General Outcomes Study Main Purpose Research Design Sample Outcome Measures Results Cross-sectional with patients matched to non-injured, healthy controls on age, sex, and education. 49 adult patients in burn sample. 82% male. Mean TBSA 35%. Mean 64 months post-burn. Symptom Checklist90-Revised (SCL-90R). Short Form Health Survey (SF-36). 22% of burn patients with Diagnostic T-score ≥ 63 on General Severity Index of SCL-90 as compared to 12% of controls. On the SF-36, burn patients scored lower on all 8 subscales, suggesting poorer health (none significant, likely due to small sample size). IV 110 adult patients at 2 months, 97 (88% follow-up) at 6 months, 69 (63% follow-up) at 12 months. Mean TBSA 24%. Burn Specific Health Scale (BSHS), Brief Symptom Inventory (BSI), Functional Assessment Screening Questionnaire, Functional Independence Measure, Pain VAS, Community Integration Questionnaire (CIQ), Satisfaction With Life Scale. BSHS subscale scores physical domain improved significantly from 2 – 6 months, then stabilized, the BSHS total, general, social and psychological domain scores did not change over time. II Altier, 2002329 To assess psychological functioning and quality of life in burned patients as compared to unburned matched subjects. Cromes, 2002350 To examine Prospective cohort. the quality of life during the 1st year after burn injury and identify predictors. Study Level of Category Evidence Prognostic Daltroy, 2000338 To evaluate the reliability and validity of the Burns Outcomes Questionnaire (BOQ) for children and adolescents. Cross-sectional. Parents filled out measure for all children. Children 11 or older also filled out questionnaire as self-report. Parents of 186 pediatric patients ages 5 to 18 from 8 burn clinics. 71% male. Mean TBSA 22%. Mean age 10. 86 adolescents also completed the measure. No data on time since burn. BOQ Social and Behavioral Domains (12 total subscales of 2 to 7 items each), Child Health Questionnaire. Internal reliability of parent Diagnostic report subscales was good Prognostic (.86 to .88), for child adequate to good (.76 to.92). Convergent validity between parent and adolescent scores on subscales moderate (.42 to .73). Subscale testretest reliability over 2 days ranged from .70 to .90. Moderate levels of convergent validity evidence for most subscales, although not all, and Child Health Questionnaire subscales. TBSA and # days since discharge significantly correlated with 2 of 4 parent-related social and behavioral subscales (family disruption, parental concern), but not compliance and school reentry. IV Fauerbach, 1999330 To examine the impact of in-hospital symptoms of posttraumatic stress on health-related quality of life at 2 months postdischarge. Prospective cohort. 86 adult patients. 78% male. Mean TBSA 17%. Davidson Trauma Scale, Beck Depression Inventory, Satisfaction with Appearance Scale, Life Orientation Test, SF-36 Health Survey. Traumatic stress Prognostic symptoms at baseline significantly predicted both physical function and psychosocial domains of SF-36 at 2 months after controlling for baseline levels. IV Fauerbach, 2000331 To examine Prospective cohort. the impact of in-hospital symptoms of body image dissatisfaction on healthrelated quality of life at 2 months postdischarge. 86 adult patients. 78% male. Mean TBSA 17%. Davidson Trauma Scale, Beck Depression Inventory, Satisfaction with Appearance Scale, Life Orientation Test, Short Form Health Survey (SF-36). Traumatic stress Prognostic symptoms at baseline significantly predicted both physical function and psychosocial domains of SF-36 at 2 months after controlling for baseline levels. IV Gorga, 1999339 To examine the impact of burn injury on physical, functional, and developmental abilities. Prospective, longitudinal, cohort study of pediatric patients from a single US burn center. 51 pediatric patients. 61% male. Mean TBSA 6%. Vancouver Scar Scale, Goniometric Range of Motion (ROM), Vineland Adaptive Behavior Scales, Denver II (D2) subscales for Home Screening Test, Peabody Developmental Motor Skills (PDMS). Mean scar scores for most Diagnostic body areas increased from 1 month to 6 months, and then dropped at 12 months. The majority of patients displayed “normal” ROM in activities at 1, 6, and 12 month follow-up. Significant improvement was observed in fine and gross motor abilities from 1-month to 12- month follow-up on the PDMS. D2 summary scores indicated that 38%, 47% and 44% had possible developmental delays at 1, 6, and 12 month followups, respectively. IV Kazis, 2002344 To develop a health outcomes questionnaire for use with young children. Cross-sectional, repeated measures, scale development. 184 pediatric The Health Outcomes burn patients Burn Questionnaire for from 8 burn Infants and Children centers. 72% follow-up rate at 6- months. The questionnaire Diagnostic subscales demonstrated adequate internal consistency reliability ranging from α = .74 - .94. Test-retest reliability ranged widely from α = .35 - .84. Factor analysis yielded 10 distinct factors. Evidence was provided for adequate criterion-related validity. IV Kent, 2000340 Prospective, longitudinal, casecontrol study of pediatric patients with burns and 3 control groups. 40 pediatric burn Child Behavior patients. 55% Checklist (CBCL) male. Mean TBSA 9%. 83% follow-up rate at 6- months. There were no significant Diagnostic psychological or behavioral differences reported by parents of children with visible (n = 17) vs. non-visible (n = 16) burn scars. IV Cross-sectional. 248 adult patients from Swedish burn centers. 80% male. Mean TBSA 23%. Burn Specific Health Scale – Abbreviated (BSHS-A). Factor analysis supported Diagnostic a nine-factor structure (heat sensitivity, affect, hand function, treatment regimens, work, sexuality, interpersonal relationships, simple abilities, body image. Adequate to good internal consistency reliabilities. III Kildal, 2002337 To test three Cross-sectional. versions of the Burn Specific Health Scale. 248 adult patients from Swedish burn centers. 80% male. Mean TBSA 23%. Abbreviated version (80 item BSHS-A), Revised version (31 item BSHS-R), Brief version (BSHS-B). III Landolt, 2002342 To identify predictors of psychological adjustment in pediatric burn survivors. 105 parents of pediatric burn patients. 65% male. Mean TBSA 18%. Correlations between three Diagnostic instruments’ total scores ranged from .81 (A & R) to .86 (A & B) to .98 (R & B). Great deal of overlap between scales (not entirely specified). Child Behavior Based on parent ratings, in Diagnostic, Checklist (CBCL), comparison to normative Prognostic Questionnaire for data, pediatric burn Child Health-Related survivors experienced Quality of Life – Parent significantly fewer positive Form (CH-QOL). emotions, but did not differ on physical symptoms, autonomy, cognitive functioning, or, social functioning. Kildal, 2001336 To examine psychological and behavioral outcomes of accidental burn injury among children. To derive a 40-item Burn Specific Health ScaleBrief (BSHSB). Cross-sectional survey of parents of pediatric burn patients 1-13 years post-burn from a single burn center in Switzerland. IV Landolt, 2000341 To investigate predictors of psychological adjustment in pediatric burn survivors with and without face/head/ neck region burns. Litlere Moi, 2003332 Meyer, 2000313 Cross-sectional survey study of a cohort of parents of patients 1-13 years post-burn from a single Swiss burn center. 104 parents of pediatric burn patients. With head burns: n = 27, 74% male, Mean TBSA 25%. Without Head Burns: n = 77, 62% male, Mean TBSA 16%. Child Behavior Checklist (CBCL). Parent reported CBCL summary scores did not differ significantly for pediatric patients with vs. without face/head/neck region burns. Prognostic IV To evaluate Cross-sectional. the reliability and validity of a translation of the Abbreviated Burn Specific Health Scale. 95 adult patients. 82% male. Mean TBSA 19%. Mean 47 months post-burn. 80-item Norwegian Burn Specific Health Scale (N-BSHS), Short Form Health Survey (SF-36). Internal consistency reliability α ≥ .86 for all subscale except sexual (.77). Strong convergent validity with SF-36 subscales (.61 to .81) and test reliability (.80 to .95) across subscales. Diagnosis IV To assess the behavioral adjustment of pediatric burn patients relative to a non-clinical, normative sample of similar age children. 33 pediatric patients. 58% male. Mean TBSA 50%. Child Behavior Checklist (CBCL). Children with burns, relative to data from a CBCL normative sample, were rated higher by their mothers on the internalizing, but not the externalizing, summary scale. The patient group scored significantly higher on the behavioral subscales of social withdrawal, depression, sleep problems, and somatic complaints. Diagnostic IV Cross-sectional follow-up survey of a “stratified, random sampling of acute burn admissions” to a burn center. Meyer, 2004343 To assess the behavioral and social adjustment of young adults who were burned as children relative to a non-clinical, normative sample of similar age peers. Cross-sectional follow-up of a cohort of adult survivors of pediatric burn injuries treated at a single burn center. 101 adult Young Adult Selfsurvivors of Report (YASR). pediatric burn. 57% male. Mean TBSA 54%. Mean time since burn 14 years. In comparison to a Diagnostic normative sample, young adult males who were burned as children were within the non-clinical range on the YASR. Young adult females who had been burned as children reported significantly more total problems and externalizing concerns. 33% of young women reported psychosocial concerns, and 25% reported continued physical concerns. IV Patterson, 2000333 To compare distress and satisfaction with life with general population norms and to test medical and psychological predictors. Prospective cohort. 295 adult patients. 82% male. Mean TBSA 18%. Only included subjects with baseline and 6 month data. No report of followup rates. Burn patients significantly Diagnostic lower life satisfaction than Prognostic norms at discharge and 6months postburn on SWL. SWL decreased from baseline to 6 months, but small effect size, predicted by marriage status, premorbid psych treatment, length of stay in ICU, amputation. Also significantly higher BSIGSI than norms at both time points, decreased from baseline to 6 months, predicted by psych treatment, alcohol use, pulmonary complications. IV Satisfaction With Life Scale (SWL). Brief Symptom Inventory, Global Severity Index: (BSI-GSI). Sheridan, 2000345 To investigate the long term quality of life in patients who, as children, survived massive burns. Walker, 2003335 Williams, 2003334 Retrospective, cross-sectional follow-up of a cohort of adult survivors of pediatric burn injuries treated at a single burn center. 60 adult burn SF-36 Health Survey. survivors who were burned as children. 69% male. Mean TBSA 82%. Mean time since burn 15 years. Median SF-36 domain Diagnostic scores were generally Prognostic similar between burn patients and scale norms. 15% and 20% of burn patients, however, were >2 standard deviations below the mean for physical functioning and physical role. Craig Handicap Burn patients had highest Diagnostic Assessment Reporting overall participation rates. Technique (CHART). Strong test-retest Functional intraclass correlations for Independence total score and all six Measure (FIM). subscales for burn patients and combined sample, good convergent validity with the FIM. IV To assess the Cross-sectional. efficacy, across a range of disability groups, of the Craig Handicap Assessment and Reporting Technique, a measure of societal participation. 1,110 total communitybased patients (SCI, TBI, MS, stroke, burn, amputation). 70 burn patients. IV To compare Prospective cohort. health outcomes of burn survivors with general population and medical / surgical samples. 304 adult Sickness Impact patients. Profile (SIP). 81% male. Mean TBSA 14%. 1month follow-up rate 78%, 1-year follow-up rate 60%, 2-year follow-up rate 39%. The Mean total SIP scores Diagnostic were improved across Prognostic each time period. Both baseline TBSA and length of stay in hospital predicted total SIP scores, as well as Physical and Psychosocial composites. IV