Analgesia Penile block 0.25% marcaine without adrenaline ABG PH 6.95, pO2 10, pCO2 80 Aspiration Dark blood slowly evacuated What next? What is the maximum dose you can give? What are the side effects? What monitoring is advised and in who? What ways can irrigation be achieved? What is the success rate? Case 3 What is the maximum dose you can give? 1000 μg What are the side effects? Hypertension, tachycardia, palpitations, headache, arrhythmia, sweating What monitoring is required and in who? BP and ECG in those with high cardiovascular risk What is the success rate with irrigation and irrigation with phenylephinerine Success rate 30%, 81% Case 3 What ways can irrigation be achieved? IN OUT Max irrigation but more haematoma risk IN OUT Less haematoma. Prepares for further procedure. Case 3 Although some improvement still in pain and erection still not resolving What next? Case 3 Surgical Shunt Ebbehoj shunt performed Following day the patient had very little pain, and his penis was full but not rigid. A duplex ultrasound was performed Peak systolic velocity- 36cm/s 1 week later he was pain free and swelling resolved. Repeat duplex Peak systolic velocity- 25cm/s 6 months later no further episodes of priapism, moderate ED controlled with PDE5 inhib MCQ- Genital trauma External genitalia accounts for 33-66% of urological injuries Genital trauma is more common in females Commonest age group is between 15-40 years Blunt scrotal and testicular trauma is bilateral in 5-10% Penetrating injuries account for 20% of genitourinary trauma MCQ- Genital trauma External genitalia accounts for 33-66% of urological injuries T Genital trauma is more common in females F Commonest age group is between 15-40 years T Blunt scrotal and testicular trauma is bilateral in 5-10% F (1%) Penetrating injuries account for 20% of genitourinary trauma T Genital Trauma: Background 33-66% of all urological involve external genitalia Commonest in male between 15-40 years 80% caused by blunt injuries Only 1% of scrotal/ testicular injuries are bilateral Genital Trauma: general principles All should have urinalysis: any haematuria requires retrogrades in male Cystoscopy recommended in female Bites: Rare in external genitalia Pasturella infections account for 50%. Recommend co-amoxiclav 10-14days Consider rabies Sexual assault Often seen after sexual abuse Usually need gynae and forensic support and advice Send swabs for spermatozoa Local protocol Thorough history and examination (+/- EUA) EAU 2014 guidelines Case 4 22 year old male Riding a bike fell onto handle bars Presents with Severe testicular pain Scrotal swelling Nausea 62 Case 4 History Mode of injury / velocity / PMH Other injury ATLS - priority to: airway with cervical spine control breathing circulation Followed by secondary survey - examination from head to toe. 63 Case 4 Urinalysis – consider urethral trauma Primary goal is to establish if tunica albuginea intact. Testis can withstand up to 50Kg pressure before rupture May reveal Ecchymosis Tenderness swelling 64 Case 4 Scrotal USS essential if testis cannot reliably be examined 65 Case 4 Rupture of tunica albuginea surgical exploration with excision of necrotic testicular tubules and closure of the tunica. This guarantees a high rate of testicular preservation and normal endocrine function. Antibiotics Goal of treatment is to maintain endocrine function 66 See Viva questions What are the features of acute epididymitis? Tell me about possible causes. How do you assess and treat such cases? Words of wisdom from my ancestors....