Cell Development II
BKA
Cell Social Media
Cell Signaling and Disease
Models
Group Members
• Nishi Bryska, UNC Charlotte
• Sharon Bullock, UNC Charlotte
• Katie Crump, VCU-IRACDA
• Teshell Greene, VCU-IRACDA
• Derek Kendig, VCU-IRACDA
• Michelle Pass, UNC Charlotte
Facilitator: Suann Yang, Presbyterian College
Context of the Teachable Unit
• General biology major’s class (cell biology
section)
• Target class size is 60 students, with 10
working groups of 6 students each
• Co-requisite coursework: general chemistry
• A one semester course, 2 lectures at end of
the semester.
• 5 hours class time total, 10 hours out of class
time.
Learning Goals
Students should understand
1. How a signal is transduced, relayed, and
amplified to lead to a biological response.
2. The regulation and termination of a
biological signal and response in normal and
diseased states.
3. How cell signaling regulates homeostasis.
Tidbit Objectives
Students should be able to:
1. Describe how a message is communicated.
2. Diagram a signaling pathway.
3. Predict how disturbing the components of
the pathway will affect cell signaling
response.
Prior Knowledge Gained
• Cell signaling terms
– Protein-protein interactions
– Receptor
– Ligand and how it interacts with receptors
– Signal relay and response
• Cell membranes are selectively permeable
• Extracellular signals elicit cellular responses
• Basics of regulation
Generic Signal Pathway
Signal
Mom
Receiver
Response
Relay/
Transducer
Group Work (4 mins)
Diagram a Signaling Model Using The Shapes Provided
-Take shapes out of the envelope
-Use shapes to model the pathway
Extracellular
Fluid
Response
Cytosol
Group Work (4 mins)
Diagram a Signaling Model Using The Shapes Provided
-Take shapes out of the envelope
-Use shapes to model the pathway
Hint:
Orange = same type of molecule
Extracellular
Fluid
Response
Cytosol
Real World Scenario
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Poll: Do you know someone with diabetes?
Diversity of People with Diabetes
Clinical Scenario
In diabetes the response of one important
pathway is to transport glucose from the
extracellular fluid (ECF)/blood into the
cytosol of cells.
This pathway becomes disrupted as part of
diabetes.
Extracellular
Fluid
Cytosol
Insulin
Insulin
Receptor
Sugar
Extracellular
Fluid
Insulin
Insulin
Receptor
Response
Cytosol
Sugar
Extracellular
Fluid
Insulin
Insulin
Receptor
Response
Cytosol
Sugar
Extracellular
Fluid
Insulin
Insulin
Receptor
Response
Cytosol
Sugar
Extracellular
Fluid
Insulin
Insulin
Receptor
Sugar
Sugar
Sugar
Response
Cytosol
Extracellular
Fluid
Insulin
Insulin
Receptor
Response
Cytosol
Sugar
Extracellular
Fluid
Insulin
Insulin
Receptor
Sugar
Sugar
Sugar
Response
Cytosol
Type II Diabetes
The process of glucose accumulation in the
extracellular fluid or blood is due to insulin
resistance (inactivation of receptor)
Glucose level
Acknowledgements
HHMI SI and Dr. Kathrin Stanger-Hall
Suann Yang
Cell Development I (Group 1)
Evolution Group (Group 4)
Dean of the College of Arts & Sciences at UNC
Charlotte
Dr. Nichols-Casebolt at VCU and the Office of
Research