The Promise of Preconception Care in Prevention of Birth Defects and Preterm Births Dr Neena Raina Regional Advisor Child and Adolescent Health WHO-SEARO WHO - SEARO 1 Structure of presentation 1. What is Pre-conception Care 2. Do we have evidence based interventions 3. Why is it important in SEAR 4. Opportunities for introducing it in SEAR 5. “Healthy Transitions” for Adolescents 6. Way forward WHO-SEARO 2 1.What is Pre-conception Care WHO-SEARO 3 Pre-pregnancy health status and health behaviors have direct or indirect implications for maternal and neonatal outcomes • Intervening after a woman is pregnant has limited impact: – First few weeks after conception are critical for fetal development • Week 5: brain, spinal cord, heart begin to form • Week 6: Neural tube closes; the heart is pumping • Week 7: Brain and face are rapidly developing • Most women do not seek prenatal advice/care before 12 weeks when it is too late to modify many risks Intervening during pregnancy is too late for many interventions Many health risk behaviours are initiated during adolescence WHO-SEARO 4 Modifiable risk factors are common to several “congenital conditions” Malformations Preterm Birth IUGR Nutrition status X X X Insufficient folic acid/vitamin X X X Smoking X X X Alcohol use / abuse X X X X Illicit drugs X X X X Obesity X X X Diabetes - getsational X X X Infectious diseases X X X X Selected medications X X X X X X Risk factor Psycho-social stressors Environment and working activity Developm. disability X X X X ICBDSR presentation in Regional Meeting 2012 WHO-SEARO 5 Modifiable risks for birth defects and prematurity that need to be addressed before conception • Undernutrition and anaemia • Folic Acid insufficiency • Obesity • Diabetes • Hypertension • Epilepsy • Alcohol use • Age at pregnancy • Too close and too many pregnancies • Infections: TORCH • Use of medications during early pregnancy • Exposure to toxins • Exposure to tobacco WHO-SEARO Many risk factors are initiated during adolescence 6 Pre-Conception Care • Preconception care is the provision of biomedical, behavioral and social health interventions to women and couples before conception occurs. Aims: • Improving health status and reducing behaviors and individual and environmental factors to improve maternal and child health outcomes. Boundary: the period before pregnancy may be divided into a proximal and a distal period: Proximal period immediately preceding pregnancy Distal adolescence (10-19 years) WHO-SEARO 7 Life course – when to intervene? 2.Do we have evidence based interventions WHO-SEARO 9 Gathering evidence: Global consultation Global consultation in WHO Headquarters, Geneva - February 2012 Meeting to develop a global consensus on preconception care to reduce maternal and childhood mortality and morbidity Three questions were answered: 1. What are the health problems, risk behaviours and risk factors contributing to maternal and childhood mortality and morbidity? 2. What are the effective interventions to address them? 3. What are the effective means of delivering these interventions? Gathering evidence: Existing reviews Using existing evidence and reviews from: • The Centers for Disease Control and Prevention • Erasmus University • Aga Khan University • Health Council of the Netherlands Evidence for Pre-Conception Care Recommendations to Improve Preconception Health – United States by the Centers for Disease Control and Prevention (2006) Systematic Review of Preconception Evidence by the Aga Khan University in Karachi, Pakistan (2011) WHO-SEARO 13 Gathering evidence: WHO departments Consultation with various relevant WHO departments: • Maternal, Newborn, Child and Adolescent Health • Reproductive Health and Research • Nutrition for Health and Development • HIV • Mental Health and Substance Abuse • Immunization, Vaccine and Biologicals • Public Health and Environment • Tobacco-Free Initiative • Violence and Injury Prevention • Partnership for Maternal, Newborn and Child Health Strength of evidence • • • There is growing experience in implementing preconception care initiatives: In high-income countries, such as Italy, the Netherlands and the United States In low- and middle-income countries, such as Bangladesh, the Philippines and Sri Lanka Preconception care has a positive effect on a range of health outcomes child mortality maternal mortality birth defects Reduced too early pregnancy Reduced abortion preterm birth congenital and neonatal infections cretinism Improved mental health Improved mother nutritional status macrosomia childhood cancers vertical transmission of HIV/STIs diarrhoea Low birth weight Underweight and stunting hypothyroidism Tobacco use and youth health: a potential for Healthy Transitions 5 million deaths in 2005 10 million deaths in 2020 20 y.o. 90% of adult smokers are estimated to have started smoking before age 20 years Exposure to environmental toxins in early life and its long term effect cigarette smoking during pregnancy reduced birth weight or increased risk of lower birth weight offspring obesity eliminating smoking before or during pregnancy could avoid 5–7% of preterm related deaths and 23–24% of cases of sudden infant death syndrome Areas addressed by preconception care package WHO-SEARO 19 Evidence-based interventions: Selected examples Area addressed by the preconception care package Nutritional conditions Evidence-based interventions • • • • • • • • • • • Screening for anemia Supplementing iron and folic acid Information, education and counselling Monitoring nutritional status Supplementing energy- and nutrient-dense food Screening for diabetes mellitus Management of diabetes mellitus Counselling people with diabetes mellitus Monitoring blood glucose (also in pregnancy) Promoting exercise Salt iodization WHO-SEARO 20 Evidence-based interventions: Selected examples Areas addressed by the preconception care package Genetic conditions Evidence-based interventions • • • • • • • • • Screening for anemia Taking a thorough family history Family planning Genetic counselling Carrier screening and testing Appropriate treatment Providing community-based education Community-wide or national screening among populations at high risk Population-wide screening WHO-SEARO 21 Evidence-based interventions: Selected examples Areas addressed by the preconception care package Too-early, unwanted and rapid successive pregnancy Evidence-based interventions • • • • • • • • • • Keeping girls in school Influencing cultural norms that support early marriage and coerced sex Creating visible, high-level support for pregnancy prevention programmes Educating girls and boys about sexuality, reproductive health and contraceptive use Building community support for preventing early pregnancy and for contraceptive provision to adolescents Enabling adolescents to obtain contraceptive services Empowering girls to resist coerced sex Engaging men and boys to critically assess norms and practices regarding gender-based violence and coerced sex Educating women and couples about the dangers to the baby and mother of short birth intervals Providing contraceptives WHO-SEARO 22 3.Why Preconception care is important in SEAR WHO-SEARO 23 MDG 5 Indicators-SEAR Countries Unmet Births Post ANC (%) Need by natal SBA CPR for caesare within 2 Countries At (%) (%) family an days of planning least 1 Atleast section child 1990 2000 2010 visit 4 visits (%) birth (%) (%) BAN 800 400 240 31 61 12 50 26 17 27 BHU 1000 430 180 58 66 12 74 77 12 MMR (per 100 000 live births) KRD IND INO MAV MMR NEP SRL THA TLS 97 600 600 830 520 770 85 54 120 390 340 190 300 360 58 66 81 200 220 60 200 170 35 48 100 58 80 95 71 36 99 99 94 50 82 85 43 50 93 80 13 8 7 32 48 70 67 27 7 3 100 75 93 99 83 58 99 99 55 61 35 46 50 68 80 21 13 29 5 24 45 71 1000 610 300 30 22 32 84 55 2 25 Source: World Health Statistics 2013 The Region is not likely to reach MDG4 Child Mortality in SEA Region in 2012 (UN-IGME Report 2013) Decline in NMR has been slower 140 120 118 100 80 81 77 60 50 39 44 40 27 MDG Target 36 20 0 1990 1995 2000 U5MR IMR 2005 NMR WHO-SEARO 2012 2015 MDG Target 25 Newborn mortality remains high in SEAR • Responsible for 54% of under-five deaths • Three congenital conditions: Prematurity, Birth Asphyxia and Birth Defects account for 35-55% of under-5 mortality • These causes of mortality share many risk factors WHO-SEARO 26 90.0 60% 80.0 50% 70.0 60.0 40% 50.0 30% 40.0 30.0 20% 20.0 10% 10.0 0.0 Distribution of causes of deaths (%) Under-5 mortality rate (per 1,000 births) Prematurity, Birth Asphyxia and Birth Defects account for 35% (Myanmar) to 55% (Thailand) of under-5 mortality 0% Birth defects Prematurity Birth asphyxia Under-5 mortality rate Source: World Health Statistics 2011 http://www.who.int/whosis/whostat/2011/en/index.html WHO-SEARO 27 Estimates of Birth Defects in SEAR Birth Defects prevalence / 1000 live births 66 64.3 64 62.2 62 60 60.8 59.9 59.3 58.6 60.3 59.9 58.5 58.4 58 56 54.1 54 52 50 Le st e nd Ti m or Th ai la an ka Sr iL ep al N ya nm ar M al di ve s M In do ne si a PR In di a Ko re a n hu ta B D B an gl ad es h 48 March of Dimes Global Report on Birth Defects (2006) WHO-SEARO 28 28 Birth Defects Situation Analysis: WHO-SEARO and US-CDC WHO-SEARO Estimates of Pre Term Births Born Too Soon Report: 2012 WHO-SEARO 30 Eleven countries with PT birth >15% by Rank Born Too Soon Report: 2012 WHO-SEARO 31 4.Preconception Care in SEAR Twin track: • Pre- and Inter-pregnancy care: Maternal Health • Healthy Transitions for adolescents: Adolescent Health WHO-SEARO 32 Is there a gap in Continuum of Care? • Healthcare provided across the lifecycle through strong public health programs can ensure that all women and babies are healthy • There is a gap in the continuum of care for adolescent girls (and boys) and women before pregnancy. 33 Family/community Outreach/outpatient Clinical Strengthening pre-conception care in the RMNCAH Continuum •Screening and management of chronic diseases especially diabetes •Genetic counselling • Multivitamin and folic acid supplementation • Family planning • Youth development programs EMERGENCY NEWBORN AND CHILD CARE CHILDBIRTH CARE -Post-abortion care - STI case management – Emergency obstetric care – Skilled obstetric care and immediate newborn care (hygiene, warmth, breastfeeding) and resuscitation – PMTCT ANTENATAL CARE - Hospital care of newborn and childhood illness including HIV care - Extra care of preterm babies including kangaroo mother care - Emergency care of sick newborns POSTNATAL CARE - Promotion of healthy behaviors - 4-visit focused ANC package - Early detection of and referral for illness - IPTp and bednets for malaria - Extra care of LBW babies - PMTCT - PMTCT • Prevention of obesity • Optimising Adolescent and pre-pregnancy nutrition • Health education and counseling on risk factors prevention INTERSECTORAL Pre-pregnancy - Counselling and preparation for newborn care, breastfeeding, birth and emergency preparedness Healthy home care including: - Newborn care (hygiene, warmth) - Nutrition including exclusive breastfeeding and appropriate complementary feeding - Seeking appropriate preventive care - Danger sign recognition and careseeking for illness - Oral rehydration salts for prevention of diarrhoea - Where referral is not available, consider case management for pneumonia, malaria, neonatal sepsis - Where skilled care is not available, consider clean delivery and immediate newborn care including hygiene, warmth and early initiation of breastfeeding Improved living and working conditions – Housing, water and sanitation, and nutrition education and female empowerment Pregnancy WHO-SEARO Birth 34 Pre-pregnancy care for prevention birth defects Life course Continuum 10-19 Ado Health Infancy U5 CH Immunization Birth Newborn Care Neonatal period SBA ANC PCC Pre-Pregnancy Pregnancy Interventions to address MH risk factors for BD and PT births WHO-SEARO 35 Sri Lanka Package for newly married couples Goal: To have improved reproductive health outcomes by improving the health of the newly married couples. WHO-SEARO 36 Package for newly married couples • RISK SCREENING • CLINICAL ASSESSMENT • IMMUNIZATION • AWARENESS AND COUNSELLING • PROVISION OF OTHER SERVICES WHO-SEARO 37 TOOLS IN THE PACKAGE • INVITATION CARD • SCREENING TOOL • GUIDE FOR HEALTH WORKERS • BOOK FOR THE NEW COUPLE • BMI CALCULATOR WHO-SEARO 38 SCREENING TOOL • Screen for risk factors by using the screening tool by PHM/MOH • Basic investigations • Physical assessment by PHM • Height, weight and BMI • Clinical examination by MOH • Refer for further diagnosis /treatment/ for specialized care • Follow up WHO-SEARO 39 Book for the New Couple ♣ SEXUALITY AND SEXUAL RELATIONSHIP ♣ SEXUALLY TRANSMITTED DISEASES AND RESPONSIBLE SEXUAL BEHAVIOUR ♣ A PLANNED FAMILY ♣ GOOD NUTRITION ♣ GOOD HEALTH HABITS/ HEALTHY BEHAVIOUR/ HEALTHY LIFE STYLE ♣ GOOD MARITAL RELATIONSHIP AND WELL BEING OF THE FAMILY ♣ BENEFITS OF NON VIOLENCE ♣ BEFORE CONCEPTION ♣ MALE PARTICIPATION AND PARENTHOOD ♣ TOBACCO AND ALCOHOL WHO-SEARO 40 5.Many health risk behaviours are initiated during adolescence: Need to catch them young “Healthy Transitions” WHO-SEARO 41 Large number of adolescents in SEAR with many health problems Adolescents in SEAR Proportion of adolescents (10-19) • Sexual and reproductive health problems • Nutritional problems • Substance use: Tobacco, alcohol 1.2 billion adolescents (10-19) globally About 350 Millions in SEAR of which 230 million in India • Injuries, accidents and violence • Mental health problems Source: World population prospects: The 2006 Revision PopulationWHO-SEARO Database. 42 Health problems start during Adolescent period • Age parameter: 10-19 years • Confounding factors: – Biological: Early or late onset of puberty – Social-cultural factors • Experiencing rapid growth and development: – – – – – Physical: Body image and form Sexual: Reproductive capacity Mental: Mind Emotional-psychological Social • Formative Phase: – Attitudes – Behaviours Heterogeneous groups and circumstances with variable needs: – Boys and girls – Urban and rural – In school and out of school – Unmarried and married: Pregnant and mothers – At home and homeless (on streets) – In employment (formal and informal 43 70 64.9 Early Marriage and childbearing 60 47.4 50 40.7 40 25.8 30 22 20 19.6 18.9 THA TLS Per cent married by Age 18 among adolescents (15-19 yrs) 11.8 10 3.9 0 BAN BHU IND INO MAV NEP SRL 45 41.5 40 35 30 25 20 25.3 19.7 18.2 14.4 15 11.8 9.6 10 7.6 7.1 5.9 5.1 17.6 5 0 Bangladesh India Indonesia Highest Quintile Proportion of adolescents who have begun childbearing Nepal Sri Lanka Timor Leste Lowest Quintile Poor women aged 15-19 are more likely to begin child bearing early Source: Bangladesh DHS 2007; India NFHS-3 2005-06; Indonesia DHS 2007; Nepal DHS 2006; Sri Lanka DHS 2005WHO-SEARO 44 06; Timor-Leste DHS 2003 Adolescent Pregnancy: Higher Child Mortality NMR 60 54 80 51 50 45 60 40 30 34 30 26 76 1.5 x 57 35 50 32 26 25 1.6 x 34 2x 14 13 64 58 56 1.8 x 23 19 20 20 10 69 64 32 29 30 16 74 50 40 22 2x 20 82 70 43 34 IMR 90 10 0 0 BAN IND INO MAV MMR NEP <20 20-29 SRL TLS BAN IND INO MAV MMR NEP <20 SRL TLS 20-29 Source: Bangladesh DHS 2011; India NFHS3 2005-06; Indonesia DHS 2007; Maldives DHS 2009; Myanmar FRHS 2007; Nepal DHS 2011; Sri Lanka DHS 2006-07; Timor-Leste DHS 2009-10WHO-SEARO 47 Large number are under-nourished and anaemic BMI Anaemia 80 80 71 70 65 64 60 53 51 50 60 52 47 50 49 25 24 24 26 30 22 20 15 11 8 3 2 IND <18.5 MAV NEP 18.5-24.5 SRL 20 10 0 BAN 39 40 33 10 56 40 40 30 70 TLS 0 BAN IND NEP TLS ≥25 WHO-SEARO 48 Source: Bangladesh DHS 2011; India NFHS3 2005-06; Nepal DHS 2011; Sri Lanka DHS 2006; Maldives DHS 2009; Timor-Leste DHS 2009-10 Dietary behaviors, Overweight & Obesity (13-15 years) 20 Percentage 15 10.8 9.9 10 9 5.8 5 3.5 6.5 5.1 2.1 1.8 4.5 4.2 2.6 2.5 0.7 0.5 0 IND INO MMR SRL THA Who went hungry most of the time during the past 30 days because there was not enough food in their home Who are overweight Who are obese Source: Latest Global school-based student health survey (GSHS) WHO-SEARO 49 Early Tobacco use among adolescents (13-15 years) 70 57 Total Male 60 53 Female 50 Percentage 41 28 30 10 23 19 7 5 BAN (2007) BHU (2009) 15 15 8 IND (2009) 6 16 15 11 7 24 20 19 12 9 25 23 8 INO (2009) MAV (2011) MMR (2011) NEP (2011) 16 16 11 5 SRL (2011) 8 THA (2011) TLS (2009) -10 Source: Latest Global Youth Tobacco Survey (GYTS) WHO-SEARO 50 Early Alcohol Consumption(13-15 years) 25 19.8 20 Percentage 15.6 15 9.9 10 5 4.9 2.6 2.7 1.9 4.4 4 0.8 1.4 0 INO MAV MMR THA Who had at least one drink containing alcohol during the past 30 days who drank so much alcohol that they were really drunk one or more times during their life who had a hang-over, felt sick, got into trouble with family or friends, missed school, or got into fights one or more times with family or friends, missed school, or got into fights one or more times as a result of drinking alcohol during their life Source: Latest Global school-based student health survey (GSHS) WHO-SEARO 51 High Unintentional Injuries and Violence(13-15 Years) 60 50 Percentage 50 40 48 47.1 45.9 40 39.8 33.7 37.9 37.2 36.9 30.4 32.9 34.1 27.2 27 30 20.8 20 46.8 19.4 14.6 10 0 INO MAV MMR SRL THA Who were physically attacked ≥1x during the past 12 months Who were in a physically fight ≥1x during the past 12 months Who were seriously injured ≥1x during the past 12 months Who were bullied on ≥1 days during the past 30 days Source: Latest Global school-based student health survey (GSHS) WHO-SEARO 52 Mental Health Problems ( 13-15 Years) 25 20 Percentage 17.2 15 10 10.1 8.4 9.9 9.6 8.7 8.1 8.5 7.6 5.6 5 4 3.8 1.4 3.6 3.5 0.7 0 IND INO MAV MMR SRL THA who felt lonely most of the time or always during the past 12 months who ever seriously considered attempting suicide during the past 12 months who have no close friends WHO-SEARO Source: Latest Global school-based student health survey (GSHS) 53 Public Health Issues with Adolescents • Nutrition Issues: – Undernutrition, Anemia, Overnutrition • Sexual And reproductive health: – – – – Early sex: unsafe Coerced sex Early marriage and child bearing STI, HIV • Mental Health: Anxiety, stress, depression, suicide • Tobacco and alcohol use • Injury and accidents • Violence: Victims and perpetrators Health Sector needs to collaborate with other sectors WHO-SEARO 54 “Home” for adolescents in health services ? Maternal and reproductive health services Disease Treatment for all Newborn and child health services Health Sector Response to improve Adolescent Health - - The “4 S framework” Collect Strategic Information Strengthen Health services For Adolescents Supportive Evidencebased Policies Support to & synergy with other sectors to ensure community support and improve demand for health services use by adolescents 56 Progress so far • Regional Strategy and National strategies (9 countries) • Country Fact sheets on AHD and Adolescent pregnancy • National Standards and implementation guidelines on AFHS (9 countries) • Training packages adapted, HWs trained (8 countries) • Quality and coverage assessments (6 countries) • Regional Program management capacity building course • Collaboration with other sectors education 57 Package of AH services: Range in SEAR Countries • • • • • • • • • Physical & mental health promotion Nutrition and micronutrients STI/RTI: Screen and manage HIV/AIDS prevention, testing Contraception, condom promotion Pregnancy and childbirth care Substance use prevention Healthy Lifestyles promotion Immunization 58 Coverage assessment: Utilization Received IFA Tabs in Last Six Month August 2013 WHO-SEARO Haryana, India 59 Adolescent Health Programme in SEAR Adolescent Health Programme being scaled up in SEAR Countries Focus has been on Sexual and Reproductive Health Opportunity to add elements of PreConception Care Package – Healthy Transitions Package August 2013 WHO-SEARO 60 We know that specific interventions are effective and can be delivered to Adolescents Evidence-based preventive and curative health interventions for adolescents Existing delivery mechanisms that could be used to deliver interventions at scale Provide age-appropriate sexual health education Delay pregnancy Provide contraceptive services including condoms Prevent, screen and manage STIs, HIV Provide Iron folic acid Immunization Prevention of Substance use Prevent NCD risk behaviours • • • School health program Nutrition program Youth programs AFHS HIV testing and counselling clinics NCD programmes Mental Health programmes “Healthy Transitions for Adolescents” package WHO-SEARO 61 ‘Healthy Transitions for adolescents’ Ensuring health across life-course • Healthy adolescence • Healthy reproductive health outcomes – Reduction in prevalence of prematurity, LBW, Birth Defects – Reduction in maternal, foetal, neonatal and child mortality • Healthy adulthood (long term) – NCD prevention – Reduction in Tobacco and harmful use of alcohol related problems and cost – STIs and HIV prevention WHO-SEARO 62 Existing Opportunities in Public Health Programmes Where Intervention / package Service type Health Facilities •RH Services •AFHS •Immunization programmes •Add preconception-related interventions •Integrate essential components of Pre-marital counseling and genetic screening •Expanded post-natal care (facility visits) • Healthy Lifestyles: NCD prevention Schools •School Health Programme •Health Promoting Schools •Integrate essential components of Pre-marital counseling •Nutrition and micronutrient supplementation •Healthy Lifestyles: NCD prevention Out Reach •Community support groups & delivery platforms •Mass media campaigns/ Social marketing •Information technology, (mHealth) •Expanded post-natal care (home visits) •Pre-marital counseling •Healthy Lifestyles: NCD prevention •Optimizing Adolescent and prepregnancy nutrition WHO-SEARO 63 Existing Opportunities in Public Health Programmes Where Intervention / package Service type Health Facilities •RH Services •AFHS •Immunization programmes •Add preconception-related interventions •Integrate essential components of Pre-marital counseling and genetic screening •Expanded post-natal care (facility visits) • Healthy Lifestyles: NCD prevention Schools •School Health Programme •Health Promoting Schools •Integrate essential components of Pre-marital counseling •Nutrition and micronutrient supplementation •Healthy Lifestyles: NCD prevention Out Reach •Community support groups & delivery platforms •Mass media campaigns/ Social marketing •Information technology, (mHealth) •Expanded post-natal care (home visits) •Pre-marital counseling •Healthy Lifestyles: NCD prevention •Optimizing Adolescent and prepregnancy nutrition WHO-SEARO 64 Preconception care in SEAR: 2 Tracks Maternal Health WHO-SEARO 10-19 AFHS Infancy U5 CH Immunization Birth Newborn Care Neonatal period SBA ANC PCC Pre-Pregnancy Pregnancy Healthy Transitions for adolescents 65 6. Way forward and challenges WHO-SEARO 66 Regional expert Group Consultation on PreConception Care: Aug 2013 WHO-SEARO and CDC-US • PCC package would address maternal mortality, neonatal morality, pregnancy wastage, birth defects, pre term births and intrauterine growth retardation. • The selected interventions would need to be implemented through integration and convergence within the health system as well as in other sectors. • Optimize on established programmes such as Maternal, Reproductive ,Newborn and Child Health and adolescent health programmes as well as the programmes like Birth Defects prevention and Non Communicable Diseases. • Expanding interventions to adolescent boys and girls would ensure better RH outcomes as well as healthy adulthood in the long term. WHO-SEARO 67 Opportunities • Global commitments and partnerships for MDG 4 and 5 – Health agenda beyond 2015 • Enhanced commitment of national governments for AH programme and earmarking of domestic resources • Better understanding of adolescent brain • Newborn and child health plans, RH plans at Global, regional and national level. • New technology: Information and communication technology (internet,Mobile phones,Social media) to connect with young people and gatekeepers • New initiatives: Newborn health, Preterm births, RH ,Birth defects prevention, Pre-conception, HPV, NCD prevention • Need for demonstration projects August 2013 WHO-SEARO 68 Every Journey begins with a single step, But you will never finish if you don’t start! miles to go… 13 Dec 2011 Regional Meeting on Birth Defects, New Delhi 71