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Course Name: Blood, Hematopoiesis, Lymphatics
Semester(s) Offered:
Spring
Class Hours:
M – F, 8:00-12:00
Class Location: WLH
Instructors:
Robert H. Broyles, PhD
Joan Parkhurst Cain, MD (requested)
Office:
BMSB 827
TCH 3B3308
Telephone:
271-2227X61213
271-5311
Email:
robert-broyles@ouhsc.edu
joan-cain@ouhsc.ed
Office Hours:
TBD
TBD
Course Description:
o This 6-week course introduces students to clinically relevant aspects of the blood and lymphatics
systems and, through the study of hematopoiesis, how these systems are developed and
maintained from embryology to old age. Specific emphasis is on disease states and how these
reveal basic system characteristics useful in diagnosis, research, and treatments.
Prerequisite(s)
o Satisfactory completion of MS I courses in Molecular and Cellular Systems; The Human Structure;
and Disease, Diagnosis, and Therapy, or evidence of equivalent education and training.
Learning Objectives
A. Stem cells
1. To understand the definition and embryonic origins of stem cells.
2. To understand hierarchies of stem cells, in terms of pluripotentiality.
3. To understand the developmental changes which occur in hematopoietic stem cells.
4. To understand factors which stimulate and regulate differentiation of hematopoietic stem
cells.
B. Anemias and hemoglobinopathies
1. To understand the genetic origins of sickle cell and hemoglobinopathies in general.
C. To understand the genetic origins of the thalassemias and how they differ from the
general hemoglobinopathies such as sickle cell disease.
2. To understand current clinical approaches to treating sickle cell and thalassemias.
C. To understand current research directions and proposed new treatments for this class of
diseases.
C. Malignancies of hematopoietic cells
1. To understand the role of stem cells and progenitor cells in malignancies.
2. To understand the concepts of “differentiated” versus “undifferentiated” cancer cells.
3. To understand the different approaches to treating hematopietic malignancies:
a. Chemotherapy
b. Cell-replacement therapy (bone marrow or stem cell transplants)
D. Immunity
1. To understand innate versus acquired immunity.
2. To understand generally how immunity is expressed during human development.
a. To understand the different anatomical site for differentiation of immune cells in the fetus
and in adults.
3. To understand how immunity is manipulated in therapeutic strategies.
E. Hemostasis and coagulation
1. To understand in outline form the coagulation/anti-coagulation pathway.
2. To understand the major classes of disease that affect blood coagulation.
3. To understand current therapeutic approaches to treating coagulation disorders.
F. Blood buffering
1. To be able to define pH.
2. To understand the biochemical and physiological regulation of serum pH.
3. To understand the roles and responses of blood cells to regulation of pH and blood
volume.
4. To understand in outline the principles behind regulation of blood and tissue glucose.
G. Blood-borne diseases and vectors
1. To understand what is known about the malaria life cycle, in outline.
2. To understand the relationship between malaria infection/resistance and sickle cell
disease and beta-thalassemias.
3. To be able to describe/identify other blood-borne diseases discussed in class in terms of
their class (viral, bacterial, or eucaryotic parasitic), names, and areas of prevalence.
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Conduct of the Course
o Format – The course will be taught with a combination of lectures and PBLs.
o Assigned reading – A list of reading for which students are responsible for completing is being
prepared.
o Assignments – Assignments will consist of papers or medical reports to read in preparation of
PBLs.
o Examinations – One examination will be given at the end of the course.
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Method of Evaluation and Grading
o The graded components of the course will be the Exam grade (50%), level of performance and
participation in PBLs (total of 40%), and Professionalism (10%).
o Grades will be assigned at three levels: Honors, Pass, or Fail.
Course Materials
o Required – a modern hematology text, such as Wintrobe’s Clinical Hematology, 11th edition (2003).
o Other useful references will be listed.
Course Outline
o A course outline detailing the material that will be covered is attached. A schedule of topics
covered in each class meeting (in preparation) will be included.
Academic Misconduct
o The policy regarding dishonest work is detailed in the Academic Misconduct Code:
http://www.ouhsc.edu/admissions/handbook/ A complete copy of the Academic Misconduct
Code is available on-line or in the Office of the Vice Provost for Academic Affairs.
o This Code applies to students, former students, and graduates.
Reasonable Accommodation for Disabilities
o The University of Oklahoma will reasonably accommodate otherwise qualified individuals with a
disability unless such accommodation would pose an undue hardship, result in a fundamental
alteration in the nature of the service, program or activity or cause undue financial or administrative
burdens.
o
http://www.ouhsc.edu/admissions/handbook/Reasonable_Accommodation.htm
HIPAA Statement
o Students in this course will be in contact with patients and should be knowledgeable of the HIPAA
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Privacy Regulations which establish national standards regarding uses and disclosures of
protected health information.
Visit http://www.ouhsc.edu/hippa/
Participating faculty:
Robert H. Broyles, PhD
Joan B. Cain, MD
Paul DeAngelis, PhD
Charles Esmon, PhD
William Meyer, MD
George Selby, MD
Bill Kern, MD
Drs. Cain, Meyer, Selby
Course Co-Director, Biochemistry & Molecular Biology
Course Co-Director, Pediatrics, Hematology/Oncology
Biochemistry & Molecular Biology
OMRF/ Biochemistry & Molecular Biology (not confirmed)
Pediatrics, Hematology/Oncology (not confirmed)
Medicine, Hematology/Oncology (not confirmed)
Pathology (not confirmed)
PBL panels
Blood, Hematopoiesis, Lymphatics
Robert H. Broyles, Ph.D.
Professor, COM
Outline by Topics
I. Hematopoiesis
A. Stem cells
B. Blood cell lineages and functions
C. Developmental changes in hematopoiesis
1. Red blood cells
2. Hematopoietic organs
3. Lymphopoiesis
D. Anemias and hemoglobinopathies
E. Malignancies of hematopoietic cells
F. Cell replacement/enhancement strategies: hematinics, transfusions (whole
blood, cellular elements, plasma), bone marrow & cord blood transplants,
other stem cell sources
II. Immunity
A. Changes during development
B. Anatomy of the immune system
1. Thymus
2. Lymphatics
3. Cell types & functions
C. Immunotherapies and immonosuppressants
III. Hemostasis and coagulation
A. Cells, molecules, and functions
B. Coagulation and anti-coagulants
C. Diseases and current therapies
IV. Blood buffering
A. Serum pH, bicarbonate, CO2
B. Cellular components
1. Red blood cell carbonic anhydrase,
hemoglobin, and molecular exchanges
2. Other cell types, regulation of blood volume
C. Molecular constitutes and their regulation
1. Blood glucose
2. Lipids
3. Other constituents
V. Blood-borne diseases and vectors
A. Viral (mononucleosis, CMV, HTLV, yellow fever, Dengue)
B. Bacterial (septic shock, Brucellosis, plague, Tularemia)
C. Eukaryotic parasites (malaria, trypanosomes)