Auburn University MRI Research
Center
Facility Overview
● Three story – 45,000 SF building
● MRI systems
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3 Tesla (T) open-bore whole body
7T whole body
● Designed to support research and clinical
operations
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Animal facilities
Short-term holding facility
Minimally-invasive procedures area
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Training for faculty/staff/students
● Funded by a $21M State bond issued in 2007
Auburn University Objectives
● Increase AU research funding
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Establish AU as a leader in MRI research
Enhance AU’s reputation as a major research
university
Attract businesses/industries to the AU
Research Park
● Provide additional healthcare capabilities
for the region
AU MRI Research Center
● Partnership between
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Auburn University
Siemens Healthcare
East Alabama Medical Center
Alabama Imaging Inc.
University of Alabama at Birmingham (UAB)
International
Central South University (China)
Siemens Corporate Technology (China)
Auburn Research Park
First Floor
Second Floor
USAARL
AU Research
The Orthopaedic Clinic
Third Floor
Rehab Works – EAMC
AU Kinesiology
Auburn Neurosurgery
Proposed Operating Scenario
● EAMC/AI controls 3T and clinical area
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8 hours/day (8AM-4PM) Mon-Fri
Lease at market value
● AU controls 3T
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16 hours/day (4PM-8AM) Mon-Fri
24 hours/day Sat, Sun, holidays
● 7T is research only
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AU control 24/7
Timeline
● June ‘09 – Order equipment
● July ‘09 – Building design
● July ‘09 – Begin seminar series
● Jan ‘10 – Begin construction
● Summer ‘10 – Begin training
● Sept ‘10 – Construction complete
● Oct ‘10 – 3T/7T install
● Oct ‘10 – Begin 3T operations
● Spring ‘11 – Begin 7T operations
Current and Potential
Research Projects
● Coil design & Manufacture
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Technology commercialization
Wireless technology
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Auburn Athletics / Andrews Orthopedics
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Autism
Psychology / Human Sciences
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● Orthopedic Injury/Rehab
● fMRI/Cognitive Neuroscience
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● Communication Disorders
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Audiology
Speech Pathology
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UAB collaboration (NIH)
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Diabetes and obesity
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MRS/MRSI
Alzheimer’s disease (NIH)
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● Advanced cardiac imaging
● Fat Imaging
● Metabolic/Molecular imaging
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3T Open-Bore MRI
● FDA certified for
clinical use
● 70 cm bore
● 173 cm length
3T Open-Bore MRI
Standard Applications
● Neurology
● Angiography
● Cardiac
● Body
● Oncology
● Orthopedic
● Pediactric
● Scientific
Spine Imaging at 3T
● 4-channel neck coil
● 24-channel spine coil
Axially-Loaded Lumbar Spine MRI
Advanced Applications - DESS
● Increased cartilage/fluid contrast
Advanced Neuro Applications
● fMRI acquisition/analysis
● Diffusion
● Perfusion
● BOLD Imaging
● Advanced Functional
Neuro
InVivo Esys fMRI System
7T MRI
MAGNETOM UHF Community (22 sites):
1.
Massachusetts General Hospital, Boston, USA
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2.
3.
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former GE system converted to Siemens
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Imaging since 05/2007
Imaging since 11/2006
Max Plank Institute, Tübingen, Germany (9.4T)
Imaging since 07/2007
CEA, Paris, France
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11.
Imaging since 09/2006
Center for Imaging in Biomedicine, Lausanne, Switzerland
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10.
First images 12/06
Erwin Hahn Institute for Magnetic Resonance, Essen, Germany
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9.
Imaging since 04/2006
Oregon Health, Portland, USA
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8.
Imaging with Siemens console since 12/2005
Gachon Medical School, Seoul, Korea
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7.
Imaging since 03/2005
Center for MR Research, Minneapolis, USA
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6.
Imaging since 02/2005
New York University, NYC, USA
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5.
12. UPMC, Pittsburgh, USA
Institute for Neuro-Biology, Magdeburg, Germany
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4.
Imaging since 08/2002
Imaging since 02/2007
CEA, Paris, France, 11.7T
13. Max Plank Institute, Leipzig, Germany
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Imaging since 07/2007
14. Medical University of Vienna, Vienna, Austria
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Imaging since 04/2008
15. DKFZ, Heidelberg, Germany
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Imaging since 08/2008
16. Forschungszentrum Jülich, Germany (9.4T/900)
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Imaging since
17. HUP, Philadelphia, PA, USA
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Imaging since 06/2008
18. MDC, Berlin, Germany
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Imaging since 12/2008
19. CAS, Beijing, China
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To be installed in Fall 2009
20. Oxford University, Oxford, UK
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To be installed in spring 2010
21. Auburn University, Auburn, Alabama, USA
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To be installed Fall 2010
22. CMRR, Minneapolis, USA
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To be installed in fall 2010
Other Siemens 7T Installations in USA
● MGH/ Harvard/ MIT
● NYU
● Penn
● Minnesota
● Portland, Oregon
● Pittsburgh
High-Field Imaging
T2-weighted imaging of the human hippocampus
1.5T
7.0T
Functional MRI (fMRI)
fMRI at 1.5T, 3.0T, 7.0T
Van der Zwaag, et al, Neuroimage. 2009 May 14
fMRI at 1.5T, 3.0T, 7.0T
Van der Zwaag, et al, Neuroimage. 2009 May 14
7.0T
1.5T
Behr, et al, Skeletal Radiol. 2009 Sep;38(9):911-7
7.0T
1.5T
Behr, et al, Skeletal Radiol. 2009 Sep;38(9):911-7
Spatial Resolution
3T
7T
fMRI BOLD
3.0 / 2.5 mm6
0.5 / 3.0 mm3
Brain
0.5 / 1.0 mm7
1.0 / 1.0 mm7
0.05 / 2.0 mm4
0.7 / 0.7 mm5
Musculoskeletal
0.30 / 2.0 mm2
0.15 / 1.0 mm1
1.
2.
3.
4.
5.
6.
7.
Regatte, et al, JMRI Vol.25, 2 Pages: 262-269
Kuhl, et al, Radiology. 2008 Apr;247(1):16-35
Yacob, et al, Neuroimage. 2007 October 1; 37(4): 1161–1177
Nakada, Brain and Development ,29 (6), July 2007, 325-335
Thomas, et al, JMRI 2008 November; 28(5): 1266–1272
Miller, et al, J Neurophysiol 99:1969-1982, 2008
Wiggins, et al, Magn Reson Med, 56(1), 216-223, 2006
Spectroscopy
● Proton spectroscopy (3T and 7T)
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Single voxel
Chemical shift imaging
● Multinuclear spectroscopy (7T only)
■ 7Li, 13C, 17O, 19F, 23Na, 31P
MRI - Coils
Small Rodent MRI
Small Animal MRI
Fat Imaging
Fat Detection & Quantification